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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3098

FusionGeneSummary for ATAD3C_HSPA14

check button Fusion gene summary
Fusion gene informationFusion gene name: ATAD3C_HSPA14
Fusion gene ID: 3098
HgeneTgene
Gene symbol

ATAD3C

HSPA14

Gene ID

219293

51182

Gene nameATPase family, AAA domain containing 3Cheat shock protein family A (Hsp70) member 14
Synonyms-HSP70-4|HSP70L1
Cytomap

1p36.33

10p13

Type of geneprotein-codingprotein-coding
DescriptionATPase family AAA domain-containing protein 3CATPase family, AAA domain containing 3Aheat shock 70 kDa protein 14HSP70-like protein 1heat shock 70kDa protein 14 isoform 1 variant 3heat shock protein HSP60heat shock protein hsp70-related protein
Modification date2018052320180523
UniProtAcc

Q5T2N8

Q0VDF9

Ensembl transtripts involved in fusion geneENST00000378785, ENST00000378372, 
ENST00000493863, ENST00000437161, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: ATAD3C [Title/Abstract] AND HSPA14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-NA-A4R0-01AATAD3Cchr1

1394611

+HSPA14chr10

14909082

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000378785ENST00000378372ATAD3Cchr1

1394611

+HSPA14chr10

14909082

+
5CDS-intronENST00000378785ENST00000493863ATAD3Cchr1

1394611

+HSPA14chr10

14909082

+
5CDS-intronENST00000378785ENST00000437161ATAD3Cchr1

1394611

+HSPA14chr10

14909082

+

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FusionProtFeatures for ATAD3C_HSPA14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATAD3C

Q5T2N8

HSPA14

Q0VDF9

Component of the ribosome-associated complex (RAC), acomplex involved in folding or maintaining nascent polypeptides ina folding-competent state. In the RAC complex, binds to thenascent polypeptide chain, while DNAJC2 stimulates its ATPaseactivity. {ECO:0000269|PubMed:16002468}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATAD3C_HSPA14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATAD3C_HSPA14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATAD3CPHKG2, GDE1, PARD6B, MCM2, DKK3, COMMD1, DLST, TRIM25HSPA14STIP1, PAF1, BARD1, BRCA1, PAXIP1, NFAM1, RPS6KB2, DNAJC17, DNAJC2, DNAJC3, KIAA0101, KIF2C, KRAS, FOXL1, HYPK, DEFA5, ASIC4, RELL2, CYB5A, SET, GPX7, XAGE1B, TRIM35, SNRNP27, GMFG, FAM107A, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATAD3C_HSPA14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATAD3C_HSPA14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHSPA14C0026636Mouth Diseases1CTD_human