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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30806

FusionGeneSummary for RBMS1_XIRP2

check button Fusion gene summary
Fusion gene informationFusion gene name: RBMS1_XIRP2
Fusion gene ID: 30806
HgeneTgene
Gene symbol

RBMS1

XIRP2

Gene ID

5937

129446

Gene nameRNA binding motif single stranded interacting protein 1xin actin binding repeat containing 2
SynonymsC2orf12|HCC-4|MSSP|MSSP-1|MSSP-2|MSSP-3|SCR2|YC1CMYA3
Cytomap

2q24.2

2q24.3

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding motif, single-stranded-interacting protein 1c-myc gene single strand binding protein 2cervical cancer oncogene 4single-stranded DNA-binding protein MSSP-1suppressor of CDC2 with RNA-binding motif 2suppressor of cdc 2 (cdc13) with RNA bindxin actin-binding repeat-containing protein 2beta-xincardiomyopathy associated 3cardiomyopathy-associated protein 3myomaxinxeplinxin repeat protein 2
Modification date2018052320180519
UniProtAcc

P29558

A4UGR9

Ensembl transtripts involved in fusion geneENST00000474820, ENST00000348849, 
ENST00000409075, ENST00000409289, 
ENST00000392753, ENST00000409972, 
ENST00000409728, ENST00000409043, 
ENST00000409195, ENST00000409756, 
ENST00000420519, ENST00000295237, 
ENST00000409273, ENST00000409605, 
Fusion gene scores* DoF score8 X 4 X 6=1924 X 3 X 3=36
# samples 84
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RBMS1 [Title/Abstract] AND XIRP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-B6-A0IO-01ARBMS1chr2

161349800

-XIRP2chr2

168067245

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000474820ENST00000409728RBMS1chr2

161349800

-XIRP2chr2

168067245

+
5UTR-3CDSENST00000474820ENST00000409043RBMS1chr2

161349800

-XIRP2chr2

168067245

+
5UTR-3CDSENST00000474820ENST00000409195RBMS1chr2

161349800

-XIRP2chr2

168067245

+
5UTR-3CDSENST00000474820ENST00000409756RBMS1chr2

161349800

-XIRP2chr2

168067245

+
5UTR-3CDSENST00000474820ENST00000420519RBMS1chr2

161349800

-XIRP2chr2

168067245

+
5UTR-3CDSENST00000474820ENST00000295237RBMS1chr2

161349800

-XIRP2chr2

168067245

+
5UTR-5UTRENST00000474820ENST00000409273RBMS1chr2

161349800

-XIRP2chr2

168067245

+
5UTR-5UTRENST00000474820ENST00000409605RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000348849ENST00000409728RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000348849ENST00000409043RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000348849ENST00000409195RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000348849ENST00000409756RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000348849ENST00000420519RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000348849ENST00000295237RBMS1chr2

161349800

-XIRP2chr2

168067245

+
5CDS-5UTRENST00000348849ENST00000409273RBMS1chr2

161349800

-XIRP2chr2

168067245

+
5CDS-5UTRENST00000348849ENST00000409605RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409075ENST00000409728RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409075ENST00000409043RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409075ENST00000409195RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409075ENST00000409756RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409075ENST00000420519RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409075ENST00000295237RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-5UTRENST00000409075ENST00000409273RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-5UTRENST00000409075ENST00000409605RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409289ENST00000409728RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409289ENST00000409043RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409289ENST00000409195RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409289ENST00000409756RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409289ENST00000420519RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409289ENST00000295237RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-5UTRENST00000409289ENST00000409273RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-5UTRENST00000409289ENST00000409605RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000392753ENST00000409728RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000392753ENST00000409043RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000392753ENST00000409195RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000392753ENST00000409756RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000392753ENST00000420519RBMS1chr2

161349800

-XIRP2chr2

168067245

+
Frame-shiftENST00000392753ENST00000295237RBMS1chr2

161349800

-XIRP2chr2

168067245

+
5CDS-5UTRENST00000392753ENST00000409273RBMS1chr2

161349800

-XIRP2chr2

168067245

+
5CDS-5UTRENST00000392753ENST00000409605RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409972ENST00000409728RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409972ENST00000409043RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409972ENST00000409195RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409972ENST00000409756RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409972ENST00000420519RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-3CDSENST00000409972ENST00000295237RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-5UTRENST00000409972ENST00000409273RBMS1chr2

161349800

-XIRP2chr2

168067245

+
intron-5UTRENST00000409972ENST00000409605RBMS1chr2

161349800

-XIRP2chr2

168067245

+

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FusionProtFeatures for RBMS1_XIRP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBMS1

P29558

XIRP2

A4UGR9

Single-stranded DNA binding protein that interacts withthe region upstream of the MYC gene. Binds specifically to the DNAsequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNAreplication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBMS1_XIRP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBMS1_XIRP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBMS1POLA1, GRK5, NDUFA7, NABP2, PPIF, TIMM44, RPS19, PPIB, SCP2, MRPL53, PQBP1, SUGP1, RPL38, SNX3, SARNP, DNM2, UBE2I, SNRPC, MRRF, SRPRB, RFX5, HRSP12, UBQLN1, RRBP1, STX7, ZC3H11A, SBDS, TFCP2, HIST1H1A, FHL3, HNRNPA1, RBFOX2, XPO1, LPXN, HIST1H1E, RRS1, FAM136A, FGF8, HTRA4, SMAP2, SMAD9, ZNF143, G3BP1XIRP2NSMAF, RAD21, NEBL, NEB, FLNC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBMS1_XIRP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBMS1_XIRP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource