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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31261

FusionGeneSummary for RIMKLB_ELP3

check button Fusion gene summary
Fusion gene informationFusion gene name: RIMKLB_ELP3
Fusion gene ID: 31261
HgeneTgene
Gene symbol

RIMKLB

ELP3

Gene ID

57494

55140

Gene nameribosomal modification protein rimK like family member Belongator acetyltransferase complex subunit 3
SynonymsFAM80B|NAAGS|NAAGS-IKAT9
Cytomap

12p13.31

8p21.1

Type of geneprotein-codingprotein-coding
Descriptionbeta-citrylglutamate synthase BN-acetyl-aspartyl-glutamate synthetase BN-acetyl-aspartylglutamate synthetase BN-acetylaspartyl-glutamate synthetase BNAAG synthetase Bbeta-citryl-glutamate synthase Bfamily with sequence similarity 80, member Bribosoelongator complex protein 3elongation protein 3 homolog
Modification date2018052320180523
UniProtAcc

Q9ULI2

Q9H9T3

Ensembl transtripts involved in fusion geneENST00000535829, ENST00000357529, 
ENST00000299673, ENST00000538135, 
ENST00000521015, ENST00000256398, 
ENST00000542181, ENST00000523760, 
ENST00000524103, ENST00000537665, 
ENST00000380353, 
Fusion gene scores* DoF score7 X 6 X 6=2523 X 3 X 3=27
# samples 73
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RIMKLB [Title/Abstract] AND ELP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneELP3

GO:0006357

regulation of transcription by RNA polymerase II

11818576

TgeneELP3

GO:0043966

histone H3 acetylation

11714725

TgeneELP3

GO:0043967

histone H4 acetylation

11714725


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D3-A1Q1-06ARIMKLBchr12

8866637

+ELP3chr8

27954736

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000535829ENST00000521015RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-5UTRENST00000535829ENST00000256398RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-5UTRENST00000535829ENST00000542181RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-3UTRENST00000535829ENST00000523760RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-intronENST00000535829ENST00000524103RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-intronENST00000535829ENST00000537665RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-5UTRENST00000535829ENST00000380353RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-5UTRENST00000357529ENST00000521015RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-5UTRENST00000357529ENST00000256398RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-5UTRENST00000357529ENST00000542181RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-3UTRENST00000357529ENST00000523760RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-intronENST00000357529ENST00000524103RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-intronENST00000357529ENST00000537665RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-5UTRENST00000357529ENST00000380353RIMKLBchr12

8866637

+ELP3chr8

27954736

+
3UTR-5UTRENST00000299673ENST00000521015RIMKLBchr12

8866637

+ELP3chr8

27954736

+
3UTR-5UTRENST00000299673ENST00000256398RIMKLBchr12

8866637

+ELP3chr8

27954736

+
3UTR-5UTRENST00000299673ENST00000542181RIMKLBchr12

8866637

+ELP3chr8

27954736

+
3UTR-3UTRENST00000299673ENST00000523760RIMKLBchr12

8866637

+ELP3chr8

27954736

+
3UTR-intronENST00000299673ENST00000524103RIMKLBchr12

8866637

+ELP3chr8

27954736

+
3UTR-intronENST00000299673ENST00000537665RIMKLBchr12

8866637

+ELP3chr8

27954736

+
3UTR-5UTRENST00000299673ENST00000380353RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-5UTRENST00000538135ENST00000521015RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-5UTRENST00000538135ENST00000256398RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-5UTRENST00000538135ENST00000542181RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-3UTRENST00000538135ENST00000523760RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-intronENST00000538135ENST00000524103RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-intronENST00000538135ENST00000537665RIMKLBchr12

8866637

+ELP3chr8

27954736

+
5CDS-5UTRENST00000538135ENST00000380353RIMKLBchr12

8866637

+ELP3chr8

27954736

+

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FusionProtFeatures for RIMKLB_ELP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RIMKLB

Q9ULI2

ELP3

Q9H9T3

Catalyzes the synthesis of beta-citryl-L-glutamate andN-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate issynthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate.{ECO:0000250|UniProtKB:Q80WS1}. Catalytic histone acetyltransferase subunit of the RNApolymerase II elongator complex, which is a component of the RNApolymerase II (Pol II) holoenzyme and is involved intranscriptional elongation. Elongator may play a role in chromatinremodeling and is involved in acetylation of histones H3 andprobably H4. Involved in acetylation of alpha-tubulin(PubMed:19185337). May also have a methyltransferase activity.Involved in cell migration. Involved in neurogenesis. Regulatesthe migration and branching of projection neurons in thedeveloping cerebral cortex, through a process depending on alpha-tubulin acetylation. {ECO:0000250|UniProtKB:Q9CZX0,ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576,ECO:0000269|PubMed:15902492, ECO:0000269|PubMed:16713582,ECO:0000269|PubMed:19185337}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RIMKLB_ELP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RIMKLB_ELP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RIMKLBUBC, EGR2, XPO1ELP3IKBKAP, POLR2A, ELP2, ELP4, PCNA, HIST2H3C, HIST1H4A, CTDP1, MMS19, SNRNP200, WRNIP1, DCP2, FAM96B, CIAO1, MPG, PCGF6, PRPS1, QPCT, SKAP1, KPTN, FAM219B, IFI30, WDR36, NTRK1, FGFR1OP, PARD6A, ANLN, SMC6, IP6K3, FOXP3, PCGF1, NANOG, POU5F1, DUSP9, CAMK2D, ISOC2, SSSCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RIMKLB_ELP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RIMKLB_ELP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource