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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 30945

FusionGeneSummary for REL_MAN1A2

check button Fusion gene summary
Fusion gene informationFusion gene name: REL_MAN1A2
Fusion gene ID: 30945
HgeneTgene
Gene symbol

REL

MAN1A2

Gene ID

5966

10905

Gene nameREL proto-oncogene, NF-kB subunitmannosidase alpha class 1A member 2
SynonymsC-RelMAN1B
Cytomap

2p16.1

1p12

Type of geneprotein-codingprotein-coding
Descriptionproto-oncogene c-Reloncogene REL, avian reticuloendotheliosisv-rel avian reticuloendotheliosis viral oncogene homologmannosyl-oligosaccharide 1,2-alpha-mannosidase IBalpha-1,2-mannosidase IBalpha1,2-mannosidaseprocessing alpha-1,2-mannosidase IB
Modification date2018052320180523
UniProtAcc

Q04864

O60476

Ensembl transtripts involved in fusion geneENST00000295025, ENST00000394479, 
ENST00000356554, ENST00000482811, 
Fusion gene scores* DoF score5 X 5 X 4=10010 X 8 X 5=400
# samples 516
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/400*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: REL [Title/Abstract] AND MAN1A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneREL

GO:0010629

negative regulation of gene expression

22065573

HgeneREL

GO:0032688

negative regulation of interferon-beta production

22065573

HgeneREL

GO:0045944

positive regulation of transcription by RNA polymerase II

1406630


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-60-2726-01ARELchr2

61147777

+MAN1A2chr1

118035769

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000295025ENST00000356554RELchr2

61147777

+MAN1A2chr1

118035769

+
5CDS-intronENST00000295025ENST00000482811RELchr2

61147777

+MAN1A2chr1

118035769

+
In-frameENST00000394479ENST00000356554RELchr2

61147777

+MAN1A2chr1

118035769

+
5CDS-intronENST00000394479ENST00000482811RELchr2

61147777

+MAN1A2chr1

118035769

+

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FusionProtFeatures for REL_MAN1A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
REL

Q04864

MAN1A2

O60476

Proto-oncogene that may play a role in differentiationand lymphopoiesis. NF-kappa-B is a pleiotropic transcriptionfactor which is present in almost all cell types and is involvedin many biological processed such as inflammation, immunity,differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-likedomain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA oftheir target genes and the individual dimers have distinctpreferences for different kappa-B sites that they can bind withdistinguishable affinity and specificity. Different dimercombinations act as transcriptional activators or repressors,respectively. NF-kappa-B is controlled by various mechanisms ofpost-translational modification and subcellularcompartmentalization as well as by interactions with othercofactors or corepressors. NF-kappa-B complexes are held in thecytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activationpathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs)in response to different activators, subsequently degraded thusliberating the active NF-kappa-B complex which translocates to thenucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is atranscriptional activator. Involved in the maturation of Asn-linkedoligosaccharides. Progressively trim alpha-1,2-linked mannoseresidues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRELchr2:61147777chr1:118035769ENST00000295025+10118_297362620DomainRHD
HgeneRELchr2:61147777chr1:118035769ENST00000295025+1011290_295362620MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAN1A2chr2:61147777chr1:118035769ENST00000356554+7132_36389642Topological domainCytoplasmic
TgeneMAN1A2chr2:61147777chr1:118035769ENST00000356554+71358_641389642Topological domainLumenal
TgeneMAN1A2chr2:61147777chr1:118035769ENST00000356554+71337_57389642TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for REL_MAN1A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_REL_ENST00000295025_chr2_61147777_+_MAN1A2_ENST00000356554_chr1_118035769_+_615aa
MASGATNPTIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQIMNTTGKGKVRITLVTKNDPTKPHPHDLVGKDCRDGYTE
AEFGQERRPLFFQNLGIRCVKKKEVKEAIITRIKAGINPFNVPEKQLNDIEDCDLNVVRLCFQVFLPDEHGNLTTALPPVVSNPITDNRA
PNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGIFSQADVHRQVAIVFKTPPTCKAITEPVTVKMQLRRPSDQE
VSESMDFRTLPDEKDTYGNKAKKQKTTLLFQKLCQDHVETGFRHVDQDGLELLTSGDPPTLASQSAGITVNFPERPRPGLLGSIGEGRYF
KKDHTSVGGLGDSFTEYLLKAWLMSDKTDHEARKMTDDAIEAIEKHLIKKSRGGLTFIGEWKNGHLEKKMGHLACFAGGMFALGADGSRA
DKAGHTLELGAEIARTCHESTDRTALKLGPESFKFDGAVEAVAVRQAEKTTILRPEVIETTWYLWRFTHDPRYRQWGWEAALAIEKTCRV

>In-frame_REL_ENST00000394479_chr2_61147777_+_MAN1A2_ENST00000356554_chr1_118035769_+_583aa
MASGATNPTIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQIMNTTGKGKVRITLVTKNDPTKPHPHDLVGKDCRDGYTE
AEFGQERRPLFFQNLGIRCVKKKEVKEAIITRIKAGINPFNVPEKQLNDIEDCDLNVVRLCFQVFLPDEHGNLTTALPPVVSNPITDNRA
PNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGIFSQADVHRQVAIVFKTPPTCKAITEPVTVKMQLRRPSDQE
VSESMDFRTLPDEKDTYGNKAKKQKTTLLFQKLCQDHVNFPERPRPGLLGSIGEGRYFKKDHTSVGGLGDSFTEYLLKAWLMSDKTDHEA
RKMTDDAIEAIEKHLIKKSRGGLTFIGEWKNGHLEKKMGHLACFAGGMFALGADGSRADKAGHTLELGAEIARTCHESTDRTALKLGPES
FKFDGAVEAVAVRQAEKTTILRPEVIETTWYLWRFTHDPRYRQWGWEAALAIEKTCRVNGGFSGVKDVTSSTPTHDDVQQSFFLAETLKT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_REL_ENST00000295025_chr2_61147777_+_MAN1A2_ENST00000356554_chr1_118035769_+_1845nt
ATGGCCTCCGGTGCGTATAACCCGTATATAGAGATAATTGAACAACCCAGGCAGAGGGGAATGCGTTTTAGATACAAATGTGAAGGGCGA
TCAGCAGGCAGCATTCCAGGGGAGCACAGCACAGACAACAACCGAACATACCCTTCTATCCAGATTATGAACTATTATGGAAAAGGAAAA
GTGAGAATTACATTAGTAACAAAGAATGACCCATATAAACCTCATCCTCATGATTTAGTTGGAAAAGACTGCAGAGACGGCTACTATGAA
GCAGAATTTGGACAAGAACGCAGACCTTTGTTTTTCCAAAATTTGGGTATTCGATGTGTGAAGAAAAAAGAAGTAAAAGAAGCTATTATT
ACAAGAATAAAGGCAGGAATCAATCCATTCAATGTCCCTGAAAAACAGCTGAATGATATTGAAGATTGTGACCTCAATGTGGTGAGACTG
TGTTTTCAAGTTTTTCTCCCTGATGAACATGGTAATTTGACGACTGCTCTTCCTCCTGTTGTCTCGAACCCAATTTATGACAACCGTGCT
CCAAATACTGCAGAATTAAGGATTTGTCGTGTAAACAAGAATTGTGGAAGTGTCAGAGGAGGAGATGAAATATTTCTACTTTGTGACAAA
GTTCAGAAAGATGACATAGAAGTTCGTTTTGTGTTGAACGATTGGGAAGCAAAAGGCATCTTTTCACAAGCTGATGTACACCGTCAAGTA
GCCATTGTTTTCAAAACTCCACCATATTGCAAAGCTATCACAGAACCCGTAACAGTAAAAATGCAGTTGCGGAGACCTTCTGACCAGGAA
GTTAGTGAATCTATGGATTTTAGATATCTGCCAGATGAAAAAGATACTTACGGCAATAAAGCAAAGAAACAAAAGACAACTCTGCTTTTC
CAGAAACTGTGCCAGGATCACGTAGAAACAGGGTTTCGCCATGTTGACCAGGATGGTCTTGAACTCCTGACATCAGGTGATCCACCCACC
TTGGCCTCCCAAAGTGCTGGGATTACAGTTAATTTTCCTGAGAGACCAAGACCTGGTCTCCTCGGTTCAATTGGAGAAGGAAGATACTTC
AAAAAAGATCATACATCTGTCGGTGGCCTGGGAGACAGTTTTTATGAATACTTACTGAAAGCATGGTTGATGTCAGATAAAACAGACCAT
GAGGCAAGAAAGATGTATGATGATGCTATTGAGGCTATAGAAAAACATCTTATTAAGAAGTCTCGTGGAGGTCTTACCTTTATTGGAGAA
TGGAAGAATGGGCACTTGGAAAAAAAGATGGGGCATTTGGCCTGCTTTGCTGGGGGAATGTTTGCACTAGGAGCAGATGGTTCCAGAGCA
GATAAAGCTGGTCATTATTTAGAGCTAGGGGCAGAAATTGCACGTACTTGTCATGAGTCATATGACAGAACTGCATTAAAGCTAGGTCCT
GAATCATTCAAGTTTGATGGTGCAGTGGAGGCTGTGGCTGTCCGGCAGGCTGAAAAGTATTATATCCTCCGTCCAGAAGTAATTGAAACC
TATTGGTACCTATGGCGATTCACTCACGATCCAAGATACAGGCAGTGGGGCTGGGAAGCAGCACTGGCCATTGAAAAGTATTGCCGAGTT
AATGGTGGGTTTTCTGGAGTCAAAGATGTATATTCCTCTACTCCTACACATGATGATGTACAGCAGAGCTTTTTTCTTGCTGAAACATTA
AAATATTTGTATCTGCTGTTCTCCGGTGATGACCTTTTACCTTTAGACCACTGGGTGTTTAATACAGAGGCTCACCCTCTGCCTGTGTTA

>In-frame_REL_ENST00000394479_chr2_61147777_+_MAN1A2_ENST00000356554_chr1_118035769_+_1749nt
ATGGCCTCCGGTGCGTATAACCCGTATATAGAGATAATTGAACAACCCAGGCAGAGGGGAATGCGTTTTAGATACAAATGTGAAGGGCGA
TCAGCAGGCAGCATTCCAGGGGAGCACAGCACAGACAACAACCGAACATACCCTTCTATCCAGATTATGAACTATTATGGAAAAGGAAAA
GTGAGAATTACATTAGTAACAAAGAATGACCCATATAAACCTCATCCTCATGATTTAGTTGGAAAAGACTGCAGAGACGGCTACTATGAA
GCAGAATTTGGACAAGAACGCAGACCTTTGTTTTTCCAAAATTTGGGTATTCGATGTGTGAAGAAAAAAGAAGTAAAAGAAGCTATTATT
ACAAGAATAAAGGCAGGAATCAATCCATTCAATGTCCCTGAAAAACAGCTGAATGATATTGAAGATTGTGACCTCAATGTGGTGAGACTG
TGTTTTCAAGTTTTTCTCCCTGATGAACATGGTAATTTGACGACTGCTCTTCCTCCTGTTGTCTCGAACCCAATTTATGACAACCGTGCT
CCAAATACTGCAGAATTAAGGATTTGTCGTGTAAACAAGAATTGTGGAAGTGTCAGAGGAGGAGATGAAATATTTCTACTTTGTGACAAA
GTTCAGAAAGATGACATAGAAGTTCGTTTTGTGTTGAACGATTGGGAAGCAAAAGGCATCTTTTCACAAGCTGATGTACACCGTCAAGTA
GCCATTGTTTTCAAAACTCCACCATATTGCAAAGCTATCACAGAACCCGTAACAGTAAAAATGCAGTTGCGGAGACCTTCTGACCAGGAA
GTTAGTGAATCTATGGATTTTAGATATCTGCCAGATGAAAAAGATACTTACGGCAATAAAGCAAAGAAACAAAAGACAACTCTGCTTTTC
CAGAAACTGTGCCAGGATCACGTTAATTTTCCTGAGAGACCAAGACCTGGTCTCCTCGGTTCAATTGGAGAAGGAAGATACTTCAAAAAA
GATCATACATCTGTCGGTGGCCTGGGAGACAGTTTTTATGAATACTTACTGAAAGCATGGTTGATGTCAGATAAAACAGACCATGAGGCA
AGAAAGATGTATGATGATGCTATTGAGGCTATAGAAAAACATCTTATTAAGAAGTCTCGTGGAGGTCTTACCTTTATTGGAGAATGGAAG
AATGGGCACTTGGAAAAAAAGATGGGGCATTTGGCCTGCTTTGCTGGGGGAATGTTTGCACTAGGAGCAGATGGTTCCAGAGCAGATAAA
GCTGGTCATTATTTAGAGCTAGGGGCAGAAATTGCACGTACTTGTCATGAGTCATATGACAGAACTGCATTAAAGCTAGGTCCTGAATCA
TTCAAGTTTGATGGTGCAGTGGAGGCTGTGGCTGTCCGGCAGGCTGAAAAGTATTATATCCTCCGTCCAGAAGTAATTGAAACCTATTGG
TACCTATGGCGATTCACTCACGATCCAAGATACAGGCAGTGGGGCTGGGAAGCAGCACTGGCCATTGAAAAGTATTGCCGAGTTAATGGT
GGGTTTTCTGGAGTCAAAGATGTATATTCCTCTACTCCTACACATGATGATGTACAGCAGAGCTTTTTTCTTGCTGAAACATTAAAATAT
TTGTATCTGCTGTTCTCCGGTGATGACCTTTTACCTTTAGACCACTGGGTGTTTAATACAGAGGCTCACCCTCTGCCTGTGTTACATTTA


* Fusion transcript sequences (Full-length transcript).
>In-frame_REL_ENST00000295025_chr2_61147777_+_MAN1A2_ENST00000356554_chr1_118035769_+_8080nt
AGCCGCGGGAAATTCCCCTCCCGCCAGGCTGCTCGCCTCTCGGCTGGGCCAGCACTCGGCTCTCCCCGCTCCGCCCCCTGCCCCTGGCTC
CCGTACGGTGGACGGCGACGCTGGGTGACCCGGGGTGCAAGAATTCAGGGGTTGGGAAGGTGTGAGCCGCAAACCCAGCGGAGGGCGGGA
AGAAGGAGGAGGCCTCTAGGGTGGTCGGGGGACTGGGGGCCCCGCCGGCAGAGGTCCCTCGGCCTCCTGACTGACTGACTGCGGCCGCCT
CCGGCCAGGACGCTGGGAGCTGCCTGCGGGAAGGTGCGGGGAGCGGAGCCATGGCCTCCGGTGCGTATAACCCGTATATAGAGATAATTG
AACAACCCAGGCAGAGGGGAATGCGTTTTAGATACAAATGTGAAGGGCGATCAGCAGGCAGCATTCCAGGGGAGCACAGCACAGACAACA
ACCGAACATACCCTTCTATCCAGATTATGAACTATTATGGAAAAGGAAAAGTGAGAATTACATTAGTAACAAAGAATGACCCATATAAAC
CTCATCCTCATGATTTAGTTGGAAAAGACTGCAGAGACGGCTACTATGAAGCAGAATTTGGACAAGAACGCAGACCTTTGTTTTTCCAAA
ATTTGGGTATTCGATGTGTGAAGAAAAAAGAAGTAAAAGAAGCTATTATTACAAGAATAAAGGCAGGAATCAATCCATTCAATGTCCCTG
AAAAACAGCTGAATGATATTGAAGATTGTGACCTCAATGTGGTGAGACTGTGTTTTCAAGTTTTTCTCCCTGATGAACATGGTAATTTGA
CGACTGCTCTTCCTCCTGTTGTCTCGAACCCAATTTATGACAACCGTGCTCCAAATACTGCAGAATTAAGGATTTGTCGTGTAAACAAGA
ATTGTGGAAGTGTCAGAGGAGGAGATGAAATATTTCTACTTTGTGACAAAGTTCAGAAAGATGACATAGAAGTTCGTTTTGTGTTGAACG
ATTGGGAAGCAAAAGGCATCTTTTCACAAGCTGATGTACACCGTCAAGTAGCCATTGTTTTCAAAACTCCACCATATTGCAAAGCTATCA
CAGAACCCGTAACAGTAAAAATGCAGTTGCGGAGACCTTCTGACCAGGAAGTTAGTGAATCTATGGATTTTAGATATCTGCCAGATGAAA
AAGATACTTACGGCAATAAAGCAAAGAAACAAAAGACAACTCTGCTTTTCCAGAAACTGTGCCAGGATCACGTAGAAACAGGGTTTCGCC
ATGTTGACCAGGATGGTCTTGAACTCCTGACATCAGGTGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGTTAATTTTCCTG
AGAGACCAAGACCTGGTCTCCTCGGTTCAATTGGAGAAGGAAGATACTTCAAAAAAGATCATACATCTGTCGGTGGCCTGGGAGACAGTT
TTTATGAATACTTACTGAAAGCATGGTTGATGTCAGATAAAACAGACCATGAGGCAAGAAAGATGTATGATGATGCTATTGAGGCTATAG
AAAAACATCTTATTAAGAAGTCTCGTGGAGGTCTTACCTTTATTGGAGAATGGAAGAATGGGCACTTGGAAAAAAAGATGGGGCATTTGG
CCTGCTTTGCTGGGGGAATGTTTGCACTAGGAGCAGATGGTTCCAGAGCAGATAAAGCTGGTCATTATTTAGAGCTAGGGGCAGAAATTG
CACGTACTTGTCATGAGTCATATGACAGAACTGCATTAAAGCTAGGTCCTGAATCATTCAAGTTTGATGGTGCAGTGGAGGCTGTGGCTG
TCCGGCAGGCTGAAAAGTATTATATCCTCCGTCCAGAAGTAATTGAAACCTATTGGTACCTATGGCGATTCACTCACGATCCAAGATACA
GGCAGTGGGGCTGGGAAGCAGCACTGGCCATTGAAAAGTATTGCCGAGTTAATGGTGGGTTTTCTGGAGTCAAAGATGTATATTCCTCTA
CTCCTACACATGATGATGTACAGCAGAGCTTTTTTCTTGCTGAAACATTAAAATATTTGTATCTGCTGTTCTCCGGTGATGACCTTTTAC
CTTTAGACCACTGGGTGTTTAATACAGAGGCTCACCCTCTGCCTGTGTTACATTTAGCCAACACCACACTTTCAGGTAATCCTGCTGTTC
GATGAAAGCAGTTCCAGAAGGACCATTCTCACCTGTGTTTTGTTTACATGGACCACTACAGAAATTAGTTTGAAGGGGCGGCTTTTGAAA
ACCTGGACCTCTATGTCAACATGACAGGGTGAAACTATTCCCCCTAAGACTGTTCAACTTGTAGATACATCAACTTTGAAATTATTCCAT
TTTATACCTGACCAAAACATGTTCTGATATGTGTAGGACAGAGACCTGGATGTGCTTTGATCGTTAATGAGGTGGTCACATGAGAAATGA
TACCTGTTACTACTGTATTGTTTTTAGAGTCCTGAAGTCTGGAGGCTAGACTTCCTGAAAGCAAGTCAAGAATATAGAGCACCTTGCAGG
AGTTCAAGATGGCCTTTGGAACCAATTATGTATTTGTTTCCTCCTACAGTGGAGCAGCATTCAAATCAAATATTTACATATTGCTTATCA
CTTTTTCTCCATTTTAATAATGGAATGAACTAAAATAAACAAGAACAAAAGAATAGTATAATTATATCAGTAACAAGAAGACTCAAAAAA
GAAACAGGAGTACCTATCCCTATCTGAATTTTCAAGTTCCCCATTGGATGACCAGACTGGCAACCATTTCAAATCCCAGTCTATTTCATT
GAAATTTCTTGGTTAAGTTTAATTTTCTCTGGGGGCATGATCTCACAAAGAATACTCAAGTCTTTTTCTTCTTATGGAATCATCGAAACT
GCTATTTATCATAATCACCACTTATGAGCCTGGGTTTGGGATTTTGTGCATGTAGTTCAGTCTAGTGTTGGTAGCATGACAGAAAGTGGG
GAAAATGCCGCAGTTTGTTGCCTTGAAACCTAAGAGCAATCCTTGGTTTTGTTGCTACATTATTTTTCCAGACCAACACATCTACCAAGT
AAATTTTATTCACTTTAATTTCATAATAAAGTTAGTAGAGTCACTCAACTTACAACTTTATTTATGTGGCTTGGCAAAAATCACTATAAG
GCAGCTCTAAATTTGCCTTGATAAGCTAAATAAATTACTTTTATAACTTACTAAAGCAGAACAAACAGTGAAACTTTCTAAAATATTCTA
TCTGGAATAGGGACAGGGGATCTTTTATTTATAATCTCATCAGATGAGTGAGTTGTTCACAGATATTTTATGTTTTTTTAATTTTCTCCA
AGAATATTTATAGAATTCCAAAGAATCAGAATAGTTTCAAAATAATTTTCAGTGATAAAAGAGTGTTGTAATTAATCATATTACACTAAA
ATTGGGATACATCTAAGGAACTTTATCTTACTATCAGTAGGTTTTGCATTGATATTTCTTTTTAAATAAACTACTAGTTCTTTATATTTT
GACAAAAAGAACTTAAATTTTATCAGGAACTGTAAGATAAATATCTAGTGCTTATAAATTTTCTGTCCTTAAATTTATGTGACAGTGCAA
GATACTTTTGCTCTTTTCATTTAATATAGGCATCTTCCATTGACATTAATAAAACTTAGAAACAGTATAATTAGTATAACATTTACTCTG
AATTTGAAGATTTCCTGAAACAAAGTTTGTACAAGAAGCCCACCTTGGAATTCTGAAGGCTTATTTTCTTGTTTGATAAGCTTTTCTTTT
AAACTTAGGTTTTAAGTTGGGGAAAGACTTAATTAACTAATATAGTATTTTCTAAGGTTGATCATCTTATACCACGAATCGTTAATTTTG
ACAGTTCTACTGATCCGTAAATGATAACCACTGCAAATTTTTTCAGTATAAAATTTTTCACTGCAAAAAAATTTCAGTAGAAAATAAGGA
TGCAGGGCCAGTTACAATAGTCCTTAAGAGAGTTAAATTATAGCACATGTTTTGACATTGTAATATCTTTTACTACTTGAACATTTAAAT
TTCTAAATGAGAAAGGTATATATATTACTGTAACTGTAGAAGGGAAAAGGGAAAGTATTTGGTTCTAAAAAATGTTAGCCTTCCTCGTAA
AAGTAGCACAAGCCCACTTATGAATCACTGAGAAAAAGTGAAAAACTTGAGTTGGCAAAGATGCAGAGCAGCAGTGCAGATGGCAATGAA
CTCTCTGAATTCTCTTTTACCTTATTTAGAAGAATGCAGAGTAAAGGGACCTTCTTGGTTCTGCAGGAACTTCTCAAGGGATGAGGAGAC
AGAACCCCTACTTCCAAGTGCTCTATTTGTATTACCCAGATGACTGAAGCTTAAGAGAAGGCAGGGAAGTATACAAGCAGAGCCAGTTCT
GGTACAAACAAAGAATTTGACAGGGACAATGGAAGGGTCTTCTTCACCACTCCTTACCTTCTATGTGATGGAAAGACTAGAGCTTATAAA
AGTACTTCCATTTTTTTATTCTCCTGAATACCAAAGGCAATTAAAGTCAGCTACAAATGACTTGCCAGTGTCATGTTTTATTTTTGTTAT
AGATTTTTAAATTATTTCCTTCAAGATCAATTCTTATCCCATATAATGCTTAGCTTCCAAGAATATTCTTTACTTTCTTCTGTCTTTTAC
AGCTCTTTGCATTTTGTAGACCTTAATACTCAGGTTAAATATTCATTGCATTTATAAGATCTTCTGCAAAAAGCCCAGAAATGGTCCTTT
TCAGGTGCCTCTTCAAAGAGCTGACACCTTACCTTGTGCCTTTGGCACAAATGTGCAGAATAGATACATCAGTTGGTGCATAATCGAAAA
AAATAGGAATTTTGAACACTGTTCTTCCTTCTACATTTATTTCTCTTCATTTTAGAATCACACTTTTTATGTTAAACCAGATTATTATTA
TTATTATTATTCAACCAGTATTAAGTTGTTAAAACCAAGGGAATGGGGCCCTAACCAAAAAGAAGTCTCAACTCAGAAAAATAAGTCCCC
AGTCAGGTGGTTCTTACTTTCTTGTGGGTTGCACATTTTGTATCTCTCTAACATCAGCGTATTCCTGACTTTAAGCAGGTGTTTATATGT
AAAATAAAACCTGGGTATCGAAGGGAAATGCATTCTTTTTATGGAGTATTGACCCTGATCCTCTATGATGTCATATAGAGCAACTCAGGG
CTATACTTGCTAGATTTTAACCAAGCAGTTTGAAATATTAATCATCATCCTCTCATCTTCTCCACTCTCCATTGCCAAAGTCTTTGTCAA
AACTCCAAATTTGTTGATAAAAGATTGTGTTTGCCATTCTCATTTATAATGCAGTTTCTCCTTAAGCCTGGAGTTTTTTGAATGAGTGCA
TGAGTAAATGAGAGAATGTGTGAACGAACATTTATGAAGTATCTAACATGTGCCAAGCATTGTGCCTGGCACTTTCAATCATTAGAATGT
TTTATGTGATTCCACAGCATTTTCTGTATGAGAGTAGCTCACAACATTTTAAATGTTTCCAATATGAATCGTGTTACAAAATTCTTAATT
TTATATTTCATATAAATTAAAGAGGAAAAAGAAAAGGTTTATAATATATTTTAAAACAATGTGTTACTGTATAATACAACTATAATTGTA
GTTAATAACTAAAACCTCTTGAAAATGTCAAAGAAATACTTGATTTCTGATGCAACTTTGACTAAAATATTTACTTTAGAAATAAAAACG
TTCTTATTTTGCTATATCACTTTAATTGCATAATTAAAAAGCAGTGTTTTATAGAAATGCTGGTTATTTTATATTCAAAAAGATTTTGTC
ACATAATTCATGGGTAAAACTTGCAGTTGTAAATTGTGTCTGCTCTGGTATGGGCCCTATTAATAGTCCCATGCTGTTAAATATAAAGAA
AAATATACTAAAATATTCAAAGTTCCAAATAACAGTTCCTAGTAATAGTATTTTGAGTTATTTTTCTTTAGGTTTCCTTATACTCAAATT
GGCTAGGTCCTATCTTTTCCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTATATATATATATATATATATATATATATGAG
AGATATATGAGATATATGAGAGATCAAGATCTATATATGTATATAAATACAATTATACACAGATAATTTTTAATACTCTTTGTTAACAAA
CACAGTTGAAAACTGGTTTCGGCTGCACAAATAAGCAGAATATTTGAGTAACTATATATGATATGGAGATATTTTAATCCATTTATCCTG
GCTCAAGAACACTGATAAAGATGATTTTCTGTTACTTTAGCTCATTCAGATCAGGATGGACATGCTCTTTTTGATCTATAACTGTTCAGC
CAGCTTCCAGATAATATTTTAGGCTATGAGAGCTATACAGTCTCTCTTATTACTCATTTCTGCTGTTGAAGTATCGAAAACAGATAGAGA
TACTATGTAAAGAATGGGCGTAGCTATGTTCCAGGAAAACTTTATTTACAAAAGCAGATGGAGGGCTGGATTTGGTCCATGGGTCATAGT
TAGTGACCCTGATCCCAAGTTTATTTTGTGTTAGACCCTCTAACCTTTGATCTGCGTCTTTTCTGTTTTGATTTACATAATTCATTTTTA
AATCAAAAAGATGTGCGTATATATGGTTGTGTGTATCTGTATAACCTAAAGCTATAATATTTTGTTGTCTTGAAAGCAGATACACTCTTC
CTGGAGTCTGTTCAGGTTTCAGGACGATTGACTATAATGAAAGAGACAGAATAGGGTAAGGGAAGATGGGTATGCTATCAGCCATTTTCT
TTGCCTTGTCATTTAATGCCATAATTTCAGATTCTCTATGTAAAAAGAAGGTCTGTGTATTGTCAAAATAATATACTCTCCAAGTTCTCC
TGCTCATTGACCCTTGAACCAGGATTCTGGATTGCTAGAGCTGCAGAAATTCACCCACTTGGGTACTCTTAGAGCTCTACAGCAAGAATA
TGATAGAATGTCTGATCTTTGTGCTGCAGAAAGCAAACTTTTGAAGAATTCTAAGCAACAGAAAATGGGTTATGTGACTCATCTGCTATT
TGGCAGCCACTATTCCTTTTTTAGACTGCAGAACGGTACTGCCCCTGTTACCTCTAGAATAGCCTGAGTCTGAGGAGTGCAGAGAAAAGA
TATATCCAAAAGGAGAATCCCTTTCTCTTGCATAACTCTCAATCCTTTACAAGTAAGTAGCATTATTTCAGAATGTCTATATGCATCATT
TTCAACTAAAGCATACCTCATCCTTAAACTTCCACTATTTAACAGCTAATCCATTTCAAACTTGGTTTGAGCCTAGCAATTGCAGAACTC
ATAAAATTGCTTGTGAAATTACACACCATATTACTAGCATATACATTGCAGTGCTCCAATCATGCTAACAGATAATAGATTTTTCTTTAA
GAATTTTATCAAATATTTCACTATTTGGGGAAATTTTAGAGGAGGGGAAGCCTGTATTCAGGATGATAGAGGGAGCAGAGACTTACTGTC
TCTCTTCCACATTATAAATGAACTGCCTTTCCAGGTCCAACATGCTGTCAGGTTGCTTCAGCTCGGTGTGAATGTAAGTGTGGGGATCAA
ACACACACACCTATACACATACATATTAATATGCAGAGGATTTTAAATAATTGCAAATGTCTTGTGGCTGTTTTATTTCTACAAAATTCT
GTAAGATGTATACCAGAAAACATAATAAAGATAAGCTCAGTTCTTCATTGGGAAAAAATATTTTTAAAGAAAATTTAGAAGTTTTTGCTG
AATTAAAGTATCTTCAATTTTAATTACTGGATTTGGAAGTTGAAATGCCATCCTTCAATATCACTGGTCTCAAATTCATTGATAGAATTT
TTTCTTAAACTAATAAGTGGGGTAAGTATAATCTCCTAAATTGGTACCCACTGGCTGCTCCTAAACTGGTTTCCAGTCATGTCCTCCAGT

