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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 31277

FusionGeneSummary for RING1_RING1

check button Fusion gene summary
Fusion gene informationFusion gene name: RING1_RING1
Fusion gene ID: 31277
HgeneTgene
Gene symbol

RING1

RING1

Gene ID

6015

6015

Gene namering finger protein 1ring finger protein 1
SynonymsRING1A|RNF1RING1A|RNF1
Cytomap

6p21.32

6p21.32

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RING1RING-type E3 ubiquitin transferase RING1polycomb complex protein RING1really interesting new gene 1 proteinE3 ubiquitin-protein ligase RING1RING-type E3 ubiquitin transferase RING1polycomb complex protein RING1really interesting new gene 1 protein
Modification date2018052320180523
UniProtAcc

Q06587

Q06587

Ensembl transtripts involved in fusion geneENST00000374656, ENST00000478431, 
ENST00000415941, ENST00000479405, 
ENST00000430233, ENST00000482708, 
ENST00000427374, ENST00000472412, 
ENST00000383212, ENST00000498835, 
ENST00000436128, ENST00000484884, 
ENST00000374656, ENST00000478431, 
ENST00000415941, ENST00000479405, 
ENST00000430233, ENST00000482708, 
ENST00000427374, ENST00000472412, 
ENST00000383212, ENST00000498835, 
ENST00000436128, ENST00000484884, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: RING1 [Title/Abstract] AND RING1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRING1

GO:0035518

histone H2A monoubiquitination

16943429

HgeneRING1

GO:0045892

negative regulation of transcription, DNA-templated

9199346

TgeneRING1

GO:0035518

histone H2A monoubiquitination

16943429

TgeneRING1

GO:0045892

negative regulation of transcription, DNA-templated

9199346


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF740184RING1chr6

4412429

-RING1chr6

4412478

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000374656ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000374656ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000374656ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000374656ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000374656ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000374656ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000374656ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000374656ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000374656ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000374656ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000374656ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000374656ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000478431ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000478431ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000478431ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000478431ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000478431ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000478431ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000478431ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000478431ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000478431ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000478431ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000478431ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000478431ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000415941ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000415941ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000415941ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000415941ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000415941ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000415941ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000415941ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000415941ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000415941ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000415941ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000415941ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000415941ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000479405ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000479405ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000479405ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000479405ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000479405ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000479405ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000479405ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000479405ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000479405ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000479405ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000479405ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000479405ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000430233ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000430233ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000430233ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000430233ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000430233ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000430233ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000430233ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000430233ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000430233ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000430233ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000430233ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000430233ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000482708ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000482708ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000482708ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000482708ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000482708ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000482708ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000482708ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000482708ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000482708ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000482708ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000482708ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000482708ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000427374ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000427374ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000427374ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000427374ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000427374ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000427374ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000427374ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000427374ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000427374ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000427374ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000427374ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000427374ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000472412ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000472412ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000472412ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000472412ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000472412ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000472412ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000472412ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000472412ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000472412ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000472412ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000472412ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000472412ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000383212ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000383212ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000383212ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000383212ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000383212ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000383212ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000383212ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000383212ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-3UTRENST00000383212ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-3UTRENST00000383212ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000383212ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000383212ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000498835ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000498835ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000498835ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000498835ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000498835ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000498835ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000498835ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000498835ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-3UTRENST00000498835ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-3UTRENST00000498835ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000498835ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
3UTR-intronENST00000498835ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000436128ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000436128ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000436128ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000436128ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000436128ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000436128ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000436128ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000436128ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000436128ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000436128ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000436128ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000436128ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000484884ENST00000374656RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000484884ENST00000478431RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000484884ENST00000415941RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000484884ENST00000479405RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000484884ENST00000430233RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000484884ENST00000482708RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000484884ENST00000427374RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000484884ENST00000472412RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000484884ENST00000383212RING1chr6

4412429

-RING1chr6

4412478

+
intron-3UTRENST00000484884ENST00000498835RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000484884ENST00000436128RING1chr6

4412429

-RING1chr6

4412478

+
intron-intronENST00000484884ENST00000484884RING1chr6

4412429

-RING1chr6

4412478

+

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FusionProtFeatures for RING1_RING1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RING1

Q06587

RING1

Q06587

Constitutes one of the E3 ubiquitin-protein ligases thatmediate monoubiquitination of 'Lys-119' of histone H2A, therebyplaying a central role in histone code and gene regulation. H2A'Lys-119' ubiquitination gives a specific tag for epigenetictranscriptional repression and participates in X chromosomeinactivation of female mammals. Essential component of a Polycombgroup (PcG) multiprotein PRC1-like complex, a complex classrequired to maintain the transcriptionally repressive state ofmany genes, including Hox genes, throughout development. PcG PRC1complex acts via chromatin remodeling and modification ofhistones, rendering chromatin heritably changed in itsexpressibility. Compared to RNF2/RING2, it does not have the mainE3 ubiquitin ligase activity on histone H2A, and it may rather actas a modulator of RNF2/RING2 activity.{ECO:0000269|PubMed:16359901}. Constitutes one of the E3 ubiquitin-protein ligases thatmediate monoubiquitination of 'Lys-119' of histone H2A, therebyplaying a central role in histone code and gene regulation. H2A'Lys-119' ubiquitination gives a specific tag for epigenetictranscriptional repression and participates in X chromosomeinactivation of female mammals. Essential component of a Polycombgroup (PcG) multiprotein PRC1-like complex, a complex classrequired to maintain the transcriptionally repressive state ofmany genes, including Hox genes, throughout development. PcG PRC1complex acts via chromatin remodeling and modification ofhistones, rendering chromatin heritably changed in itsexpressibility. Compared to RNF2/RING2, it does not have the mainE3 ubiquitin ligase activity on histone H2A, and it may rather actas a modulator of RNF2/RING2 activity.{ECO:0000269|PubMed:16359901}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RING1_RING1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RING1_RING1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RING1_RING1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RING1_RING1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource