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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31157

FusionGeneSummary for RHCG_TULP4

check button Fusion gene summary
Fusion gene informationFusion gene name: RHCG_TULP4
Fusion gene ID: 31157
HgeneTgene
Gene symbol

RHCG

TULP4

Gene ID

51458

56995

Gene nameRh family C glycoproteintubby like protein 4
SynonymsC15orf6|PDRC2|RHGK|SLC42A3TUSP
Cytomap

15q26.1

6q25.3

Type of geneprotein-codingprotein-coding
Descriptionammonium transporter Rh type CRh type C glycoproteinRhesus blood group, C glycoproteinrh family type C glycoproteinrh glycoprotein kidneyrhesus blood group family type C glycoproteintumor-related protein DRC2tubby-related protein 4tubby super-family proteintubby superfamily protein
Modification date2018052320180523
UniProtAcc

Q9UBD6

Q9NRJ4

Ensembl transtripts involved in fusion geneENST00000544600, ENST00000268122, 
ENST00000367094, ENST00000367097, 
Fusion gene scores* DoF score4 X 4 X 3=481 X 1 X 1=1
# samples 41
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: RHCG [Title/Abstract] AND TULP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRHCG

GO:0006873

cellular ion homeostasis

14761968

HgeneRHCG

GO:0015696

ammonium transport

14761968|15929723|16580862|18032481

HgeneRHCG

GO:0070634

transepithelial ammonium transport

18032481


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ351152RHCGchr15

90016359

+TULP4chr6

158915672

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000544600ENST00000367094RHCGchr15

90016359

+TULP4chr6

158915672

+
intron-intronENST00000544600ENST00000367097RHCGchr15

90016359

+TULP4chr6

158915672

+
intron-intronENST00000268122ENST00000367094RHCGchr15

90016359

+TULP4chr6

158915672

+
intron-intronENST00000268122ENST00000367097RHCGchr15

90016359

+TULP4chr6

158915672

+

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FusionProtFeatures for RHCG_TULP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RHCG

Q9UBD6

TULP4

Q9NRJ4

Functions as an electroneutral and bidirectionalammonium transporter. May regulate transepithelial ammoniasecretion. {ECO:0000269|PubMed:11062476,ECO:0000269|PubMed:14761968, ECO:0000269|PubMed:15929723,ECO:0000269|PubMed:16477434}. May be a substrate-recognition component of a SCF-likeECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complexwhich mediates the ubiquitination and subsequent proteasomaldegradation of target proteins. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RHCG_TULP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RHCG_TULP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RHCG_TULP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RHCG_TULP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource