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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30815

FusionGeneSummary for RBMS3_RDX

check button Fusion gene summary
Fusion gene informationFusion gene name: RBMS3_RDX
Fusion gene ID: 30815
HgeneTgene
Gene symbol

RBMS3

RDX

Gene ID

27303

5962

Gene nameRNA binding motif single stranded interacting protein 3radixin
Synonyms-DFNB24
Cytomap

3p24.1

11q22.3

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding motif, single-stranded-interacting protein 3RNA binding motif, single stranded interacting proteinRNA-binding proteinradixin
Modification date2018052320180523
UniProtAcc

Q6XE24

P35241

Ensembl transtripts involved in fusion geneENST00000434693, ENST00000396583, 
ENST00000383767, ENST00000445033, 
ENST00000273139, ENST00000383766, 
ENST00000452462, ENST00000456853, 
ENST00000473799, 
ENST00000528498, 
ENST00000528900, ENST00000405097, 
ENST00000530301, ENST00000343115, 
ENST00000544551, 
Fusion gene scores* DoF score5 X 5 X 3=758 X 8 X 3=192
# samples 58
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBMS3 [Title/Abstract] AND RDX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU145394RBMS3chr3

30005840

+RDXchr5

148877155

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000434693ENST00000528498RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000434693ENST00000528900RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000434693ENST00000405097RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000434693ENST00000530301RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000434693ENST00000343115RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000434693ENST00000544551RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000396583ENST00000528498RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000396583ENST00000528900RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000396583ENST00000405097RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000396583ENST00000530301RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000396583ENST00000343115RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000396583ENST00000544551RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383767ENST00000528498RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383767ENST00000528900RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383767ENST00000405097RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383767ENST00000530301RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383767ENST00000343115RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383767ENST00000544551RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000445033ENST00000528498RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000445033ENST00000528900RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000445033ENST00000405097RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000445033ENST00000530301RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000445033ENST00000343115RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000445033ENST00000544551RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000273139ENST00000528498RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000273139ENST00000528900RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000273139ENST00000405097RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000273139ENST00000530301RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000273139ENST00000343115RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000273139ENST00000544551RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383766ENST00000528498RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383766ENST00000528900RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383766ENST00000405097RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383766ENST00000530301RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383766ENST00000343115RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000383766ENST00000544551RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000452462ENST00000528498RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000452462ENST00000528900RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000452462ENST00000405097RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000452462ENST00000530301RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000452462ENST00000343115RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000452462ENST00000544551RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000456853ENST00000528498RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000456853ENST00000528900RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000456853ENST00000405097RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000456853ENST00000530301RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000456853ENST00000343115RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000456853ENST00000544551RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000473799ENST00000528498RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000473799ENST00000528900RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000473799ENST00000405097RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000473799ENST00000530301RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000473799ENST00000343115RBMS3chr3

30005840

+RDXchr5

148877155

-
intron-intronENST00000473799ENST00000544551RBMS3chr3

30005840

+RDXchr5

148877155

-

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FusionProtFeatures for RBMS3_RDX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBMS3

Q6XE24

RDX

P35241

Binds poly(A) and poly(U) oligoribonucleotides.{ECO:0000269|PubMed:10675610}. Probably plays a crucial role in the binding of thebarbed end of actin filaments to the plasma membrane.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBMS3_RDX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBMS3_RDX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBMS3_RDX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBMS3_RDX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRDXC0008370Cholestasis1CTD_human
TgeneRDXC1970239DEAFNESS, AUTOSOMAL RECESSIVE, 241CTD_human;UNIPROT