|
Fusion gene ID: 31277 |
FusionGeneSummary for RING1_RING1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: RING1_RING1 | Fusion gene ID: 31277 | Hgene | Tgene | Gene symbol | RING1 | RING1 | Gene ID | 6015 | 6015 |
Gene name | ring finger protein 1 | ring finger protein 1 | |
Synonyms | RING1A|RNF1 | RING1A|RNF1 | |
Cytomap | 6p21.32 | 6p21.32 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase RING1RING-type E3 ubiquitin transferase RING1polycomb complex protein RING1really interesting new gene 1 protein | E3 ubiquitin-protein ligase RING1RING-type E3 ubiquitin transferase RING1polycomb complex protein RING1really interesting new gene 1 protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q06587 | Q06587 | |
Ensembl transtripts involved in fusion gene | ENST00000374656, ENST00000478431, ENST00000415941, ENST00000479405, ENST00000430233, ENST00000482708, ENST00000427374, ENST00000472412, ENST00000383212, ENST00000498835, ENST00000436128, ENST00000484884, | ENST00000374656, ENST00000478431, ENST00000415941, ENST00000479405, ENST00000430233, ENST00000482708, ENST00000427374, ENST00000472412, ENST00000383212, ENST00000498835, ENST00000436128, ENST00000484884, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: RING1 [Title/Abstract] AND RING1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RING1 | GO:0035518 | histone H2A monoubiquitination | 16943429 |
Hgene | RING1 | GO:0045892 | negative regulation of transcription, DNA-templated | 9199346 |
Tgene | RING1 | GO:0035518 | histone H2A monoubiquitination | 16943429 |
Tgene | RING1 | GO:0045892 | negative regulation of transcription, DNA-templated | 9199346 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF740184 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000374656 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000374656 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000374656 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000374656 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000374656 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000374656 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000374656 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000374656 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000374656 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000374656 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000374656 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000374656 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000478431 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000478431 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000478431 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000478431 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000478431 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000478431 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000478431 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000478431 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000478431 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000478431 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000478431 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000478431 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000415941 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000415941 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000415941 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000415941 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000415941 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000415941 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000415941 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000415941 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000415941 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000415941 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000415941 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000415941 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000479405 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000479405 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000479405 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000479405 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000479405 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000479405 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000479405 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000479405 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000479405 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000479405 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000479405 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000479405 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000430233 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000430233 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000430233 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000430233 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000430233 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000430233 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000430233 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000430233 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000430233 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000430233 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000430233 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000430233 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000482708 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000482708 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000482708 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000482708 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000482708 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000482708 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000482708 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000482708 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000482708 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000482708 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000482708 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000482708 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000427374 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000427374 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000427374 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000427374 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000427374 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000427374 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000427374 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000427374 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000427374 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000427374 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000427374 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000427374 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000472412 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000472412 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000472412 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000472412 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000472412 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000472412 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000472412 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000472412 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000472412 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000472412 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000472412 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000472412 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000383212 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000383212 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000383212 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000383212 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000383212 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000383212 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000383212 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000383212 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-3UTR | ENST00000383212 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-3UTR | ENST00000383212 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000383212 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000383212 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000498835 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000498835 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000498835 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000498835 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000498835 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000498835 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000498835 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000498835 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-3UTR | ENST00000498835 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-3UTR | ENST00000498835 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000498835 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
3UTR-intron | ENST00000498835 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000436128 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000436128 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000436128 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000436128 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000436128 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000436128 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000436128 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000436128 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000436128 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000436128 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000436128 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000436128 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000484884 | ENST00000374656 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000484884 | ENST00000478431 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000484884 | ENST00000415941 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000484884 | ENST00000479405 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000484884 | ENST00000430233 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000484884 | ENST00000482708 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000484884 | ENST00000427374 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000484884 | ENST00000472412 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000484884 | ENST00000383212 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-3UTR | ENST00000484884 | ENST00000498835 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000484884 | ENST00000436128 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
intron-intron | ENST00000484884 | ENST00000484884 | RING1 | chr6 | 4412429 | - | RING1 | chr6 | 4412478 | + |
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FusionProtFeatures for RING1_RING1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
RING1 | RING1 |
Constitutes one of the E3 ubiquitin-protein ligases thatmediate monoubiquitination of 'Lys-119' of histone H2A, therebyplaying a central role in histone code and gene regulation. H2A'Lys-119' ubiquitination gives a specific tag for epigenetictranscriptional repression and participates in X chromosomeinactivation of female mammals. Essential component of a Polycombgroup (PcG) multiprotein PRC1-like complex, a complex classrequired to maintain the transcriptionally repressive state ofmany genes, including Hox genes, throughout development. PcG PRC1complex acts via chromatin remodeling and modification ofhistones, rendering chromatin heritably changed in itsexpressibility. Compared to RNF2/RING2, it does not have the mainE3 ubiquitin ligase activity on histone H2A, and it may rather actas a modulator of RNF2/RING2 activity.{ECO:0000269|PubMed:16359901}. | Constitutes one of the E3 ubiquitin-protein ligases thatmediate monoubiquitination of 'Lys-119' of histone H2A, therebyplaying a central role in histone code and gene regulation. H2A'Lys-119' ubiquitination gives a specific tag for epigenetictranscriptional repression and participates in X chromosomeinactivation of female mammals. Essential component of a Polycombgroup (PcG) multiprotein PRC1-like complex, a complex classrequired to maintain the transcriptionally repressive state ofmany genes, including Hox genes, throughout development. PcG PRC1complex acts via chromatin remodeling and modification ofhistones, rendering chromatin heritably changed in itsexpressibility. Compared to RNF2/RING2, it does not have the mainE3 ubiquitin ligase activity on histone H2A, and it may rather actas a modulator of RNF2/RING2 activity.{ECO:0000269|PubMed:16359901}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RING1_RING1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RING1_RING1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RING1_RING1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RING1_RING1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |