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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30813

FusionGeneSummary for RBMS3_NMNAT3

check button Fusion gene summary
Fusion gene informationFusion gene name: RBMS3_NMNAT3
Fusion gene ID: 30813
HgeneTgene
Gene symbol

RBMS3

NMNAT3

Gene ID

27303

349565

Gene nameRNA binding motif single stranded interacting protein 3nicotinamide nucleotide adenylyltransferase 3
Synonyms-FKSG76|PNAT-3|PNAT3
Cytomap

3p24.1

3q23

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding motif, single-stranded-interacting protein 3RNA binding motif, single stranded interacting proteinRNA-binding proteinnicotinamide/nicotinic acid mononucleotide adenylyltransferase 3NMN adenylyltransferase 3NMN/NaMN adenylyltransferase 3NaMN adenylyltransferase 3nicotinamide mononucleotide adenylyltransferase 3nicotinate-nucleotide adenylyltransferase 3pyridine nuc
Modification date2018052320180523
UniProtAcc

Q6XE24

Q96T66

Ensembl transtripts involved in fusion geneENST00000434693, ENST00000396583, 
ENST00000383767, ENST00000445033, 
ENST00000273139, ENST00000383766, 
ENST00000452462, ENST00000456853, 
ENST00000473799, 		ENST00000406164, 
ENST00000406824, ENST00000339837, 
ENST00000413939, ENST00000296202, 
ENST00000511444, ENST00000512391, 
ENST00000514703, ENST00000507242, 
Fusion gene scores* DoF score5 X 5 X 3=756 X 4 X 4=96
# samples 56
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBMS3 [Title/Abstract] AND NMNAT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-HT-7477-01BRBMS3chr3

29224620

+NMNAT3chr3

139346603

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000434693ENST00000406164RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000434693ENST00000406824RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000434693ENST00000339837RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000434693ENST00000413939RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000434693ENST00000296202RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000434693ENST00000511444RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000434693ENST00000512391RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000434693ENST00000514703RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000434693ENST00000507242RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000396583ENST00000406164RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000396583ENST00000406824RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000396583ENST00000339837RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000396583ENST00000413939RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000396583ENST00000296202RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000396583ENST00000511444RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000396583ENST00000512391RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000396583ENST00000514703RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000396583ENST00000507242RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383767ENST00000406164RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383767ENST00000406824RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000383767ENST00000339837RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383767ENST00000413939RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383767ENST00000296202RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000383767ENST00000511444RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383767ENST00000512391RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383767ENST00000514703RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000383767ENST00000507242RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000445033ENST00000406164RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000445033ENST00000406824RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000445033ENST00000339837RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000445033ENST00000413939RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000445033ENST00000296202RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000445033ENST00000511444RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000445033ENST00000512391RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000445033ENST00000514703RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000445033ENST00000507242RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000273139ENST00000406164RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000273139ENST00000406824RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000273139ENST00000339837RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000273139ENST00000413939RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000273139ENST00000296202RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000273139ENST00000511444RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000273139ENST00000512391RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000273139ENST00000514703RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000273139ENST00000507242RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383766ENST00000406164RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383766ENST00000406824RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000383766ENST00000339837RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383766ENST00000413939RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383766ENST00000296202RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000383766ENST00000511444RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383766ENST00000512391RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000383766ENST00000514703RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000383766ENST00000507242RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000452462ENST00000406164RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000452462ENST00000406824RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000452462ENST00000339837RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000452462ENST00000413939RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000452462ENST00000296202RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000452462ENST00000511444RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000452462ENST00000512391RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000452462ENST00000514703RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000452462ENST00000507242RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000456853ENST00000406164RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000456853ENST00000406824RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000456853ENST00000339837RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000456853ENST00000413939RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000456853ENST00000296202RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000456853ENST00000511444RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000456853ENST00000512391RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000456853ENST00000514703RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000456853ENST00000507242RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000473799ENST00000406164RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000473799ENST00000406824RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000473799ENST00000339837RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000473799ENST00000413939RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000473799ENST00000296202RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000473799ENST00000511444RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000473799ENST00000512391RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-5UTRENST00000473799ENST00000514703RBMS3chr3

29224620

+NMNAT3chr3

139346603

-
intron-intronENST00000473799ENST00000507242RBMS3chr3

29224620

+NMNAT3chr3

139346603

-

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FusionProtFeatures for RBMS3_NMNAT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBMS3

Q6XE24

NMNAT3

Q96T66

Binds poly(A) and poly(U) oligoribonucleotides.{ECO:0000269|PubMed:10675610}. Catalyzes the formation of NAD(+) from nicotinamidemononucleotide (NMN) and ATP. Can also use the deamidated form;nicotinic acid mononucleotide (NaMN) as substrate with the sameefficiency. Can use triazofurin monophosphate (TrMP) as substrate.Can also use GTP and ITP as nucleotide donors. Also catalyzes thereverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+).For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD,nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamideguanine dinucleotide (NGD) as substrates. Fails to cleavephosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protectsagainst axonal degeneration following injury.{ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBMS3_NMNAT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBMS3_NMNAT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBMS3MRPL9, SART3, MRPL40, MRPL55, MRPL19, ICT1, NGRN, MRPL30, MRPS18ANMNAT3HS2ST1, DCX, SPTB, HSPA8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RBMS3_NMNAT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBMS3_NMNAT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNMNAT3C0032460Polycystic Ovary Syndrome1CTD_human