FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 30791

FusionGeneSummary for RBM6_IDH2

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM6_IDH2
Fusion gene ID: 30791
HgeneTgene
Gene symbol

RBM6

IDH2

Gene ID

10180

3418

Gene nameRNA binding motif protein 6isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Synonyms3G2|DEF-3|DEF3|HLC-11|NY-LU-12|g16D2HGA2|ICD-M|IDH|IDHM|IDP|IDPM|mNADP-IDH
Cytomap

3p21.31

15q26.1

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 6RNA-binding protein DEF-3lung cancer antigen NY-LU-12lung cancer protooncogene 11isocitrate dehydrogenase [NADP], mitochondrialNADP(+)-specific ICDHisocitrate dehydrogenase 2 (NADP+), mitochondrialoxalosuccinate decarboxylase
Modification date2018051920180522
UniProtAcc

P78332

P48735

Ensembl transtripts involved in fusion geneENST00000442092, ENST00000266022, 
ENST00000443081, ENST00000539992, 
ENST00000441115, ENST00000422955, 
ENST00000421682, 
ENST00000330062, 
ENST00000539790, ENST00000559482, 
ENST00000540499, 
Fusion gene scores* DoF score13 X 10 X 6=7804 X 4 X 3=48
# samples 135
** MAII scorelog2(13/780*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RBM6 [Title/Abstract] AND IDH2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-85-A53L-01ARBM6chr3

49977658

+IDH2chr15

90634876

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000442092ENST00000330062RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-intronENST00000442092ENST00000539790RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-intronENST00000442092ENST00000559482RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-5UTRENST00000442092ENST00000540499RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-3CDSENST00000266022ENST00000330062RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-intronENST00000266022ENST00000539790RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-intronENST00000266022ENST00000559482RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-5UTRENST00000266022ENST00000540499RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-3CDSENST00000443081ENST00000330062RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-intronENST00000443081ENST00000539790RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-intronENST00000443081ENST00000559482RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-5UTRENST00000443081ENST00000540499RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-3CDSENST00000539992ENST00000330062RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-intronENST00000539992ENST00000539790RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-intronENST00000539992ENST00000559482RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-5UTRENST00000539992ENST00000540499RBM6chr3

49977658

+IDH2chr15

90634876

-
3UTR-3CDSENST00000441115ENST00000330062RBM6chr3

49977658

+IDH2chr15

90634876

-
3UTR-intronENST00000441115ENST00000539790RBM6chr3

49977658

+IDH2chr15

90634876

-
3UTR-intronENST00000441115ENST00000559482RBM6chr3

49977658

+IDH2chr15

90634876

-
3UTR-5UTRENST00000441115ENST00000540499RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-3CDSENST00000422955ENST00000330062RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-intronENST00000422955ENST00000539790RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-intronENST00000422955ENST00000559482RBM6chr3

49977658

+IDH2chr15

90634876

-
5UTR-5UTRENST00000422955ENST00000540499RBM6chr3

49977658

+IDH2chr15

90634876

-
intron-3CDSENST00000421682ENST00000330062RBM6chr3

49977658

+IDH2chr15

90634876

-
intron-intronENST00000421682ENST00000539790RBM6chr3

49977658

+IDH2chr15

90634876

-
intron-intronENST00000421682ENST00000559482RBM6chr3

49977658

+IDH2chr15

90634876

-
intron-5UTRENST00000421682ENST00000540499RBM6chr3

49977658

+IDH2chr15

90634876

-

Top

FusionProtFeatures for RBM6_IDH2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBM6

P78332

IDH2

P48735

Specifically binds poly(G) RNA homopolymers in vitro. Plays a role in intermediary metabolism and energyproduction. It may tightly associate or interact with the pyruvatedehydrogenase complex.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RBM6_IDH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RBM6_IDH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBM6SIRT7, TAF7, SF3B3, ASB12, ASB18, EEF1G, SHMT2, NXF1, FGL1, HNRNPA1, PPP1CB, EMC2, MATR3, PAPD5, MMGT1, NAGK, MITF, CEPT1, ALS2, ZC3H18, PAK7, TRIM25, BRCA1IDH2CDK2, HDAC1, ADRB2, PYGL, EGFR, KCMF1, IDH1, G6PD, IDH3A, IDH3B, IDH3G, NTRK1, MUS81, KBTBD7, ZNF746, SLC39A9, C1orf85, MAS1, SLC15A1, PA2G4, TRAP1, SND1, ANXA5, SNRPB2, EIF5B, GPI, PDIA3, UBE2N, MRPL12, CRNN, ZNF207, COQ2, SOAT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RBM6_IDH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RBM6_IDH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIDH2C0014084Enchondromatosis2CTD_human;HPO;ORPHANET
TgeneIDH2C0079774Peripheral T-Cell Lymphoma2CTD_human
TgeneIDH2C0936248Chondroma2CTD_human
TgeneIDH2C2750850GLIOMA SUSCEPTIBILITY 12UNIPROT
TgeneIDH2C0018916Hemangioma1CTD_human
TgeneIDH2C0020981Angioimmunoblastic Lymphadenopathy1CTD_human
TgeneIDH2C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneIDH2C0023487Acute Promyelocytic Leukemia1CTD_human
TgeneIDH2C0027643Neoplasm Recurrence, Local1CTD_human
TgeneIDH2C0028945oligodendroglioma1CTD_human;ORPHANET
TgeneIDH2C0029408Degenerative polyarthritis1CTD_human
TgeneIDH2C0029456Osteoporosis1CTD_human
TgeneIDH2C0206698Cholangiocarcinoma1CTD_human
TgeneIDH2C3150909D-2-HYDROXYGLUTARIC ACIDURIA 21UNIPROT