FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 30814

FusionGeneSummary for RBMS3_PLGRKT

check button Fusion gene summary
Fusion gene informationFusion gene name: RBMS3_PLGRKT
Fusion gene ID: 30814
HgeneTgene
Gene symbol

RBMS3

PLGRKT

Gene ID

27303

55848

Gene nameRNA binding motif single stranded interacting protein 3plasminogen receptor with a C-terminal lysine
Synonyms-AD025|C9orf46|MDS030|PLG-RKT|Plg-R(KT)
Cytomap

3p24.1

9p24.1

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding motif, single-stranded-interacting protein 3RNA binding motif, single stranded interacting proteinRNA-binding proteinplasminogen receptor (KT)5033414D02Rikplasminogen receptor, C-terminal lysine transmembrane proteintransmembrane protein C9orf46
Modification date2018052320180519
UniProtAcc

Q6XE24

Q9HBL7

Ensembl transtripts involved in fusion geneENST00000434693, ENST00000396583, 
ENST00000383767, ENST00000445033, 
ENST00000273139, ENST00000383766, 
ENST00000452462, ENST00000456853, 
ENST00000473799, 		ENST00000223864, 
ENST00000482696, 
Fusion gene scores* DoF score5 X 5 X 3=759 X 3 X 8=216
# samples 59
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBMS3 [Title/Abstract] AND PLGRKT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-DU-7014-01ARBMS3chr3

28617987

+PLGRKTchr9

5361888

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000434693ENST00000223864RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-5UTRENST00000434693ENST00000482696RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-3CDSENST00000396583ENST00000223864RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-5UTRENST00000396583ENST00000482696RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-3CDSENST00000383767ENST00000223864RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-5UTRENST00000383767ENST00000482696RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-3CDSENST00000445033ENST00000223864RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-5UTRENST00000445033ENST00000482696RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-3CDSENST00000273139ENST00000223864RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-5UTRENST00000273139ENST00000482696RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-3CDSENST00000383766ENST00000223864RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-5UTRENST00000383766ENST00000482696RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-3CDSENST00000452462ENST00000223864RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-5UTRENST00000452462ENST00000482696RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-3CDSENST00000456853ENST00000223864RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-5UTRENST00000456853ENST00000482696RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-3CDSENST00000473799ENST00000223864RBMS3chr3

28617987

+PLGRKTchr9

5361888

-
intron-5UTRENST00000473799ENST00000482696RBMS3chr3

28617987

+PLGRKTchr9

5361888

-

Top

FusionProtFeatures for RBMS3_PLGRKT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBMS3

Q6XE24

PLGRKT

Q9HBL7

Binds poly(A) and poly(U) oligoribonucleotides.{ECO:0000269|PubMed:10675610}. Receptor for plasminogen. Regulates urokinaseplasminogen activator-dependent and stimulates tissue-typeplasminogen activator-dependent cell surface plasminogenactivation. Proposed to be part of a local catecholaminergic cellplasminogen activation system that regulates neuroendocrineprohormone processing. Involved in regulation of inflammatoryresponse; regulates monocyte chemotactic migration and matrixmetallproteinase activation, such as of MMP2 and MMP9.{ECO:0000269|PubMed:21940822}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RBMS3_PLGRKT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RBMS3_PLGRKT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBMS3MRPL9, SART3, MRPL40, MRPL55, MRPL19, ICT1, NGRN, MRPL30, MRPS18APLGRKTXRCC6, SAT1, EEF1G, GOLT1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RBMS3_PLGRKT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RBMS3_PLGRKT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource