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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30822

FusionGeneSummary for RBP4_GPC3

check button Fusion gene summary
Fusion gene informationFusion gene name: RBP4_GPC3
Fusion gene ID: 30822
HgeneTgene
Gene symbol

RBP4

GPC3

Gene ID

5950

2719

Gene nameretinol binding protein 4glypican 3
SynonymsMCOPCB10|RDCCASDGSX|GTR2-2|MXR7|OCI-5|SDYS|SGB|SGBS|SGBS1
Cytomap

10q23.33

Xq26.2

Type of geneprotein-codingprotein-coding
Descriptionretinol-binding protein 4PRBPRBPplasma retinol-binding proteinretinol binding protein 4, plasmaretinol-binding protein 4, interstitialglypican-3glypican proteoglycan 3heparan sulphate proteoglycanintestinal protein OCI-5secreted glypican-3
Modification date2018052720180527
UniProtAcc

P02753

P51654

Ensembl transtripts involved in fusion geneENST00000371464, ENST00000371467, 
ENST00000371469, 
ENST00000370818, 
ENST00000394299, ENST00000543339, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 6 X 4=168
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBP4 [Title/Abstract] AND GPC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBP4

GO:0030277

maintenance of gastrointestinal epithelium

10944490

HgeneRBP4

GO:0032526

response to retinoic acid

571335

HgeneRBP4

GO:0042593

glucose homeostasis

17003346


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-BW-A5NO-01ARBP4chr10

95360150

-GPC3chrX

132670321

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000371464ENST00000370818RBP4chr10

95360150

-GPC3chrX

132670321

-
Frame-shiftENST00000371464ENST00000394299RBP4chr10

95360150

-GPC3chrX

132670321

-
In-frameENST00000371464ENST00000543339RBP4chr10

95360150

-GPC3chrX

132670321

-
In-frameENST00000371467ENST00000370818RBP4chr10

95360150

-GPC3chrX

132670321

-
In-frameENST00000371467ENST00000394299RBP4chr10

95360150

-GPC3chrX

132670321

-
Frame-shiftENST00000371467ENST00000543339RBP4chr10

95360150

-GPC3chrX

132670321

-
In-frameENST00000371469ENST00000370818RBP4chr10

95360150

-GPC3chrX

132670321

-
In-frameENST00000371469ENST00000394299RBP4chr10

95360150

-GPC3chrX

132670321

-
Frame-shiftENST00000371469ENST00000543339RBP4chr10

95360150

-GPC3chrX

132670321

-

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FusionProtFeatures for RBP4_GPC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBP4

P02753

GPC3

P51654

Retinol-binding protein that mediates retinol transportin blood plasma (PubMed:5541771). Delivers retinol from the liverstores to the peripheral tissues (Probable). Transfers the boundall-trans retinol to STRA6, that then facilitates retinoltransport across the cell membrane (PubMed:22665496).{ECO:0000269|PubMed:22665496, ECO:0000305,ECO:0000305|PubMed:5541771}. Cell surface proteoglycan that bears heparan sulfate.Inhibits the dipeptidyl peptidase activity of DPP4. May beinvolved in the suppression/modulation of growth in thepredominantly mesodermal tissues and organs. May play a role inthe modulation of IGF2 interactions with its receptor and therebymodulate its function. May regulate growth and tumorpredisposition. {ECO:0000269|PubMed:17549790}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBP4_GPC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RBP4_ENST00000371464_chr10_95360150_-_GPC3_ENST00000543339_chrX_132670321_-_175aa
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCAD

>In-frame_RBP4_ENST00000371467_chr10_95360150_-_GPC3_ENST00000370818_chrX_132670321_-_175aa
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCAD

>In-frame_RBP4_ENST00000371467_chr10_95360150_-_GPC3_ENST00000394299_chrX_132670321_-_175aa
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCAD

>In-frame_RBP4_ENST00000371469_chr10_95360150_-_GPC3_ENST00000370818_chrX_132670321_-_173aa
MNYSKIPAQVDLRRQTERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMV

>In-frame_RBP4_ENST00000371469_chr10_95360150_-_GPC3_ENST00000394299_chrX_132670321_-_173aa
MNYSKIPAQVDLRRQTERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RBP4_ENST00000371464_chr10_95360150_-_GPC3_ENST00000543339_chrX_132670321_-_525nt
ATGAAGTGGGTGTGGGCGCTCTTGCTGTTGGCGGCGCTGGGCAGCGGCCGCGCGGAGCGCGACTGCCGAGTGAGCAGCTTCCGAGTCAAG
GAGAACTTCGACAAGGCTCGCTTCTCTGGGACCTGGTACGCCATGGCCAAGAAGGACCCCGAGGGCCTCTTTCTGCAGGACAACATCGTC
GCGGAGTTCTCCGTGGACGAGACCGGCCAGATGAGCGCCACAGCCAAGGGCCGAGTCCGTCTTTTGAATAACTGGGACGTGTGCGCAGAC
ATGGTGGGCACCTTCACAGACACCGAGGACCCTGCCAAGTTCAAGATGAAGTACTGGGGCGTAGCCTCCTTTCTCCAGAAAGGAAAACTG
GCCTATGATCTGGATGTGGATGATGCGCCTGGAAACAGTCAGCAGGCAACTCCGAAGGACAACGAGATAAGCACCTTTCACAACCTCGGG

>In-frame_RBP4_ENST00000371467_chr10_95360150_-_GPC3_ENST00000370818_chrX_132670321_-_525nt
ATGAAGTGGGTGTGGGCGCTCTTGCTGTTGGCGGCGCTGGGCAGCGGCCGCGCGGAGCGCGACTGCCGAGTGAGCAGCTTCCGAGTCAAG
GAGAACTTCGACAAGGCTCGCTTCTCTGGGACCTGGTACGCCATGGCCAAGAAGGACCCCGAGGGCCTCTTTCTGCAGGACAACATCGTC
GCGGAGTTCTCCGTGGACGAGACCGGCCAGATGAGCGCCACAGCCAAGGGCCGAGTCCGTCTTTTGAATAACTGGGACGTGTGCGCAGAC
ATGGTGGGCACCTTCACAGACACCGAGGACCCTGCCAAGTTCAAGATGAAGTACTGGGGCGTAGCCTCCTTTCTCCAGAAAGGAAAACTG
GCCTATGATCTGGATGTGGATGATGCGCCTGGAAACAGTCAGCAGGCAACTCCGAAGGACAACGAGATAAGCACCTTTCACAACCTCGGG

>In-frame_RBP4_ENST00000371467_chr10_95360150_-_GPC3_ENST00000394299_chrX_132670321_-_525nt
ATGAAGTGGGTGTGGGCGCTCTTGCTGTTGGCGGCGCTGGGCAGCGGCCGCGCGGAGCGCGACTGCCGAGTGAGCAGCTTCCGAGTCAAG
GAGAACTTCGACAAGGCTCGCTTCTCTGGGACCTGGTACGCCATGGCCAAGAAGGACCCCGAGGGCCTCTTTCTGCAGGACAACATCGTC
GCGGAGTTCTCCGTGGACGAGACCGGCCAGATGAGCGCCACAGCCAAGGGCCGAGTCCGTCTTTTGAATAACTGGGACGTGTGCGCAGAC
ATGGTGGGCACCTTCACAGACACCGAGGACCCTGCCAAGTTCAAGATGAAGTACTGGGGCGTAGCCTCCTTTCTCCAGAAAGGAAAACTG
GCCTATGATCTGGATGTGGATGATGCGCCTGGAAACAGTCAGCAGGCAACTCCGAAGGACAACGAGATAAGCACCTTTCACAACCTCGGG

>In-frame_RBP4_ENST00000371469_chr10_95360150_-_GPC3_ENST00000370818_chrX_132670321_-_519nt
ATGAATTATTCCAAAATTCCTGCACAAGTGGACCTCAGAAGGCAGACGGAGCGCGACTGCCGAGTGAGCAGCTTCCGAGTCAAGGAGAAC
TTCGACAAGGCTCGCTTCTCTGGGACCTGGTACGCCATGGCCAAGAAGGACCCCGAGGGCCTCTTTCTGCAGGACAACATCGTCGCGGAG
TTCTCCGTGGACGAGACCGGCCAGATGAGCGCCACAGCCAAGGGCCGAGTCCGTCTTTTGAATAACTGGGACGTGTGCGCAGACATGGTG
GGCACCTTCACAGACACCGAGGACCCTGCCAAGTTCAAGATGAAGTACTGGGGCGTAGCCTCCTTTCTCCAGAAAGGAAAACTGGCCTAT
GATCTGGATGTGGATGATGCGCCTGGAAACAGTCAGCAGGCAACTCCGAAGGACAACGAGATAAGCACCTTTCACAACCTCGGGAACGTT

>In-frame_RBP4_ENST00000371469_chr10_95360150_-_GPC3_ENST00000394299_chrX_132670321_-_519nt
ATGAATTATTCCAAAATTCCTGCACAAGTGGACCTCAGAAGGCAGACGGAGCGCGACTGCCGAGTGAGCAGCTTCCGAGTCAAGGAGAAC
TTCGACAAGGCTCGCTTCTCTGGGACCTGGTACGCCATGGCCAAGAAGGACCCCGAGGGCCTCTTTCTGCAGGACAACATCGTCGCGGAG
TTCTCCGTGGACGAGACCGGCCAGATGAGCGCCACAGCCAAGGGCCGAGTCCGTCTTTTGAATAACTGGGACGTGTGCGCAGACATGGTG
GGCACCTTCACAGACACCGAGGACCCTGCCAAGTTCAAGATGAAGTACTGGGGCGTAGCCTCCTTTCTCCAGAAAGGAAAACTGGCCTAT
GATCTGGATGTGGATGATGCGCCTGGAAACAGTCAGCAGGCAACTCCGAAGGACAACGAGATAAGCACCTTTCACAACCTCGGGAACGTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_RBP4_ENST00000371464_chr10_95360150_-_GPC3_ENST00000543339_chrX_132670321_-_599nt
GCTCCACGCGCGCCCGGACTCGGCGGCCAGGCTTGCGCGCGGTTCCCCTCCCGGTGGGCGGATTCCTGGGCAAGATGAAGTGGGTGTGGG
CGCTCTTGCTGTTGGCGGCGCTGGGCAGCGGCCGCGCGGAGCGCGACTGCCGAGTGAGCAGCTTCCGAGTCAAGGAGAACTTCGACAAGG
CTCGCTTCTCTGGGACCTGGTACGCCATGGCCAAGAAGGACCCCGAGGGCCTCTTTCTGCAGGACAACATCGTCGCGGAGTTCTCCGTGG
ACGAGACCGGCCAGATGAGCGCCACAGCCAAGGGCCGAGTCCGTCTTTTGAATAACTGGGACGTGTGCGCAGACATGGTGGGCACCTTCA
CAGACACCGAGGACCCTGCCAAGTTCAAGATGAAGTACTGGGGCGTAGCCTCCTTTCTCCAGAAAGGAAAACTGGCCTATGATCTGGATG
TGGATGATGCGCCTGGAAACAGTCAGCAGGCAACTCCGAAGGACAACGAGATAAGCACCTTTCACAACCTCGGGAACGTTCATTCCCCGC

