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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31116

FusionGeneSummary for RGS22_LDHC

check button Fusion gene summary
Fusion gene informationFusion gene name: RGS22_LDHC
Fusion gene ID: 31116
HgeneTgene
Gene symbol

RGS22

LDHC

Gene ID

26166

3948

Gene nameregulator of G protein signaling 22lactate dehydrogenase C
SynonymsCT145|PRTD-NY2CT32|LDH3|LDHX
Cytomap

8q22.2

11p15.1

Type of geneprotein-codingprotein-coding
Descriptionregulator of G-protein signaling 22L-lactate dehydrogenase C chainLDH testis subunitLDH-CLDH-Xcancer/testis antigen 32lactate dehydrogenase C4lactate dehydrogenase c variant 1lactate dehydrogenase c variant 3lactate dehydrogenase c variant 4lactate dehydrogenase c variant 5testis
Modification date2018040320180519
UniProtAcc

Q8NE09

P07864

Ensembl transtripts involved in fusion geneENST00000360863, ENST00000523287, 
ENST00000523437, ENST00000519421, 
ENST00000541669, ENST00000280704, 
ENST00000544105, ENST00000536880, 
ENST00000535809, ENST00000537486, 
ENST00000546146, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: RGS22 [Title/Abstract] AND LDHC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU569321RGS22chr8

100990196

-LDHCchr11

18472647

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000360863ENST00000541669RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3CDSENST00000360863ENST00000280704RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000360863ENST00000544105RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000360863ENST00000536880RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000360863ENST00000535809RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000360863ENST00000537486RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000360863ENST00000546146RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3CDSENST00000523287ENST00000541669RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3CDSENST00000523287ENST00000280704RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000523287ENST00000544105RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000523287ENST00000536880RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000523287ENST00000535809RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000523287ENST00000537486RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000523287ENST00000546146RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3CDSENST00000523437ENST00000541669RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3CDSENST00000523437ENST00000280704RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000523437ENST00000544105RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000523437ENST00000536880RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000523437ENST00000535809RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000523437ENST00000537486RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000523437ENST00000546146RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3CDSENST00000519421ENST00000541669RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3CDSENST00000519421ENST00000280704RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000519421ENST00000544105RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000519421ENST00000536880RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000519421ENST00000535809RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000519421ENST00000537486RGS22chr8

100990196

-LDHCchr11

18472647

+
intron-3UTRENST00000519421ENST00000546146RGS22chr8

100990196

-LDHCchr11

18472647

+

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FusionProtFeatures for RGS22_LDHC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RGS22

Q8NE09

LDHC

P07864

Inhibits signal transduction by increasing the GTPaseactivity of G protein alpha subunits thereby driving them intotheir inactive GDP-bound form. {ECO:0000250}. Possible role in sperm motility.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RGS22_LDHC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RGS22_LDHC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RGS22_LDHC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RGS22_LDHC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLDHCC0021364Male infertility2CTD_human
TgeneLDHCC0024115Lung diseases1CTD_human