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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31119

FusionGeneSummary for RGS3_AFF3

check button Fusion gene summary
Fusion gene informationFusion gene name: RGS3_AFF3
Fusion gene ID: 31119
HgeneTgene
Gene symbol

RGS3

AFF3

Gene ID

5998

3899

Gene nameregulator of G protein signaling 3AF4/FMR2 family member 3
SynonymsC2PA|RGP3LAF4|MLLT2-like
Cytomap

9q32

2q11.2

Type of geneprotein-codingprotein-coding
Descriptionregulator of G-protein signaling 3regulator of G-protein signalling 3AF4/FMR2 family member 3MLLT2-related proteinlymphoid nuclear protein 4lymphoid nuclear protein related to AF4protein LAF-4
Modification date2018051920180523
UniProtAcc

P49796

P51826

Ensembl transtripts involved in fusion geneENST00000374140, ENST00000350696, 
ENST00000317613, ENST00000343817, 
ENST00000394646, ENST00000374136, 
ENST00000462143, ENST00000463806, 
ENST00000342620, ENST00000374134, 
ENST00000462403, 
ENST00000409236, 
ENST00000356421, ENST00000317233, 
ENST00000409579, ENST00000483600, 
Fusion gene scores* DoF score5 X 5 X 5=1257 X 7 X 4=196
# samples 67
** MAII scorelog2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RGS3 [Title/Abstract] AND AFF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG013798RGS3chr9

116310626

-AFF3chr2

100547750

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000374140ENST00000409236RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374140ENST00000356421RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374140ENST00000317233RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374140ENST00000409579RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374140ENST00000483600RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000350696ENST00000409236RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000350696ENST00000356421RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000350696ENST00000317233RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000350696ENST00000409579RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000350696ENST00000483600RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000317613ENST00000409236RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000317613ENST00000356421RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000317613ENST00000317233RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000317613ENST00000409579RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000317613ENST00000483600RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000343817ENST00000409236RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000343817ENST00000356421RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000343817ENST00000317233RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000343817ENST00000409579RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000343817ENST00000483600RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000394646ENST00000409236RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000394646ENST00000356421RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000394646ENST00000317233RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000394646ENST00000409579RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000394646ENST00000483600RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374136ENST00000409236RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374136ENST00000356421RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374136ENST00000317233RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374136ENST00000409579RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374136ENST00000483600RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000462143ENST00000409236RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000462143ENST00000356421RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000462143ENST00000317233RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000462143ENST00000409579RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000462143ENST00000483600RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000463806ENST00000409236RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000463806ENST00000356421RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000463806ENST00000317233RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000463806ENST00000409579RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000463806ENST00000483600RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000342620ENST00000409236RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000342620ENST00000356421RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000342620ENST00000317233RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000342620ENST00000409579RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000342620ENST00000483600RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374134ENST00000409236RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374134ENST00000356421RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374134ENST00000317233RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374134ENST00000409579RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000374134ENST00000483600RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000462403ENST00000409236RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000462403ENST00000356421RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000462403ENST00000317233RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000462403ENST00000409579RGS3chr9

116310626

-AFF3chr2

100547750

+
intron-intronENST00000462403ENST00000483600RGS3chr9

116310626

-AFF3chr2

100547750

+

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FusionProtFeatures for RGS3_AFF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RGS3

P49796

AFF3

P51826


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RGS3_AFF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RGS3_AFF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RGS3_AFF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RGS3_AFF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRGS3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneAFF3C0003873Rheumatoid Arthritis2CTD_human
TgeneAFF3C0236969Substance-Related Disorders1CTD_human