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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31204

FusionGeneSummary for RHOT1_FGFR1

check button Fusion gene summary
Fusion gene informationFusion gene name: RHOT1_FGFR1
Fusion gene ID: 31204
HgeneTgene
Gene symbol

RHOT1

FGFR1

Gene ID

55288

2260

Gene nameras homolog family member T1fibroblast growth factor receptor 1
SynonymsARHT1|MIRO-1|MIRO1BFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1
Cytomap

17q11.2

8p11.23

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial Rho GTPase 1mitochondrial Rho (MIRO) GTPase 1rac-GTP binding protein-like proteinras homolog gene family, member T1fibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgr
Modification date2018052720180527
UniProtAcc

Q8IXI2

P11362

Ensembl transtripts involved in fusion geneENST00000333942, ENST00000358365, 
ENST00000583994, ENST00000545287, 
ENST00000354266, ENST00000394692, 
ENST00000581094, ENST00000580976, 
ENST00000425967, ENST00000397091, 
ENST00000447712, ENST00000341462, 
ENST00000532791, ENST00000397113, 
ENST00000356207, ENST00000335922, 
ENST00000326324, ENST00000397103, 
ENST00000397108, ENST00000496629, 
Fusion gene scores* DoF score8 X 5 X 5=2009 X 8 X 4=288
# samples 812
** MAII scorelog2(8/200*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/288*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RHOT1 [Title/Abstract] AND FGFR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGFR1

GO:0008284

positive regulation of cell proliferation

8663044

TgeneFGFR1

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

TgeneFGFR1

GO:0010863

positive regulation of phospholipase C activity

18480409

TgeneFGFR1

GO:0018108

peptidyl-tyrosine phosphorylation

8622701|18480409

TgeneFGFR1

GO:0043406

positive regulation of MAP kinase activity

8622701|18480409

TgeneFGFR1

GO:0046777

protein autophosphorylation

8622701

TgeneFGFR1

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

21885851


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A18U-01ARHOT1chr17

30469748

+FGFR1chr8

38315052

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000333942ENST00000425967RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000333942ENST00000397091RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000333942ENST00000447712RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000333942ENST00000341462RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000333942ENST00000532791RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000333942ENST00000397113RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000333942ENST00000356207RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000333942ENST00000335922RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000333942ENST00000326324RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-intronENST00000333942ENST00000397103RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000333942ENST00000397108RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-intronENST00000333942ENST00000496629RHOT1chr17

30469748

+FGFR1chr8

38315052

-
Frame-shiftENST00000358365ENST00000425967RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000358365ENST00000397091RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000358365ENST00000447712RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000358365ENST00000341462RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000358365ENST00000532791RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000358365ENST00000397113RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000358365ENST00000356207RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000358365ENST00000335922RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000358365ENST00000326324RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-intronENST00000358365ENST00000397103RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000358365ENST00000397108RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-intronENST00000358365ENST00000496629RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-3CDSENST00000583994ENST00000425967RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000583994ENST00000397091RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000583994ENST00000447712RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000583994ENST00000341462RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000583994ENST00000532791RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000583994ENST00000397113RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000583994ENST00000356207RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000583994ENST00000335922RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000583994ENST00000326324RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-intronENST00000583994ENST00000397103RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000583994ENST00000397108RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-intronENST00000583994ENST00000496629RHOT1chr17

30469748

+FGFR1chr8

38315052

-
Frame-shiftENST00000545287ENST00000425967RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000545287ENST00000397091RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000545287ENST00000447712RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000545287ENST00000341462RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000545287ENST00000532791RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000545287ENST00000397113RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000545287ENST00000356207RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000545287ENST00000335922RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000545287ENST00000326324RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-intronENST00000545287ENST00000397103RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000545287ENST00000397108RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-intronENST00000545287ENST00000496629RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-3CDSENST00000354266ENST00000425967RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000354266ENST00000397091RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000354266ENST00000447712RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000354266ENST00000341462RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000354266ENST00000532791RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000354266ENST00000397113RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000354266ENST00000356207RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000354266ENST00000335922RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000354266ENST00000326324RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-intronENST00000354266ENST00000397103RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-5UTRENST00000354266ENST00000397108RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5UTR-intronENST00000354266ENST00000496629RHOT1chr17

30469748

+FGFR1chr8

38315052

-
Frame-shiftENST00000394692ENST00000425967RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000394692ENST00000397091RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000394692ENST00000447712RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000394692ENST00000341462RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000394692ENST00000532791RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000394692ENST00000397113RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000394692ENST00000356207RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000394692ENST00000335922RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000394692ENST00000326324RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-intronENST00000394692ENST00000397103RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000394692ENST00000397108RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-intronENST00000394692ENST00000496629RHOT1chr17

30469748

+FGFR1chr8

38315052

-
Frame-shiftENST00000581094ENST00000425967RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000581094ENST00000397091RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000581094ENST00000447712RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000581094ENST00000341462RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000581094ENST00000532791RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000581094ENST00000397113RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000581094ENST00000356207RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000581094ENST00000335922RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000581094ENST00000326324RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-intronENST00000581094ENST00000397103RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-5UTRENST00000581094ENST00000397108RHOT1chr17

30469748

+FGFR1chr8

38315052

-
5CDS-intronENST00000581094ENST00000496629RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-3CDSENST00000580976ENST00000425967RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-5UTRENST00000580976ENST00000397091RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-5UTRENST00000580976ENST00000447712RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-5UTRENST00000580976ENST00000341462RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-5UTRENST00000580976ENST00000532791RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-5UTRENST00000580976ENST00000397113RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-5UTRENST00000580976ENST00000356207RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-5UTRENST00000580976ENST00000335922RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-5UTRENST00000580976ENST00000326324RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-intronENST00000580976ENST00000397103RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-5UTRENST00000580976ENST00000397108RHOT1chr17

30469748

+FGFR1chr8

38315052

-
3UTR-intronENST00000580976ENST00000496629RHOT1chr17

30469748

+FGFR1chr8

38315052

-

Top

FusionProtFeatures for RHOT1_FGFR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RHOT1

Q8IXI2

FGFR1

P11362


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RHOT1_FGFR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RHOT1_FGFR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RHOT1AMFR, IRAK1, PINK1, PARK2, CFTR, ILK, PCSK9, ERLIN2, NXF1, TRAK2, PEX19, NTRK1, COQ9, APOOL, RHOT2, PTPN18, CDK20FGFR1FDPS, FRS3, NCAM1, FGF1, FGFR1, FRS2, PLCG1, FGF2, SHB, GRB14, BNIP2, KPNB1, CREBBP, STAT3, JAK2, SRC, NEDD4, PPP2R1B, FGF23, PTK6, ITK, NCK1, VAV1, HSP90AA1, ERBB3, CTPS2, CDK9, RPS6KA3, CDC20, TSPAN3, CEACAM21, IL20RB, LGALS8, TGFBR2, GINM1, DLK1, LTBR, TNFRSF10B, EVI2A, MREG, HEPACAM2, GOLGA7B, LDLRAD4, CRK, CTNNB1, CDH1, FGF8, SOS1, PIK3R1, PKM, FGF3, FGF5, FGF6, FGF9, FGF10, FGF17, CD44, RPS6KA1, SLA, PIK3R2, SH3BP2, NCK2, TENC1, RTN1, RTN3, PVRL1, EPHA4, YES1, L1CAM, TNK2, AKT1, PDP1, FGFR2, FAM8A1, TMEM30B, LRRN2, LITAF, C16orf58, ZDHHC11, IFNGR1, GAD1, FCGRT, IL27RA, RAET1E, SLC1A1, C14orf37, MANSC1, TPCN2, CD79B, SCN3B, C19orf45, HTR1A, FLRT1, KAL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RHOT1_FGFR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGFR1P11362DB00039PaliferminFibroblast growth factor receptor 1biotechapproved
TgeneFGFR1P11362DB08896RegorafenibFibroblast growth factor receptor 1small moleculeapproved
TgeneFGFR1P11362DB09079NintedanibFibroblast growth factor receptor 1small moleculeapproved
TgeneFGFR1P11362DB00398SorafenibFibroblast growth factor receptor 1small moleculeapproved|investigational
TgeneFGFR1P11362DB01109HeparinFibroblast growth factor receptor 1small moleculeapproved|investigational
TgeneFGFR1P11362DB08901PonatinibFibroblast growth factor receptor 1small moleculeapproved|investigational
TgeneFGFR1P11362DB09078LenvatinibFibroblast growth factor receptor 1small moleculeapproved|investigational

Top

RelatedDiseases for RHOT1_FGFR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFGFR1C1563720Kallmann Syndrome 2 (disorder)14ORPHANET;UNIPROT
TgeneFGFR1C0011570Mental Depression5PSYGENET
TgeneFGFR1C0011581Depressive disorder5CTD_human;HPO;PSYGENET
TgeneFGFR1C0005586Bipolar Disorder3PSYGENET
TgeneFGFR1C0041696Unipolar Depression3PSYGENET
TgeneFGFR1C1269683Major Depressive Disorder3PSYGENET
TgeneFGFR1C0027022Myeloproliferative disease2CTD_human
TgeneFGFR1C0220658Pfeiffer Syndrome2UNIPROT
TgeneFGFR1C0406612Encephalocraniocutaneous lipomatosis2ORPHANET;UNIPROT
TgeneFGFR1C0432283Osteoglophonic dwarfism2CTD_human;ORPHANET;UNIPROT
TgeneFGFR1C1458155Mammary Neoplasms2CTD_human
TgeneFGFR1C1845146Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate2ORPHANET;UNIPROT
TgeneFGFR1C0004114Astrocytoma1CTD_human
TgeneFGFR1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneFGFR1C0007137Squamous cell carcinoma1CTD_human
TgeneFGFR1C0008924Cleft Lip1CTD_human;HPO
TgeneFGFR1C0008925Cleft Palate1CTD_human;HPO
TgeneFGFR1C0017638Glioma1CTD_human
TgeneFGFR1C0024121Lung Neoplasms1CTD_human
TgeneFGFR1C0036341Schizophrenia1CTD_human
TgeneFGFR1C0149925Small cell carcinoma of lung1CTD_human
TgeneFGFR1C0376634Craniofacial Abnormalities1CTD_human
TgeneFGFR1C0432122Interfrontal craniofaciosynostosis1CTD_human;UNIPROT