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Fusion gene ID: 30997 |
FusionGeneSummary for REV1_LYG2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: REV1_LYG2 | Fusion gene ID: 30997 | Hgene | Tgene | Gene symbol | REV1 | LYG2 | Gene ID | 51455 | 254773 |
| Gene name | REV1, DNA directed polymerase | lysozyme g2 | |
| Synonyms | AIBP80|REV1L | LYGH|LYSG2 | |
| Cytomap | 2q11.2 | 2q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA repair protein REV1REV1 homologREV1, polymerase (DNA directed)REV1- likealpha integrin-binding protein 80rev1-like terminal deoxycytidyl transferase | lysozyme g-like protein 2lysozyme G-like 2 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9UBZ9 | Q86SG7 | |
| Ensembl transtripts involved in fusion gene | ENST00000393445, ENST00000258428, ENST00000465835, | ENST00000409238, ENST00000333017, ENST00000423800, ENST00000409679, | |
| Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 3 X 2 X 3=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/224*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: REV1 [Title/Abstract] AND LYG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | REV1 | GO:0009411 | response to UV | 11485998 |
| Tgene | LYG2 | GO:0042742 | defense response to bacterium | 21093056 |
| Tgene | LYG2 | GO:0050830 | defense response to Gram-positive bacterium | 21093056 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-FD-A5BZ-01A | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393445 | ENST00000409238 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| In-frame | ENST00000393445 | ENST00000333017 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| Frame-shift | ENST00000393445 | ENST00000423800 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| In-frame | ENST00000393445 | ENST00000409679 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| In-frame | ENST00000258428 | ENST00000409238 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| In-frame | ENST00000258428 | ENST00000333017 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| Frame-shift | ENST00000258428 | ENST00000423800 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| In-frame | ENST00000258428 | ENST00000409679 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| intron-3CDS | ENST00000465835 | ENST00000409238 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| intron-3CDS | ENST00000465835 | ENST00000333017 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| intron-3CDS | ENST00000465835 | ENST00000423800 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
| intron-3CDS | ENST00000465835 | ENST00000409679 | REV1 | chr2 | 100078958 | - | LYG2 | chr2 | 99863283 | - |
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FusionProtFeatures for REV1_LYG2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| REV1 | LYG2 |
| Deoxycytidyl transferase involved in DNA repair.Transfers a dCMP residue from dCTP to the 3'-end of a DNA primerin a template-dependent reaction. May assist in the first step inthe bypass of abasic lesions by the insertion of a nucleotideopposite the lesion. Required for normal induction of mutations byphysical and chemical agents. {ECO:0000269|PubMed:10536157,ECO:0000269|PubMed:10760286, ECO:0000269|PubMed:11278384,ECO:0000269|PubMed:11485998, ECO:0000269|PubMed:22266823}. | May act as a potent antibacterial protein that may playa role in the innate immunity. {ECO:0000269|PubMed:21093056}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >REV1 | chr2:100078958 | chr2:99863283 | ENST00000258428 | - | 3 | 23 | 419_653 | 60 | 1252 | Domain | UmuC |
| Hgene | >REV1 | chr2:100078958 | chr2:99863283 | ENST00000258428 | - | 3 | 23 | 44_131 | 60 | 1252 | Domain | BRCT |
| Hgene | >REV1 | chr2:100078958 | chr2:99863283 | ENST00000393445 | - | 3 | 23 | 419_653 | 60 | 1251 | Domain | UmuC |
| Hgene | >REV1 | chr2:100078958 | chr2:99863283 | ENST00000393445 | - | 3 | 23 | 44_131 | 60 | 1251 | Domain | BRCT |
| Hgene | >REV1 | chr2:100078958 | chr2:99863283 | ENST00000258428 | - | 3 | 23 | 1071_1078 | 60 | 1252 | Motif | Nuclear localization signal |
| Hgene | >REV1 | chr2:100078958 | chr2:99863283 | ENST00000393445 | - | 3 | 23 | 1071_1078 | 60 | 1251 | Motif | Nuclear localization signal |
| Hgene | >REV1 | chr2:100078958 | chr2:99863283 | ENST00000258428 | - | 3 | 23 | 423_427 | 60 | 1252 | Nucleotide binding | dCTP binding |
| Hgene | >REV1 | chr2:100078958 | chr2:99863283 | ENST00000258428 | - | 3 | 23 | 510_516 | 60 | 1252 | Nucleotide binding | dCTP binding |
| Hgene | >REV1 | chr2:100078958 | chr2:99863283 | ENST00000393445 | - | 3 | 23 | 423_427 | 60 | 1251 | Nucleotide binding | dCTP binding |
| Hgene | >REV1 | chr2:100078958 | chr2:99863283 | ENST00000393445 | - | 3 | 23 | 510_516 | 60 | 1251 | Nucleotide binding | dCTP binding |
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FusionGeneSequence for REV1_LYG2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_REV1_ENST00000393445_chr2_100078958_-_LYG2_ENST00000409238_chr2_99863283_-_259aa MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIM TMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYH >In-frame_REV1_ENST00000393445_chr2_100078958_-_LYG2_ENST00000333017_chr2_99863283_-_259aa MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIM TMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYH >In-frame_REV1_ENST00000393445_chr2_100078958_-_LYG2_ENST00000409679_chr2_99863283_-_229aa MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIM TMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYH >In-frame_REV1_ENST00000258428_chr2_100078958_-_LYG2_ENST00000409238_chr2_99863283_-_259aa MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIM TMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYH >In-frame_REV1_ENST00000258428_chr2_100078958_-_LYG2_ENST00000333017_chr2_99863283_-_259aa MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIM TMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYH >In-frame_REV1_ENST00000258428_chr2_100078958_-_LYG2_ENST00000409679_chr2_99863283_-_229aa MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTGTSRGSYPFSHSMKPHLHPRLYHGCYGDIM TMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDHRGLKFGLMQLDKQTYH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_REV1_ENST00000393445_chr2_100078958_-_LYG2_ENST00000409238_chr2_99863283_-_777nt ATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAG GAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACA GGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATG ACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTG AGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGG GAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCAC CCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCC ACGTGGAGTGTTGCTCAGCACCTCAAAGGTGGTCTCTCAGCTTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAAT >In-frame_REV1_ENST00000393445_chr2_100078958_-_LYG2_ENST00000333017_chr2_99863283_-_777nt ATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAG GAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACA GGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATG ACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTG AGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGG GAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCAC CCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCC ACGTGGAGTGTTGCTCAGCACCTCAAAGGTGGTCTCTCAGCTTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAAT >In-frame_REV1_ENST00000393445_chr2_100078958_-_LYG2_ENST00000409679_chr2_99863283_-_687nt ATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAG GAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACA GGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATG ACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTG AGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGG GAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCAC CCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCC >In-frame_REV1_ENST00000258428_chr2_100078958_-_LYG2_ENST00000409238_chr2_99863283_-_777nt ATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAG GAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACA GGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATG ACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTG AGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGG GAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCAC CCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCC ACGTGGAGTGTTGCTCAGCACCTCAAAGGTGGTCTCTCAGCTTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAAT >In-frame_REV1_ENST00000258428_chr2_100078958_-_LYG2_ENST00000333017_chr2_99863283_-_777nt ATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAG GAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACA GGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATG ACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTG AGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGG GAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCAC CCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCC ACGTGGAGTGTTGCTCAGCACCTCAAAGGTGGTCTCTCAGCTTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAAT >In-frame_REV1_ENST00000258428_chr2_100078958_-_LYG2_ENST00000409679_chr2_99863283_-_687nt ATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAG GAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACA GGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATG ACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTG AGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGG GAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCAC CCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_REV1_ENST00000393445_chr2_100078958_-_LYG2_ENST00000409238_chr2_99863283_-_1062nt GGGAGCGTGGACCGCGGCGCTGCTCAGCGGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGG GGCCGGGGTCCGCAAGGCCGGAGAAGGCCGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTG GATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGAT CAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGG GCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCT CTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAAC CTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCG GATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCT GGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTG CTCAGCACCTCAAAGGTGGTCTCTCAGCTTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATG ATATCATTGCTCGAGCTAAGTTCTATAAAAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCC >In-frame_REV1_ENST00000393445_chr2_100078958_-_LYG2_ENST00000333017_chr2_99863283_-_1054nt GGGAGCGTGGACCGCGGCGCTGCTCAGCGGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGG GGCCGGGGTCCGCAAGGCCGGAGAAGGCCGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTG GATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGAT CAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGG GCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCT CTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAAC CTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCG GATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCT GGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTG CTCAGCACCTCAAAGGTGGTCTCTCAGCTTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATG ATATCATTGCTCGAGCTAAGTTCTATAAAAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCC >In-frame_REV1_ENST00000393445_chr2_100078958_-_LYG2_ENST00000409679_chr2_99863283_-_1038nt GGGAGCGTGGACCGCGGCGCTGCTCAGCGGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGG GGCCGGGGTCCGCAAGGCCGGAGAAGGCCGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTG GATGGAGGAAGCGAGCTGAAAATGATGGCTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGAT CAGATGCTGCTATGCAGAAGGATGGGACTTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGG GCTCATACCCCTTCAGTCACTCAATGAAGCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCT CTGGGGCCACTTGTGATGCAAACAGTGTGATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAAC CTTACCAGACTCTGATCAAAGAAGTCGGGCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCG GATCTGTCCTGCAAGACGGCTGGGACCACAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCT GGGATAGCAAAGAGCACCTTTCACAGGCTACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTG CTCAGCACCTCAAAGGTAGGCTGTATTCTGAGTACTTTGTTTAAATGAGCAATGAATGAGACCACTGAAGGCCAGTGTGACCCGAGACTC CCTGGGAGCATTTCCACGGGGTCAGCAGTGGCCCTGGGAGGAGCTGTCTAGAGGCTGCATTTGCATTCCCTGAACCACTGAGTTACTTTG >In-frame_REV1_ENST00000258428_chr2_100078958_-_LYG2_ENST00000409238_chr2_99863283_-_1124nt CGGAGGGGGAGGGGCGGAGAGCCACCGCGGAGCGCGCGCGGGGTTGGTTGCCGCGAGCGTGGGGGAGCGTGGACCGCGGCGCTGCTCAGC GGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGGGGCCGGGGTCCGCAAGGCCGGAGAAGGC CGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGG CTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGAC TTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAA GCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGT GATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGG GCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCA CAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGC TACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTGCTCAGCACCTCAAAGGTGGTCTCTCAGC TTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATGATATCATTGCTCGAGCTAAGTTCTATAA AAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCCGCCTTTGAGAGTTTTACGTGAATGTGTT >In-frame_REV1_ENST00000258428_chr2_100078958_-_LYG2_ENST00000333017_chr2_99863283_-_1116nt CGGAGGGGGAGGGGCGGAGAGCCACCGCGGAGCGCGCGCGGGGTTGGTTGCCGCGAGCGTGGGGGAGCGTGGACCGCGGCGCTGCTCAGC GGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGGGGCCGGGGTCCGCAAGGCCGGAGAAGGC CGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGG CTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGAC TTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAA GCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGT GATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGG GCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCA CAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGC TACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTGCTCAGCACCTCAAAGGTGGTCTCTCAGC TTTTAAGTCAGGAATTGAAGCGATTGCCACCCCATCGGACATAGACAATGACTTCGTCAATGATATCATTGCTCGAGCTAAGTTCTATAA AAGACAAAGCTTCTAGGCAAAGCTCTGTGGGTGGGCCAGGTTGGCAGAGTGCTCAGATGGCCGCCTTTGAGAGTTTTACGTGAATGTGTT >In-frame_REV1_ENST00000258428_chr2_100078958_-_LYG2_ENST00000409679_chr2_99863283_-_1100nt CGGAGGGGGAGGGGCGGAGAGCCACCGCGGAGCGCGCGCGGGGTTGGTTGCCGCGAGCGTGGGGGAGCGTGGACCGCGGCGCTGCTCAGC GGTGGGGCTGCCTTCCCCCGGCCCTCCTCCCTGGTCCCTGGCGAGGGCACTGGCGGCGGCGGGGCCGGGGTCCGCAAGGCCGGAGAAGGC CGCCGGGCCCGGGCATGGTGGTCTGGGGCAACGCGGAAGAAGCTCCACCATGAGGCGAGGTGGATGGAGGAAGCGAGCTGAAAATGATGG CTGGGAAACATGGGGTGGGTATATGGCTGCCAAGGTCCAGAAATTGGAGGAACAGTTTCGATCAGATGCTGCTATGCAGAAGGATGGGAC TTCATCTACAATTTTTAGTGGAGTTGCCATCTATGTTAATGGATACACAGGCACTTCCAGGGGCTCATACCCCTTCAGTCACTCAATGAA GCCTCACCTACATCCACGCCTGTACCACGGCTGCTATGGGGACATCATGACCATGAAGACCTCTGGGGCCACTTGTGATGCAAACAGTGT GATGAACTGCGGGATCCGTGGTTCTGAAATGTTTGCTGAGATGGATTTGAGGGCCATAAAACCTTACCAGACTCTGATCAAAGAAGTCGG GCAGAGACATTGCGTGGACCCTGCTGTCATCGCAGCCATCATCTCCAGGGAAAGCCATGGCGGATCTGTCCTGCAAGACGGCTGGGACCA CAGGGGACTTAAATTTGGCTTGATGCAGCTTGATAAACAAACGTACCACCCTGTCGGTGCCTGGGATAGCAAAGAGCACCTTTCACAGGC TACTGGGATTCTAACAGAGAGAATTAAGGCAATCCAGAAAAAATTCCCCACGTGGAGTGTTGCTCAGCACCTCAAAGGTAGGCTGTATTC TGAGTACTTTGTTTAAATGAGCAATGAATGAGACCACTGAAGGCCAGTGTGACCCGAGACTCCCTGGGAGCATTTCCACGGGGTCAGCAG TGGCCCTGGGAGGAGCTGTCTAGAGGCTGCATTTGCATTCCCTGAACCACTGAGTTACTTTGAGAGGTCCTCCATCCTCAACCTCCATTT |
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FusionGenePPI for REV1_LYG2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| REV1 | MAD2L2, POLH, POLDIP2, HSP90AA1, HSP90AB1, PCNA, UBC, MYC, POLK, POLI, REV3L, C1orf86, REV1, CDC27, BRCA1, MSH2, POLD3, RELA, CLK1, PIAS4, TP53, FANCD2, FANCI, FHL2, TSC22D2 | LYG2 | TEX35, RAB11B, DOLPP1, SGOL2, APIP, PYHIN1, NID2, SPATA20, IL31RA, FBXL4, VPS33B, VIPAS39, NSMAF, OAZ3, ZMAT4, RPN2, BIRC2, KIF3A, MRPL38, ZER1, CPLX3, SEMG2, LACC1, COL4A2, SETDB2, PPP2R2D, TRAF2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | REV1 | chr2:100078958 | chr2:99863283 | ENST00000258428 | - | 3 | 23 | 352_362 | 60 | 1252 | target DNA |
| Hgene | REV1 | chr2:100078958 | chr2:99863283 | ENST00000258428 | - | 3 | 23 | 653_656 | 60 | 1252 | target DNA |
| Hgene | REV1 | chr2:100078958 | chr2:99863283 | ENST00000258428 | - | 3 | 23 | 709_717 | 60 | 1252 | target DNA |
| Hgene | REV1 | chr2:100078958 | chr2:99863283 | ENST00000393445 | - | 3 | 23 | 352_362 | 60 | 1251 | target DNA |
| Hgene | REV1 | chr2:100078958 | chr2:99863283 | ENST00000393445 | - | 3 | 23 | 653_656 | 60 | 1251 | target DNA |
| Hgene | REV1 | chr2:100078958 | chr2:99863283 | ENST00000393445 | - | 3 | 23 | 709_717 | 60 | 1251 | target DNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for REV1_LYG2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for REV1_LYG2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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