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Fusion gene ID: 31188 |
FusionGeneSummary for RHOD_PFDN4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RHOD_PFDN4 | Fusion gene ID: 31188 | Hgene | Tgene | Gene symbol | RHOD | PFDN4 | Gene ID | 29984 | 5203 |
| Gene name | ras homolog family member D | prefoldin subunit 4 | |
| Synonyms | ARHD|RHOHP1|RHOM|Rho | C1|PFD4 | |
| Cytomap | 11q13.2 | 20q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho-related GTP-binding protein RhoDRho-related protein HP1ras homolog Dras homolog gene family, member Aras homolog gene family, member D | prefoldin subunit 4prefoldin 4protein C-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O00212 | Q9NQP4 | |
| Ensembl transtripts involved in fusion gene | ENST00000308831, ENST00000533360, ENST00000532559, | ENST00000371419, ENST00000487129, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 4=64 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RHOD [Title/Abstract] AND PFDN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A1-A0SN-01A | RHOD | chr11 | 66834318 | + | PFDN4 | chr20 | 52830890 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000308831 | ENST00000371419 | RHOD | chr11 | 66834318 | + | PFDN4 | chr20 | 52830890 | + |
| 5CDS-3UTR | ENST00000308831 | ENST00000487129 | RHOD | chr11 | 66834318 | + | PFDN4 | chr20 | 52830890 | + |
| In-frame | ENST00000533360 | ENST00000371419 | RHOD | chr11 | 66834318 | + | PFDN4 | chr20 | 52830890 | + |
| 5CDS-3UTR | ENST00000533360 | ENST00000487129 | RHOD | chr11 | 66834318 | + | PFDN4 | chr20 | 52830890 | + |
| intron-3CDS | ENST00000532559 | ENST00000371419 | RHOD | chr11 | 66834318 | + | PFDN4 | chr20 | 52830890 | + |
| intron-3UTR | ENST00000532559 | ENST00000487129 | RHOD | chr11 | 66834318 | + | PFDN4 | chr20 | 52830890 | + |
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FusionProtFeatures for RHOD_PFDN4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RHOD | PFDN4 |
| Involved in endosome dynamics. May coordinate membranetransport with the function of the cytoskeleton. Involved in theinternalization and trafficking of activated tyrosine kinasereceptors such as PDGFRB. Participates in the reorganization ofactin cytoskeleton; the function seems to involve WHAMM andincludes regulation of filopodia formation and actin filamentbundling. Can modulate the effect of DAPK3 in reorganization ofactin cytoskeleton and focal adhesion dissolution.{ECO:0000269|PubMed:23087206, ECO:0000269|PubMed:23454120,ECO:0000269|PubMed:24102721}. | Binds specifically to cytosolic chaperonin (c-CPN) andtransfers target proteins to it. Binds to nascent polypeptidechain and promotes folding in an environment in which there aremany competing pathways for nonnative proteins.{ECO:0000269|PubMed:9630229}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RHOD | chr11:66834318 | chr20:52830890 | ENST00000308831 | + | 3 | 5 | 46_54 | 110 | 211 | Motif | Effector region |
| Hgene | RHOD | chr11:66834318 | chr20:52830890 | ENST00000308831 | + | 3 | 5 | 24_31 | 110 | 211 | Nucleotide binding | GTP |
