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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31041

FusionGeneSummary for RFTN1_ZNF438

check button Fusion gene summary
Fusion gene informationFusion gene name: RFTN1_ZNF438
Fusion gene ID: 31041
HgeneTgene
Gene symbol

RFTN1

ZNF438

Gene ID

23180

220929

Gene nameraftlin, lipid raft linker 1zinc finger protein 438
SynonymsMIG2|PIB10|PIG9|RAFTLINbA330O11.1
Cytomap

3p24.3

10p11.23

Type of geneprotein-codingprotein-coding
Descriptionraftlincell migration-inducing gene 2 proteinproliferation-inducing protein 10proliferation-inducing protein 9raft-linking proteinzinc finger protein 438
Modification date2018051920180523
UniProtAcc

Q14699

Q7Z4V0

Ensembl transtripts involved in fusion geneENST00000432519, ENST00000334133, 
ENST00000483671, 
ENST00000331737, 
ENST00000361310, ENST00000413025, 
ENST00000436087, ENST00000452305, 
ENST00000442986, ENST00000538351, 
ENST00000375311, ENST00000444692, 
Fusion gene scores* DoF score5 X 6 X 5=1505 X 7 X 5=175
# samples 812
** MAII scorelog2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/175*10)=-0.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RFTN1 [Title/Abstract] AND ZNF438 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-HP-A5N0-01ARFTN1chr3

16535232

-ZNF438chr10

31230580

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000432519ENST00000331737RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000432519ENST00000361310RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000432519ENST00000413025RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000432519ENST00000436087RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000432519ENST00000452305RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000432519ENST00000442986RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000432519ENST00000538351RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000432519ENST00000375311RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-intronENST00000432519ENST00000444692RFTN1chr3

16535232

-ZNF438chr10

31230580

-
5CDS-5UTRENST00000334133ENST00000331737RFTN1chr3

16535232

-ZNF438chr10

31230580

-
5CDS-5UTRENST00000334133ENST00000361310RFTN1chr3

16535232

-ZNF438chr10

31230580

-
5CDS-5UTRENST00000334133ENST00000413025RFTN1chr3

16535232

-ZNF438chr10

31230580

-
5CDS-5UTRENST00000334133ENST00000436087RFTN1chr3

16535232

-ZNF438chr10

31230580

-
5CDS-5UTRENST00000334133ENST00000452305RFTN1chr3

16535232

-ZNF438chr10

31230580

-
5CDS-5UTRENST00000334133ENST00000442986RFTN1chr3

16535232

-ZNF438chr10

31230580

-
5CDS-5UTRENST00000334133ENST00000538351RFTN1chr3

16535232

-ZNF438chr10

31230580

-
5CDS-5UTRENST00000334133ENST00000375311RFTN1chr3

16535232

-ZNF438chr10

31230580

-
5CDS-intronENST00000334133ENST00000444692RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000483671ENST00000331737RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000483671ENST00000361310RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000483671ENST00000413025RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000483671ENST00000436087RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000483671ENST00000452305RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000483671ENST00000442986RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000483671ENST00000538351RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-5UTRENST00000483671ENST00000375311RFTN1chr3

16535232

-ZNF438chr10

31230580

-
intron-intronENST00000483671ENST00000444692RFTN1chr3

16535232

-ZNF438chr10

31230580

-

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FusionProtFeatures for RFTN1_ZNF438


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RFTN1

Q14699

ZNF438

Q7Z4V0

Involved in protein trafficking via association withclathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Uponbacterial lipopolysaccharide stimulation, mediates internalizationof TLR4 to endosomes in dendritic cells and macrophages; andinternalization of poly(I:C) to TLR3-positive endosomes in myeloiddendritic cells and epithelial cells; resulting in activation ofTICAM1-mediated signaling and subsequent IFNB1 production(PubMed:27022195, PubMed:21266579). Involved in T-cell antigenreceptor-mediated signaling by regulating tyrosine kinase LCKlocalization, T-cell dependent antibody production and cytokinesecretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role inthe formation and/or maintenance of lipid rafts (PubMed:12805216).{ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216,ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. Isoform 1 acts as a transcriptional repressor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RFTN1_ZNF438


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RFTN1_ZNF438


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RFTN1SLC25A41, UNC119, MUS81, PTEN, CTDSPL, RABGAP1L, TGM5, ATG2A, SDC1, GJB7ZNF438


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RFTN1_ZNF438


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RFTN1_ZNF438


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZNF438C0025202melanoma1CTD_human