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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30920

FusionGeneSummary for REG1A_GNA11

check button Fusion gene summary
Fusion gene informationFusion gene name: REG1A_GNA11
Fusion gene ID: 30920
HgeneTgene
Gene symbol

REG1A

GNA11

Gene ID

5967

2767

Gene nameregenerating family member 1 alphaG protein subunit alpha 11
SynonymsICRF|P19|PSP|PSPS|PSPS1|PTP|REGFBH|FBH2|FHH2|GNA-11|HHC2|HYPOC2
Cytomap

2p12

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionlithostathine-1-alphaREG-1-alphaislet cells regeneration factorislet of langerhans regenerating proteinpancreatic stone protein, secretorypancreatic thread proteinprotein-Xregenerating islet-derived protein 1-alpharegenerating protein I alphaguanine nucleotide-binding protein subunit alpha-11g alpha-11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)guanine nucleotide-binding protein G(y) subunit alpha
Modification date2018052320180523
UniProtAcc

P05451

P29992

Ensembl transtripts involved in fusion geneENST00000233735, ENST00000078429, 
ENST00000586180, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 43
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/8*10)=1.90689059560852
Context

PubMed: REG1A [Title/Abstract] AND GNA11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CK818890REG1Achr2

79350483

-GNA11chr19

3119254

-
ChiTaRS3.1BM126025REG1Achr2

79350483

-GNA11chr19

3119254

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000233735ENST00000078429REG1Achr2

79350483

-GNA11chr19

3119254

-
3UTR-3UTRENST00000233735ENST00000586180REG1Achr2

79350483

-GNA11chr19

3119254

-

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FusionProtFeatures for REG1A_GNA11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
REG1A

P05451

GNA11

P29992

Might act as an inhibitor of spontaneous calciumcarbonate precipitation. May be associated with neuronal sproutingin brain, and with brain and pancreas regeneration. Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. Acts as an activator of phospholipase C.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for REG1A_GNA11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for REG1A_GNA11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for REG1A_GNA11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for REG1A_GNA11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGNA11C0220633Uveal melanoma3CTD_human;ORPHANET
TgeneGNA11C3809243HYPOCALCEMIA, AUTOSOMAL DOMINANT 22UNIPROT
TgeneGNA11C0018798Congenital Heart Defects1CTD_human
TgeneGNA11C0025202melanoma1CTD_human
TgeneGNA11C1840347HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE II (disorder)1ORPHANET;UNIPROT