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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30785

FusionGeneSummary for RBM6_BCR

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM6_BCR
Fusion gene ID: 30785
HgeneTgene
Gene symbol

RBM6

BCR

Gene ID

10180

613

Gene nameRNA binding motif protein 6BCR, RhoGEF and GTPase activating protein
Synonyms3G2|DEF-3|DEF3|HLC-11|NY-LU-12|g16ALL|BCR1|CML|D22S11|D22S662|PHL
Cytomap

3p21.31

22q11.23

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 6RNA-binding protein DEF-3lung cancer antigen NY-LU-12lung cancer protooncogene 11breakpoint cluster region proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26
Modification date2018051920180527
UniProtAcc

P78332

P11274

Ensembl transtripts involved in fusion geneENST00000442092, ENST00000266022, 
ENST00000443081, ENST00000539992, 
ENST00000441115, ENST00000422955, 
ENST00000421682, 
ENST00000305877, 
ENST00000359540, ENST00000398512, 
ENST00000436990, 
Fusion gene scores* DoF score13 X 10 X 6=7806 X 12 X 4=288
# samples 1315
** MAII scorelog2(13/780*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/288*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBM6 [Title/Abstract] AND BCR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN425514RBM6chr3

50000120

+BCRchr22

23530035

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000442092ENST00000305877RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000442092ENST00000359540RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000442092ENST00000398512RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000442092ENST00000436990RBM6chr3

50000120

+BCRchr22

23530035

+
5CDS-intronENST00000266022ENST00000305877RBM6chr3

50000120

+BCRchr22

23530035

+
5CDS-intronENST00000266022ENST00000359540RBM6chr3

50000120

+BCRchr22

23530035

+
5CDS-intronENST00000266022ENST00000398512RBM6chr3

50000120

+BCRchr22

23530035

+
5CDS-intronENST00000266022ENST00000436990RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000443081ENST00000305877RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000443081ENST00000359540RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000443081ENST00000398512RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000443081ENST00000436990RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000539992ENST00000305877RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000539992ENST00000359540RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000539992ENST00000398512RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000539992ENST00000436990RBM6chr3

50000120

+BCRchr22

23530035

+
3UTR-intronENST00000441115ENST00000305877RBM6chr3

50000120

+BCRchr22

23530035

+
3UTR-intronENST00000441115ENST00000359540RBM6chr3

50000120

+BCRchr22

23530035

+
3UTR-intronENST00000441115ENST00000398512RBM6chr3

50000120

+BCRchr22

23530035

+
3UTR-intronENST00000441115ENST00000436990RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000422955ENST00000305877RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000422955ENST00000359540RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000422955ENST00000398512RBM6chr3

50000120

+BCRchr22

23530035

+
5UTR-intronENST00000422955ENST00000436990RBM6chr3

50000120

+BCRchr22

23530035

+
intron-intronENST00000421682ENST00000305877RBM6chr3

50000120

+BCRchr22

23530035

+
intron-intronENST00000421682ENST00000359540RBM6chr3

50000120

+BCRchr22

23530035

+
intron-intronENST00000421682ENST00000398512RBM6chr3

50000120

+BCRchr22

23530035

+
intron-intronENST00000421682ENST00000436990RBM6chr3

50000120

+BCRchr22

23530035

+

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FusionProtFeatures for RBM6_BCR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBM6

P78332

BCR

P11274

Specifically binds poly(G) RNA homopolymers in vitro. GTPase-activating protein for RAC1 and CDC42. Promotesthe exchange of RAC or CDC42-bound GDP by GTP, thereby activatingthem. Displays serine/threonine kinase activity.{ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:1903516}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBM6_BCR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBM6_BCR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBM6_BCR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneBCRP11274DB06616BosutinibBreakpoint cluster region proteinsmall moleculeapproved
TgeneBCRP11274DB01254DasatinibBreakpoint cluster region proteinsmall moleculeapproved|investigational
TgeneBCRP11274DB08901PonatinibBreakpoint cluster region proteinsmall moleculeapproved|investigational

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RelatedDiseases for RBM6_BCR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBCRC0005586Bipolar Disorder4PSYGENET
TgeneBCRC0023473Myeloid Leukemia, Chronic3CTD_human;HPO;ORPHANET
TgeneBCRC0005699Blast Phase1CTD_human
TgeneBCRC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneBCRC0027022Myeloproliferative disease1CTD_human;HPO
TgeneBCRC0027540Necrosis1CTD_human
TgeneBCRC0027659Neoplasms, Experimental1CTD_human
TgeneBCRC0041696Unipolar Depression1PSYGENET
TgeneBCRC1269683Major Depressive Disorder1PSYGENET