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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30950

FusionGeneSummary for REPIN1_REPIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: REPIN1_REPIN1
Fusion gene ID: 30950
HgeneTgene
Gene symbol

REPIN1

REPIN1

Gene ID

29803

29803

Gene namereplication initiator 1replication initiator 1
SynonymsAP4|RIP60|ZNF464|Zfp464AP4|RIP60|ZNF464|Zfp464
Cytomap

7q36.1

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionreplication initiator 160 kDa origin-specific DNA-binding protein60 kDa replication initiation region proteinATT-binding proteinDHFR oribeta-binding protein RIP60H_DJ0584D14.12replication initiation region protein (60kD)zinc finger protein 464 (RIPreplication initiator 160 kDa origin-specific DNA-binding protein60 kDa replication initiation region proteinATT-binding proteinDHFR oribeta-binding protein RIP60H_DJ0584D14.12replication initiation region protein (60kD)zinc finger protein 464 (RIP
Modification date2018051920180519
UniProtAcc

Q9BWE0

Q9BWE0

Ensembl transtripts involved in fusion geneENST00000479668, ENST00000540729, 
ENST00000444957, ENST00000397281, 
ENST00000466559, ENST00000489432, 
ENST00000482680, ENST00000518514, 
ENST00000518462, ENST00000425389, 
ENST00000479668, ENST00000540729, 
ENST00000444957, ENST00000397281, 
ENST00000466559, ENST00000489432, 
ENST00000482680, ENST00000518514, 
ENST00000518462, ENST00000425389, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: REPIN1 [Title/Abstract] AND REPIN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU630092REPIN1chr7

150070657

-REPIN1chr7

150070619

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000479668ENST00000479668REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000479668ENST00000540729REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000479668ENST00000444957REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000479668ENST00000397281REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000479668ENST00000466559REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000479668ENST00000489432REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000479668ENST00000482680REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000479668ENST00000518514REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000479668ENST00000518462REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000479668ENST00000425389REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000540729ENST00000479668REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000540729ENST00000540729REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000540729ENST00000444957REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000540729ENST00000397281REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000540729ENST00000466559REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000540729ENST00000489432REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000540729ENST00000482680REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000540729ENST00000518514REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000540729ENST00000518462REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000540729ENST00000425389REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000444957ENST00000479668REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000444957ENST00000540729REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000444957ENST00000444957REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000444957ENST00000397281REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000444957ENST00000466559REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000444957ENST00000489432REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000444957ENST00000482680REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000444957ENST00000518514REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000444957ENST00000518462REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000444957ENST00000425389REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000397281ENST00000479668REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000397281ENST00000540729REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000397281ENST00000444957REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000397281ENST00000397281REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000397281ENST00000466559REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000397281ENST00000489432REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000397281ENST00000482680REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000397281ENST00000518514REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000397281ENST00000518462REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000397281ENST00000425389REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000466559ENST00000479668REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000466559ENST00000540729REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000466559ENST00000444957REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000466559ENST00000397281REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000466559ENST00000466559REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000466559ENST00000489432REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000466559ENST00000482680REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000466559ENST00000518514REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000466559ENST00000518462REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000466559ENST00000425389REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000489432ENST00000479668REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000489432ENST00000540729REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000489432ENST00000444957REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000489432ENST00000397281REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000489432ENST00000466559REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000489432ENST00000489432REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000489432ENST00000482680REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000489432ENST00000518514REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000489432ENST00000518462REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000489432ENST00000425389REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000482680ENST00000479668REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000482680ENST00000540729REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000482680ENST00000444957REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000482680ENST00000397281REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000482680ENST00000466559REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000482680ENST00000489432REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000482680ENST00000482680REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000482680ENST00000518514REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000482680ENST00000518462REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000482680ENST00000425389REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000518514ENST00000479668REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518514ENST00000540729REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000518514ENST00000444957REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000518514ENST00000397281REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518514ENST00000466559REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518514ENST00000489432REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518514ENST00000482680REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518514ENST00000518514REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518514ENST00000518462REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000518514ENST00000425389REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000518462ENST00000479668REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518462ENST00000540729REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000518462ENST00000444957REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000518462ENST00000397281REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518462ENST00000466559REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518462ENST00000489432REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518462ENST00000482680REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518462ENST00000518514REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-intronENST00000518462ENST00000518462REPIN1chr7

150070657

-REPIN1chr7

150070619

+
intron-3UTRENST00000518462ENST00000425389REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000425389ENST00000479668REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000425389ENST00000540729REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000425389ENST00000444957REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000425389ENST00000397281REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000425389ENST00000466559REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000425389ENST00000489432REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000425389ENST00000482680REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000425389ENST00000518514REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-intronENST00000425389ENST00000518462REPIN1chr7

150070657

-REPIN1chr7

150070619

+
3UTR-3UTRENST00000425389ENST00000425389REPIN1chr7

150070657

-REPIN1chr7

150070619

+

Top

FusionProtFeatures for REPIN1_REPIN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
REPIN1

Q9BWE0

REPIN1

Q9BWE0

Sequence-specific double-stranded DNA-binding proteinrequired for initiation of chromosomal DNA replication. Binds on5'-ATT-3' reiterated sequences downstream of the origin ofbidirectional replication (OBR) and a second, homologous ATTsequence of opposite orientation situated within the OBR zone.Facilitates DNA bending. Sequence-specific double-stranded DNA-binding proteinrequired for initiation of chromosomal DNA replication. Binds on5'-ATT-3' reiterated sequences downstream of the origin ofbidirectional replication (OBR) and a second, homologous ATTsequence of opposite orientation situated within the OBR zone.Facilitates DNA bending.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for REPIN1_REPIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for REPIN1_REPIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for REPIN1_REPIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for REPIN1_REPIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource