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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31196

FusionGeneSummary for RHOJ_C6orf52

check button Fusion gene summary
Fusion gene informationFusion gene name: RHOJ_C6orf52
Fusion gene ID: 31196
HgeneTgene
Gene symbol

RHOJ

C6orf52

Gene ID

57381

347744

Gene nameras homolog family member Jchromosome 6 open reading frame 52
SynonymsARHJ|RASL7B|TC10B|TCL-
Cytomap

14q23.2

6p24.2

Type of geneprotein-codingprotein-coding
Descriptionrho-related GTP-binding protein RhoJRAS-like, family 7, member BTC10-like Rho GTPaseras homolog gene family, member Jras-like protein family member 7Btc10-like GTP-binding proteinputative uncharacterized protein C6orf52
Modification date2018052320180402
UniProtAcc

Q9H4E5

Q5T4I8

Ensembl transtripts involved in fusion geneENST00000316754, ENST00000557133, 
ENST00000555125, 
ENST00000460742, 
ENST00000259983, ENST00000426700, 
ENST00000467832, ENST00000379586, 
ENST00000503680, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 4=64
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RHOJ [Title/Abstract] AND C6orf52 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-27-1835-01ARHOJchr14

63671765

+C6orf52chr6

10671831

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000316754ENST00000460742RHOJchr14

63671765

+C6orf52chr6

10671831

-
Frame-shiftENST00000316754ENST00000259983RHOJchr14

63671765

+C6orf52chr6

10671831

-
Frame-shiftENST00000316754ENST00000426700RHOJchr14

63671765

+C6orf52chr6

10671831

-
5CDS-5UTRENST00000316754ENST00000467832RHOJchr14

63671765

+C6orf52chr6

10671831

-
5CDS-5UTRENST00000316754ENST00000379586RHOJchr14

63671765

+C6orf52chr6

10671831

-
5CDS-5UTRENST00000316754ENST00000503680RHOJchr14

63671765

+C6orf52chr6

10671831

-
3UTR-3CDSENST00000557133ENST00000460742RHOJchr14

63671765

+C6orf52chr6

10671831

-
3UTR-3CDSENST00000557133ENST00000259983RHOJchr14

63671765

+C6orf52chr6

10671831

-
3UTR-3CDSENST00000557133ENST00000426700RHOJchr14

63671765

+C6orf52chr6

10671831

-
3UTR-5UTRENST00000557133ENST00000467832RHOJchr14

63671765

+C6orf52chr6

10671831

-
3UTR-5UTRENST00000557133ENST00000379586RHOJchr14

63671765

+C6orf52chr6

10671831

-
3UTR-5UTRENST00000557133ENST00000503680RHOJchr14

63671765

+C6orf52chr6

10671831

-
In-frameENST00000555125ENST00000460742RHOJchr14

63671765

+C6orf52chr6

10671831

-
Frame-shiftENST00000555125ENST00000259983RHOJchr14

63671765

+C6orf52chr6

10671831

-
Frame-shiftENST00000555125ENST00000426700RHOJchr14

63671765

+C6orf52chr6

10671831

-
5CDS-5UTRENST00000555125ENST00000467832RHOJchr14

63671765

+C6orf52chr6

10671831

-
5CDS-5UTRENST00000555125ENST00000379586RHOJchr14

63671765

+C6orf52chr6

10671831

-
5CDS-5UTRENST00000555125ENST00000503680RHOJchr14

63671765

+C6orf52chr6

10671831

-

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FusionProtFeatures for RHOJ_C6orf52


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RHOJ

Q9H4E5

C6orf52

Q5T4I8

GTP-binding protein with GTPase activity. Elicits theformation of F-actin-rich structures in fibroblasts and isinvolved in the regulation of cell morphology (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRHOJchr14:63671765chr6:10671831ENST00000316754+1550_5859215MotifEffector region
HgeneRHOJchr14:63671765chr6:10671831ENST00000316754+1528_3559215Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRHOJchr14:63671765chr6:10671831ENST00000316754+15133_13659215Nucleotide bindingGTP
HgeneRHOJchr14:63671765chr6:10671831ENST00000316754+1575_7959215Nucleotide bindingGTP


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FusionGeneSequence for RHOJ_C6orf52


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RHOJ_ENST00000316754_chr14_63671765_+_C6orf52_ENST00000460742_chr6_10671831_-_107aa
MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYADPHLHLNIEESNQEFMVKSEELYDSLMNCHW

>In-frame_RHOJ_ENST00000555125_chr14_63671765_+_C6orf52_ENST00000460742_chr6_10671831_-_107aa
MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYADPHLHLNIEESNQEFMVKSEELYDSLMNCHW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RHOJ_ENST00000316754_chr14_63671765_+_C6orf52_ENST00000460742_chr6_10671831_-_321nt
ATGAACTGCAAAGAGGGAACTGACAGCAGCTGCGGCTGCAGGGGCAACGACGAGAAGAAGATGTTGAAGTGTGTGGTGGTGGGGGACGGT
GCCGTGGGGAAAACCTGCCTGCTGATGAGCTACGCCAACGACGCCTTCCCAGAGGAATACGTGCCCACTGTGTTTGACCACTATGCAGAT
CCACATCTTCATTTGAATATTGAGGAATCAAACCAAGAGTTTATGGTGAAAAGTGAAGAACTCTACGACTCCCTCATGAATTGCCACTGG

>In-frame_RHOJ_ENST00000555125_chr14_63671765_+_C6orf52_ENST00000460742_chr6_10671831_-_321nt
ATGAACTGCAAAGAGGGAACTGACAGCAGCTGCGGCTGCAGGGGCAACGACGAGAAGAAGATGTTGAAGTGTGTGGTGGTGGGGGACGGT
GCCGTGGGGAAAACCTGCCTGCTGATGAGCTACGCCAACGACGCCTTCCCAGAGGAATACGTGCCCACTGTGTTTGACCACTATGCAGAT
CCACATCTTCATTTGAATATTGAGGAATCAAACCAAGAGTTTATGGTGAAAAGTGAAGAACTCTACGACTCCCTCATGAATTGCCACTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_RHOJ_ENST00000316754_chr14_63671765_+_C6orf52_ENST00000460742_chr6_10671831_-_821nt
CGGCAAGCTGGAGGAAGCAAAGGGAAAAAAACTCCATTAAAAAGCCCAGCTTTCCTCCATGTTAGATGTGACTTGGAAAATGAGAAAGAT
TTAGCAAAATTCCACCGTATCTTTTGCCAGGCTAGAGACAGGGAGAGCAGAGTAAAACCCTCAGGCTGCTGAAATTTCTAGGCTGTTAGG
AAGCCCCTCGAATTCTGTGAAAATGAGGGTTTCTTAACTCACACTGAGAGCGGAAAGGGGCAGACCCTTTTCATAACTCCCTCAAGTGTG
TGTTACCTTTCTTTACCAGCATGGTAAGCAACAGGACATATCCCAGCCTCGGACATGTCTGTATGATCCAAGGTACCCAAAGTCAGACAG
AGTAAACTCAAGCCTGGCACTGGCTTTCTGCCGCTTCATGTGCTTTGGAAAAAGCAGGAGAAGCAATAGCAGCAGGAGTCCCCAGCAGCT
GGAGCCGCAAGAATGAACTGCAAAGAGGGAACTGACAGCAGCTGCGGCTGCAGGGGCAACGACGAGAAGAAGATGTTGAAGTGTGTGGTG
GTGGGGGACGGTGCCGTGGGGAAAACCTGCCTGCTGATGAGCTACGCCAACGACGCCTTCCCAGAGGAATACGTGCCCACTGTGTTTGAC
CACTATGCAGATCCACATCTTCATTTGAATATTGAGGAATCAAACCAAGAGTTTATGGTGAAAAGTGAAGAACTCTACGACTCCCTCATG
AATTGCCACTGGCAGCCTCTGGACACAGTTCACTCCGAAATCCCAGATGAGACCCCGAAGTGAAGCAAGGTGTTCATTAAACTCCGCAAT

>In-frame_RHOJ_ENST00000555125_chr14_63671765_+_C6orf52_ENST00000460742_chr6_10671831_-_370nt
GAGCCGCAAGAATGAACTGCAAAGAGGGAACTGACAGCAGCTGCGGCTGCAGGGGCAACGACGAGAAGAAGATGTTGAAGTGTGTGGTGG
TGGGGGACGGTGCCGTGGGGAAAACCTGCCTGCTGATGAGCTACGCCAACGACGCCTTCCCAGAGGAATACGTGCCCACTGTGTTTGACC
ACTATGCAGATCCACATCTTCATTTGAATATTGAGGAATCAAACCAAGAGTTTATGGTGAAAAGTGAAGAACTCTACGACTCCCTCATGA
ATTGCCACTGGCAGCCTCTGGACACAGTTCACTCCGAAATCCCAGATGAGACCCCGAAGTGAAGCAAGGTGTTCATTAAACTCCGCAATT


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FusionGenePPI for RHOJ_C6orf52


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RHOJWAS, PAK1, MEOX2, PAK2, BLZF1, BHLHE40, WASL, TRIP10, SSX3, CDC42EP1, ADAMTSL4, PAK6, PARD6B, EIF5B, PRKCI, CSNK1D, FAM177A1, USP24, AARSD1, PARD6GC6orf52


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RHOJ_C6orf52


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RHOJ_C6orf52


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRHOJC0009375Colonic Neoplasms1CTD_human
HgeneRHOJC0878544Cardiomyopathies1CTD_human