| Hgene | RHOD | chr11:66834318 | chr20:52830890 | ENST00000308831 | + | 3 | 5 | 71_75 | 110 | 211 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RHOD | chr11:66834318 | chr20:52830890 | ENST00000308831 | + | 3 | 5 | 129_132 | 110 | 211 | Nucleotide binding | GTP |
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FusionGeneSequence for RHOD_PFDN4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RHOD_ENST00000308831_chr11_66834318_+_PFDN4_ENST00000371419_chr20_52830890_+_237aa MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDAS VLLLCFDVTSPNSFDNIFNRAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISH >In-frame_RHOD_ENST00000533360_chr11_66834318_+_PFDN4_ENST00000371419_chr20_52830890_+_237aa MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDAS VLLLCFDVTSPNSFDNIFNRAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RHOD_ENST00000308831_chr11_66834318_+_PFDN4_ENST00000371419_chr20_52830890_+_711nt ATGACGGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCGGTCCGTCAAGGTGGTCCTGGTGGGCGACGGCGGCTGCGGGAAG ACGTCGCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGAGCTACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTG AAAGGCAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGC GTCCTGCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAACATCTTTAACCGGGCTGCAGAAGATGTCAATGTTACTTTCGAA GATCAACAAAAGATAAACAAATTTGCACGGAATACAAGTAGAATCACAGAGCTGAAGGAAGAAATAGAAGTAAAAAAGAAACAACTCCAA AACCTAGAAGATGCTTGTGATGACATCATGCTTGCAGATGATGATTGCTTAATGATACCTTATCAAATTGGTGATGTCTTCATTAGCCAT TCTCAAGAAGAAACGCAAGAAATGTTAGAAGAAGCAAAGAAAAATTTGCAAGAAGAAATTGACGCCTTAGAATCCAGAGTGGAATCAATT >In-frame_RHOD_ENST00000533360_chr11_66834318_+_PFDN4_ENST00000371419_chr20_52830890_+_711nt ATGACGGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCGGTCCGTCAAGGTGGTCCTGGTGGGCGACGGCGGCTGCGGGAAG ACGTCGCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGAGCTACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTG AAAGGCAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGC GTCCTGCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAACATCTTTAACCGGGCTGCAGAAGATGTCAATGTTACTTTCGAA GATCAACAAAAGATAAACAAATTTGCACGGAATACAAGTAGAATCACAGAGCTGAAGGAAGAAATAGAAGTAAAAAAGAAACAACTCCAA AACCTAGAAGATGCTTGTGATGACATCATGCTTGCAGATGATGATTGCTTAATGATACCTTATCAAATTGGTGATGTCTTCATTAGCCAT TCTCAAGAAGAAACGCAAGAAATGTTAGAAGAAGCAAAGAAAAATTTGCAAGAAGAAATTGACGCCTTAGAATCCAGAGTGGAATCAATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RHOD_ENST00000308831_chr11_66834318_+_PFDN4_ENST00000371419_chr20_52830890_+_1599nt ATTCCTGCCCCGCCGGGCCTGCCCCGCGCAGTCTGGGTCTCTGCGCCGCAGCCGCCCGCCCGCCCGCTCAGCGCCCGGCCCCGGGATGAC GGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCGGTCCGTCAAGGTGGTCCTGGTGGGCGACGGCGGCTGCGGGAAGACGTC GCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGAGCTACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGG CAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCT GCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAACATCTTTAACCGGGCTGCAGAAGATGTCAATGTTACTTTCGAAGATCA ACAAAAGATAAACAAATTTGCACGGAATACAAGTAGAATCACAGAGCTGAAGGAAGAAATAGAAGTAAAAAAGAAACAACTCCAAAACCT AGAAGATGCTTGTGATGACATCATGCTTGCAGATGATGATTGCTTAATGATACCTTATCAAATTGGTGATGTCTTCATTAGCCATTCTCA AGAAGAAACGCAAGAAATGTTAGAAGAAGCAAAGAAAAATTTGCAAGAAGAAATTGACGCCTTAGAATCCAGAGTGGAATCAATTCAGCG AGTGTTAGCAGATTTGAAAGTTCAGTTGTATGCAAAATTCGGGAGCAACATAAACCTTGAAGCTGATGAAAGTTAAACATTTTATAATAC TTTTTTTATTTGTTTAATAAACTTGAATATTGTTTAAAATGATAATTTTCCTTCTTCAAATGACATGGAAAGCAAAACTTTCTTTTTTAA AAATTTTCATTTATTTAATGGAAACTTGCCCATTTTCACATGTCTGCTTATTTATTTTATATTTTTAAAAGAAGACAGTATTCACCTATG TATTTTGCATAACGATTATATCAAGTCTAGGGGCTTCATGTCATGTTATTAAAATCAGTTAAGCAATCTTTTATGTTTCTATATTATTTA GAATATTTGTTGTTGCAATTTTCACATAAGAAAATTTAACAGTTGTGTCATGTTGTTTCTGTCTGATTTTAATTGCTGTCTAATGACGGG GAAAGCACGATGAAAAGATGTACAATCCTGCATCCTTGCTTATTTCACAACTAAAGCTTTGTCATAGACTTCAAAATATATATGTATATA TTTTATTTAAATATATGTTACATATTATATTTAAACATACATATTTAACATTTTTTACATATCTATCAATATCAGAGATTTGGGTAAAAG AATGGGTAATGTTTAAACATGTGGAGGCATGTGGAGCTTTATACAAACAGGGCAGAACCACAGAAGAACGTTTTAGAAACCAAGAGATGT GCAGAAAGAAATGTTTAGTGTTTTTTCGTTTTAAATTTTAGATTTTATTTTAGTGCTTTGTAATTAATTGGGGTTTATATTGATAAAGAT >In-frame_RHOD_ENST00000533360_chr11_66834318_+_PFDN4_ENST00000371419_chr20_52830890_+_1557nt GCGCCGCAGCCGCCCGCCCGCCCGCTCAGCGCCCGGCCCCGGGATGACGGCGGCCCAGGCCGCGGGTGAGGAGGCGCCACCAGGCGTGCG GTCCGTCAAGGTGGTCCTGGTGGGCGACGGCGGCTGCGGGAAGACGTCGCTGCTGATGGTCTTCGCCGATGGGGCCTTCCCCGAGAGCTA CACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGA TGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAA CATCTTTAACCGGGCTGCAGAAGATGTCAATGTTACTTTCGAAGATCAACAAAAGATAAACAAATTTGCACGGAATACAAGTAGAATCAC AGAGCTGAAGGAAGAAATAGAAGTAAAAAAGAAACAACTCCAAAACCTAGAAGATGCTTGTGATGACATCATGCTTGCAGATGATGATTG CTTAATGATACCTTATCAAATTGGTGATGTCTTCATTAGCCATTCTCAAGAAGAAACGCAAGAAATGTTAGAAGAAGCAAAGAAAAATTT GCAAGAAGAAATTGACGCCTTAGAATCCAGAGTGGAATCAATTCAGCGAGTGTTAGCAGATTTGAAAGTTCAGTTGTATGCAAAATTCGG GAGCAACATAAACCTTGAAGCTGATGAAAGTTAAACATTTTATAATACTTTTTTTATTTGTTTAATAAACTTGAATATTGTTTAAAATGA TAATTTTCCTTCTTCAAATGACATGGAAAGCAAAACTTTCTTTTTTAAAAATTTTCATTTATTTAATGGAAACTTGCCCATTTTCACATG TCTGCTTATTTATTTTATATTTTTAAAAGAAGACAGTATTCACCTATGTATTTTGCATAACGATTATATCAAGTCTAGGGGCTTCATGTC ATGTTATTAAAATCAGTTAAGCAATCTTTTATGTTTCTATATTATTTAGAATATTTGTTGTTGCAATTTTCACATAAGAAAATTTAACAG TTGTGTCATGTTGTTTCTGTCTGATTTTAATTGCTGTCTAATGACGGGGAAAGCACGATGAAAAGATGTACAATCCTGCATCCTTGCTTA TTTCACAACTAAAGCTTTGTCATAGACTTCAAAATATATATGTATATATTTTATTTAAATATATGTTACATATTATATTTAAACATACAT ATTTAACATTTTTTACATATCTATCAATATCAGAGATTTGGGTAAAAGAATGGGTAATGTTTAAACATGTGGAGGCATGTGGAGCTTTAT ACAAACAGGGCAGAACCACAGAAGAACGTTTTAGAAACCAAGAGATGTGCAGAAAGAAATGTTTAGTGTTTTTTCGTTTTAAATTTTAGA TTTTATTTTAGTGCTTTGTAATTAATTGGGGTTTATATTGATAAAGATGTGGAAGTTAAACAGCTATGTATGTAAAAGTAAGGCTTATTT |
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FusionGenePPI for RHOD_PFDN4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RHOD | DIAPH2, PLXNA1, IHH, ADCK5, ADRB2, ANKFY1, SPTB, PLXNB2, DAAM1, TTC19, CETN3, TRMT61B, DIAPH1, PCBP3, C1orf198, TRIM25 | PFDN4 | PRPF4, SPATA2, TUBA3E, PFDN2, VBP1, PFDN5, PFDN6, PFDN1, SORD, ABL1, PDRG1, METTL21B, MAPK7, RAN, FBXW11, DCAF5, DDB2, EIF6, FLNA, GFPT1, MSH2, ACAT2, COMMD4, GOLPH3, NUP50, PPM1G, PUS1, SIL1, SLMAP, UXT, BTRC, B9D1, SCLT1, POC1A, POC1B, STIL, CENPJ, PTPN21, DUSP19, DUSP9, RPUSD2, KATNB1, RC3H2, KATNA1, SPIN2B, ERCC8, ATF2, MTFR1L, MIOS, FBXO28, BANP, GNB2, SPIN3, NEDD1, TRAF7, ZZZ3, CTU2, ZBTB33, CREB1, UBB, WDR86, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RHOD_PFDN4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RHOD_PFDN4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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