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Fusion gene ID: 30849 |
FusionGeneSummary for RCAN1_CD180 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RCAN1_CD180 | Fusion gene ID: 30849 | Hgene | Tgene | Gene symbol | RCAN1 | CD180 | Gene ID | 1827 | 4064 |
| Gene name | regulator of calcineurin 1 | CD180 molecule | |
| Synonyms | ADAPT78|CSP1|DSC1|DSCR1|MCIP1|RCN1 | LY64|Ly78|RP105 | |
| Cytomap | 21q22.12 | 5q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcipressin-1Down syndrome candidate region 1Down syndrome critical region gene 1calcium and oxidant-inducible mRNAmodulatory calcineurin-interacting protein 1myocyte-enriched calcineurin-interacting protein 1near DSCR proline-rich protein | CD180 antigenlymphocyte antigen 64lymphocyte antigen-64, radioprotective, 105kDaradioprotective 105 kDa protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P53805 | Q99467 | |
| Ensembl transtripts involved in fusion gene | ENST00000487990, ENST00000399272, ENST00000489903, ENST00000313806, ENST00000443408, ENST00000482533, ENST00000481448, ENST00000381132, ENST00000381135, ENST00000492600, | ENST00000256447, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/64*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RCAN1 [Title/Abstract] AND CD180 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-0158-01A | RCAN1 | chr21 | 35893797 | - | CD180 | chr5 | 66481845 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000487990 | ENST00000256447 | RCAN1 | chr21 | 35893797 | - | CD180 | chr5 | 66481845 | - |
| Frame-shift | ENST00000399272 | ENST00000256447 | RCAN1 | chr21 | 35893797 | - | CD180 | chr5 | 66481845 | - |
| 5UTR-3CDS | ENST00000489903 | ENST00000256447 | RCAN1 | chr21 | 35893797 | - | CD180 | chr5 | 66481845 | - |
| Frame-shift | ENST00000313806 | ENST00000256447 | RCAN1 | chr21 | 35893797 | - | CD180 | chr5 | 66481845 | - |
| In-frame | ENST00000443408 | ENST00000256447 | RCAN1 | chr21 | 35893797 | - | CD180 | chr5 | 66481845 | - |
| Frame-shift | ENST00000482533 | ENST00000256447 | RCAN1 | chr21 | 35893797 | - | CD180 | chr5 | 66481845 | - |
| In-frame | ENST00000481448 | ENST00000256447 | RCAN1 | chr21 | 35893797 | - | CD180 | chr5 | 66481845 | - |
| Frame-shift | ENST00000381132 | ENST00000256447 | RCAN1 | chr21 | 35893797 | - | CD180 | chr5 | 66481845 | - |
| Frame-shift | ENST00000381135 | ENST00000256447 | RCAN1 | chr21 | 35893797 | - | CD180 | chr5 | 66481845 | - |
| intron-3CDS | ENST00000492600 | ENST00000256447 | RCAN1 | chr21 | 35893797 | - | CD180 | chr5 | 66481845 | - |
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FusionProtFeatures for RCAN1_CD180 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RCAN1 | CD180 |
| May cooperate with MD-1 and TLR4 to mediate the innateimmune response to bacterial lipopolysaccharide (LPS) in B-cells.Leads to NF-kappa-B activation. Also involved in the life/deathdecision of B-cells (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RCAN1_CD180 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RCAN1_ENST00000443408_chr21_35893797_-_CD180_ENST00000256447_chr5_66481845_-_632aa KEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETS LNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNN VKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQL QELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSL QLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNH FQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQS TINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQH >In-frame_RCAN1_ENST00000481448_chr21_35893797_-_CD180_ENST00000256447_chr5_66481845_-_632aa KEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETS LNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNN VKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQL QELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSL QLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNH FQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQS TINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RCAN1_ENST00000443408_chr21_35893797_-_CD180_ENST00000256447_chr5_66481845_-_1896nt AAAGAAGCCAACAAAACATATAACTGTGAAAATTTAGGTCTCAGTGAAATCCCTGACACTCTACCAAACACAACAGAATTTTTGGAATTC AGCTTTAATTTTTTGCCTACAATTCACAATAGAACCTTCAGCAGACTCATGAATCTTACCTTTTTGGATTTAACTAGGTGCCAGATTAAC TGGATACATGAAGACACTTTTCAAAGCCATCATCAATTAAGCACACTTGTGTTAACTGGAAATCCCCTGATATTCATGGCAGAAACATCG CTTAATGGGCCCAAGTCACTGAAGCATCTTTTCTTAATCCAAACGGGAATATCCAATCTCGAGTTTATTCCAGTGCACAATCTGGAAAAC TTGGAAAGCTTGTATCTTGGAAGCAACCATATTTCCTCCATTAAGTTCCCCAAAGACTTCCCAGCACGGAATCTGAAAGTACTGGATTTT CAGAATAATGCTATACACTACATCTCTAGAGAAGACATGAGGTCTCTGGAGCAGGCCATCAACCTAAGCCTGAACTTCAATGGCAATAAT GTTAAAGGTATTGAGCTTGGGGCTTTTGATTCAACGATCTTCCAAAGTTTGAACTTTGGAGGAACTCCAAATTTGTCTGTTATATTCAAT GGTCTGCAGAACTCTACTACTCAGTCTCTCTGGCTGGGAACATTTGAGGACATTGATGACGAAGATATTAGTTCAGCCATGCTCAAGGGA CTCTGTGAAATGTCTGTTGAGAGCCTCAACCTGCAGGAACACCGCTTCTCTGACATCTCATCCACCACATTTCAGTGCTTCACCCAACTC CAAGAATTGGATCTGACAGCAACTCACTTGAAAGGGTTACCCTCTGGGATGAAGGGTCTGAACTTGCTCAAGAAATTAGTTCTCAGTGTA AATCATTTCGATCAATTGTGTCAAATCAGTGCTGCCAATTTCCCCTCCCTTACACACCTCTACATCAGAGGCAACGTGAAGAAACTTCAC CTTGGTGTTGGCTGCTTGGAGAAACTAGGAAACCTTCAGACACTTGATTTAAGCCATAATGACATAGAGGCTTCTGACTGCTGCAGTCTG CAACTCAAAAACCTGTCCCACTTGCAAACCTTAAACCTGAGCCACAATGAGCCTCTTGGTCTCCAGAGTCAGGCATTCAAAGAATGTCCT CAGCTAGAACTCCTCGATTTGGCATTTACCCGCTTACACATTAATGCTCCACAAAGTCCCTTCCAAAACCTCCATTTCCTTCAGGTTCTG AATCTCACTTACTGCTTCCTTGATACCAGCAATCAGCATCTTCTAGCAGGCCTACCAGTTCTCCGGCATCTCAACTTAAAAGGGAATCAC TTTCAAGATGGGACTATCACGAAGACCAACCTACTTCAGACCGTGGGCAGCTTGGAGGTTCTGATTTTGTCCTCTTGTGGTCTCCTCTCT ATAGACCAGCAAGCATTCCACAGCTTGGGAAAAATGAGCCATGTAGACTTAAGCCACAACAGCCTGACATGCGACAGCATTGATTCTCTT AGCCATCTTAAGGGAATCTACCTCAATCTGGCTGCCAACAGCATTAACATCATCTCACCCCGTCTCCTCCCTATCTTGTCCCAGCAGAGC ACCATTAATTTAAGTCATAACCCCCTGGACTGCACTTGCTCGAATATTCATTTCTTAACATGGTACAAAGAAAACCTGCACAAACTTGAA GGCTCGGAGGAGACCACGTGTGCAAACCCGCCATCTCTAAGGGGAGTTAAGCTATCTGATGTCAAGCTTTCCTGTGGGATTACAGCCATA GGCATTTTCTTTCTCATAGTATTTCTATTATTGTTGGCTATTCTGCTATTTTTTGCAGTTAAATACCTTCTCAGGTGGAAATACCAACAC >In-frame_RCAN1_ENST00000481448_chr21_35893797_-_CD180_ENST00000256447_chr5_66481845_-_1896nt AAAGAAGCCAACAAAACATATAACTGTGAAAATTTAGGTCTCAGTGAAATCCCTGACACTCTACCAAACACAACAGAATTTTTGGAATTC AGCTTTAATTTTTTGCCTACAATTCACAATAGAACCTTCAGCAGACTCATGAATCTTACCTTTTTGGATTTAACTAGGTGCCAGATTAAC TGGATACATGAAGACACTTTTCAAAGCCATCATCAATTAAGCACACTTGTGTTAACTGGAAATCCCCTGATATTCATGGCAGAAACATCG CTTAATGGGCCCAAGTCACTGAAGCATCTTTTCTTAATCCAAACGGGAATATCCAATCTCGAGTTTATTCCAGTGCACAATCTGGAAAAC TTGGAAAGCTTGTATCTTGGAAGCAACCATATTTCCTCCATTAAGTTCCCCAAAGACTTCCCAGCACGGAATCTGAAAGTACTGGATTTT CAGAATAATGCTATACACTACATCTCTAGAGAAGACATGAGGTCTCTGGAGCAGGCCATCAACCTAAGCCTGAACTTCAATGGCAATAAT GTTAAAGGTATTGAGCTTGGGGCTTTTGATTCAACGATCTTCCAAAGTTTGAACTTTGGAGGAACTCCAAATTTGTCTGTTATATTCAAT GGTCTGCAGAACTCTACTACTCAGTCTCTCTGGCTGGGAACATTTGAGGACATTGATGACGAAGATATTAGTTCAGCCATGCTCAAGGGA CTCTGTGAAATGTCTGTTGAGAGCCTCAACCTGCAGGAACACCGCTTCTCTGACATCTCATCCACCACATTTCAGTGCTTCACCCAACTC CAAGAATTGGATCTGACAGCAACTCACTTGAAAGGGTTACCCTCTGGGATGAAGGGTCTGAACTTGCTCAAGAAATTAGTTCTCAGTGTA AATCATTTCGATCAATTGTGTCAAATCAGTGCTGCCAATTTCCCCTCCCTTACACACCTCTACATCAGAGGCAACGTGAAGAAACTTCAC CTTGGTGTTGGCTGCTTGGAGAAACTAGGAAACCTTCAGACACTTGATTTAAGCCATAATGACATAGAGGCTTCTGACTGCTGCAGTCTG CAACTCAAAAACCTGTCCCACTTGCAAACCTTAAACCTGAGCCACAATGAGCCTCTTGGTCTCCAGAGTCAGGCATTCAAAGAATGTCCT CAGCTAGAACTCCTCGATTTGGCATTTACCCGCTTACACATTAATGCTCCACAAAGTCCCTTCCAAAACCTCCATTTCCTTCAGGTTCTG AATCTCACTTACTGCTTCCTTGATACCAGCAATCAGCATCTTCTAGCAGGCCTACCAGTTCTCCGGCATCTCAACTTAAAAGGGAATCAC TTTCAAGATGGGACTATCACGAAGACCAACCTACTTCAGACCGTGGGCAGCTTGGAGGTTCTGATTTTGTCCTCTTGTGGTCTCCTCTCT ATAGACCAGCAAGCATTCCACAGCTTGGGAAAAATGAGCCATGTAGACTTAAGCCACAACAGCCTGACATGCGACAGCATTGATTCTCTT AGCCATCTTAAGGGAATCTACCTCAATCTGGCTGCCAACAGCATTAACATCATCTCACCCCGTCTCCTCCCTATCTTGTCCCAGCAGAGC ACCATTAATTTAAGTCATAACCCCCTGGACTGCACTTGCTCGAATATTCATTTCTTAACATGGTACAAAGAAAACCTGCACAAACTTGAA GGCTCGGAGGAGACCACGTGTGCAAACCCGCCATCTCTAAGGGGAGTTAAGCTATCTGATGTCAAGCTTTCCTGTGGGATTACAGCCATA GGCATTTTCTTTCTCATAGTATTTCTATTATTGTTGGCTATTCTGCTATTTTTTGCAGTTAAATACCTTCTCAGGTGGAAATACCAACAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RCAN1_ENST00000443408_chr21_35893797_-_CD180_ENST00000256447_chr5_66481845_-_2981nt CCCCCTGCGCTCTCGCCATCGCCCCGCATTTACTCGCTGGAGGAGGGGGTCACCTCATTCCTAGGGAGGAGGAAACAGACATTGAGCGGC GACGTGACTCAGTGTTCATAAATAGGACGACGTCCCTGCATTCCCAATCTGCACTATTGGAAGAAAAGCCAATGTTTGGGCCAAATTTGA GTCCCTCTTTAGGACGTATGACAAGGACATCACCTTTCAGTATTTTAAGAGCTTCAAACGAGTCAGAATAAACTTCAGCAACCCCTTCTC CGCAGCAGATGCCAGGCTCCAGCTGCATAAGACTGAGTTTCTGGGAAAGGAAATGAAGTTATATTTTGCTCAGACCTTACACATAGGAAG CTCACACCTGGCTCCGCCAAATCCAGACAAGCAGTTTCTGATCTCCCCTCCCGCCTCTCCGCCAGTGGGATGGAAACAAGTGGAAGATGC GACCCCAGTCATAAACTATGATCTCTTATATGCCATCTCCAAGCTGGGGCCAGAAAGAAGCCAACAAAACATATAACTGTGAAAATTTAG GTCTCAGTGAAATCCCTGACACTCTACCAAACACAACAGAATTTTTGGAATTCAGCTTTAATTTTTTGCCTACAATTCACAATAGAACCT TCAGCAGACTCATGAATCTTACCTTTTTGGATTTAACTAGGTGCCAGATTAACTGGATACATGAAGACACTTTTCAAAGCCATCATCAAT TAAGCACACTTGTGTTAACTGGAAATCCCCTGATATTCATGGCAGAAACATCGCTTAATGGGCCCAAGTCACTGAAGCATCTTTTCTTAA TCCAAACGGGAATATCCAATCTCGAGTTTATTCCAGTGCACAATCTGGAAAACTTGGAAAGCTTGTATCTTGGAAGCAACCATATTTCCT CCATTAAGTTCCCCAAAGACTTCCCAGCACGGAATCTGAAAGTACTGGATTTTCAGAATAATGCTATACACTACATCTCTAGAGAAGACA TGAGGTCTCTGGAGCAGGCCATCAACCTAAGCCTGAACTTCAATGGCAATAATGTTAAAGGTATTGAGCTTGGGGCTTTTGATTCAACGA TCTTCCAAAGTTTGAACTTTGGAGGAACTCCAAATTTGTCTGTTATATTCAATGGTCTGCAGAACTCTACTACTCAGTCTCTCTGGCTGG GAACATTTGAGGACATTGATGACGAAGATATTAGTTCAGCCATGCTCAAGGGACTCTGTGAAATGTCTGTTGAGAGCCTCAACCTGCAGG AACACCGCTTCTCTGACATCTCATCCACCACATTTCAGTGCTTCACCCAACTCCAAGAATTGGATCTGACAGCAACTCACTTGAAAGGGT TACCCTCTGGGATGAAGGGTCTGAACTTGCTCAAGAAATTAGTTCTCAGTGTAAATCATTTCGATCAATTGTGTCAAATCAGTGCTGCCA ATTTCCCCTCCCTTACACACCTCTACATCAGAGGCAACGTGAAGAAACTTCACCTTGGTGTTGGCTGCTTGGAGAAACTAGGAAACCTTC AGACACTTGATTTAAGCCATAATGACATAGAGGCTTCTGACTGCTGCAGTCTGCAACTCAAAAACCTGTCCCACTTGCAAACCTTAAACC TGAGCCACAATGAGCCTCTTGGTCTCCAGAGTCAGGCATTCAAAGAATGTCCTCAGCTAGAACTCCTCGATTTGGCATTTACCCGCTTAC ACATTAATGCTCCACAAAGTCCCTTCCAAAACCTCCATTTCCTTCAGGTTCTGAATCTCACTTACTGCTTCCTTGATACCAGCAATCAGC ATCTTCTAGCAGGCCTACCAGTTCTCCGGCATCTCAACTTAAAAGGGAATCACTTTCAAGATGGGACTATCACGAAGACCAACCTACTTC AGACCGTGGGCAGCTTGGAGGTTCTGATTTTGTCCTCTTGTGGTCTCCTCTCTATAGACCAGCAAGCATTCCACAGCTTGGGAAAAATGA GCCATGTAGACTTAAGCCACAACAGCCTGACATGCGACAGCATTGATTCTCTTAGCCATCTTAAGGGAATCTACCTCAATCTGGCTGCCA ACAGCATTAACATCATCTCACCCCGTCTCCTCCCTATCTTGTCCCAGCAGAGCACCATTAATTTAAGTCATAACCCCCTGGACTGCACTT GCTCGAATATTCATTTCTTAACATGGTACAAAGAAAACCTGCACAAACTTGAAGGCTCGGAGGAGACCACGTGTGCAAACCCGCCATCTC TAAGGGGAGTTAAGCTATCTGATGTCAAGCTTTCCTGTGGGATTACAGCCATAGGCATTTTCTTTCTCATAGTATTTCTATTATTGTTGG CTATTCTGCTATTTTTTGCAGTTAAATACCTTCTCAGGTGGAAATACCAACACATTTAGTGCTGAAGGTTTCCAGAGAAAGCAAATAAGT GTGCTTAGCAAAATTGCTCTAAGTGAAAGAACTGTCATCTGCTGGTGACCAGACCAGACTTTTCAGATTGCTTCCTGGAACTGGGCAGGG ACTCACTGTGCTTTTCTGAGCTTCTTACTCCTGTGAGTCCCAGAGCTAAAGAACCTTCTAGGCAAGTACACCGAATGACTCAGTCCAGAG GGTCAGATGCTGCTGTGAGAGGCACAGAGCCCTTTCCGCATGTGGAAGAGTGGGAGGAAGCAGAGGGAGGGACTGGGCAGGGACTGCCGG CCCCGGAGTCTCCCACAGGGAGGCCATTCCCCTTCTACTCACCGACATCCCTCCCAGCACCACACACCCCGCCCCTGAAAGGAGATCATC AGCCCCCACAATTTGTCAGAGCTGAAGCCAGCCCACTACCCACCCCCACTACAGCATTGTGCTTGGGTCTGGGTTCTCAGTAATGTAGCC ATTTGAGAAACTTACTTGGGGACAAAGTCTCAATCCTTATTTTAAATGAAAAAAGAAAAGAAAAGCATAATAAATTTAAAAGAAAAGGCT >In-frame_RCAN1_ENST00000481448_chr21_35893797_-_CD180_ENST00000256447_chr5_66481845_-_3521nt ATAAGCACCAGCTCAAGAAGGAACCTACAGCCTCTTGGAAAGGAATCTCACTAGGGGCTTGACTGCGTGGGTCTGTAGCGCTTTCACTGT AAGAAAGCAAGATGCATTTTAGAAACTTTAACTACAGTTTTAGCTCCCTGATTGCCTGTGTGGCAAACAGTGATATCTTCAGCGAAAGTG AAACCAGGCCCTGAACCTGTATTCTAAAAATATTCTTCAAAGTCATCTCTCCCAAATTCTGAATCATAACTTCAAAACTAAACAGTGGGT CACAGTGCCTATTGATGAGGTCATACAAAATTCCAAATGTACGAAGACACACTTTTGCCAGAAACTTGCCCGTGCTCAAGAGAGGTGGGG AAAAAGAGTGAGAGGCGGCCAGATGAACTCTACCGTCCGCCAGCTCCGCGTTCCTTCGCACGTGCCTCTGCGGGATCCCTCGTGGGAAAG TCTCAGAAATGTCCCTAAACTGAAGAAAAGCCGGGGAATGCAAGGAGAGCAAGGTCGTAGGTTGTTCCGACTGCTCCTTAACGACCTGCC TGGCAGGGACCGACTACCCTGCTCCTACCCGCAGCCCCATGTGGAGCAGGCATCCACCAGTGCCTCCCCGCGCTTGCTAGCAGTGAACAT TCCTGAAGACACTCTCCTCTCTTATCCTGAATCCTCGCTCCCACTGCAGAGACACTGCGCCTTCCATAGGTTCTCCAAGGCCAAATTTGA GTCCCTCTTTAGGACGTATGACAAGGACATCACCTTTCAGTATTTTAAGAGCTTCAAACGAGTCAGAATAAACTTCAGCAACCCCTTCTC CGCAGCAGATGCCAGGCTCCAGCTGCATAAGACTGAGTTTCTGGGAAAGGAAATGAAGTTATATTTTGCTCAGACCTTACACATAGGAAG CTCACACCTGGCTCCGCCAAATCCAGACAAGCAGTTTCTGATCTCCCCTCCCGCCTCTCCGCCAGTGGGATGGAAACAAGTGGAAGATGC GACCCCAGTCATAAACTATGATCTCTTATATGCCATCTCCAAGCTGGGGCCAGAAAGAAGCCAACAAAACATATAACTGTGAAAATTTAG GTCTCAGTGAAATCCCTGACACTCTACCAAACACAACAGAATTTTTGGAATTCAGCTTTAATTTTTTGCCTACAATTCACAATAGAACCT TCAGCAGACTCATGAATCTTACCTTTTTGGATTTAACTAGGTGCCAGATTAACTGGATACATGAAGACACTTTTCAAAGCCATCATCAAT TAAGCACACTTGTGTTAACTGGAAATCCCCTGATATTCATGGCAGAAACATCGCTTAATGGGCCCAAGTCACTGAAGCATCTTTTCTTAA TCCAAACGGGAATATCCAATCTCGAGTTTATTCCAGTGCACAATCTGGAAAACTTGGAAAGCTTGTATCTTGGAAGCAACCATATTTCCT CCATTAAGTTCCCCAAAGACTTCCCAGCACGGAATCTGAAAGTACTGGATTTTCAGAATAATGCTATACACTACATCTCTAGAGAAGACA TGAGGTCTCTGGAGCAGGCCATCAACCTAAGCCTGAACTTCAATGGCAATAATGTTAAAGGTATTGAGCTTGGGGCTTTTGATTCAACGA TCTTCCAAAGTTTGAACTTTGGAGGAACTCCAAATTTGTCTGTTATATTCAATGGTCTGCAGAACTCTACTACTCAGTCTCTCTGGCTGG GAACATTTGAGGACATTGATGACGAAGATATTAGTTCAGCCATGCTCAAGGGACTCTGTGAAATGTCTGTTGAGAGCCTCAACCTGCAGG AACACCGCTTCTCTGACATCTCATCCACCACATTTCAGTGCTTCACCCAACTCCAAGAATTGGATCTGACAGCAACTCACTTGAAAGGGT TACCCTCTGGGATGAAGGGTCTGAACTTGCTCAAGAAATTAGTTCTCAGTGTAAATCATTTCGATCAATTGTGTCAAATCAGTGCTGCCA ATTTCCCCTCCCTTACACACCTCTACATCAGAGGCAACGTGAAGAAACTTCACCTTGGTGTTGGCTGCTTGGAGAAACTAGGAAACCTTC AGACACTTGATTTAAGCCATAATGACATAGAGGCTTCTGACTGCTGCAGTCTGCAACTCAAAAACCTGTCCCACTTGCAAACCTTAAACC TGAGCCACAATGAGCCTCTTGGTCTCCAGAGTCAGGCATTCAAAGAATGTCCTCAGCTAGAACTCCTCGATTTGGCATTTACCCGCTTAC ACATTAATGCTCCACAAAGTCCCTTCCAAAACCTCCATTTCCTTCAGGTTCTGAATCTCACTTACTGCTTCCTTGATACCAGCAATCAGC