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Fusion gene ID: 31204 |
FusionGeneSummary for RHOT1_FGFR1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: RHOT1_FGFR1 | Fusion gene ID: 31204 | Hgene | Tgene | Gene symbol | RHOT1 | FGFR1 | Gene ID | 55288 | 2260 |
Gene name | ras homolog family member T1 | fibroblast growth factor receptor 1 | |
Synonyms | ARHT1|MIRO-1|MIRO1 | BFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1 | |
Cytomap | 17q11.2 | 8p11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | mitochondrial Rho GTPase 1mitochondrial Rho (MIRO) GTPase 1rac-GTP binding protein-like proteinras homolog gene family, member T1 | fibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgr | |
Modification date | 20180527 | 20180527 | |
UniProtAcc | Q8IXI2 | P11362 | |
Ensembl transtripts involved in fusion gene | ENST00000333942, ENST00000358365, ENST00000583994, ENST00000545287, ENST00000354266, ENST00000394692, ENST00000581094, ENST00000580976, | ENST00000425967, ENST00000397091, ENST00000447712, ENST00000341462, ENST00000532791, ENST00000397113, ENST00000356207, ENST00000335922, ENST00000326324, ENST00000397103, ENST00000397108, ENST00000496629, | |
Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 9 X 8 X 4=288 |
# samples | 8 | 12 | |
** MAII score | log2(8/200*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/288*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RHOT1 [Title/Abstract] AND FGFR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FGFR1 | GO:0008284 | positive regulation of cell proliferation | 8663044 |
Tgene | FGFR1 | GO:0008543 | fibroblast growth factor receptor signaling pathway | 8663044 |
Tgene | FGFR1 | GO:0010863 | positive regulation of phospholipase C activity | 18480409 |
Tgene | FGFR1 | GO:0018108 | peptidyl-tyrosine phosphorylation | 8622701|18480409 |
Tgene | FGFR1 | GO:0043406 | positive regulation of MAP kinase activity | 8622701|18480409 |
Tgene | FGFR1 | GO:0046777 | protein autophosphorylation | 8622701 |
Tgene | FGFR1 | GO:2000546 | positive regulation of endothelial cell chemotaxis to fibroblast growth factor | 21885851 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-BH-A18U-01A | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000333942 | ENST00000425967 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000333942 | ENST00000397091 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000333942 | ENST00000447712 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000333942 | ENST00000341462 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000333942 | ENST00000532791 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000333942 | ENST00000397113 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000333942 | ENST00000356207 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000333942 | ENST00000335922 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000333942 | ENST00000326324 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000333942 | ENST00000397103 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000333942 | ENST00000397108 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000333942 | ENST00000496629 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
Frame-shift | ENST00000358365 | ENST00000425967 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000358365 | ENST00000397091 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000358365 | ENST00000447712 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000358365 | ENST00000341462 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000358365 | ENST00000532791 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000358365 | ENST00000397113 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000358365 | ENST00000356207 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000358365 | ENST00000335922 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000358365 | ENST00000326324 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000358365 | ENST00000397103 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000358365 | ENST00000397108 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000358365 | ENST00000496629 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-3CDS | ENST00000583994 | ENST00000425967 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000583994 | ENST00000397091 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000583994 | ENST00000447712 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000583994 | ENST00000341462 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000583994 | ENST00000532791 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000583994 | ENST00000397113 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000583994 | ENST00000356207 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000583994 | ENST00000335922 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000583994 | ENST00000326324 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-intron | ENST00000583994 | ENST00000397103 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000583994 | ENST00000397108 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-intron | ENST00000583994 | ENST00000496629 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
Frame-shift | ENST00000545287 | ENST00000425967 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000545287 | ENST00000397091 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000545287 | ENST00000447712 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000545287 | ENST00000341462 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000545287 | ENST00000532791 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000545287 | ENST00000397113 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000545287 | ENST00000356207 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000545287 | ENST00000335922 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000545287 | ENST00000326324 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000545287 | ENST00000397103 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000545287 | ENST00000397108 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000545287 | ENST00000496629 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-3CDS | ENST00000354266 | ENST00000425967 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000354266 | ENST00000397091 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000354266 | ENST00000447712 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000354266 | ENST00000341462 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000354266 | ENST00000532791 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000354266 | ENST00000397113 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000354266 | ENST00000356207 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000354266 | ENST00000335922 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000354266 | ENST00000326324 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-intron | ENST00000354266 | ENST00000397103 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-5UTR | ENST00000354266 | ENST00000397108 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5UTR-intron | ENST00000354266 | ENST00000496629 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
