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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 31132

FusionGeneSummary for RGS6_RGS6

check button Fusion gene summary
Fusion gene informationFusion gene name: RGS6_RGS6
Fusion gene ID: 31132
HgeneTgene
Gene symbol

RGS6

RGS6

Gene ID

9628

9628

Gene nameregulator of G protein signaling 6regulator of G protein signaling 6
SynonymsGAP|HA117|S914GAP|HA117|S914
Cytomap

14q24.2

14q24.2

Type of geneprotein-codingprotein-coding
Descriptionregulator of G-protein signaling 6regulator of G-protein signalling 6regulator of G-protein signaling 6regulator of G-protein signalling 6
Modification date2018052220180522
UniProtAcc

P49758

P49758

Ensembl transtripts involved in fusion geneENST00000553525, ENST00000555571, 
ENST00000553530, ENST00000556437, 
ENST00000355512, ENST00000406236, 
ENST00000404301, ENST00000407322, 
ENST00000402788, ENST00000343854, 
ENST00000434263, ENST00000554782, 
ENST00000553690, 
ENST00000553525, 
ENST00000555571, ENST00000553530, 
ENST00000556437, ENST00000355512, 
ENST00000406236, ENST00000404301, 
ENST00000407322, ENST00000402788, 
ENST00000343854, ENST00000434263, 
ENST00000554782, ENST00000553690, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 4 X 5=120
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RGS6 [Title/Abstract] AND RGS6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRGS6

GO:0043547

positive regulation of GTPase activity

10521509

TgeneRGS6

GO:0043547

positive regulation of GTPase activity

10521509


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF119880RGS6chr14

72472959

+RGS6chr14

72473568

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000553525ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553525ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000555571ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553530ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000556437ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000355512ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000406236ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000404301ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000407322ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000402788ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000343854ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000434263ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000554782ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000553525RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000555571RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000553530RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000556437RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000355512RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000406236RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000404301RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000407322RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000402788RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000343854RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000434263RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000554782RGS6chr14

72472959

+RGS6chr14

72473568

-
intron-intronENST00000553690ENST00000553690RGS6chr14

72472959

+RGS6chr14

72473568

-

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FusionProtFeatures for RGS6_RGS6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RGS6

P49758

RGS6

P49758


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RGS6_RGS6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RGS6_RGS6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RGS6_RGS6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RGS6_RGS6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRGS6C0525045Mood Disorders1PSYGENET
TgeneRGS6C0525045Mood Disorders1PSYGENET