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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30889

FusionGeneSummary for RCOR3_FRMPD1

check button Fusion gene summary
Fusion gene informationFusion gene name: RCOR3_FRMPD1
Fusion gene ID: 30889
HgeneTgene
Gene symbol

RCOR3

FRMPD1

Gene ID

55758

22844

Gene nameREST corepressor 3FERM and PDZ domain containing 1
Synonyms-FRMD2
Cytomap

1q32.2-q32.3

9p13.2

Type of geneprotein-codingprotein-coding
DescriptionREST corepressor 3FERM and PDZ domain-containing protein 1FERM domain-containing protein 2
Modification date2018052320180523
UniProtAcc

Q9P2K3

Q5SYB0

Ensembl transtripts involved in fusion geneENST00000367006, ENST00000452621, 
ENST00000419091, ENST00000367005, 
ENST00000526255, 
ENST00000377765, 
ENST00000539465, ENST00000536622, 
ENST00000541302, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: RCOR3 [Title/Abstract] AND FRMPD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF091851RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000367006ENST00000377765RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000367006ENST00000539465RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000367006ENST00000536622RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000367006ENST00000541302RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
5CDS-intronENST00000452621ENST00000377765RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
5CDS-intronENST00000452621ENST00000539465RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
5CDS-intronENST00000452621ENST00000536622RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
5CDS-intronENST00000452621ENST00000541302RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000419091ENST00000377765RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000419091ENST00000539465RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000419091ENST00000536622RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000419091ENST00000541302RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000367005ENST00000377765RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000367005ENST00000539465RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000367005ENST00000536622RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000367005ENST00000541302RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000526255ENST00000377765RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000526255ENST00000539465RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000526255ENST00000536622RCOR3chr1

211486319

+FRMPD1chr9

37741757

-
intron-intronENST00000526255ENST00000541302RCOR3chr1

211486319

+FRMPD1chr9

37741757

-

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FusionProtFeatures for RCOR3_FRMPD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RCOR3

Q9P2K3

FRMPD1

Q5SYB0

May act as a component of a corepressor complex thatrepresses transcription. {ECO:0000305}. Stabilizes membrane-bound GPSM1, and thereby promotesits interaction with GNAI1. {ECO:0000269|PubMed:18566450}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RCOR3_FRMPD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RCOR3_FRMPD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RCOR3_FRMPD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RCOR3_FRMPD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource