FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 30992

FusionGeneSummary for RET_CCDC6

check button Fusion gene summary
Fusion gene informationFusion gene name: RET_CCDC6
Fusion gene ID: 30992
HgeneTgene
Gene symbol

RET

CCDC6

Gene ID

5979

8030

Gene nameret proto-oncogenecoiled-coil domain containing 6
SynonymsCDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1D10S170|H4|PTC|TPC|TST1
Cytomap

10q11.21

10q21.2

Type of geneprotein-codingprotein-coding
Descriptionproto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullarycoiled-coil domain-containing protein 6papillary thyroid carcinoma-encoded protein
Modification date2018052720180522
UniProtAcc

P07949

Q16204

Ensembl transtripts involved in fusion geneENST00000355710, ENST00000340058, 
ENST00000263102, 
Fusion gene scores* DoF score3 X 2 X 1=68 X 5 X 5=200
# samples 39
** MAII scorelog2(3/6*10)=2.32192809488736log2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RET [Title/Abstract] AND CCDC6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRET

GO:0030155

regulation of cell adhesion

21357690

HgeneRET

GO:0030335

positive regulation of cell migration

20702524

HgeneRET

GO:0033619

membrane protein proteolysis

21357690

HgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

HgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

HgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-DJ-A4V5-01ARETchr10

43610184

+CCDC6chr10

61612460

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355710ENST00000263102RETchr10

43610184

+CCDC6chr10

61612460

-
In-frameENST00000340058ENST00000263102RETchr10

43610184

+CCDC6chr10

61612460

-

Top

FusionProtFeatures for RET_CCDC6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RET

P07949

CCDC6

Q16204

Receptor tyrosine-protein kinase involved in numerouscellular mechanisms including cell proliferation, neuronalnavigation, cell migration, and cell differentiation upon bindingwith glial cell derived neurotrophic factor family ligands.Phosphorylates PTK2/FAK1. Regulates both cell death/survivalbalance and positional information. Required for the molecularmechanisms orchestration during intestine organogenesis; involvedin the development of enteric nervous system and renalorganogenesis during embryonic life, and promotes the formation ofPeyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via itscleavage by caspase in sympathetic neurons and mediates cellmigration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner.Involved in the development of the neural crest. Active in theabsence of ligand, triggering apoptosis through a mechanism thatrequires receptor intracellular caspase cleavage. Acts as adependence receptor; in the presence of the ligand GDNF insomatotrophs (within pituitary), promotes survival and downregulates growth hormone (GH) production, but triggers apoptosisin absence of GDNF. Regulates nociceptor survival and size.Triggers the differentiation of rapidly adapting (RA)mechanoreceptors. Mediator of several diseases such asneuroendocrine cancers; these diseases are characterized byaberrant integrins-regulated cell migration. Mediates, throughinteraction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways(PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 incomplex with GFRAL induces higher activation of MAPK-signalingpathway than isoform 2 in complex with GFRAL (PubMed:28846099).{ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503,ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690,ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:28846097,ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRETchr10:43610184chr10:61612460ENST00000340058+1119168_2727121073DomainCadherin
HgeneRETchr10:43610184chr10:61612460ENST00000355710+1120168_2727121115DomainCadherin
HgeneRETchr10:43610184chr10:61612460ENST00000340058+111929_6357121073Topological domainExtracellular
HgeneRETchr10:43610184chr10:61612460ENST00000355710+112029_6357121115Topological domainExtracellular
HgeneRETchr10:43610184chr10:61612460ENST00000340058+1119636_6577121073TransmembraneHelical
HgeneRETchr10:43610184chr10:61612460ENST00000355710+1120636_6577121115TransmembraneHelical
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-09253_332101475Coiled coilOntology_term=ECO:0000255
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-09440_448101475Compositional biasNote=Poly-Pro
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-09442_451101475MotifSH3-binding
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-09106_235101475RegionNote=5 X 29 AA tandem repeats
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-09106_134101475RepeatNote=1
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-09135_163101475RepeatNote=2
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-09164_192101475RepeatNote=3
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-09193_206101475RepeatNote=4%3B approximate
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-09207_235101475RepeatNote=5

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRETchr10:43610184chr10:61612460ENST00000340058+1119724_10167121073DomainProtein kinase
HgeneRETchr10:43610184chr10:61612460ENST00000355710+1120724_10167121115DomainProtein kinase
HgeneRETchr10:43610184chr10:61612460ENST00000340058+1119730_7387121073Nucleotide bindingATP
HgeneRETchr10:43610184chr10:61612460ENST00000355710+1120730_7387121115Nucleotide bindingATP
HgeneRETchr10:43610184chr10:61612460ENST00000340058+1119805_8077121073RegionNote=Inhibitors binding
HgeneRETchr10:43610184chr10:61612460ENST00000355710+1120805_8077121115RegionNote=Inhibitors binding
HgeneRETchr10:43610184chr10:61612460ENST00000340058+1119658_11147121073Topological domainCytoplasmic
HgeneRETchr10:43610184chr10:61612460ENST00000355710+1120658_11147121115Topological domainCytoplasmic
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-0953_237101475Coiled coilOntology_term=ECO:0000255
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-0917_20101475Compositional biasNote=Poly-Ser
TgeneCCDC6chr10:43610184chr10:61612460ENST00000263102-0932_44101475Compositional biasNote=Poly-Gly


Top

FusionGeneSequence for RET_CCDC6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RET_ENST00000355710_chr10_43610184_+_CCDC6_ENST00000263102_chr10_61612460_-_1086aa
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLTVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDTRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSTVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGTGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILQARAEQEE
EFISNTLFKKIQALQKEKETLAVNTEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREK
IDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQ
TLEEERHMREENLRLQRKLQREMERREALCRQLSESESSLEMDDERTFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSTASHTVGF
TPPTSLTRAGMSTYNSPGLHVQHMGTSHGITRPSPRRSNSPDKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPTVPSAATSQPTPSQHSAH

>In-frame_RET_ENST00000340058_chr10_43610184_+_CCDC6_ENST00000263102_chr10_61612460_-_1086aa
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLTVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDTRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSTVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGTGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILQARAEQEE
EFISNTLFKKIQALQKEKETLAVNTEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREK
IDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQ
TLEEERHMREENLRLQRKLQREMERREALCRQLSESESSLEMDDERTFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSTASHTVGF
TPPTSLTRAGMSTYNSPGLHVQHMGTSHGITRPSPRRSNSPDKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPTVPSAATSQPTPSQHSAH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RET_ENST00000355710_chr10_43610184_+_CCDC6_ENST00000263102_chr10_61612460_-_3258nt
ATGGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCTGCTGTTGCTGCTGCTGCTGCCGCTGCTAGGCAAAGTGGCATTGGGCCTCTAC
TTCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGACCAGGCAGCCGGCACGCCCTTGCTGTACGTCCATGCCCTGCGGGACGCCCCT
GAGGAGGTGCCCAGCTTCCGCCTGGGCCAGCATCTCTACGGCACGTACCGCACACGGCTGCATGAGAACAACTGGATCTGCATCCAGGAG
GACACCGGCCTCCTCTACCTTAACCGGAGCCTGGACCATAGCTCCTGGGAGAAGCTCAGTGTCCGCAACCGCGGCTTTCCCCTGCTCACC
GTCTACCTCAAGGTCTTCCTGTCACCCACATCCCTTCGTGAGGGCGAGTGCCAGTGGCCAGGCTGTGCCCGCGTATACTTCTCCTTCTTC
AACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCGGGAGCTCTGCTTCCCAGAGACAAGGCCCTCCTTCCGCATTCGGGAGAACCGA
CCCCCAGGCACCTTCCACCAGTTCCGCCTGCTGCCTGTGCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAG
GGTCTGCCCTTCCGCTGCGCCCCGGACAGCCTGGAGGTGAGCACGCGCTGGGCCCTGGACCGCGAGCAGCGGGAGAAGTACGAGCTGGTG
GCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGTGGTGATGGTGCCCTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCC
ACCTTCCCCGCGGGCGTCGACACCGCCAGCGCCGTGGTGGAGTTCAAGCGGAAGGAGGACACCGTGGTGGCCACGCTGCGTGTCTTCGAT
GCAGACGTGGTACCTGCATCAGGGGAGCTGGTGAGGCGGTACACAAGCACGCTGCTCCCCGGGGACACCTGGGCCCAGCAGACCTTCCGG
GTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCCAACGGCAGCTTCGTGCGGGCGACCGTACATGACTATAGGCTGGTTCTCAACCGG
AACCTCTCCATCTCGGAGAACCGCACCATGCAGCTGGCGGTGCTGGTCAATGACTCAGACTTCCAGGGCCCAGGAGCGGGCGTCCTCTTG
CTCCACTTCAACGTGTCGGTGCTGCCGGTCAGCCTGCACCTGCCCAGTACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGCC
CAGATCGGGAAAGTCTGTGTGGAAAACTGCCAGGCATTCAGTGGCATCAACGTCCAGTACAAGCTGCATTCCTCTGGTGCCAACTGCAGC
ACGCTAGGGGTGGTCACCTCAGCCGAGGACACCTCGGGGATCCTGTTTGTGAATGACACCAAGGCCCTGCGGCGGCCCAAGTGTGCCGAA
CTTCACTACATGGTGGTGGCCACCGACCAGCAGACCTCTAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATATGTGGCC
GAGGAGGCGGGCTGCCCCCTGTCCTGTGCAGTCAGCAAGAGACGGCTGGAGTGTGAGGAGTGTGGCGGCCTGGGCTCCCCAACAGGCAGG
TGTGAGTGGAGGCAAGGAGATGGCAAAGGGATCACCAGGAACTTCTCCACCTGCTCTCCCAGCACCAAGACCTGCCCCGACGGCCACTGC
GATGTTGTGGAGACCCAAGACATCAACATTTGCCCTCAGGACTGCCTCCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGG
GGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGC
GACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTAC
CACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCC
GGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGCAAGCCAGGGCTGAGCAGGAAGAA
GAATTCATTAGTAACACTTTATTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAA
TTCCTCACTAATGAGCTCTCCAGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAAGAGCAGGAATTT
CAGGTCAACAAACTGATGAAGAAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTGAGACGGGAGAAG
ATTGACCTTGAAAATACATTGGAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAAGCTGAAAAGCGA
ATCCTGCAGGAAAAATTAGACCAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCAGAAAATATGATG
CGTCACATCAGGTTTTTAAAGAATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAGAAAATGGCACAG
TATCTGGAGGAGGAACGTCACATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGAGAAGCCCTCTGT
CGACAGCTCTCCGAGAGTGAGTCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTAAGACCTCGCACT
GTGTCCAGCCCGATCCCTTACACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCACACGGTTGGTTTC
ACGCCACCAACTTCACTGACTAGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACATCCCATGGTATC
ACAAGGCCTTCACCACGGAGAAGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAGACCCCAGTCCAG
CCACCTCCGCCTCCACCTCCGCCACCCATGCAGCCCACGGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAACATTCGGCGCAC

>In-frame_RET_ENST00000340058_chr10_43610184_+_CCDC6_ENST00000263102_chr10_61612460_-_3258nt
ATGGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCTGCTGTTGCTGCTGCTGCTGCCGCTGCTAGGCAAAGTGGCATTGGGCCTCTAC
TTCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGACCAGGCAGCCGGCACGCCCTTGCTGTACGTCCATGCCCTGCGGGACGCCCCT
GAGGAGGTGCCCAGCTTCCGCCTGGGCCAGCATCTCTACGGCACGTACCGCACACGGCTGCATGAGAACAACTGGATCTGCATCCAGGAG
GACACCGGCCTCCTCTACCTTAACCGGAGCCTGGACCATAGCTCCTGGGAGAAGCTCAGTGTCCGCAACCGCGGCTTTCCCCTGCTCACC
GTCTACCTCAAGGTCTTCCTGTCACCCACATCCCTTCGTGAGGGCGAGTGCCAGTGGCCAGGCTGTGCCCGCGTATACTTCTCCTTCTTC
AACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCGGGAGCTCTGCTTCCCAGAGACAAGGCCCTCCTTCCGCATTCGGGAGAACCGA
CCCCCAGGCACCTTCCACCAGTTCCGCCTGCTGCCTGTGCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAG
GGTCTGCCCTTCCGCTGCGCCCCGGACAGCCTGGAGGTGAGCACGCGCTGGGCCCTGGACCGCGAGCAGCGGGAGAAGTACGAGCTGGTG
GCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGTGGTGATGGTGCCCTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCC
ACCTTCCCCGCGGGCGTCGACACCGCCAGCGCCGTGGTGGAGTTCAAGCGGAAGGAGGACACCGTGGTGGCCACGCTGCGTGTCTTCGAT
GCAGACGTGGTACCTGCATCAGGGGAGCTGGTGAGGCGGTACACAAGCACGCTGCTCCCCGGGGACACCTGGGCCCAGCAGACCTTCCGG
GTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCCAACGGCAGCTTCGTGCGGGCGACCGTACATGACTATAGGCTGGTTCTCAACCGG
AACCTCTCCATCTCGGAGAACCGCACCATGCAGCTGGCGGTGCTGGTCAATGACTCAGACTTCCAGGGCCCAGGAGCGGGCGTCCTCTTG
CTCCACTTCAACGTGTCGGTGCTGCCGGTCAGCCTGCACCTGCCCAGTACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGCC
CAGATCGGGAAAGTCTGTGTGGAAAACTGCCAGGCATTCAGTGGCATCAACGTCCAGTACAAGCTGCATTCCTCTGGTGCCAACTGCAGC
ACGCTAGGGGTGGTCACCTCAGCCGAGGACACCTCGGGGATCCTGTTTGTGAATGACACCAAGGCCCTGCGGCGGCCCAAGTGTGCCGAA
CTTCACTACATGGTGGTGGCCACCGACCAGCAGACCTCTAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATATGTGGCC
GAGGAGGCGGGCTGCCCCCTGTCCTGTGCAGTCAGCAAGAGACGGCTGGAGTGTGAGGAGTGTGGCGGCCTGGGCTCCCCAACAGGCAGG
TGTGAGTGGAGGCAAGGAGATGGCAAAGGGATCACCAGGAACTTCTCCACCTGCTCTCCCAGCACCAAGACCTGCCCCGACGGCCACTGC
GATGTTGTGGAGACCCAAGACATCAACATTTGCCCTCAGGACTGCCTCCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGG
GGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGC
GACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTAC
CACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCC
GGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGCAAGCCAGGGCTGAGCAGGAAGAA
GAATTCATTAGTAACACTTTATTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAA
TTCCTCACTAATGAGCTCTCCAGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAAGAGCAGGAATTT
CAGGTCAACAAACTGATGAAGAAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTGAGACGGGAGAAG
ATTGACCTTGAAAATACATTGGAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAAGCTGAAAAGCGA
ATCCTGCAGGAAAAATTAGACCAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCAGAAAATATGATG
CGTCACATCAGGTTTTTAAAGAATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAGAAAATGGCACAG
TATCTGGAGGAGGAACGTCACATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGAGAAGCCCTCTGT
CGACAGCTCTCCGAGAGTGAGTCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTAAGACCTCGCACT
GTGTCCAGCCCGATCCCTTACACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCACACGGTTGGTTTC
ACGCCACCAACTTCACTGACTAGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACATCCCATGGTATC
ACAAGGCCTTCACCACGGAGAAGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAGACCCCAGTCCAG
CCACCTCCGCCTCCACCTCCGCCACCCATGCAGCCCACGGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAACATTCGGCGCAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_RET_ENST00000355710_chr10_43610184_+_CCDC6_ENST00000263102_chr10_61612460_-_7644nt
CCCTACCCGCTCCTCCGGCGCAGCCGGCGCTTACCTCGCTTCAGTCCCGCGACCGAAGCAGGGCGCGCAGCAGCGCTGAGTGCCCCGGAA
CGTGCGTCGCGCCCCCAGTGTCCGTCGCGTCCGCCGCGCCCCGGGCGGGGATGGGGCGGCCAGACTGAGCGCCGCACCCGCCATCCAGAC
CCGCCGGCCCTAGCCGCAGTCCCTCCAGCCGTGGCCCCAGCGCGCACGGGCGATGGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCT
GCTGTTGCTGCTGCTGCTGCCGCTGCTAGGCAAAGTGGCATTGGGCCTCTACTTCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGA
CCAGGCAGCCGGCACGCCCTTGCTGTACGTCCATGCCCTGCGGGACGCCCCTGAGGAGGTGCCCAGCTTCCGCCTGGGCCAGCATCTCTA
CGGCACGTACCGCACACGGCTGCATGAGAACAACTGGATCTGCATCCAGGAGGACACCGGCCTCCTCTACCTTAACCGGAGCCTGGACCA
TAGCTCCTGGGAGAAGCTCAGTGTCCGCAACCGCGGCTTTCCCCTGCTCACCGTCTACCTCAAGGTCTTCCTGTCACCCACATCCCTTCG
TGAGGGCGAGTGCCAGTGGCCAGGCTGTGCCCGCGTATACTTCTCCTTCTTCAACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCG
GGAGCTCTGCTTCCCAGAGACAAGGCCCTCCTTCCGCATTCGGGAGAACCGACCCCCAGGCACCTTCCACCAGTTCCGCCTGCTGCCTGT
GCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAGGGTCTGCCCTTCCGCTGCGCCCCGGACAGCCTGGAGGT
GAGCACGCGCTGGGCCCTGGACCGCGAGCAGCGGGAGAAGTACGAGCTGGTGGCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGT
GGTGATGGTGCCCTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCCACCTTCCCCGCGGGCGTCGACACCGCCAGCGCCGTGGT
GGAGTTCAAGCGGAAGGAGGACACCGTGGTGGCCACGCTGCGTGTCTTCGATGCAGACGTGGTACCTGCATCAGGGGAGCTGGTGAGGCG
GTACACAAGCACGCTGCTCCCCGGGGACACCTGGGCCCAGCAGACCTTCCGGGTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCCAA
CGGCAGCTTCGTGCGGGCGACCGTACATGACTATAGGCTGGTTCTCAACCGGAACCTCTCCATCTCGGAGAACCGCACCATGCAGCTGGC
GGTGCTGGTCAATGACTCAGACTTCCAGGGCCCAGGAGCGGGCGTCCTCTTGCTCCACTTCAACGTGTCGGTGCTGCCGGTCAGCCTGCA
CCTGCCCAGTACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGCCCAGATCGGGAAAGTCTGTGTGGAAAACTGCCAGGCATT
CAGTGGCATCAACGTCCAGTACAAGCTGCATTCCTCTGGTGCCAACTGCAGCACGCTAGGGGTGGTCACCTCAGCCGAGGACACCTCGGG
GATCCTGTTTGTGAATGACACCAAGGCCCTGCGGCGGCCCAAGTGTGCCGAACTTCACTACATGGTGGTGGCCACCGACCAGCAGACCTC
TAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATATGTGGCCGAGGAGGCGGGCTGCCCCCTGTCCTGTGCAGTCAGCAA
GAGACGGCTGGAGTGTGAGGAGTGTGGCGGCCTGGGCTCCCCAACAGGCAGGTGTGAGTGGAGGCAAGGAGATGGCAAAGGGATCACCAG
GAACTTCTCCACCTGCTCTCCCAGCACCAAGACCTGCCCCGACGGCCACTGCGATGTTGTGGAGACCCAAGACATCAACATTTGCCCTCA
GGACTGCCTCCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGGGGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCC
TGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGCGACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCT
CTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTACCACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGA
GATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCCGGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCA
GGTCTCCGTGGATGCCTTCAAGATCCTGCAAGCCAGGGCTGAGCAGGAAGAAGAATTCATTAGTAACACTTTATTCAAGAAAATTCAGGC
TTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAATTCCTCACTAATGAGCTCTCCAGAAAATTGATGCAGTT
GCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAAGAGCAGGAATTTCAGGTCAACAAACTGATGAAGAAAATTAAAAAACTGGA
GAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTGAGACGGGAGAAGATTGACCTTGAAAATACATTGGAACAAGAACAAGAAGC
ACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAAGCTGAAAAGCGAATCCTGCAGGAAAAATTAGACCAGCCCGTCTCTGCTCC
ACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCAGAAAATATGATGCGTCACATCAGGTTTTTAAAGAATGAAGTGGAACGGCT
GAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAGAAAATGGCACAGTATCTGGAGGAGGAACGTCACATGAGAGAAGAGAACTT
GAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGAGAAGCCCTCTGTCGACAGCTCTCCGAGAGTGAGTCCAGCTTAGAAATGGA
CGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTAAGACCTCGCACTGTGTCCAGCCCGATCCCTTACACACCTTCTCCGAGTTC
AAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCACACGGTTGGTTTCACGCCACCAACTTCACTGACTAGAGCTGGAATGTCTTA
TTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACATCCCATGGTATCACAAGGCCTTCACCACGGAGAAGCAACAGTCCTGACAA
ATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAGACCCCAGTCCAGCCACCTCCGCCTCCACCTCCGCCACCCATGCAGCCCAC
GGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAACATTCGGCGCACCCCTCCTCCCAGCCTTAATGCATGAGCTTAGTCTGAAT
TTCAAGTTGGGACTCATCCAATGGAGCCGTCTACTCAACGCCAAAGGCTTCCTTCTCTGGCATATTTGGATATGACTTATTTGCACTGAG
GTTATCTAGGCTTCACTATCCATTGTGTTGTAAATGTTTGTCAGAAATGCAGCCAGTGTTGTGGGTCTACAACACTAACCAGACGACTTT
TTCCATCAGTGTTTTACTTGAATCTTCATGTACGTCCATTCCCTGGCTGGAACCTTCGCTGTTTGGTATTTGGTATTTCAGCAGCAGTGT
GCAATTTTTGCTTGGCCCAGAGCTTCATTCTCCTGGCTTTTAGGTTTGTAAAAGAAAAAGGGATATCTTTTTTATATTTTTTTCCATGAA
TCTGCAGAAAATTACTGAGCTGTTGTTACCCTCCTCTCATTATAATAGTGTTTACCAAACATACCAATAATTCAGCACTACAATTCAGAC
CTTTGAAAATCTGGCTTTCAGTGTAGAACAGAAAGTTAGATGAATCAGTGCCCAAGACATATTTTCTGTTTAACAGAACTTTCTACAGAT
ACATTTTTTACAGGTTATTTTCATTGTGTTATTGACATCCATGTCTCTCGTAAAACAGATGGCCCAAAGTAATGAATCATGTGGCTGTAC
CTTCTCCACATAAATGGGATGGATAATTATCGTATATTAAGATGTGATTCTCTTTTTTATCCTTAATGTTAATCTACTTAACCTGGCCCC
CTCTAACATGAGTCGATAAATGTTGTCCTACTCACCGGTGGTTTCAATGGCTAATTAGAATGTGTTATTTGATTTCTGCTGCAGAAGGCA
GTGTGATTGTAACAAAAACAATGCGGCTTCCCCCTTTCGTACTTCATTTGTGTTCTCTTAAAATAGAGTTTGAACAAATATTTTAAAGGT
GCAAAATACCATTAGAAAATACTATTTGAAATGGACATTATCGCATTATCTTGGCATAATGGCCAGAAAATATTGTATTGCTTGGCAGAA
AAGAAAATAAGGTCTAAAGGAAAGTAGCACATTAGCATTGATGGCTGTTCATTTCACCCAGTATAAGCAAGTGCAGTGTACAAAGAAGTA
TATTCTGAATACATTATTTCCATTCATTTAGCACAAATAAATCATTTGGTTTCACTTTGCAGTGGAACACTGAGTCACTCTTTTCTTAAC
ACGTGCAACATCTTAATTTTTGTTTTTCAGCAGTTGCTGTTTTGTACTTTGGTAGTAAAGTGATTTTTACCACCTGTGTTTGCATATTTA
TATATGCTGTGGATGAAAATAACTTACTAGAGAATGTATATTTTATGACAAGAATGTGTATCTGTTGGATATAATCAGAGAACTGAAAAG
TAATTTATCAGTAATTTTTAAGAGTCCATGTTTTGTGACAACCATCTCTAATAGCCAACTCTTTATTAAACACACTCCTAAAAATAAGGA
ACCATGACATTGTAGATATTTAATATTGTACAGTATAGAAACCTCCATTTTTGCCTTCGAATGCATATTTAAGAGTTAACAGAATGAAAA
AAAAAAGTCTTGTTGGATAATAGTGTTTGACTAGCGTTTTAAGAACTTGAGAGTAAAAGCAACAATAAGATTTTTTCACCTCTTCCTGCT
TCCACCCCCAAACTGAGAACATCACTCAATTGTTTGGAAGAAACTGTAGGTCTATATAAATTTTATTTATAATGTATGTGTAATATACAT
AATCATAATACAGTTCTCAGATGCAGGGAAGAAGTTTGGCATTTAATCATTGAGGCTTTAGGTTTTTGATGTGATCAGACTGGGCCATGT
CAAACCCGGAATTTTCACCAACAGTTCACTCACCCTCCTGGTACATTGCCATTCCAAGGAATTCTGAGAGTAGGCAAACAAATTTTGCCT
TCATGGTACAGTTCTCAGTTTTTCTTATAGGAGAAATATGGTATATGTTTATAAGAATCTTTTATGAGATTATAGATTTCAATGCTGTGG
ATAGTGTCTTGCACCCAAACAAGAAAGTCCATAATGGAATGATCTTCCCTCAGCTTCCTATCGATTTAGTTACCTCTTGAAAGCACAAAA
ATTAAAACATTGCCATATGTTGAATTTTTAAAAAGCACTTGGAGTGAGCGAACATTTCCTGATAAATGCCTTTTAGAGATAGGTTCTTGA
TATTCAGACATCTGCAGAAATGTTCTGGTTCCCAAAGTCATTTCACTTCGAAATAAAACACAGCTCCTTCAAACAGCACTTTTTCCACAT
AAATCTAGTTGCCTCTCCCTGTGGACATTCAGAACTGATAGAACAAACACTACTCTTTTGAATTTGATGGTTCGTGTCCTTTAAAGTGTT
TGAGGACCTATGCAGAGCCTGTAACACTTGGGTAGTACCTGCTAGGACAATTTCTTGGCAATTGTCTTACTACTAGGGATCAGTAAGATT
TAGATTCTGAGCCCATAATGGCAACAGCCCCCTCACCTATGGGAAGCTGACTTCCCTCAGTCGGGCACTTCTCATGGGGGCTGAACATGG
TTCCTGCCATTCTGTTACCCACTCTCCCAGGTGAGCCCTGGATTGGCTCCCAGAAGGCCTTTGTAAAATCAGTAGCCGTCCTGCAGGCAG
GTGGGAGCAACAGGGGCTTCAGTAGCTTCATTTTCCTGTCTTGCAGACAGAGACCCTTGGCTACCACTGTGCTGCTAATAGGATAAGTAC
TCTGTTGCCAGATTACCATGCCTTTTATACAAAACCAAATTAACTTACCTAATACCTGACACCTCTTTGGGCTCTGAACTGCTTTCTCTC
ATCAAGCATGCTAGCACTCTAGACAGAATTCTAGAAATTTGGCAGATAGTGGAAGCCTTTAATTGAACTTACTCCTTCGTTGACTGAAAG
GAGTTTTAAATTCTGAGCTCCTGAGATACTGACTAGCAACCATGGAATGAATGTGTGACCAGAAAGTGGCTTTGACACCAAGTGCTACTG
TCCCTTTGTAATTGGCTTCTAACAGAATTCAACCAGAAATAATTGATAATGTGAATTTTTGTTAATTGTTCACTTGTAGGAAAATAGAAC
ATGTATCACCCTTTGTTAGGTAGACATGAACTTTTCCTGCACAAAGCCTTGCTTTTAGAGAATGCCCAATAAGGCAAGAAAAAGCATAGT
AACTTGTGCTTTGAGAGCTCAATATTTGTATCTTATCAGTACAGAAGAAATATTTCTGTGTAACTTGATCTTCTGTCTAGTACTTGTCTT
ATAGGTAACCAACACTGAAAACTTTGTAGTGATGACTACCAAAGAAATACATAGTAAAACAACCTTTTATTTCCAAATTGTTAAAGAGCC
AGCCATTGATGCTGCTACATGAGTTCCATGCTCAAGAGCCATTGTAAGAGATTAAGGGGTTTCTAGGTTTTTGGTGATTTTTTGTTTGTT
TTTTTCTTTGTTTTTTAGGGTTTTTTTTTCTTCTTTAATTTTTTGATTAAAACATACACACAGCTGTTAGCATAAAGTCGTGGGGGGCAT
TTTCTGGAATGCTCAGCAGTTCTGATTAACTGCCAAGCCCAGGTTGCCTCTCATGAGGCAACTGAAAAAATCCTGTGTCTTGATAGCATG
GGTGCTGTGTGTGTGCATGTGTGTGTCTGCATTCATGCCTTAACTCGGGTTACTGCACAACTTTAGTTCTTGACTTAGTCTGCACCGTCA
TCTAGATTGTATTGTACATCTCGGTCTGAACTTCATCCTGGCAAAAACAAAGTTGCAGGCACAACAGTTTAAGAATGCATTCCTCCAGAA
GAGTATCTGGTCAGGTTGACCCCTGAGCCTTCTTTGGACTTGATTTGGAACTTAGCCTGGAAAGCGAAAGTGGACTGTCCAACAGAAAGA
TGTCAACAAGGAAAAGAGGAGAGCCAAGCGCTAGCATGCCTTTTGCCTCTGCATATCTGTGCACACTGTATGTTGTTCATGATAGCTTGT
CTACAACTTGACTAGGTTGGAGTTCTGGTAATAGTGGCAATCTTGACATTCTTGGTCAGAGTTTAGAGAGATGTAAGACTTTCAATTAAT

>In-frame_RET_ENST00000340058_chr10_43610184_+_CCDC6_ENST00000263102_chr10_61612460_-_7592nt
CCGAAGCAGGGCGCGCAGCAGCGCTGAGTGCCCCGGAACGTGCGTCGCGCCCCCAGTGTCCGTCGCGTCCGCCGCGCCCCGGGCGGGGAT
GGGGCGGCCAGACTGAGCGCCGCACCCGCCATCCAGACCCGCCGGCCCTAGCCGCAGTCCCTCCAGCCGTGGCCCCAGCGCGCACGGGCG
ATGGCGAAGGCGACGTCCGGTGCCGCGGGGCTGCGTCTGCTGTTGCTGCTGCTGCTGCCGCTGCTAGGCAAAGTGGCATTGGGCCTCTAC
TTCTCGAGGGATGCTTACTGGGAGAAGCTGTATGTGGACCAGGCAGCCGGCACGCCCTTGCTGTACGTCCATGCCCTGCGGGACGCCCCT
GAGGAGGTGCCCAGCTTCCGCCTGGGCCAGCATCTCTACGGCACGTACCGCACACGGCTGCATGAGAACAACTGGATCTGCATCCAGGAG
GACACCGGCCTCCTCTACCTTAACCGGAGCCTGGACCATAGCTCCTGGGAGAAGCTCAGTGTCCGCAACCGCGGCTTTCCCCTGCTCACC
GTCTACCTCAAGGTCTTCCTGTCACCCACATCCCTTCGTGAGGGCGAGTGCCAGTGGCCAGGCTGTGCCCGCGTATACTTCTCCTTCTTC
AACACCTCCTTTCCAGCCTGCAGCTCCCTCAAGCCCCGGGAGCTCTGCTTCCCAGAGACAAGGCCCTCCTTCCGCATTCGGGAGAACCGA
CCCCCAGGCACCTTCCACCAGTTCCGCCTGCTGCCTGTGCAGTTCTTGTGCCCCAACATCAGCGTGGCCTACAGGCTCCTGGAGGGTGAG
GGTCTGCCCTTCCGCTGCGCCCCGGACAGCCTGGAGGTGAGCACGCGCTGGGCCCTGGACCGCGAGCAGCGGGAGAAGTACGAGCTGGTG
GCCGTGTGCACCGTGCACGCCGGCGCGCGCGAGGAGGTGGTGATGGTGCCCTTCCCGGTGACCGTGTACGACGAGGACGACTCGGCGCCC
ACCTTCCCCGCGGGCGTCGACACCGCCAGCGCCGTGGTGGAGTTCAAGCGGAAGGAGGACACCGTGGTGGCCACGCTGCGTGTCTTCGAT
GCAGACGTGGTACCTGCATCAGGGGAGCTGGTGAGGCGGTACACAAGCACGCTGCTCCCCGGGGACACCTGGGCCCAGCAGACCTTCCGG
GTGGAACACTGGCCCAACGAGACCTCGGTCCAGGCCAACGGCAGCTTCGTGCGGGCGACCGTACATGACTATAGGCTGGTTCTCAACCGG
AACCTCTCCATCTCGGAGAACCGCACCATGCAGCTGGCGGTGCTGGTCAATGACTCAGACTTCCAGGGCCCAGGAGCGGGCGTCCTCTTG
CTCCACTTCAACGTGTCGGTGCTGCCGGTCAGCCTGCACCTGCCCAGTACCTACTCCCTCTCCGTGAGCAGGAGGGCTCGCCGATTTGCC
CAGATCGGGAAAGTCTGTGTGGAAAACTGCCAGGCATTCAGTGGCATCAACGTCCAGTACAAGCTGCATTCCTCTGGTGCCAACTGCAGC
ACGCTAGGGGTGGTCACCTCAGCCGAGGACACCTCGGGGATCCTGTTTGTGAATGACACCAAGGCCCTGCGGCGGCCCAAGTGTGCCGAA
CTTCACTACATGGTGGTGGCCACCGACCAGCAGACCTCTAGGCAGGCCCAGGCCCAGCTGCTTGTAACAGTGGAGGGGTCATATGTGGCC
GAGGAGGCGGGCTGCCCCCTGTCCTGTGCAGTCAGCAAGAGACGGCTGGAGTGTGAGGAGTGTGGCGGCCTGGGCTCCCCAACAGGCAGG
TGTGAGTGGAGGCAAGGAGATGGCAAAGGGATCACCAGGAACTTCTCCACCTGCTCTCCCAGCACCAAGACCTGCCCCGACGGCCACTGC
GATGTTGTGGAGACCCAAGACATCAACATTTGCCCTCAGGACTGCCTCCGGGGCAGCATTGTTGGGGGACACGAGCCTGGGGAGCCCCGG
GGGATTAAAGCTGGCTATGGCACCTGCAACTGCTTCCCTGAGGAGGAGAAGTGCTTCTGCGAGCCCGAAGACATCCAGGATCCACTGTGC
GACGAGCTGTGCCGCACGGTGATCGCAGCCGCTGTCCTCTTCTCCTTCATCGTCTCGGTGCTGCTGTCTGCCTTCTGCATCCACTGCTAC
CACAAGTTTGCCCACAAGCCACCCATCTCCTCAGCTGAGATGACCTTCCGGAGGCCCGCCCAGGCCTTCCCGGTCAGCTACTCCTCTTCC
GGTGCCCGCCGGCCCTCGCTGGACTCCATGGAGAACCAGGTCTCCGTGGATGCCTTCAAGATCCTGCAAGCCAGGGCTGAGCAGGAAGAA
GAATTCATTAGTAACACTTTATTCAAGAAAATTCAGGCTTTGCAGAAGGAGAAAGAAACCCTTGCTGTAAATTATGAGAAAGAAGAAGAA
TTCCTCACTAATGAGCTCTCCAGAAAATTGATGCAGTTGCAGCATGAGAAAGCCGAACTAGAACAGCATCTTGAACAAGAGCAGGAATTT
CAGGTCAACAAACTGATGAAGAAAATTAAAAAACTGGAGAATGACACCATTTCTAAGCAACTTACATTAGAACAGTTGAGACGGGAGAAG
ATTGACCTTGAAAATACATTGGAACAAGAACAAGAAGCACTAGTTAATCGCCTCTGGAAAAGGATGGATAAGCTTGAAGCTGAAAAGCGA
ATCCTGCAGGAAAAATTAGACCAGCCCGTCTCTGCTCCACCATCGCCTAGAGATATCTCCATGGAGATTGATTCTCCAGAAAATATGATG
CGTCACATCAGGTTTTTAAAGAATGAAGTGGAACGGCTGAAGAAGCAACTGAGAGCTGCTCAGTTACAGCATTCAGAGAAAATGGCACAG
TATCTGGAGGAGGAACGTCACATGAGAGAAGAGAACTTGAGGCTCCAGAGGAAGCTGCAGAGGGAGATGGAGAGAAGAGAAGCCCTCTGT
CGACAGCTCTCCGAGAGTGAGTCCAGCTTAGAAATGGACGACGAAAGGTATTTTAATGAGATGTCTGCACAAGGATTAAGACCTCGCACT
GTGTCCAGCCCGATCCCTTACACACCTTCTCCGAGTTCAAGCAGGCCTATATCACCTGGTCTATCATATGCAAGTCACACGGTTGGTTTC
ACGCCACCAACTTCACTGACTAGAGCTGGAATGTCTTATTACAATTCCCCGGGTCTTCACGTGCAGCACATGGGAACATCCCATGGTATC
ACAAGGCCTTCACCACGGAGAAGCAACAGTCCTGACAAATTCAAACGGCCCACGCCGCCTCCATCTCCCAACACACAGACCCCAGTCCAG
CCACCTCCGCCTCCACCTCCGCCACCCATGCAGCCCACGGTCCCCTCAGCAGCCACCTCGCAGCCTACTCCTTCGCAACATTCGGCGCAC
CCCTCCTCCCAGCCTTAATGCATGAGCTTAGTCTGAATTTCAAGTTGGGACTCATCCAATGGAGCCGTCTACTCAACGCCAAAGGCTTCC
TTCTCTGGCATATTTGGATATGACTTATTTGCACTGAGGTTATCTAGGCTTCACTATCCATTGTGTTGTAAATGTTTGTCAGAAATGCAG
CCAGTGTTGTGGGTCTACAACACTAACCAGACGACTTTTTCCATCAGTGTTTTACTTGAATCTTCATGTACGTCCATTCCCTGGCTGGAA
CCTTCGCTGTTTGGTATTTGGTATTTCAGCAGCAGTGTGCAATTTTTGCTTGGCCCAGAGCTTCATTCTCCTGGCTTTTAGGTTTGTAAA
AGAAAAAGGGATATCTTTTTTATATTTTTTTCCATGAATCTGCAGAAAATTACTGAGCTGTTGTTACCCTCCTCTCATTATAATAGTGTT
TACCAAACATACCAATAATTCAGCACTACAATTCAGACCTTTGAAAATCTGGCTTTCAGTGTAGAACAGAAAGTTAGATGAATCAGTGCC
CAAGACATATTTTCTGTTTAACAGAACTTTCTACAGATACATTTTTTACAGGTTATTTTCATTGTGTTATTGACATCCATGTCTCTCGTA
AAACAGATGGCCCAAAGTAATGAATCATGTGGCTGTACCTTCTCCACATAAATGGGATGGATAATTATCGTATATTAAGATGTGATTCTC
TTTTTTATCCTTAATGTTAATCTACTTAACCTGGCCCCCTCTAACATGAGTCGATAAATGTTGTCCTACTCACCGGTGGTTTCAATGGCT
AATTAGAATGTGTTATTTGATTTCTGCTGCAGAAGGCAGTGTGATTGTAACAAAAACAATGCGGCTTCCCCCTTTCGTACTTCATTTGTG
TTCTCTTAAAATAGAGTTTGAACAAATATTTTAAAGGTGCAAAATACCATTAGAAAATACTATTTGAAATGGACATTATCGCATTATCTT
GGCATAATGGCCAGAAAATATTGTATTGCTTGGCAGAAAAGAAAATAAGGTCTAAAGGAAAGTAGCACATTAGCATTGATGGCTGTTCAT
TTCACCCAGTATAAGCAAGTGCAGTGTACAAAGAAGTATATTCTGAATACATTATTTCCATTCATTTAGCACAAATAAATCATTTGGTTT
CACTTTGCAGTGGAACACTGAGTCACTCTTTTCTTAACACGTGCAACATCTTAATTTTTGTTTTTCAGCAGTTGCTGTTTTGTACTTTGG
TAGTAAAGTGATTTTTACCACCTGTGTTTGCATATTTATATATGCTGTGGATGAAAATAACTTACTAGAGAATGTATATTTTATGACAAG
AATGTGTATCTGTTGGATATAATCAGAGAACTGAAAAGTAATTTATCAGTAATTTTTAAGAGTCCATGTTTTGTGACAACCATCTCTAAT
AGCCAACTCTTTATTAAACACACTCCTAAAAATAAGGAACCATGACATTGTAGATATTTAATATTGTACAGTATAGAAACCTCCATTTTT
GCCTTCGAATGCATATTTAAGAGTTAACAGAATGAAAAAAAAAAGTCTTGTTGGATAATAGTGTTTGACTAGCGTTTTAAGAACTTGAGA
GTAAAAGCAACAATAAGATTTTTTCACCTCTTCCTGCTTCCACCCCCAAACTGAGAACATCACTCAATTGTTTGGAAGAAACTGTAGGTC
TATATAAATTTTATTTATAATGTATGTGTAATATACATAATCATAATACAGTTCTCAGATGCAGGGAAGAAGTTTGGCATTTAATCATTG
AGGCTTTAGGTTTTTGATGTGATCAGACTGGGCCATGTCAAACCCGGAATTTTCACCAACAGTTCACTCACCCTCCTGGTACATTGCCAT
TCCAAGGAATTCTGAGAGTAGGCAAACAAATTTTGCCTTCATGGTACAGTTCTCAGTTTTTCTTATAGGAGAAATATGGTATATGTTTAT
AAGAATCTTTTATGAGATTATAGATTTCAATGCTGTGGATAGTGTCTTGCACCCAAACAAGAAAGTCCATAATGGAATGATCTTCCCTCA
GCTTCCTATCGATTTAGTTACCTCTTGAAAGCACAAAAATTAAAACATTGCCATATGTTGAATTTTTAAAAAGCACTTGGAGTGAGCGAA
CATTTCCTGATAAATGCCTTTTAGAGATAGGTTCTTGATATTCAGACATCTGCAGAAATGTTCTGGTTCCCAAAGTCATTTCACTTCGAA
ATAAAACACAGCTCCTTCAAACAGCACTTTTTCCACATAAATCTAGTTGCCTCTCCCTGTGGACATTCAGAACTGATAGAACAAACACTA
CTCTTTTGAATTTGATGGTTCGTGTCCTTTAAAGTGTTTGAGGACCTATGCAGAGCCTGTAACACTTGGGTAGTACCTGCTAGGACAATT
TCTTGGCAATTGTCTTACTACTAGGGATCAGTAAGATTTAGATTCTGAGCCCATAATGGCAACAGCCCCCTCACCTATGGGAAGCTGACT
TCCCTCAGTCGGGCACTTCTCATGGGGGCTGAACATGGTTCCTGCCATTCTGTTACCCACTCTCCCAGGTGAGCCCTGGATTGGCTCCCA
GAAGGCCTTTGTAAAATCAGTAGCCGTCCTGCAGGCAGGTGGGAGCAACAGGGGCTTCAGTAGCTTCATTTTCCTGTCTTGCAGACAGAG
ACCCTTGGCTACCACTGTGCTGCTAATAGGATAAGTACTCTGTTGCCAGATTACCATGCCTTTTATACAAAACCAAATTAACTTACCTAA
TACCTGACACCTCTTTGGGCTCTGAACTGCTTTCTCTCATCAAGCATGCTAGCACTCTAGACAGAATTCTAGAAATTTGGCAGATAGTGG
AAGCCTTTAATTGAACTTACTCCTTCGTTGACTGAAAGGAGTTTTAAATTCTGAGCTCCTGAGATACTGACTAGCAACCATGGAATGAAT
GTGTGACCAGAAAGTGGCTTTGACACCAAGTGCTACTGTCCCTTTGTAATTGGCTTCTAACAGAATTCAACCAGAAATAATTGATAATGT
GAATTTTTGTTAATTGTTCACTTGTAGGAAAATAGAACATGTATCACCCTTTGTTAGGTAGACATGAACTTTTCCTGCACAAAGCCTTGC
TTTTAGAGAATGCCCAATAAGGCAAGAAAAAGCATAGTAACTTGTGCTTTGAGAGCTCAATATTTGTATCTTATCAGTACAGAAGAAATA
TTTCTGTGTAACTTGATCTTCTGTCTAGTACTTGTCTTATAGGTAACCAACACTGAAAACTTTGTAGTGATGACTACCAAAGAAATACAT
AGTAAAACAACCTTTTATTTCCAAATTGTTAAAGAGCCAGCCATTGATGCTGCTACATGAGTTCCATGCTCAAGAGCCATTGTAAGAGAT
TAAGGGGTTTCTAGGTTTTTGGTGATTTTTTGTTTGTTTTTTTCTTTGTTTTTTAGGGTTTTTTTTTCTTCTTTAATTTTTTGATTAAAA
CATACACACAGCTGTTAGCATAAAGTCGTGGGGGGCATTTTCTGGAATGCTCAGCAGTTCTGATTAACTGCCAAGCCCAGGTTGCCTCTC
ATGAGGCAACTGAAAAAATCCTGTGTCTTGATAGCATGGGTGCTGTGTGTGTGCATGTGTGTGTCTGCATTCATGCCTTAACTCGGGTTA
CTGCACAACTTTAGTTCTTGACTTAGTCTGCACCGTCATCTAGATTGTATTGTACATCTCGGTCTGAACTTCATCCTGGCAAAAACAAAG
TTGCAGGCACAACAGTTTAAGAATGCATTCCTCCAGAAGAGTATCTGGTCAGGTTGACCCCTGAGCCTTCTTTGGACTTGATTTGGAACT
TAGCCTGGAAAGCGAAAGTGGACTGTCCAACAGAAAGATGTCAACAAGGAAAAGAGGAGAGCCAAGCGCTAGCATGCCTTTTGCCTCTGC
ATATCTGTGCACACTGTATGTTGTTCATGATAGCTTGTCTACAACTTGACTAGGTTGGAGTTCTGGTAATAGTGGCAATCTTGACATTCT
TGGTCAGAGTTTAGAGAGATGTAAGACTTTCAATTAATGTCTTATTTACTCCTTTATGTTGATTAGTCTTTGATACATGTGCTGAATCAG


Top

FusionGenePPI for RET_CCDC6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26CCDC6PPP4C, USP7, CREB1, ATF2, PPP1CA, HDAC1, ELAVL1, CUL1, SKP1, FBXW7, CSNK2A1, YWHAB, BRCC3, SF3A1, CD2AP, GAPVD1, HNRNPR, NR3C1, PAAF1, PPP4R2, TRIM28, PPP2R1A, CEP170, PPP2CB, RASSF7, ZNF444, TCL1B, MAFF, DDI2, NUDC, SARS, SEPT2, NTRK1, XPO1, P4HB, PPP2CA, PPP4R1, POLG2, GSK3B, CCNB1, CDK1, MTMR7, CEP55, TRPC4AP, C1S, RALBP1, MTUS2, LZTS3, EXOC1, ZNF331, PDE4DIP, FBXO42, CCDC102A, SMEK2, SMEK1, TCP10L, PCBP3, APC, LPXN, ZNF445, NECAB1, RPTOR, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RET_CCDC6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRETP07949DB05294VandetanibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
HgeneRETP07949DB08896RegorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
HgeneRETP07949DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
HgeneRETP07949DB08875CabozantinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
HgeneRETP07949DB08901PonatinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational

Top

RelatedDiseases for RET_CCDC6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 115UNIPROT
HgeneRETC0025268Multiple Endocrine Neoplasia Type 2a14CTD_human;ORPHANET;UNIPROT
HgeneRETC1833921Familial medullary thyroid carcinoma14CTD_human;ORPHANET;UNIPROT
HgeneRETC0025269Multiple Endocrine Neoplasia Type 2b8CTD_human;ORPHANET;UNIPROT
HgeneRETC1275808Congenital central hypoventilation4CTD_human;ORPHANET;UNIPROT
HgeneRETC0009404Colorectal Neoplasms2CTD_human
HgeneRETC0019569Hirschsprung Disease2CTD_human;HPO;ORPHANET
HgeneRETC0006413Burkitt Lymphoma1CTD_human
HgeneRETC0027662Multiple Endocrine Neoplasia1CTD_human
HgeneRETC0031511Pheochromocytoma1CTD_human;HPO;UNIPROT
HgeneRETC0038220Status Epilepticus1CTD_human
HgeneRETC0040136Thyroid Neoplasm1CTD_human
HgeneRETC0206693Medullary carcinoma1CTD_human
HgeneRETC0238462Medullary carcinoma of thyroid1CTD_human;HPO
HgeneRETC0740340Amyloidosis, Familial1CTD_human
HgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;ORPHANET