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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31202

FusionGeneSummary for RHOT1_ASIC2

check button Fusion gene summary
Fusion gene informationFusion gene name: RHOT1_ASIC2
Fusion gene ID: 31202
HgeneTgene
Gene symbol

RHOT1

ASIC2

Gene ID

55288

40

Gene nameras homolog family member T1acid sensing ion channel subunit 2
SynonymsARHT1|MIRO-1|MIRO1ACCN|ACCN1|ASIC2a|BNC1|BNaC1|MDEG|hBNaC1
Cytomap

17q11.2

17q11.2-q12

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial Rho GTPase 1mitochondrial Rho (MIRO) GTPase 1rac-GTP binding protein-like proteinras homolog gene family, member T1acid-sensing ion channel 2acid sensing (proton gated) ion channel 2amiloride-sensitive cation channel 1, neuronalbrain sodium channel 1mammalian degenerin homologneuronal amiloride-sensitive cation channel 1
Modification date2018052720180519
UniProtAcc

Q8IXI2

Q16515

Ensembl transtripts involved in fusion geneENST00000333942, ENST00000358365, 
ENST00000583994, ENST00000545287, 
ENST00000354266, ENST00000394692, 
ENST00000581094, ENST00000580976, 
ENST00000225823, ENST00000359872, 
ENST00000448983, 
Fusion gene scores* DoF score8 X 5 X 5=20010 X 9 X 5=450
# samples 812
** MAII scorelog2(8/200*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/450*10)=-1.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RHOT1 [Title/Abstract] AND ASIC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-06-0174-01ARHOT1chr17

30469748

+ASIC2chr17

31439085

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000333942ENST00000225823RHOT1chr17

30469748

+ASIC2chr17

31439085

-
Frame-shiftENST00000333942ENST00000359872RHOT1chr17

30469748

+ASIC2chr17

31439085

-
5CDS-5UTRENST00000333942ENST00000448983RHOT1chr17

30469748

+ASIC2chr17

31439085

-
Frame-shiftENST00000358365ENST00000225823RHOT1chr17

30469748

+ASIC2chr17

31439085

-
Frame-shiftENST00000358365ENST00000359872RHOT1chr17

30469748

+ASIC2chr17

31439085

-
5CDS-5UTRENST00000358365ENST00000448983RHOT1chr17

30469748

+ASIC2chr17

31439085

-
5UTR-3CDSENST00000583994ENST00000225823RHOT1chr17

30469748

+ASIC2chr17

31439085

-
5UTR-3CDSENST00000583994ENST00000359872RHOT1chr17

30469748

+ASIC2chr17

31439085

-
5UTR-5UTRENST00000583994ENST00000448983RHOT1chr17

30469748

+ASIC2chr17

31439085

-
Frame-shiftENST00000545287ENST00000225823RHOT1chr17

30469748

+ASIC2chr17

31439085

-
Frame-shiftENST00000545287ENST00000359872RHOT1chr17

30469748

+ASIC2chr17

31439085

-
5CDS-5UTRENST00000545287ENST00000448983RHOT1chr17

30469748

+ASIC2chr17

31439085

-
5UTR-3CDSENST00000354266ENST00000225823RHOT1chr17

30469748

+ASIC2chr17

31439085

-
5UTR-3CDSENST00000354266ENST00000359872RHOT1chr17

30469748

+ASIC2chr17

31439085

-
5UTR-5UTRENST00000354266ENST00000448983RHOT1chr17

30469748

+ASIC2chr17

31439085

-
Frame-shiftENST00000394692ENST00000225823RHOT1chr17

30469748

+ASIC2chr17

31439085

-
Frame-shiftENST00000394692ENST00000359872RHOT1chr17

30469748

+ASIC2chr17

31439085

-
5CDS-5UTRENST00000394692ENST00000448983RHOT1chr17

30469748

+ASIC2chr17

31439085

-
Frame-shiftENST00000581094ENST00000225823RHOT1chr17

30469748

+ASIC2chr17

31439085

-
Frame-shiftENST00000581094ENST00000359872RHOT1chr17

30469748

+ASIC2chr17

31439085

-
5CDS-5UTRENST00000581094ENST00000448983RHOT1chr17

30469748

+ASIC2chr17

31439085

-
3UTR-3CDSENST00000580976ENST00000225823RHOT1chr17

30469748

+ASIC2chr17

31439085

-
3UTR-3CDSENST00000580976ENST00000359872RHOT1chr17

30469748

+ASIC2chr17

31439085

-
3UTR-5UTRENST00000580976ENST00000448983RHOT1chr17

30469748

+ASIC2chr17

31439085

-

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FusionProtFeatures for RHOT1_ASIC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RHOT1

Q8IXI2

ASIC2

Q16515

Cation channel with high affinity for sodium, which isgated by extracellular protons and inhibited by the diureticamiloride. Also permeable for Li(+) and K(+). Generates a biphasiccurrent with a fast inactivating and a slow sustained phase.Heteromeric channel assembly seems to modulate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RHOT1_ASIC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RHOT1_ASIC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RHOT1AMFR, IRAK1, PINK1, PARK2, CFTR, ILK, PCSK9, ERLIN2, NXF1, TRAK2, PEX19, NTRK1, COQ9, APOOL, RHOT2, PTPN18, CDK20ASIC2ASIC3, STOM, ASIC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RHOT1_ASIC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneASIC2Q16515DB00594AmilorideAcid-sensing ion channel 2 {ECO:0000303|PubMed:10842183}small moleculeapproved

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RelatedDiseases for RHOT1_ASIC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneASIC2C0004352Autistic Disorder1CTD_human
TgeneASIC2C0021368Inflammation1CTD_human