>In-frame_REL_ENST00000394479_chr2_61147777_+_MAN1A2_ENST00000356554_chr1_118035769_+_7849nt
CAGGGGTTGGGAAGGTGTGAGCCGCAAACCCAGCGGAGGGCGGGAAGAAGGAGGAGGCCTCTAGGGTGGTCGGGGGACTGGGGGCCCCGC
CGGCAGAGGTCCCTCGGCCTCCTGACTGACTGACTGCGGCCGCCTCCGGCCAGGACGCTGGGAGCTGCCTGCGGGAAGGTGCGGGGAGCG
GAGCCATGGCCTCCGGTGCGTATAACCCGTATATAGAGATAATTGAACAACCCAGGCAGAGGGGAATGCGTTTTAGATACAAATGTGAAG
GGCGATCAGCAGGCAGCATTCCAGGGGAGCACAGCACAGACAACAACCGAACATACCCTTCTATCCAGATTATGAACTATTATGGAAAAG
GAAAAGTGAGAATTACATTAGTAACAAAGAATGACCCATATAAACCTCATCCTCATGATTTAGTTGGAAAAGACTGCAGAGACGGCTACT
ATGAAGCAGAATTTGGACAAGAACGCAGACCTTTGTTTTTCCAAAATTTGGGTATTCGATGTGTGAAGAAAAAAGAAGTAAAAGAAGCTA
TTATTACAAGAATAAAGGCAGGAATCAATCCATTCAATGTCCCTGAAAAACAGCTGAATGATATTGAAGATTGTGACCTCAATGTGGTGA
GACTGTGTTTTCAAGTTTTTCTCCCTGATGAACATGGTAATTTGACGACTGCTCTTCCTCCTGTTGTCTCGAACCCAATTTATGACAACC
GTGCTCCAAATACTGCAGAATTAAGGATTTGTCGTGTAAACAAGAATTGTGGAAGTGTCAGAGGAGGAGATGAAATATTTCTACTTTGTG
ACAAAGTTCAGAAAGATGACATAGAAGTTCGTTTTGTGTTGAACGATTGGGAAGCAAAAGGCATCTTTTCACAAGCTGATGTACACCGTC
AAGTAGCCATTGTTTTCAAAACTCCACCATATTGCAAAGCTATCACAGAACCCGTAACAGTAAAAATGCAGTTGCGGAGACCTTCTGACC
AGGAAGTTAGTGAATCTATGGATTTTAGATATCTGCCAGATGAAAAAGATACTTACGGCAATAAAGCAAAGAAACAAAAGACAACTCTGC
TTTTCCAGAAACTGTGCCAGGATCACGTTAATTTTCCTGAGAGACCAAGACCTGGTCTCCTCGGTTCAATTGGAGAAGGAAGATACTTCA
AAAAAGATCATACATCTGTCGGTGGCCTGGGAGACAGTTTTTATGAATACTTACTGAAAGCATGGTTGATGTCAGATAAAACAGACCATG
AGGCAAGAAAGATGTATGATGATGCTATTGAGGCTATAGAAAAACATCTTATTAAGAAGTCTCGTGGAGGTCTTACCTTTATTGGAGAAT
GGAAGAATGGGCACTTGGAAAAAAAGATGGGGCATTTGGCCTGCTTTGCTGGGGGAATGTTTGCACTAGGAGCAGATGGTTCCAGAGCAG
ATAAAGCTGGTCATTATTTAGAGCTAGGGGCAGAAATTGCACGTACTTGTCATGAGTCATATGACAGAACTGCATTAAAGCTAGGTCCTG
AATCATTCAAGTTTGATGGTGCAGTGGAGGCTGTGGCTGTCCGGCAGGCTGAAAAGTATTATATCCTCCGTCCAGAAGTAATTGAAACCT
ATTGGTACCTATGGCGATTCACTCACGATCCAAGATACAGGCAGTGGGGCTGGGAAGCAGCACTGGCCATTGAAAAGTATTGCCGAGTTA
ATGGTGGGTTTTCTGGAGTCAAAGATGTATATTCCTCTACTCCTACACATGATGATGTACAGCAGAGCTTTTTTCTTGCTGAAACATTAA
AATATTTGTATCTGCTGTTCTCCGGTGATGACCTTTTACCTTTAGACCACTGGGTGTTTAATACAGAGGCTCACCCTCTGCCTGTGTTAC
ATTTAGCCAACACCACACTTTCAGGTAATCCTGCTGTTCGATGAAAGCAGTTCCAGAAGGACCATTCTCACCTGTGTTTTGTTTACATGG
ACCACTACAGAAATTAGTTTGAAGGGGCGGCTTTTGAAAACCTGGACCTCTATGTCAACATGACAGGGTGAAACTATTCCCCCTAAGACT
GTTCAACTTGTAGATACATCAACTTTGAAATTATTCCATTTTATACCTGACCAAAACATGTTCTGATATGTGTAGGACAGAGACCTGGAT
GTGCTTTGATCGTTAATGAGGTGGTCACATGAGAAATGATACCTGTTACTACTGTATTGTTTTTAGAGTCCTGAAGTCTGGAGGCTAGAC
TTCCTGAAAGCAAGTCAAGAATATAGAGCACCTTGCAGGAGTTCAAGATGGCCTTTGGAACCAATTATGTATTTGTTTCCTCCTACAGTG
GAGCAGCATTCAAATCAAATATTTACATATTGCTTATCACTTTTTCTCCATTTTAATAATGGAATGAACTAAAATAAACAAGAACAAAAG
AATAGTATAATTATATCAGTAACAAGAAGACTCAAAAAAGAAACAGGAGTACCTATCCCTATCTGAATTTTCAAGTTCCCCATTGGATGA
CCAGACTGGCAACCATTTCAAATCCCAGTCTATTTCATTGAAATTTCTTGGTTAAGTTTAATTTTCTCTGGGGGCATGATCTCACAAAGA
ATACTCAAGTCTTTTTCTTCTTATGGAATCATCGAAACTGCTATTTATCATAATCACCACTTATGAGCCTGGGTTTGGGATTTTGTGCAT
GTAGTTCAGTCTAGTGTTGGTAGCATGACAGAAAGTGGGGAAAATGCCGCAGTTTGTTGCCTTGAAACCTAAGAGCAATCCTTGGTTTTG
TTGCTACATTATTTTTCCAGACCAACACATCTACCAAGTAAATTTTATTCACTTTAATTTCATAATAAAGTTAGTAGAGTCACTCAACTT
ACAACTTTATTTATGTGGCTTGGCAAAAATCACTATAAGGCAGCTCTAAATTTGCCTTGATAAGCTAAATAAATTACTTTTATAACTTAC
TAAAGCAGAACAAACAGTGAAACTTTCTAAAATATTCTATCTGGAATAGGGACAGGGGATCTTTTATTTATAATCTCATCAGATGAGTGA
GTTGTTCACAGATATTTTATGTTTTTTTAATTTTCTCCAAGAATATTTATAGAATTCCAAAGAATCAGAATAGTTTCAAAATAATTTTCA
GTGATAAAAGAGTGTTGTAATTAATCATATTACACTAAAATTGGGATACATCTAAGGAACTTTATCTTACTATCAGTAGGTTTTGCATTG
ATATTTCTTTTTAAATAAACTACTAGTTCTTTATATTTTGACAAAAAGAACTTAAATTTTATCAGGAACTGTAAGATAAATATCTAGTGC
TTATAAATTTTCTGTCCTTAAATTTATGTGACAGTGCAAGATACTTTTGCTCTTTTCATTTAATATAGGCATCTTCCATTGACATTAATA
AAACTTAGAAACAGTATAATTAGTATAACATTTACTCTGAATTTGAAGATTTCCTGAAACAAAGTTTGTACAAGAAGCCCACCTTGGAAT
TCTGAAGGCTTATTTTCTTGTTTGATAAGCTTTTCTTTTAAACTTAGGTTTTAAGTTGGGGAAAGACTTAATTAACTAATATAGTATTTT
CTAAGGTTGATCATCTTATACCACGAATCGTTAATTTTGACAGTTCTACTGATCCGTAAATGATAACCACTGCAAATTTTTTCAGTATAA
AATTTTTCACTGCAAAAAAATTTCAGTAGAAAATAAGGATGCAGGGCCAGTTACAATAGTCCTTAAGAGAGTTAAATTATAGCACATGTT
TTGACATTGTAATATCTTTTACTACTTGAACATTTAAATTTCTAAATGAGAAAGGTATATATATTACTGTAACTGTAGAAGGGAAAAGGG
AAAGTATTTGGTTCTAAAAAATGTTAGCCTTCCTCGTAAAAGTAGCACAAGCCCACTTATGAATCACTGAGAAAAAGTGAAAAACTTGAG
TTGGCAAAGATGCAGAGCAGCAGTGCAGATGGCAATGAACTCTCTGAATTCTCTTTTACCTTATTTAGAAGAATGCAGAGTAAAGGGACC
TTCTTGGTTCTGCAGGAACTTCTCAAGGGATGAGGAGACAGAACCCCTACTTCCAAGTGCTCTATTTGTATTACCCAGATGACTGAAGCT
TAAGAGAAGGCAGGGAAGTATACAAGCAGAGCCAGTTCTGGTACAAACAAAGAATTTGACAGGGACAATGGAAGGGTCTTCTTCACCACT
CCTTACCTTCTATGTGATGGAAAGACTAGAGCTTATAAAAGTACTTCCATTTTTTTATTCTCCTGAATACCAAAGGCAATTAAAGTCAGC
TACAAATGACTTGCCAGTGTCATGTTTTATTTTTGTTATAGATTTTTAAATTATTTCCTTCAAGATCAATTCTTATCCCATATAATGCTT
AGCTTCCAAGAATATTCTTTACTTTCTTCTGTCTTTTACAGCTCTTTGCATTTTGTAGACCTTAATACTCAGGTTAAATATTCATTGCAT
TTATAAGATCTTCTGCAAAAAGCCCAGAAATGGTCCTTTTCAGGTGCCTCTTCAAAGAGCTGACACCTTACCTTGTGCCTTTGGCACAAA
TGTGCAGAATAGATACATCAGTTGGTGCATAATCGAAAAAAATAGGAATTTTGAACACTGTTCTTCCTTCTACATTTATTTCTCTTCATT
TTAGAATCACACTTTTTATGTTAAACCAGATTATTATTATTATTATTATTCAACCAGTATTAAGTTGTTAAAACCAAGGGAATGGGGCCC
TAACCAAAAAGAAGTCTCAACTCAGAAAAATAAGTCCCCAGTCAGGTGGTTCTTACTTTCTTGTGGGTTGCACATTTTGTATCTCTCTAA
CATCAGCGTATTCCTGACTTTAAGCAGGTGTTTATATGTAAAATAAAACCTGGGTATCGAAGGGAAATGCATTCTTTTTATGGAGTATTG
ACCCTGATCCTCTATGATGTCATATAGAGCAACTCAGGGCTATACTTGCTAGATTTTAACCAAGCAGTTTGAAATATTAATCATCATCCT
CTCATCTTCTCCACTCTCCATTGCCAAAGTCTTTGTCAAAACTCCAAATTTGTTGATAAAAGATTGTGTTTGCCATTCTCATTTATAATG
CAGTTTCTCCTTAAGCCTGGAGTTTTTTGAATGAGTGCATGAGTAAATGAGAGAATGTGTGAACGAACATTTATGAAGTATCTAACATGT
GCCAAGCATTGTGCCTGGCACTTTCAATCATTAGAATGTTTTATGTGATTCCACAGCATTTTCTGTATGAGAGTAGCTCACAACATTTTA
AATGTTTCCAATATGAATCGTGTTACAAAATTCTTAATTTTATATTTCATATAAATTAAAGAGGAAAAAGAAAAGGTTTATAATATATTT
TAAAACAATGTGTTACTGTATAATACAACTATAATTGTAGTTAATAACTAAAACCTCTTGAAAATGTCAAAGAAATACTTGATTTCTGAT
GCAACTTTGACTAAAATATTTACTTTAGAAATAAAAACGTTCTTATTTTGCTATATCACTTTAATTGCATAATTAAAAAGCAGTGTTTTA
TAGAAATGCTGGTTATTTTATATTCAAAAAGATTTTGTCACATAATTCATGGGTAAAACTTGCAGTTGTAAATTGTGTCTGCTCTGGTAT
GGGCCCTATTAATAGTCCCATGCTGTTAAATATAAAGAAAAATATACTAAAATATTCAAAGTTCCAAATAACAGTTCCTAGTAATAGTAT
TTTGAGTTATTTTTCTTTAGGTTTCCTTATACTCAAATTGGCTAGGTCCTATCTTTTCCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT
CTCTCTCTATATATATATATATATATATATATATATGAGAGATATATGAGATATATGAGAGATCAAGATCTATATATGTATATAAATACA
ATTATACACAGATAATTTTTAATACTCTTTGTTAACAAACACAGTTGAAAACTGGTTTCGGCTGCACAAATAAGCAGAATATTTGAGTAA
CTATATATGATATGGAGATATTTTAATCCATTTATCCTGGCTCAAGAACACTGATAAAGATGATTTTCTGTTACTTTAGCTCATTCAGAT
CAGGATGGACATGCTCTTTTTGATCTATAACTGTTCAGCCAGCTTCCAGATAATATTTTAGGCTATGAGAGCTATACAGTCTCTCTTATT
ACTCATTTCTGCTGTTGAAGTATCGAAAACAGATAGAGATACTATGTAAAGAATGGGCGTAGCTATGTTCCAGGAAAACTTTATTTACAA
AAGCAGATGGAGGGCTGGATTTGGTCCATGGGTCATAGTTAGTGACCCTGATCCCAAGTTTATTTTGTGTTAGACCCTCTAACCTTTGAT
CTGCGTCTTTTCTGTTTTGATTTACATAATTCATTTTTAAATCAAAAAGATGTGCGTATATATGGTTGTGTGTATCTGTATAACCTAAAG
CTATAATATTTTGTTGTCTTGAAAGCAGATACACTCTTCCTGGAGTCTGTTCAGGTTTCAGGACGATTGACTATAATGAAAGAGACAGAA
TAGGGTAAGGGAAGATGGGTATGCTATCAGCCATTTTCTTTGCCTTGTCATTTAATGCCATAATTTCAGATTCTCTATGTAAAAAGAAGG
TCTGTGTATTGTCAAAATAATATACTCTCCAAGTTCTCCTGCTCATTGACCCTTGAACCAGGATTCTGGATTGCTAGAGCTGCAGAAATT
CACCCACTTGGGTACTCTTAGAGCTCTACAGCAAGAATATGATAGAATGTCTGATCTTTGTGCTGCAGAAAGCAAACTTTTGAAGAATTC
TAAGCAACAGAAAATGGGTTATGTGACTCATCTGCTATTTGGCAGCCACTATTCCTTTTTTAGACTGCAGAACGGTACTGCCCCTGTTAC
CTCTAGAATAGCCTGAGTCTGAGGAGTGCAGAGAAAAGATATATCCAAAAGGAGAATCCCTTTCTCTTGCATAACTCTCAATCCTTTACA
AGTAAGTAGCATTATTTCAGAATGTCTATATGCATCATTTTCAACTAAAGCATACCTCATCCTTAAACTTCCACTATTTAACAGCTAATC
CATTTCAAACTTGGTTTGAGCCTAGCAATTGCAGAACTCATAAAATTGCTTGTGAAATTACACACCATATTACTAGCATATACATTGCAG
TGCTCCAATCATGCTAACAGATAATAGATTTTTCTTTAAGAATTTTATCAAATATTTCACTATTTGGGGAAATTTTAGAGGAGGGGAAGC
CTGTATTCAGGATGATAGAGGGAGCAGAGACTTACTGTCTCTCTTCCACATTATAAATGAACTGCCTTTCCAGGTCCAACATGCTGTCAG
GTTGCTTCAGCTCGGTGTGAATGTAAGTGTGGGGATCAAACACACACACCTATACACATACATATTAATATGCAGAGGATTTTAAATAAT
TGCAAATGTCTTGTGGCTGTTTTATTTCTACAAAATTCTGTAAGATGTATACCAGAAAACATAATAAAGATAAGCTCAGTTCTTCATTGG
GAAAAAATATTTTTAAAGAAAATTTAGAAGTTTTTGCTGAATTAAAGTATCTTCAATTTTAATTACTGGATTTGGAAGTTGAAATGCCAT
CCTTCAATATCACTGGTCTCAAATTCATTGATAGAATTTTTTCTTAAACTAATAAGTGGGGTAAGTATAATCTCCTAAATTGGTACCCAC
TGGCTGCTCCTAAACTGGTTTCCAGTCATGTCCTCCAGTATGTGATTTTTATAAATTAAAGGTAATATTGTATATTAAAGTTCAAATAAA


