FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 308

FusionGeneSummary for ACACA_FAM104A

check button Fusion gene summary
Fusion gene informationFusion gene name: ACACA_FAM104A
Fusion gene ID: 308
HgeneTgene
Gene symbol

ACACA

FAM104A

Gene ID

31

84923

Gene nameacetyl-CoA carboxylase alphafamily with sequence similarity 104 member A
SynonymsACAC|ACACAD|ACC|ACC1|ACCA-
Cytomap

17q12

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionacetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alphaprotein FAM104A
Modification date2018052220180519
UniProtAcc

Q13085

Q969W3

Ensembl transtripts involved in fusion geneENST00000353139, ENST00000360679, 
ENST00000394406, ENST00000335166, 
ENST00000416895, ENST00000361253, 
ENST00000588142, ENST00000589665, 
ENST00000403627, ENST00000405159, 
ENST00000583178, ENST00000580032, 
ENST00000581110, ENST00000583024, 
Fusion gene scores* DoF score23 X 13 X 11=32894 X 3 X 3=36
# samples 214
** MAII scorelog2(21/3289*10)=-3.96918777516928
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ACACA [Title/Abstract] AND FAM104A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0DD-01AACACAchr17

35631084

-FAM104Achr17

71205907

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000353139ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000353139ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000353139ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000353139ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000353139ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000353139ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
In-frameENST00000360679ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000360679ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000360679ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000360679ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000360679ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000360679ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000394406ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000394406ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000394406ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000394406ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000394406ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000394406ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000335166ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
Frame-shiftENST00000335166ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000335166ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000335166ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000335166ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
5CDS-5UTRENST00000335166ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000416895ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000416895ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000416895ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000416895ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000416895ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000416895ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000361253ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000361253ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000361253ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000361253ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000361253ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000361253ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000588142ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000588142ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000588142ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000588142ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000588142ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000588142ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000589665ENST00000403627ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-3CDSENST00000589665ENST00000405159ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000589665ENST00000583178ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000589665ENST00000580032ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000589665ENST00000581110ACACAchr17

35631084

-FAM104Achr17

71205907

-
intron-5UTRENST00000589665ENST00000583024ACACAchr17

35631084

-FAM104Achr17

71205907

-

Top

FusionProtFeatures for ACACA_FAM104A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACACA

Q13085

FAM104A

Q969W3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-956315_3203362384Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-855117_6182212269DomainNote=Biotin carboxylation
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-8551576_19142212269DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-8551918_22342212269DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-855275_4662212269DomainATP-grasp
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-855745_8192212269DomainBiotinyl-binding
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-956117_6183362384DomainNote=Biotin carboxylation
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-9561576_19143362384DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-9561918_22343362384DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-956275_4663362384DomainATP-grasp
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-956745_8193362384DomainBiotinyl-binding
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-754117_6182412289DomainNote=Biotin carboxylation
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-7541576_19142412289DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-7541918_22342412289DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-754275_4662412289DomainATP-grasp
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-754745_8192412289DomainBiotinyl-binding
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-956117_6182992347DomainNote=Biotin carboxylation
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-9561576_19142992347DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-9561918_22342992347DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-956275_4662992347DomainATP-grasp
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-956745_8192992347DomainBiotinyl-binding
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-855315_3202212269Nucleotide bindingATP
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-754315_3202412289Nucleotide bindingATP
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-956315_3202992347Nucleotide bindingATP
HgeneACACAchr17:35631084chr17:71205907ENST00000335166-8551576_22342212269RegionCarboxyltransferase
HgeneACACAchr17:35631084chr17:71205907ENST00000353139-9561576_22343362384RegionCarboxyltransferase
HgeneACACAchr17:35631084chr17:71205907ENST00000360679-7541576_22342412289RegionCarboxyltransferase
HgeneACACAchr17:35631084chr17:71205907ENST00000394406-9561576_22342992347RegionCarboxyltransferase
TgeneFAM104Achr17:35631084chr17:71205907ENST00000403627-1394_145107187Compositional biasNote=Ser-rich
TgeneFAM104Achr17:35631084chr17:71205907ENST00000405159-2494_145128208Compositional biasNote=Ser-rich


Top

FusionGeneSequence for ACACA_FAM104A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ACACA_ENST00000353139_chr17_35631084_-_FAM104A_ENST00000403627_chr17_71205907_-_416aa
MWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPAS
VGSDTLSDLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYE
MFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPP
SQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQSSGSDSGGSSSSSSSSINSPDRAS

>In-frame_ACACA_ENST00000360679_chr17_35631084_-_FAM104A_ENST00000403627_chr17_71205907_-_321aa
MEGSPEENKEMRYYMLQRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNE
RAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMW
ALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQSSGSDSGGSSSSSSSSINSPDRASGPEGS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ACACA_ENST00000353139_chr17_35631084_-_FAM104A_ENST00000403627_chr17_71205907_-_1248nt
ATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATATCTACTCAGACAGTAAGAATTATAAGAGCTGTA
AGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGCTGAACCAGCACTCTCGATTCATAATAGGTTCT
GTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGGAGGAGAAGGAGGGCTCCTTGTCACCTGCTTCT
GTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCTTGCACATAAGGTCCAGCATGTCTGGCTTGCAC
CTAGTAAAGCAGGGCCGAGACAGAAAGAAAATAGATTCTCAACGAGATTTCACTGTGGCTTCTCCAGCAGAATTTGTTACTCGCTTTGGG
GGAAATAAAGTGATTGAGAAGGTTCTTATTGCTAACAATGGCATTGCAGCAGTGAAATGCATGCGGTCTATCCGTAGGTGGTCTTATGAA
ATGTTTCGAAATGAACGTGCAATTAGATTCGTTGTCATGGTCACACCTGAAGACCTTAAAGCCAATGCAGAATACATTAAGATGGCAGAT
CACTATGTGCCAGTGCCTGGAGGACCAAACAACAACAACTATGCAAATGTGGAATTAATTCTTGATATTGCTAAAAGGATCCCAGTACAA
GCAGTGTGGGCTGGCTGGGGTCATGCTTCTGAGAATCCCAAACTACCGGAACTTCTCTTGAAAAATGGCATTGCCTTCATGGGTCCTCCA
AGCCAGGCCATGTGGGCTTTAGGGGATAAGATTGCATCTTCCATAGTGGCTCAAACTGCAGGTATCCCAACTCTTCCCTGGAGCGGCAGT
GGTCTTCGTGTGGACTGGCAGGAAAATGATTTTTCAAAACGTATCTTAAATGTTCCCCAGGAGCTATATGAAAAAGGTTATGTGAAAGAT
GTGGATGATGGGCTACAGTCTTCAGGCAGTGACAGTGGTGGGAGCAGCAGCAGCAGCAGCAGCAGCATCAATAGCCCGGACAGGGCCAGC
GGGCCGGAAGGCAGCTTGAGCCAGACCATGGCCGGATCCAGCCCTAACACGCCTCAGCCCGTGCCCGAGCAGTCCGCGCTGTGCCAAGGC

>In-frame_ACACA_ENST00000360679_chr17_35631084_-_FAM104A_ENST00000403627_chr17_71205907_-_963nt
ATGGAGGGTTCTCCAGAGGAAAATAAGGAAATGAGATATTACATGCTTCAAAGGTCCAGCATGTCTGGCTTGCACCTAGTAAAGCAGGGC
CGAGACAGAAAGAAAATAGATTCTCAACGAGATTTCACTGTGGCTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATT
GAGAAGGTTCTTATTGCTAACAATGGCATTGCAGCAGTGAAATGCATGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAA
CGTGCAATTAGATTCGTTGTCATGGTCACACCTGAAGACCTTAAAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCAGTG
CCTGGAGGACCAAACAACAACAACTATGCAAATGTGGAATTAATTCTTGATATTGCTAAAAGGATCCCAGTACAAGCAGTGTGGGCTGGC
TGGGGTCATGCTTCTGAGAATCCCAAACTACCGGAACTTCTCTTGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGCCATGTGG
GCTTTAGGGGATAAGATTGCATCTTCCATAGTGGCTCAAACTGCAGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGAC
TGGCAGGAAAATGATTTTTCAAAACGTATCTTAAATGTTCCCCAGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTA
CAGTCTTCAGGCAGTGACAGTGGTGGGAGCAGCAGCAGCAGCAGCAGCAGCATCAATAGCCCGGACAGGGCCAGCGGGCCGGAAGGCAGC
TTGAGCCAGACCATGGCCGGATCCAGCCCTAACACGCCTCAGCCCGTGCCCGAGCAGTCCGCGCTGTGCCAAGGCCTCTACTTCCACATC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ACACA_ENST00000353139_chr17_35631084_-_FAM104A_ENST00000403627_chr17_71205907_-_3906nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGTGGATAT
CTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTGGAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGC
TGAACCAGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGTTGGACCTACTGG
AGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTAGCCTACAGGATGGCTTGGCCT
TGCACATAAGGTCCAGCATGTCTGGCTTGCACCTAGTAAAGCAGGGCCGAGACAGAAAGAAAATAGATTCTCAACGAGATTTCACTGTGG
CTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAGGTTCTTATTGCTAACAATGGCATTGCAGCAGTGAAAT
GCATGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTCGTTGTCATGGTCACACCTGAAGACCTTA
AAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCAGTGCCTGGAGGACCAAACAACAACAACTATGCAAATGTGGAATTAA
TTCTTGATATTGCTAAAAGGATCCCAGTACAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCTGAGAATCCCAAACTACCGGAACTTCTCT
TGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGCCATGTGGGCTTTAGGGGATAAGATTGCATCTTCCATAGTGGCTCAAACTG
CAGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGATTTTTCAAAACGTATCTTAAATGTTCCCC
AGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTACAGTCTTCAGGCAGTGACAGTGGTGGGAGCAGCAGCAGCAGCA
GCAGCAGCATCAATAGCCCGGACAGGGCCAGCGGGCCGGAAGGCAGCTTGAGCCAGACCATGGCCGGATCCAGCCCTAACACGCCTCAGC
CCGTGCCCGAGCAGTCCGCGCTGTGCCAAGGCCTCTACTTCCACATCAACCAGACCCTGAGGGAGGCCCACTTCCACAGCCTACAGCACC
GAGGGCGGCCTCTGACATGATGTGCCGGCAGTTTCTTGCCTTCTGTGAAGGGACAGCGCTGTGCAGATTTGATATTTCAACTTACAACTT
GTTTTAAAAGAAAAATTGCACACGAAAAATGCCTGTTGGCTTTTCAGTCTATATTTGAAATAACAGGTTAACAGGCAGTTGTTTACTTGT
GGTTTTGCTGCACTATTGCAATTTCAAAGGGGCTTTGAAGCAATTTTTTATAGGATTCTTTTGAGGGAGGGTATCAAATCTATGTCAAGG
TAGTGGTTTGAGGAAAACTCATTCTGTGTGTTGAATCCATAGTATGTCCCATTCAGACTGATTTCCAAATCTGTCAACTAGAAACTCTAC
TTTATGTAAAGGGCCTTTTAAAAATGCGGGATCTTCAATTTTTTTTATTCAATAAACTAGTAAAGAGTATCTAGTTTCCATGAAAAAACA
TAAGTTTTTTTCCAAAATATAGGAAGCTTGATTCAGTCTTGCACTGAAATTAACTGCCATACTACCTCTCAGTATGTAGATGTTCTATTG
AAAGTACTCTCTCCTGTGTAACAGGAGAACAATCAGATCCAATTCAGACTGTCAGTGAAGCACACTCCCTAATAATAGTCTCTACTCTTT
GTTATATATTTGTATTTCCAGAGAGAATGTCTTTTAGATTCTTGTATACCCAGATAACTTCTGTGTCACTATTCCACCAGAGTCTGCACC
TCAGACTTTAGTAGGAAACATGGCACAGTTCTGCAAGTAAAGTAATATGTAATGACTTTTTGTCCTACAAACTTGGTCAGTCAGCAGCTT
ACATGATCTCATTGACAATTCCACCTTGTAGTGTCAACAATTAAGGTGTTGTTGAACGCTGATAAAATGTAAGCTACCTGAACTGATGTC
TAAAGCAACAAGTATTGTGAAATTTTGGGACAAGGATTAACTTGATGCTTAAAGTAACCCCCAACAGTAACTAGGGGGCCACATTCCATC
AGTGAAACTGGAAAGATTGGTGTGGCTGAGAATCAGATGAGCAGAGGCACCTTTAGAAGAAATAATGTGGTAGTATTTATTTAGGGAGAG
ACAGATGTGTTGCCATGTTACTTAGTCATACTAGAGAGCCAGCCAAGTTTGAATAATGAAGGTGCAGACGTGTTGTCTTCTTCACTGACA
AGCTGTCTGAACAAGGAGCCAGGAACTGTCGGGTCACCAGCTGTGGAGCGTGCCGGGGGGACAACCTGCCATTGGATGTAGAGAAAAGTG
CCTTAGAGTTGGCCTGAGCCCTCCTGCCCACTCGCCCTCCGCGCGACGCCACTCGGAGTCCACACGGCACACACAAGCGGAGCTGAGAAG
CACGATGGCTCTAGTCAGAGGACTTTGCTGTCGGTCCAGATTTGAAGAGGACACGGAACAGCATGAGCCTTTGTGACAAAACTAGAATTT
GGAAATGAGGACTGTCTTGGGAAAAGGGTAGACACAGGCACTTCTCTCCACAGCCTGCTAACCTAATGTGGGCAGAACTGAAAGATCACT
GCAGTGGAAACTGTTCTGGAAGAGGCTGCAACATAGCCCATGCTTAGGGACTGGATGGTTTTTGCAAGAGCTTTTTTTTTTTTTAAACTA
CCATCTCCCAACTTTTAAAGCCAGATACTTGACAAGGATTTTAGATCTTAATGGGTTCGATGGTAGGGAATACGGAAAGGATACACTGCT
AATATTGTGTCTAACAATAAAGCAAACAACTCGATGCTGTAAGAAGACAAGCTGTTTGAGCTTTCAAACACACATGCACACAGCACAATT
CAGAAATACCCAGGAGGATTCCTGCAGGCTTAACAGTTGGCATCGTACTGAAATGAAACGTGTATTAACAAGAAAATGTCAAACTTTTGG
GGAAACAAATTTTCTGTTACTTCCCACCCAACTAAAAGGGAAGATAAAACCATCATCACCAGAACAAAACAGATTTTCTCCAAACAAGTA
CAATGATAGTGCCGGGTTGGCAGTTAACTCTTTCACCCTACTAAATTCAAGAGCTCATCTCCACCCTGTCCTGTATATTTTCTACATTTC
TATTAAGAGGCTACTTGGTAGTGTCAGCGGGCATCTTTTACACCTTCTAGTAGCTCAAGCTAGTAAAACCTTGTACTTCTCTATTGCGCC

>In-frame_ACACA_ENST00000360679_chr17_35631084_-_FAM104A_ENST00000403627_chr17_71205907_-_3574nt
GGCAGCCAGGAGAGGCAGTGGAGCTTTTCTCCGTTGACTGTCAGAAGAAAGTGACTGTTGTTGAAAATGTTTGCTGCAACTAAAGGAGAG
CTGCTAAGATCTACTTTCTAGTTAAACAAGCTTTTATATTTCTCCCCGGCTCCTCTCAGTTCCCTTGGGAAATCAACTAATTGTGTGTGT
AAGCTAAGTGTGTGGAGGAGAGAAGATGCAAAAAGGAAGAGAAAGGTGGGGAAAGAAGGAAATTGGGAACAATTAGACAAAAAGACTATA
GTTTGAGGCCATCAGGAGTATTCTAGTCTGACTGAAGCCAGGCAGAAGGCACAGTATCTCTTGTCCTCCTGGGTTTTAAGCAGCTGCAAC
AGGAGGAGGAACTGCGGCTTGTGTTTACAAGGCCGAAATCTGAAGAAAAAGCTTCCATTCTTTTCCCATCTTGATATGGAGGGTTCTCCA
GAGGAAAATAAGGAAATGAGATATTACATGCTTCAAAGGTCCAGCATGTCTGGCTTGCACCTAGTAAAGCAGGGCCGAGACAGAAAGAAA
ATAGATTCTCAACGAGATTTCACTGTGGCTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAGGTTCTTATT
GCTAACAATGGCATTGCAGCAGTGAAATGCATGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTC
GTTGTCATGGTCACACCTGAAGACCTTAAAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCAGTGCCTGGAGGACCAAAC
AACAACAACTATGCAAATGTGGAATTAATTCTTGATATTGCTAAAAGGATCCCAGTACAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCT
GAGAATCCCAAACTACCGGAACTTCTCTTGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGCCATGTGGGCTTTAGGGGATAAG
ATTGCATCTTCCATAGTGGCTCAAACTGCAGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGAT
TTTTCAAAACGTATCTTAAATGTTCCCCAGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTACAGTCTTCAGGCAGT
GACAGTGGTGGGAGCAGCAGCAGCAGCAGCAGCAGCATCAATAGCCCGGACAGGGCCAGCGGGCCGGAAGGCAGCTTGAGCCAGACCATG
GCCGGATCCAGCCCTAACACGCCTCAGCCCGTGCCCGAGCAGTCCGCGCTGTGCCAAGGCCTCTACTTCCACATCAACCAGACCCTGAGG
GAGGCCCACTTCCACAGCCTACAGCACCGAGGGCGGCCTCTGACATGATGTGCCGGCAGTTTCTTGCCTTCTGTGAAGGGACAGCGCTGT
GCAGATTTGATATTTCAACTTACAACTTGTTTTAAAAGAAAAATTGCACACGAAAAATGCCTGTTGGCTTTTCAGTCTATATTTGAAATA
ACAGGTTAACAGGCAGTTGTTTACTTGTGGTTTTGCTGCACTATTGCAATTTCAAAGGGGCTTTGAAGCAATTTTTTATAGGATTCTTTT
GAGGGAGGGTATCAAATCTATGTCAAGGTAGTGGTTTGAGGAAAACTCATTCTGTGTGTTGAATCCATAGTATGTCCCATTCAGACTGAT
TTCCAAATCTGTCAACTAGAAACTCTACTTTATGTAAAGGGCCTTTTAAAAATGCGGGATCTTCAATTTTTTTTATTCAATAAACTAGTA
AAGAGTATCTAGTTTCCATGAAAAAACATAAGTTTTTTTCCAAAATATAGGAAGCTTGATTCAGTCTTGCACTGAAATTAACTGCCATAC
TACCTCTCAGTATGTAGATGTTCTATTGAAAGTACTCTCTCCTGTGTAACAGGAGAACAATCAGATCCAATTCAGACTGTCAGTGAAGCA
CACTCCCTAATAATAGTCTCTACTCTTTGTTATATATTTGTATTTCCAGAGAGAATGTCTTTTAGATTCTTGTATACCCAGATAACTTCT
GTGTCACTATTCCACCAGAGTCTGCACCTCAGACTTTAGTAGGAAACATGGCACAGTTCTGCAAGTAAAGTAATATGTAATGACTTTTTG
TCCTACAAACTTGGTCAGTCAGCAGCTTACATGATCTCATTGACAATTCCACCTTGTAGTGTCAACAATTAAGGTGTTGTTGAACGCTGA
TAAAATGTAAGCTACCTGAACTGATGTCTAAAGCAACAAGTATTGTGAAATTTTGGGACAAGGATTAACTTGATGCTTAAAGTAACCCCC
AACAGTAACTAGGGGGCCACATTCCATCAGTGAAACTGGAAAGATTGGTGTGGCTGAGAATCAGATGAGCAGAGGCACCTTTAGAAGAAA
TAATGTGGTAGTATTTATTTAGGGAGAGACAGATGTGTTGCCATGTTACTTAGTCATACTAGAGAGCCAGCCAAGTTTGAATAATGAAGG
TGCAGACGTGTTGTCTTCTTCACTGACAAGCTGTCTGAACAAGGAGCCAGGAACTGTCGGGTCACCAGCTGTGGAGCGTGCCGGGGGGAC
AACCTGCCATTGGATGTAGAGAAAAGTGCCTTAGAGTTGGCCTGAGCCCTCCTGCCCACTCGCCCTCCGCGCGACGCCACTCGGAGTCCA
CACGGCACACACAAGCGGAGCTGAGAAGCACGATGGCTCTAGTCAGAGGACTTTGCTGTCGGTCCAGATTTGAAGAGGACACGGAACAGC
ATGAGCCTTTGTGACAAAACTAGAATTTGGAAATGAGGACTGTCTTGGGAAAAGGGTAGACACAGGCACTTCTCTCCACAGCCTGCTAAC
CTAATGTGGGCAGAACTGAAAGATCACTGCAGTGGAAACTGTTCTGGAAGAGGCTGCAACATAGCCCATGCTTAGGGACTGGATGGTTTT
TGCAAGAGCTTTTTTTTTTTTTAAACTACCATCTCCCAACTTTTAAAGCCAGATACTTGACAAGGATTTTAGATCTTAATGGGTTCGATG
GTAGGGAATACGGAAAGGATACACTGCTAATATTGTGTCTAACAATAAAGCAAACAACTCGATGCTGTAAGAAGACAAGCTGTTTGAGCT
TTCAAACACACATGCACACAGCACAATTCAGAAATACCCAGGAGGATTCCTGCAGGCTTAACAGTTGGCATCGTACTGAAATGAAACGTG
TATTAACAAGAAAATGTCAAACTTTTGGGGAAACAAATTTTCTGTTACTTCCCACCCAACTAAAAGGGAAGATAAAACCATCATCACCAG
AACAAAACAGATTTTCTCCAAACAAGTACAATGATAGTGCCGGGTTGGCAGTTAACTCTTTCACCCTACTAAATTCAAGAGCTCATCTCC
ACCCTGTCCTGTATATTTTCTACATTTCTATTAAGAGGCTACTTGGTAGTGTCAGCGGGCATCTTTTACACCTTCTAGTAGCTCAAGCTA


Top

FusionGenePPI for ACACA_FAM104A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACACABRCA1, CHGB, PRKAA2, MLLT3, MLLT1, NPM1, AKR1B10, SIRT1, ARRB1, SIRT7, UBE2N, ATXN1, INPPL1, CBL, UBASH3B, PIK3R2, SHC1, AP2M1, ERCC6L, IKBKAP, CA9, VCP, FN1, IFIT1, FBXO6, CCT3, COPB1, DCAF6, EPB41L1, KIF5B, NUP50, PSMB7, SMEK1, EEF2K, STK25, PHKG2, ADRBK1, CSNK1A1, CSNK1E, PRKAA1, STK3, ILK, RPS6KA1, RIOK2, PRKAB1, PRKAG1, FUS, ENO1, MOV10, NXF1, MDM2, SUZ12, RNF2, BMI1, EGFR, SOCS6, SGCZ, C20orf195, PSG1, ARHGAP25, LIPH, IARS, PSMB2, PSMC6, PSMD2, NTRK1, PTEN, NDUFA4, C15orf48, COQ9, ZNF746, OAS2, LGALS3BP, C4orf26, TRIM25FAM104AVCP, MOV10, NXF1, UBXN2B, UBXN6, NSFL1C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ACACA_FAM104A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneACACAQ13085DB00121BiotinAcetyl-CoA carboxylase 1small moleculeapproved|investigational|nutraceutical

Top

RelatedDiseases for ACACA_FAM104A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACACAC0018801Heart failure1CTD_human
HgeneACACAC2239176Liver carcinoma1CTD_human