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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31013

FusionGeneSummary for REV3L_TXLNB

check button Fusion gene summary
Fusion gene informationFusion gene name: REV3L_TXLNB
Fusion gene ID: 31013
HgeneTgene
Gene symbol

REV3L

TXLNB

Gene ID

5980

167838

Gene nameREV3 like, DNA directed polymerase zeta catalytic subunittaxilin beta
SynonymsPOLZ|REV3C6orf198|LST001|MDP77|dJ522B19.2
Cytomap

6q21

6q24.1

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase zeta catalytic subunitREV3-like, polymerase (DNA directed), zeta, catalytic subunitRev-3, yeast, homolog-like (polymerase, DNA, zeta)beta-taxilinmuscle-derived protein 77
Modification date2018052320180519
UniProtAcc

O60673

Q8N3L3

Ensembl transtripts involved in fusion geneENST00000368802, ENST00000368805, 
ENST00000435970, ENST00000358835, 
ENST00000462119, 
ENST00000358430, 
Fusion gene scores* DoF score12 X 11 X 9=11882 X 2 X 2=8
# samples 182
** MAII scorelog2(18/1188*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: REV3L [Title/Abstract] AND TXLNB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG393386REV3Lchr6

111694979

+TXLNBchr6

139562362

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000368802ENST00000358430REV3Lchr6

111694979

+TXLNBchr6

139562362

-
intron-3UTRENST00000368805ENST00000358430REV3Lchr6

111694979

+TXLNBchr6

139562362

-
intron-3UTRENST00000435970ENST00000358430REV3Lchr6

111694979

+TXLNBchr6

139562362

-
intron-3UTRENST00000358835ENST00000358430REV3Lchr6

111694979

+TXLNBchr6

139562362

-
intron-3UTRENST00000462119ENST00000358430REV3Lchr6

111694979

+TXLNBchr6

139562362

-

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FusionProtFeatures for REV3L_TXLNB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
REV3L

O60673

TXLNB

Q8N3L3

Catalytic subunit of the DNA polymerase zeta complex, anerror-prone polymerase specialized in translesion DNA synthesis(TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus hasno proofreading function. {ECO:0000269|PubMed:24449906}. Promotes motor nerve regeneration (By similarity). Maybe involved in intracellular vesicle traffic. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for REV3L_TXLNB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for REV3L_TXLNB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for REV3L_TXLNB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for REV3L_TXLNB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource