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Fusion gene ID: 31187 |
FusionGeneSummary for RHOC_SPIDR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RHOC_SPIDR | Fusion gene ID: 31187 | Hgene | Tgene | Gene symbol | RHOC | SPIDR | Gene ID | 389 | 23514 |
| Gene name | ras homolog family member C | scaffold protein involved in DNA repair | |
| Synonyms | ARH9|ARHC|H9|RHOH9 | KIAA0146 | |
| Cytomap | 1p13.2 | 8q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho-related GTP-binding protein RhoCRAS-related homolog 9oncogene RHO H9ras homolog gene family, member Crho cDNA clone 9rhoC GTPasesmall GTP binding protein RhoC | DNA repair-scaffolding proteinscaffolding protein involved in DNA repair | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P08134 | Q14159 | |
| Ensembl transtripts involved in fusion gene | ENST00000339083, ENST00000369633, ENST00000369642, ENST00000285735, ENST00000369638, ENST00000369637, ENST00000369636, ENST00000369632, | ENST00000297423, ENST00000518074, ENST00000541342, ENST00000521214, ENST00000517693, ENST00000518060, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 12 X 13 X 8=1248 |
| # samples | 2 | 18 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(18/1248*10)=-2.79354912253257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RHOC [Title/Abstract] AND SPIDR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RHOC | GO:0000281 | mitotic cytokinesis | 16236794 |
| Hgene | RHOC | GO:0043297 | apical junction assembly | 20974804 |
| Hgene | RHOC | GO:0060193 | positive regulation of lipase activity | 19887681 |
| Tgene | SPIDR | GO:0006974 | cellular response to DNA damage stimulus | 23509288 |
| Tgene | SPIDR | GO:0010569 | regulation of double-strand break repair via homologous recombination | 23754376 |
| Tgene | SPIDR | GO:0031334 | positive regulation of protein complex assembly | 23509288 |
| Tgene | SPIDR | GO:0070202 | regulation of establishment of protein localization to chromosome | 23509288 |
| Tgene | SPIDR | GO:0071479 | cellular response to ionizing radiation | 23509288|23754376 |
| Tgene | SPIDR | GO:0072711 | cellular response to hydroxyurea | 23509288 |
| Tgene | SPIDR | GO:0072757 | cellular response to camptothecin | 23509288 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF927466 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000339083 | ENST00000297423 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000339083 | ENST00000518074 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000339083 | ENST00000541342 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000339083 | ENST00000521214 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000339083 | ENST00000517693 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000339083 | ENST00000518060 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369633 | ENST00000297423 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369633 | ENST00000518074 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369633 | ENST00000541342 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369633 | ENST00000521214 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369633 | ENST00000517693 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369633 | ENST00000518060 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369642 | ENST00000297423 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369642 | ENST00000518074 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369642 | ENST00000541342 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369642 | ENST00000521214 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369642 | ENST00000517693 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369642 | ENST00000518060 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000285735 | ENST00000297423 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000285735 | ENST00000518074 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000285735 | ENST00000541342 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000285735 | ENST00000521214 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000285735 | ENST00000517693 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000285735 | ENST00000518060 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369638 | ENST00000297423 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369638 | ENST00000518074 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369638 | ENST00000541342 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369638 | ENST00000521214 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369638 | ENST00000517693 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369638 | ENST00000518060 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369637 | ENST00000297423 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369637 | ENST00000518074 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369637 | ENST00000541342 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369637 | ENST00000521214 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369637 | ENST00000517693 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369637 | ENST00000518060 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369636 | ENST00000297423 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369636 | ENST00000518074 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369636 | ENST00000541342 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369636 | ENST00000521214 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369636 | ENST00000517693 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369636 | ENST00000518060 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369632 | ENST00000297423 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369632 | ENST00000518074 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369632 | ENST00000541342 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369632 | ENST00000521214 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369632 | ENST00000517693 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
| intron-intron | ENST00000369632 | ENST00000518060 | RHOC | chr1 | 113244200 | + | SPIDR | chr8 | 48616535 | - |
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FusionProtFeatures for RHOC_SPIDR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RHOC | SPIDR |
| Regulates a signal transduction pathway linking plasmamembrane receptors to the assembly of focal adhesions and actinstress fibers. Serves as a microtubule-dependent signal that isrequired for the myosin contractile ring formation during cellcycle cytokinesis. Regulates apical junction formation inbronchial epithelial cells. {ECO:0000269|PubMed:16236794,ECO:0000269|PubMed:20974804}. | Plays a role in DNA double-strand break (DBS) repair viahomologous recombination (HR). Serves as a scaffolding proteinthat helps to promote the recruitment of DNA-processing enzymeslike the helicase BLM and recombinase RAD51 to site of DNA damage,and hence contributes to maintain genomic integrity.{ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RHOC_SPIDR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RHOC_SPIDR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RHOC_SPIDR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RHOC_SPIDR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RHOC | C0151744 | Myocardial Ischemia | 1 | CTD_human |
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