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Fusion gene ID: 30853 |
FusionGeneSummary for RCAN2_DOCK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RCAN2_DOCK2 | Fusion gene ID: 30853 | Hgene | Tgene | Gene symbol | RCAN2 | DOCK2 | Gene ID | 10231 | 1794 |
| Gene name | regulator of calcineurin 2 | dedicator of cytokinesis 2 | |
| Synonyms | CSP2|DSCR1L1|MCIP2|RCN2|ZAKI-4|ZAKI4 | IMD40 | |
| Cytomap | 6p12.3 | 5q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcipressin-2Down syndrome candidate region 1-like 1Down syndrome critical region gene 1-like 1myocyte-enriched calcineurin-interacting protein 2thyroid hormone-responsive (skin fibroblasts)thyroid hormone-responsive protein ZAKI-4 | dedicator of cytokinesis protein 2dedicator of cyto-kinesis 2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q14206 | Q92608 | |
| Ensembl transtripts involved in fusion gene | ENST00000330430, ENST00000371374, ENST00000306764, ENST00000405162, | ENST00000256935, ENST00000540750, ENST00000520908, ENST00000523351, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 9 X 7 X 6=378 |
| # samples | 5 | 9 | |
| ** MAII score | log2(5/8*10)=2.64385618977472 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RCAN2 [Title/Abstract] AND DOCK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-FX-A2QS-01A | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000330430 | ENST00000256935 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-5UTR | ENST00000330430 | ENST00000540750 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-5UTR | ENST00000330430 | ENST00000520908 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-3UTR | ENST00000330430 | ENST00000523351 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| Frame-shift | ENST00000371374 | ENST00000256935 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-5UTR | ENST00000371374 | ENST00000540750 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-5UTR | ENST00000371374 | ENST00000520908 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-3UTR | ENST00000371374 | ENST00000523351 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| In-frame | ENST00000306764 | ENST00000256935 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-5UTR | ENST00000306764 | ENST00000540750 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-5UTR | ENST00000306764 | ENST00000520908 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-3UTR | ENST00000306764 | ENST00000523351 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| Frame-shift | ENST00000405162 | ENST00000256935 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-5UTR | ENST00000405162 | ENST00000540750 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-5UTR | ENST00000405162 | ENST00000520908 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
| 5CDS-3UTR | ENST00000405162 | ENST00000523351 | RCAN2 | chr6 | 46214485 | - | DOCK2 | chr5 | 169267761 | + |
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FusionProtFeatures for RCAN2_DOCK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RCAN2 | DOCK2 |
| Inhibits calcineurin-dependent transcriptional responsesby binding to the catalytic domain of calcineurin A. Could play arole during central nervous system development. | Involved in cytoskeletal rearrangements required forlymphocyte migration in response of chemokines. Activates RAC1 andRAC2, but not CDC42, by functioning as a guanine nucleotideexchange factor (GEF), which exchanges bound GDP for free GTP. Mayalso participate in IL2 transcriptional activation via theactivation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RCAN2_DOCK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RCAN2_ENST00000306764_chr6_46214485_-_DOCK2_ENST00000256935_chr5_169267761_+_930aa AFTYHHIQEIMVQLLRTVNRTVITMGRDHILISHFVACMTAILNQMGDQHYSFYIETFQTSSELVDFLMETFIMFKDLIGKNVYPGDWMA MSMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNK ICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSV ENFVNLVKGLLEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQ VMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQG FPSFLRNKVFIYRGKEYERREDFQMQLMTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQR FHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANEKILMMINQYQSDETLPINPLSMLL NGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVRE MPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFAD EKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RCAN2_ENST00000306764_chr6_46214485_-_DOCK2_ENST00000256935_chr5_169267761_+_2790nt GCCTTCACCTACCACCATATCCAGGAGATCATGGTCCAGCTGCTGCGGACAGTGAACCGGACAGTCATCACCATGGGCCGGGATCACATT CTGATTAGTCACTTTGTGGCATGTATGACAGCCATCTTAAACCAGATGGGTGACCAGCACTACTCCTTCTACATTGAGACCTTCCAGACC AGCTCTGAACTTGTGGACTTCTTGATGGAGACCTTCATCATGTTCAAGGACCTCATTGGAAAGAACGTGTACCCTGGAGACTGGATGGCC ATGAGCATGGTTCAAAACAGGGTCTTCCTGAGAGCTATCAACAAGTTTGCAGAAACCATGAACCAGAAGTTCCTAGAACACACGAACTTT GAGTTCCAGCTGTGGAACAACTATTTTCATCTGGCAGTGGCTTTTATCACCCAGGATTCTCTGCAGCTGGAGCAGTTCTCACACGCCAAA TACAACAAAATCCTGAATAAGTATGGGGACATGAGACGGCTAATTGGCTTCTCCATCCGTGATATGTGGTACAAGCTTGGTCAGAACAAA ATCTGCTTCATCCCAGGCATGGTAGGACCTATATTAGAGATGACACTTATCCCTGAGGCTGAGCTCCGGAAAGCCACCATACCAATCTTC TTCGACATGATGCTGTGTGAATATCAAAGAAGTGGGGATTTCAAAAAGTTTGAAAACGAAATCATCCTGAAGCTGGACCACGAGGTAGAA GGGGGCCGAGGCGACGAGCAGTACATGCAGCTCCTGGAGTCAATCCTGATGGAATGTGCTGCAGAGCACCCAACCATTGCCAAGTCGGTG GAGAACTTCGTGAACCTGGTCAAAGGCCTCCTGGAGAAGCTGCTGGATTACCGGGGTGTGATGACAGATGAGAGCAAAGACAACCGCATG AGCTGCACCGTGAACCTGCTGAATTTCTACAAAGATAACAACAGGGAGGAGATGTACATAAGGTACCTGTACAAACTCCGCGATCTTCAC CTGGACTGTGACAATTACACAGAGGCTGCCTACACGCTCCTTCTCCACACCTGGCTTCTCAAGTGGTCGGATGAGCAGTGTGCATCACAG GTCATGCAGACAGGCCAGCAGCACCCCCAGACACACCGGCAGCTGAAGGAGACGCTCTACGAGACCATCATAGGCTACTTTGACAAAGGA AAGATGTGGGAAGAGGCCATAAGTCTGTGCAAGGAGCTGGCGGAACAGTACGAGATGGAGATCTTTGACTATGAGCTGCTCAGCCAGAAC CTGATCCAGCAGGCAAAATTCTATGAAAGCATCATGAAAATCCTCAGGCCCAAACCAGACTACTTTGCTGTTGGATACTACGGCCAGGGA TTCCCCTCCTTCCTGCGGAACAAAGTGTTCATCTACCGCGGGAAGGAATATGAGCGAAGAGAAGATTTCCAGATGCAGCTGATGACCCAG TTCCCCAATGCAGAGAAGATGAACACCACCTCTGCCCCGGGAGATGATGTGAAGAATGCCCCAGGCCAGTATATCCAGTGCTTCACTGTC CAGCCTGTCTTGGATGAACATCCCAGGTTCAAGAATAAGCCAGTGCCTGACCAGATTATAAACTTCTACAAATCCAACTACGTGCAAAGG TTCCACTACTCCCGGCCCGTGCGCAGGGGGACCGTAGACCCAGAGAATGAGTTTGCTTCCATGTGGATTGAGAGAACCTCCTTCGTGACT GCATACAAGCTGCCGGGGATCCTGCGCTGGTTTGAGGTGGTGCACATGTCGCAGACCACAATTAGTCCTCTGGAGAATGCCATAGAAACC ATGTCCACGGCCAATGAGAAGATCCTGATGATGATAAACCAGTACCAGAGTGATGAGACCCTCCCCATCAACCCACTCTCCATGCTCCTG AACGGGATTGTGGACCCTGCTGTCATGGGAGGCTTCGCCAAGTATGAGAAGGCCTTCTTCACTGAAGAGTATGTCAGGGACCACCCTGAG GACCAGGACAAGCTGACCCACCTCAAGGACCTGATTGCATGGCAGATCCCCTTCTTGGGAGCTGGGATTAAGATCCATGAGAAAAGGGTG TCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAAAATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAG ATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATACAGACAGATGTCCATCATCTCTCTGGCTTCCATG AATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATTAGCATCACCCAAGACGCCGAGAGTGGAGCAGGAG GAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAAGAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGAT GAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCATGAGTGACACCAACCTCTCGGAGCATGCGGCCATC CCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTACCATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATC CCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACTCTCAGATGGTGACAAGAAGACACTCACACGGAAG AAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAAACAGATCCCAGACTCGCTGTCCACGGACCTGTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RCAN2_ENST00000306764_chr6_46214485_-_DOCK2_ENST00000256935_chr5_169267761_+_3990nt CCAGAGGGCGCCAGCGCCCACCAAGCGCAGAAGCCCGGGAGGACCATCCAGGGGCTCCCCGACATTTCCTCAGTTAGCCAGAGTCGGGGG GCTCAGACATCTGGAATGAGGGGAGAATCATACTTCATCGGAATGAGGAGCCCAGGGCAGCAGGGACACGTCCCTGAAGATGGAGGACTT TTCTTACTGTGCTGCATAGACAGGGACTGGGCTGTCACTCGTTGTTTTGCAGAAGAAGCCTTTCAAGCAATCACTGACTTCAATGACCTC CCCAACTCGTTGTTTGCGTGCAATGTTCACCAGTCAGTGTTTGAAGGAGAAGAGAGCAAGGAAAAATTTGAGGGACTGTTTCGGACTTAT GATGACTGTGTGACGTTCCAGCTATTTAAGAGTTTCAGACGTGTCCGTATAAACTTCAGCAATCCTAAATCTGCAGCCCGAGCTAGGATA GAGCTTCATGAAACCCAATTCAGAGGGAAAAAATTAAAGCTCTACTTTGCACAGGTTCAGACTCCAGAGACAGATGGAGACAAACTGCAC TTGGCTCCACCCCAGCCTGCCAAACAGTTTCTCATCTCGCCCCCTTCCTCCCCACCTGTTGGCTGGCAGCCCATCAACGATGCCACGCCA GTCCTCAACTATGACCTCCTCTATGCTGTGGCCAAACTAGGACCAGGCCTTCACCTACCACCATATCCAGGAGATCATGGTCCAGCTGCT GCGGACAGTGAACCGGACAGTCATCACCATGGGCCGGGATCACATTCTGATTAGTCACTTTGTGGCATGTATGACAGCCATCTTAAACCA GATGGGTGACCAGCACTACTCCTTCTACATTGAGACCTTCCAGACCAGCTCTGAACTTGTGGACTTCTTGATGGAGACCTTCATCATGTT CAAGGACCTCATTGGAAAGAACGTGTACCCTGGAGACTGGATGGCCATGAGCATGGTTCAAAACAGGGTCTTCCTGAGAGCTATCAACAA GTTTGCAGAAACCATGAACCAGAAGTTCCTAGAACACACGAACTTTGAGTTCCAGCTGTGGAACAACTATTTTCATCTGGCAGTGGCTTT TATCACCCAGGATTCTCTGCAGCTGGAGCAGTTCTCACACGCCAAATACAACAAAATCCTGAATAAGTATGGGGACATGAGACGGCTAAT TGGCTTCTCCATCCGTGATATGTGGTACAAGCTTGGTCAGAACAAAATCTGCTTCATCCCAGGCATGGTAGGACCTATATTAGAGATGAC ACTTATCCCTGAGGCTGAGCTCCGGAAAGCCACCATACCAATCTTCTTCGACATGATGCTGTGTGAATATCAAAGAAGTGGGGATTTCAA AAAGTTTGAAAACGAAATCATCCTGAAGCTGGACCACGAGGTAGAAGGGGGCCGAGGCGACGAGCAGTACATGCAGCTCCTGGAGTCAAT CCTGATGGAATGTGCTGCAGAGCACCCAACCATTGCCAAGTCGGTGGAGAACTTCGTGAACCTGGTCAAAGGCCTCCTGGAGAAGCTGCT GGATTACCGGGGTGTGATGACAGATGAGAGCAAAGACAACCGCATGAGCTGCACCGTGAACCTGCTGAATTTCTACAAAGATAACAACAG GGAGGAGATGTACATAAGGTACCTGTACAAACTCCGCGATCTTCACCTGGACTGTGACAATTACACAGAGGCTGCCTACACGCTCCTTCT CCACACCTGGCTTCTCAAGTGGTCGGATGAGCAGTGTGCATCACAGGTCATGCAGACAGGCCAGCAGCACCCCCAGACACACCGGCAGCT GAAGGAGACGCTCTACGAGACCATCATAGGCTACTTTGACAAAGGAAAGATGTGGGAAGAGGCCATAAGTCTGTGCAAGGAGCTGGCGGA ACAGTACGAGATGGAGATCTTTGACTATGAGCTGCTCAGCCAGAACCTGATCCAGCAGGCAAAATTCTATGAAAGCATCATGAAAATCCT CAGGCCCAAACCAGACTACTTTGCTGTTGGATACTACGGCCAGGGATTCCCCTCCTTCCTGCGGAACAAAGTGTTCATCTACCGCGGGAA GGAATATGAGCGAAGAGAAGATTTCCAGATGCAGCTGATGACCCAGTTCCCCAATGCAGAGAAGATGAACACCACCTCTGCCCCGGGAGA TGATGTGAAGAATGCCCCAGGCCAGTATATCCAGTGCTTCACTGTCCAGCCTGTCTTGGATGAACATCCCAGGTTCAAGAATAAGCCAGT GCCTGACCAGATTATAAACTTCTACAAATCCAACTACGTGCAAAGGTTCCACTACTCCCGGCCCGTGCGCAGGGGGACCGTAGACCCAGA GAATGAGTTTGCTTCCATGTGGATTGAGAGAACCTCCTTCGTGACTGCATACAAGCTGCCGGGGATCCTGCGCTGGTTTGAGGTGGTGCA CATGTCGCAGACCACAATTAGTCCTCTGGAGAATGCCATAGAAACCATGTCCACGGCCAATGAGAAGATCCTGATGATGATAAACCAGTA CCAGAGTGATGAGACCCTCCCCATCAACCCACTCTCCATGCTCCTGAACGGGATTGTGGACCCTGCTGTCATGGGAGGCTTCGCCAAGTA TGAGAAGGCCTTCTTCACTGAAGAGTATGTCAGGGACCACCCTGAGGACCAGGACAAGCTGACCCACCTCAAGGACCTGATTGCATGGCA GATCCCCTTCTTGGGAGCTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTT CAAGAACCTGAAAATGAAGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTAT GCTGCGCTCATACAGACAGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTT TGACCTGGAATTAGCATCACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCG GAGGTCCAAGAAGAGGACAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAA GCATGAGTTCATGAGTGACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCA GTCCATGCCTACCATCCCAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGAC CTTCCTCCAACTCTCAGATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGC TGAAGAAGGCAAACAGATCCCAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGT TTCTGGAAGAGGAAAGCCATGCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGA GAGGCCAATCAGGTCCCAGAGCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGA TTCCTGAACTCAAGGTACCAGCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAG GTGTAAGAAACTGTTTTTATCTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAG ATTAACAGTTTTGTACTTTACATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGA |
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FusionGenePPI for RCAN2_DOCK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RCAN2 | PPP3CA, TCEB1, PPP3CB, PPP3CC, GSTZ1, PPP3R1, ZG16B, AMY1C, SERPINA12, MUC7, SPRR3, GSK3B, GSK3A, CRNN, CST4, CST2, C6orf211, CST1, HSBP1, GNB3, IGHA1, TFG | DOCK2 | RAC1, RAC2, PAK2, CD247, CRKL, VAV1, TERF1, KHDRBS1, TRIM23, HNRNPK, KRTAP5-9, MDFI, PLSCR1, CALCOCO2, MTUS2, CCNDBP1, KRTAP9-2, KRTAP9-4, KRTAP4-2, KRT40, KHDRBS2, KRTAP10-9, KRTAP10-1, KRTAP10-8, KRTAP10-3, NOTCH2NL, MCM2, SNW1, ELMO1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RCAN2_DOCK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RCAN2_DOCK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DOCK2 | C0279628 | Adenocarcinoma Of Esophagus | 1 | CTD_human |
| Tgene | DOCK2 | C4225328 | IMMUNODEFICIENCY 40 | 1 | ORPHANET;UNIPROT |
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