>In-frame_RBP4_ENST00000371467_chr10_95360150_-_GPC3_ENST00000370818_chrX_132670321_-_1224nt
GCCAATTTGGCATGGCCAGGGCCTGGGCACTCACGCACCAGGGAGCCTCGCGGGTCCGCTCTCGCTCTGTGAGGCCACGGTCTTCCCGCC
AGGTTGACTCGAGCCTCCTGCCAGAGCCACTGGCCCCGGAGGCCACCCTAGACCGCAGCTGGCGGCCGCTGGCACGAGTGCAGGGTAACT
GAGCCAGGGCCGCTGGCGCATTTGGCCTGGCCGAGGCCACCCCGCGCGGCCGCTCCACTGTGCCCGAGGCTGTCCTGGAGGTGAGGCCGG
CCCACAGGGACCCTGCCCGTGCCCGGGCTCCGGGCGGATTCCTGGGCAAGATGAAGTGGGTGTGGGCGCTCTTGCTGTTGGCGGCGCTGG
GCAGCGGCCGCGCGGAGCGCGACTGCCGAGTGAGCAGCTTCCGAGTCAAGGAGAACTTCGACAAGGCTCGCTTCTCTGGGACCTGGTACG
CCATGGCCAAGAAGGACCCCGAGGGCCTCTTTCTGCAGGACAACATCGTCGCGGAGTTCTCCGTGGACGAGACCGGCCAGATGAGCGCCA
CAGCCAAGGGCCGAGTCCGTCTTTTGAATAACTGGGACGTGTGCGCAGACATGGTGGGCACCTTCACAGACACCGAGGACCCTGCCAAGT
TCAAGATGAAGTACTGGGGCGTAGCCTCCTTTCTCCAGAAAGGAAAACTGGCCTATGATCTGGATGTGGATGATGCGCCTGGAAACAGTC
AGCAGGCAACTCCGAAGGACAACGAGATAAGCACCTTTCACAACCTCGGGAACGTTCATTCCCCGCTGAAGCTTCTCACCAGCATGGCCA
TCTCGGTGGTGTGCTTCTTCTTCCTGGTGCACTGACTGCCTGGTGCCCAGCACATGTGCTGCCCTACAGCACCCTGTGGTCTTCCTCGAT
AAAGGGAACCACTTTCTTATTTTTTTCTATTTTTTTTTTTTTGTTATCCTGTATACCTCCTCCAGCCATGAAGTAGAGGACTAACCATGT
GTTATGTTTTCGAAAATCAAATGGTATCTTTTGGAGGAAGATACATTTTAGTGGTAGCATATAGATTGTCCTTTTGCAAAGAAAGAAAAA
AAACCATCAAGTTGTGCCAAATTATTCTCCTATGTTTGGCTGCTAGAACATGGTTACCATGTCTTTCTCTCTCACTCCCTCCCTTTCTAT

>In-frame_RBP4_ENST00000371467_chr10_95360150_-_GPC3_ENST00000394299_chrX_132670321_-_1215nt
GCCAATTTGGCATGGCCAGGGCCTGGGCACTCACGCACCAGGGAGCCTCGCGGGTCCGCTCTCGCTCTGTGAGGCCACGGTCTTCCCGCC
AGGTTGACTCGAGCCTCCTGCCAGAGCCACTGGCCCCGGAGGCCACCCTAGACCGCAGCTGGCGGCCGCTGGCACGAGTGCAGGGTAACT
GAGCCAGGGCCGCTGGCGCATTTGGCCTGGCCGAGGCCACCCCGCGCGGCCGCTCCACTGTGCCCGAGGCTGTCCTGGAGGTGAGGCCGG
CCCACAGGGACCCTGCCCGTGCCCGGGCTCCGGGCGGATTCCTGGGCAAGATGAAGTGGGTGTGGGCGCTCTTGCTGTTGGCGGCGCTGG
GCAGCGGCCGCGCGGAGCGCGACTGCCGAGTGAGCAGCTTCCGAGTCAAGGAGAACTTCGACAAGGCTCGCTTCTCTGGGACCTGGTACG
CCATGGCCAAGAAGGACCCCGAGGGCCTCTTTCTGCAGGACAACATCGTCGCGGAGTTCTCCGTGGACGAGACCGGCCAGATGAGCGCCA
CAGCCAAGGGCCGAGTCCGTCTTTTGAATAACTGGGACGTGTGCGCAGACATGGTGGGCACCTTCACAGACACCGAGGACCCTGCCAAGT
TCAAGATGAAGTACTGGGGCGTAGCCTCCTTTCTCCAGAAAGGAAAACTGGCCTATGATCTGGATGTGGATGATGCGCCTGGAAACAGTC
AGCAGGCAACTCCGAAGGACAACGAGATAAGCACCTTTCACAACCTCGGGAACGTTCATTCCCCGCTGAAGCTTCTCACCAGCATGGCCA
TCTCGGTGGTGTGCTTCTTCTTCCTGGTGCACTGACTGCCTGGTGCCCAGCACATGTGCTGCCCTACAGCACCCTGTGGTCTTCCTCGAT
AAAGGGAACCACTTTCTTATTTTTTTCTATTTTTTTTTTTTTGTTATCCTGTATACCTCCTCCAGCCATGAAGTAGAGGACTAACCATGT
GTTATGTTTTCGAAAATCAAATGGTATCTTTTGGAGGAAGATACATTTTAGTGGTAGCATATAGATTGTCCTTTTGCAAAGAAAGAAAAA
AAACCATCAAGTTGTGCCAAATTATTCTCCTATGTTTGGCTGCTAGAACATGGTTACCATGTCTTTCTCTCTCACTCCCTCCCTTTCTAT

>In-frame_RBP4_ENST00000371469_chr10_95360150_-_GPC3_ENST00000370818_chrX_132670321_-_926nt
ATCCTTTATAAAATGAAAAACTACTTGGATGAATTATTCCAAAATTCCTGCACAAGTGGACCTCAGAAGGCAGACGGAGCGCGACTGCCG
AGTGAGCAGCTTCCGAGTCAAGGAGAACTTCGACAAGGCTCGCTTCTCTGGGACCTGGTACGCCATGGCCAAGAAGGACCCCGAGGGCCT
CTTTCTGCAGGACAACATCGTCGCGGAGTTCTCCGTGGACGAGACCGGCCAGATGAGCGCCACAGCCAAGGGCCGAGTCCGTCTTTTGAA
TAACTGGGACGTGTGCGCAGACATGGTGGGCACCTTCACAGACACCGAGGACCCTGCCAAGTTCAAGATGAAGTACTGGGGCGTAGCCTC
CTTTCTCCAGAAAGGAAAACTGGCCTATGATCTGGATGTGGATGATGCGCCTGGAAACAGTCAGCAGGCAACTCCGAAGGACAACGAGAT
AAGCACCTTTCACAACCTCGGGAACGTTCATTCCCCGCTGAAGCTTCTCACCAGCATGGCCATCTCGGTGGTGTGCTTCTTCTTCCTGGT
GCACTGACTGCCTGGTGCCCAGCACATGTGCTGCCCTACAGCACCCTGTGGTCTTCCTCGATAAAGGGAACCACTTTCTTATTTTTTTCT
ATTTTTTTTTTTTTGTTATCCTGTATACCTCCTCCAGCCATGAAGTAGAGGACTAACCATGTGTTATGTTTTCGAAAATCAAATGGTATC
TTTTGGAGGAAGATACATTTTAGTGGTAGCATATAGATTGTCCTTTTGCAAAGAAAGAAAAAAAACCATCAAGTTGTGCCAAATTATTCT
CCTATGTTTGGCTGCTAGAACATGGTTACCATGTCTTTCTCTCTCACTCCCTCCCTTTCTATCGTTCTCTCTTTGCATGGATTTCTTTGA

>In-frame_RBP4_ENST00000371469_chr10_95360150_-_GPC3_ENST00000394299_chrX_132670321_-_917nt
ATCCTTTATAAAATGAAAAACTACTTGGATGAATTATTCCAAAATTCCTGCACAAGTGGACCTCAGAAGGCAGACGGAGCGCGACTGCCG
AGTGAGCAGCTTCCGAGTCAAGGAGAACTTCGACAAGGCTCGCTTCTCTGGGACCTGGTACGCCATGGCCAAGAAGGACCCCGAGGGCCT
CTTTCTGCAGGACAACATCGTCGCGGAGTTCTCCGTGGACGAGACCGGCCAGATGAGCGCCACAGCCAAGGGCCGAGTCCGTCTTTTGAA
TAACTGGGACGTGTGCGCAGACATGGTGGGCACCTTCACAGACACCGAGGACCCTGCCAAGTTCAAGATGAAGTACTGGGGCGTAGCCTC
CTTTCTCCAGAAAGGAAAACTGGCCTATGATCTGGATGTGGATGATGCGCCTGGAAACAGTCAGCAGGCAACTCCGAAGGACAACGAGAT
AAGCACCTTTCACAACCTCGGGAACGTTCATTCCCCGCTGAAGCTTCTCACCAGCATGGCCATCTCGGTGGTGTGCTTCTTCTTCCTGGT
GCACTGACTGCCTGGTGCCCAGCACATGTGCTGCCCTACAGCACCCTGTGGTCTTCCTCGATAAAGGGAACCACTTTCTTATTTTTTTCT
ATTTTTTTTTTTTTGTTATCCTGTATACCTCCTCCAGCCATGAAGTAGAGGACTAACCATGTGTTATGTTTTCGAAAATCAAATGGTATC
TTTTGGAGGAAGATACATTTTAGTGGTAGCATATAGATTGTCCTTTTGCAAAGAAAGAAAAAAAACCATCAAGTTGTGCCAAATTATTCT
CCTATGTTTGGCTGCTAGAACATGGTTACCATGTCTTTCTCTCTCACTCCCTCCCTTTCTATCGTTCTCTCTTTGCATGGATTTCTTTGA


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FusionGenePPI for RBP4_GPC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBP4TTR, GRB2, RBBP6, LAMTOR5, FTH1, MSRB3, MARCKSL1, CRYBA4, MTO1, TMEM205, HESX1, POLR3D, KLHL24GPC3FGF2, TAZ, GPR183, LMAN2, LRRTM2, PIP5K1A, CAMKV, ULBP1, C4orf26, SIGLECL1, SCGB2A2, FGF1, TSPYL1, NRN1, MOXD1, ISLR, LIPG


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBP4_GPC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRBP4P02753DB00755TretinoinRetinol-binding protein 4small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for RBP4_GPC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRBP4C3554593RETINAL DYSTROPHY, IRIS COLOBOMA, AND COMEDOGENIC ACNE SYNDROME2ORPHANET;UNIPROT
HgeneRBP4C0000786Spontaneous abortion1CTD_human
HgeneRBP4C0018801Heart failure1CTD_human
HgeneRBP4C0022658Kidney Diseases1CTD_human
HgeneRBP4C0023896Alcoholic Liver Diseases1CTD_human
HgeneRBP4C0024667Animal Mammary Neoplasms1CTD_human
HgeneRBP4C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneRBP4C0027540Necrosis1CTD_human
HgeneRBP4C0032460Polycystic Ovary Syndrome1CTD_human
HgeneRBP4C0038356Stomach Neoplasms1CTD_human
HgeneRBP4C0042842Vitamin A Deficiency1CTD_human
HgeneRBP4C0152455Keratomalacia1CTD_human
HgeneRBP4C4225330MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 101UNIPROT
TgeneGPC3C0025500Mesothelioma1CTD_human
TgeneGPC3C0796154SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 11CTD_human;ORPHANET;UNIPROT
TgeneGPC3C2239176Liver carcinoma1CTD_human