ATCTTCTAGCAGGCCTACCAGTTCTCCGGCATCTCAACTTAAAAGGGAATCACTTTCAAGATGGGACTATCACGAAGACCAACCTACTTC AGACCGTGGGCAGCTTGGAGGTTCTGATTTTGTCCTCTTGTGGTCTCCTCTCTATAGACCAGCAAGCATTCCACAGCTTGGGAAAAATGA GCCATGTAGACTTAAGCCACAACAGCCTGACATGCGACAGCATTGATTCTCTTAGCCATCTTAAGGGAATCTACCTCAATCTGGCTGCCA ACAGCATTAACATCATCTCACCCCGTCTCCTCCCTATCTTGTCCCAGCAGAGCACCATTAATTTAAGTCATAACCCCCTGGACTGCACTT GCTCGAATATTCATTTCTTAACATGGTACAAAGAAAACCTGCACAAACTTGAAGGCTCGGAGGAGACCACGTGTGCAAACCCGCCATCTC TAAGGGGAGTTAAGCTATCTGATGTCAAGCTTTCCTGTGGGATTACAGCCATAGGCATTTTCTTTCTCATAGTATTTCTATTATTGTTGG CTATTCTGCTATTTTTTGCAGTTAAATACCTTCTCAGGTGGAAATACCAACACATTTAGTGCTGAAGGTTTCCAGAGAAAGCAAATAAGT GTGCTTAGCAAAATTGCTCTAAGTGAAAGAACTGTCATCTGCTGGTGACCAGACCAGACTTTTCAGATTGCTTCCTGGAACTGGGCAGGG ACTCACTGTGCTTTTCTGAGCTTCTTACTCCTGTGAGTCCCAGAGCTAAAGAACCTTCTAGGCAAGTACACCGAATGACTCAGTCCAGAG GGTCAGATGCTGCTGTGAGAGGCACAGAGCCCTTTCCGCATGTGGAAGAGTGGGAGGAAGCAGAGGGAGGGACTGGGCAGGGACTGCCGG CCCCGGAGTCTCCCACAGGGAGGCCATTCCCCTTCTACTCACCGACATCCCTCCCAGCACCACACACCCCGCCCCTGAAAGGAGATCATC AGCCCCCACAATTTGTCAGAGCTGAAGCCAGCCCACTACCCACCCCCACTACAGCATTGTGCTTGGGTCTGGGTTCTCAGTAATGTAGCC ATTTGAGAAACTTACTTGGGGACAAAGTCTCAATCCTTATTTTAAATGAAAAAAGAAAAGAAAAGCATAATAAATTTAAAAGAAAAGGCT |
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FusionGenePPI for RCAN1_CD180 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RCAN1 | PPP3CA, STAT2, TOLLIP, IRAK1, TRAF6, HSP90AA1, BTRC, FBXW4, FBXW11, APP, FAM122A, PPP3CC, USP22, PPP3CB, GSK3A, PPP3R1, C6orf211, SRBD1, CST2, CST5, AMY1C, GSK3B, ZG16B, IGHA1, CLEC3A, TRIM25 | CD180 | LY86 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RCAN1_CD180 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | RCAN1 | P53805 | DB00975 | Dipyridamole | Calcipressin-1 | small molecule | approved |
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RelatedDiseases for RCAN1_CD180 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RCAN1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Hgene | RCAN1 | C0013080 | Down Syndrome | 1 | CTD_human |
| Hgene | RCAN1 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
| Hgene | RCAN1 | C0020179 | Huntington Disease | 1 | CTD_human |
| Hgene | RCAN1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
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