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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31178

FusionGeneSummary for RHOBTB2_STK40

check button Fusion gene summary
Fusion gene informationFusion gene name: RHOBTB2_STK40
Fusion gene ID: 31178
HgeneTgene
Gene symbol

RHOBTB2

STK40

Gene ID

23221

83931

Gene nameRho related BTB domain containing 2serine/threonine kinase 40
SynonymsDBC2SHIK|SgK495
Cytomap

8p21.3

1p34.3

Type of geneprotein-codingprotein-coding
Descriptionrho-related BTB domain-containing protein 2deleted in breast cancer 2 gene proteinp83serine/threonine-protein kinase 40SINK-homologous serine/threonine-protein kinaseSer/Thr-like kinasesugen kinase 495
Modification date2018052320180519
UniProtAcc

Q9BYZ6

Q8N2I9

Ensembl transtripts involved in fusion geneENST00000519685, ENST00000522948, 
ENST00000251822, ENST00000523918, 
ENST00000373129, ENST00000373130, 
ENST00000373132, ENST00000482458, 
ENST00000359297, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 1=16
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RHOBTB2 [Title/Abstract] AND STK40 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF445312RHOBTB2chr8

22877951

+STK40chr1

36823513

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000519685ENST00000373129RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000519685ENST00000373130RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000519685ENST00000373132RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000519685ENST00000482458RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000519685ENST00000359297RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000522948ENST00000373129RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000522948ENST00000373130RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000522948ENST00000373132RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000522948ENST00000482458RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000522948ENST00000359297RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000251822ENST00000373129RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000251822ENST00000373130RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000251822ENST00000373132RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000251822ENST00000482458RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000251822ENST00000359297RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000523918ENST00000373129RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000523918ENST00000373130RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000523918ENST00000373132RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000523918ENST00000482458RHOBTB2chr8

22877951

+STK40chr1

36823513

+
intron-intronENST00000523918ENST00000359297RHOBTB2chr8

22877951

+STK40chr1

36823513

+

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FusionProtFeatures for RHOBTB2_STK40


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RHOBTB2

Q9BYZ6

STK40

Q8N2I9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RHOBTB2_STK40


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RHOBTB2_STK40


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RHOBTB2_STK40


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RHOBTB2_STK40


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRHOBTB2C0031117Peripheral Neuropathy1CTD_human