Frame-shift | ENST00000394692 | ENST00000425967 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000394692 | ENST00000397091 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000394692 | ENST00000447712 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000394692 | ENST00000341462 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000394692 | ENST00000532791 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000394692 | ENST00000397113 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000394692 | ENST00000356207 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000394692 | ENST00000335922 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000394692 | ENST00000326324 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000394692 | ENST00000397103 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000394692 | ENST00000397108 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000394692 | ENST00000496629 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
Frame-shift | ENST00000581094 | ENST00000425967 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000581094 | ENST00000397091 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000581094 | ENST00000447712 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000581094 | ENST00000341462 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000581094 | ENST00000532791 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000581094 | ENST00000397113 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000581094 | ENST00000356207 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000581094 | ENST00000335922 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000581094 | ENST00000326324 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000581094 | ENST00000397103 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-5UTR | ENST00000581094 | ENST00000397108 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
5CDS-intron | ENST00000581094 | ENST00000496629 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-3CDS | ENST00000580976 | ENST00000425967 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-5UTR | ENST00000580976 | ENST00000397091 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-5UTR | ENST00000580976 | ENST00000447712 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-5UTR | ENST00000580976 | ENST00000341462 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-5UTR | ENST00000580976 | ENST00000532791 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-5UTR | ENST00000580976 | ENST00000397113 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-5UTR | ENST00000580976 | ENST00000356207 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-5UTR | ENST00000580976 | ENST00000335922 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-5UTR | ENST00000580976 | ENST00000326324 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-intron | ENST00000580976 | ENST00000397103 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-5UTR | ENST00000580976 | ENST00000397108 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
3UTR-intron | ENST00000580976 | ENST00000496629 | RHOT1 | chr17 | 30469748 | + | FGFR1 | chr8 | 38315052 | - |
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FusionProtFeatures for RHOT1_FGFR1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
RHOT1 | FGFR1 |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RHOT1_FGFR1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RHOT1_FGFR1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RHOT1 | AMFR, IRAK1, PINK1, PARK2, CFTR, ILK, PCSK9, ERLIN2, NXF1, TRAK2, PEX19, NTRK1, COQ9, APOOL, RHOT2, PTPN18, CDK20 | FGFR1 | FDPS, FRS3, NCAM1, FGF1, FGFR1, FRS2, PLCG1, FGF2, SHB, GRB14, BNIP2, KPNB1, CREBBP, STAT3, JAK2, SRC, NEDD4, PPP2R1B, FGF23, PTK6, ITK, NCK1, VAV1, HSP90AA1, ERBB3, CTPS2, CDK9, RPS6KA3, CDC20, TSPAN3, CEACAM21, IL20RB, LGALS8, TGFBR2, GINM1, DLK1, LTBR, TNFRSF10B, EVI2A, MREG, HEPACAM2, GOLGA7B, LDLRAD4, CRK, CTNNB1, CDH1, FGF8, SOS1, PIK3R1, PKM, FGF3, FGF5, FGF6, FGF9, FGF10, FGF17, CD44, RPS6KA1, SLA, PIK3R2, SH3BP2, NCK2, TENC1, RTN1, RTN3, PVRL1, EPHA4, YES1, L1CAM, TNK2, AKT1, PDP1, FGFR2, FAM8A1, TMEM30B, LRRN2, LITAF, C16orf58, ZDHHC11, IFNGR1, GAD1, FCGRT, IL27RA, RAET1E, SLC1A1, C14orf37, MANSC1, TPCN2, CD79B, SCN3B, C19orf45, HTR1A, FLRT1, KAL1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RHOT1_FGFR1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | FGFR1 | P11362 | DB00039 | Palifermin | Fibroblast growth factor receptor 1 | biotech | approved |
Tgene | FGFR1 | P11362 | DB08896 | Regorafenib | Fibroblast growth factor receptor 1 | small molecule | approved |
Tgene | FGFR1 | P11362 | DB09079 | Nintedanib | Fibroblast growth factor receptor 1 | small molecule | approved |
Tgene | FGFR1 | P11362 | DB00398 | Sorafenib | Fibroblast growth factor receptor 1 | small molecule | approved|investigational |
Tgene | FGFR1 | P11362 | DB01109 | Heparin | Fibroblast growth factor receptor 1 | small molecule | approved|investigational |
Tgene | FGFR1 | P11362 | DB08901 | Ponatinib | Fibroblast growth factor receptor 1 | small molecule | approved|investigational |
Tgene | FGFR1 | P11362 | DB09078 | Lenvatinib | Fibroblast growth factor receptor 1 | small molecule | approved|investigational |
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RelatedDiseases for RHOT1_FGFR1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FGFR1 | C1563720 | Kallmann Syndrome 2 (disorder) | 14 | ORPHANET;UNIPROT |
Tgene | FGFR1 | C0011570 | Mental Depression | 5 | PSYGENET |
Tgene | FGFR1 | C0011581 | Depressive disorder | 5 | CTD_human;HPO;PSYGENET |
Tgene | FGFR1 | C0005586 | Bipolar Disorder | 3 | PSYGENET |
Tgene | FGFR1 | C0041696 | Unipolar Depression | 3 | PSYGENET |
Tgene | FGFR1 | C1269683 | Major Depressive Disorder | 3 | PSYGENET |
Tgene | FGFR1 | C0027022 | Myeloproliferative disease | 2 | CTD_human |
Tgene | FGFR1 | C0220658 | Pfeiffer Syndrome | 2 | UNIPROT |
Tgene | FGFR1 | C0406612 | Encephalocraniocutaneous lipomatosis | 2 | ORPHANET;UNIPROT |
Tgene | FGFR1 | C0432283 | Osteoglophonic dwarfism | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | FGFR1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Tgene | FGFR1 | C1845146 | Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate | 2 | ORPHANET;UNIPROT |
Tgene | FGFR1 | C0004114 | Astrocytoma | 1 | CTD_human |
Tgene | FGFR1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | FGFR1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | FGFR1 | C0008924 | Cleft Lip | 1 | CTD_human;HPO |
Tgene | FGFR1 | C0008925 | Cleft Palate | 1 | CTD_human;HPO |
Tgene | FGFR1 | C0017638 | Glioma | 1 | CTD_human |
Tgene | FGFR1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | FGFR1 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | FGFR1 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
Tgene | FGFR1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Tgene | FGFR1 | C0432122 | Interfrontal craniofaciosynostosis | 1 | CTD_human;UNIPROT |