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FusionGenePPI for REL_MAN1A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RELPPP4C, MAP3K8, PAPOLA, RELA, NFKB1, NFKB2, TBK1, TNIP2, NFKBIE, ELF1, SRF, TBP, GTF2B, SP1, NKRF, MTPN, MAPK8, NFKBIA, NFKBIB, CDK2, CREBBP, EP300, FOXP3, DPF2, HSPA4, COMMD1, SOCS3, CXCL14, AAAS, CLIC4, TMEM165, C9orf91, AR, ADRB2, ADSL, ARNT2, BZRAP1, DGCR6, FHIT, MVP, NDE1, PARK2, PRKAB2, TDO2, ACTN3, AES, ALOX5, BID, SEPT7, CDKN2C, CKS1B, COL8A1, DHPS, DNTT, EIF4EBP1, EIF5A, EPHB6, FHL2, FKBP1B, FLNA, GRB2, HIP1, UBE2K, HLA-DOA, LASP1, LMO1, LMO2, LNPEP, FOXO4, NEDD9, NUCB1, PLCB4, POLE2, POLR2L, PSMA1, PTGER3, PTK6, RABIF, SAT1, ATXN1, SDCBP, SLC6A12, RECK, NCK2, HAT1, CGGBP1, STK16, EIF3A, EIF3D, EIF4E2, RBM39, KIAA0100, EPM2AIP1, ACOT8, CHAF1A, TSSC4, ARIH2, MAD2L2, GADD45G, MORF4L1, EXOSC8, R3HDM2, SEC31A, SZT2, TENC1, DAAM2, EML2, POLR1A, NDUFAF3, NECAP1, IL36RN, OSTF1, HSPB7, RSPH14, CPSF1, NME7, OSGIN1, A1CF, NEUROG3, EXOSC1, MEMO1, CHCHD2, DYNC1LI1, POP5, CINP, HDAC7, OAZ3, TRAPPC2L, UBASH3A, OTUD4, TTC19, SLC41A3, C1orf109, TXNL4B, MAGOHB, NAGK, ASAP3, NXT2, CABP5, EIF5A2, LGALS14, AGPAT4, MAP3K7CL, EXOSC5, PRDM10, CTNNBIP1, COL20A1, RNF213, LSM2, NGB, DMRT3, TMEM8A, PARVG, UBE2Z, OTUB2, C20orf195, ATG9A, CCNJL, SNRNP25, NOL9, FLAD1, TSSK3, RASSF5, C11orf68, PLEKHN1, MIEN1, VPS25, CEP19, KRTAP9-4, BMF, SLC39A13, ATPAF2, ZNF765, RIPPLY1, EGLN3, EFHC1, KLHL32, CIB3, PIH1D2, MRPL10, NR2C2AP, KLHL40, GLYCTK, ZNF572, ZNF417, TSTD2, PATE1, ZNF550, ZNF564, FUT11, TTC21A, STRA13, C9orf72, CPNE2, NEIL2, ZDHHC24, NUDT14, SEC14L4, BARHL2, RAB41, TRIM74, C12orf75, REXO1L6P, BTRC, RELB, TSR3, AURKA, XPO1, BIRC3, RGS3, HIF1AN, NFKBIDMAN1A2SMAD9, CLDND1, CD1B, SCARA3, CLU, C5AR2, CD1E, SCGB2A2, TMEM30B, IL13RA2, ADAM32, PMEL, B4GAT1, TLR5, TRHDE, PTPRO


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for REL_MAN1A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for REL_MAN1A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRELC0003873Rheumatoid Arthritis3CTD_human
HgeneRELC0018843Heat Stroke1CTD_human
HgeneRELC0019829Hodgkin Disease1CTD_human
HgeneRELC0025261Memory Disorders1CTD_human
HgeneRELC0033860Psoriasis1CTD_human