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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30949

FusionGeneSummary for RENBP_RAD23A

check button Fusion gene summary
Fusion gene informationFusion gene name: RENBP_RAD23A
Fusion gene ID: 30949
HgeneTgene
Gene symbol

RENBP

RAD23A

Gene ID

5973

5886

Gene namerenin binding proteinRAD23 homolog A, nucleotide excision repair protein
SynonymsRBP|RNBPHHR23A|HR23A
Cytomap

Xq28

19p13.13

Type of geneprotein-codingprotein-coding
DescriptionN-acylglucosamine 2-epimeraseAGEGlcNAc 2-epimeraseN-acetyl-D-glucosamine 2-epimeraseUV excision repair protein RAD23 homolog ARAD23, yeast homolog, A
Modification date2018052320180523
UniProtAcc

P51606

P54725

Ensembl transtripts involved in fusion geneENST00000393700, ENST00000412763, 
ENST00000369997, ENST00000462086, 
ENST00000541222, ENST00000316856, 
ENST00000586534, ENST00000592268, 
ENST00000588826, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 7 X 6=378
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RENBP [Title/Abstract] AND RAD23A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAD23A

GO:0006289

nucleotide-excision repair

9372924

TgeneRAD23A

GO:0032434

regulation of proteasomal ubiquitin-dependent protein catabolic process

12643283


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF799253RENBPchrX

153205691

-RAD23Achr19

13059069

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000393700ENST00000541222RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000393700ENST00000316856RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000393700ENST00000586534RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000393700ENST00000592268RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-3UTRENST00000393700ENST00000588826RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000412763ENST00000541222RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000412763ENST00000316856RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000412763ENST00000586534RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000412763ENST00000592268RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-3UTRENST00000412763ENST00000588826RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000369997ENST00000541222RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000369997ENST00000316856RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000369997ENST00000586534RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000369997ENST00000592268RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-3UTRENST00000369997ENST00000588826RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000462086ENST00000541222RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000462086ENST00000316856RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000462086ENST00000586534RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-5UTRENST00000462086ENST00000592268RENBPchrX

153205691

-RAD23Achr19

13059069

+
intron-3UTRENST00000462086ENST00000588826RENBPchrX

153205691

-RAD23Achr19

13059069

+

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FusionProtFeatures for RENBP_RAD23A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RENBP

P51606

RAD23A

P54725

Catalyzes the interconversion of N-acetylglucosamine toN-acetylmannosamine. Binds to renin forming a protein complexcalled high molecular weight (HMW) renin and inhibits reninactivity. Involved in the N-glycolylneuraminic acid (Neu5Gc)degradation pathway: although human is not able to catalyzeformation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc ispresent in food and must be degraded.{ECO:0000269|PubMed:9990133}. Multiubiquitin chain receptor involved in modulation ofproteasomal degradation. Binds to 'Lys-48'-linked polyubiquitinchains in a length-dependent manner and with a lower affinity to'Lys-63'-linked polyubiquitin chains. Proposed to be capable tobind simultaneously to the 26S proteasome and to polyubiquitinatedsubstrates and to deliver ubiquitinated proteins to theproteasome. Involved in nucleotide excision repair and is thought tobe functional equivalent for RAD23B in global genome nucleotideexcision repair (GG-NER) by association with XPC. In vitro, theXPC:RAD23A dimer has NER activity. Can stabilize XPC. (Microbial infection) Involved in Vpr-dependentreplication of HIV-1 in non-proliferating cells and primarymacrophages. Required for the association of HIV-1 Vpr with thehost proteasome. {ECO:0000269|PubMed:20614012}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RENBP_RAD23A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RENBP_RAD23A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RENBP_RAD23A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RENBP_RAD23A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRENBPC0007193Cardiomyopathy, Dilated1CTD_human
TgeneRAD23AC0038356Stomach Neoplasms1CTD_human