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Fusion gene ID: 30781 |
FusionGeneSummary for RBM5_CYB561D2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RBM5_CYB561D2 | Fusion gene ID: 30781 | Hgene | Tgene | Gene symbol | RBM5 | CYB561D2 | Gene ID | 10181 | 11068 |
| Gene name | RNA binding motif protein 5 | cytochrome b561 family member D2 | |
| Synonyms | G15|H37|LUCA15|RMB5 | 101F6|TSP10|XXcos-LUCA11.4 | |
| Cytomap | 3p21.31 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein 5putative tumor suppressor LUCA15renal carcinoma antigen NY-REN-9 | cytochrome b561 domain-containing protein 2putative tumor suppressor protein 101F6 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P52756 | O14569 | |
| Ensembl transtripts involved in fusion gene | ENST00000347869, ENST00000469838, ENST00000441812, | ENST00000425346, ENST00000424512, ENST00000232508, ENST00000418577, ENST00000419046, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RBM5 [Title/Abstract] AND CYB561D2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RBM5 | GO:0000245 | spliceosomal complex assembly | 18951082 |
| Hgene | RBM5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 18840686|18951082 |
| Hgene | RBM5 | GO:0043065 | positive regulation of apoptotic process | 18840686 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-MG-AAMC-01A | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000347869 | ENST00000425346 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| Frame-shift | ENST00000347869 | ENST00000424512 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| Frame-shift | ENST00000347869 | ENST00000232508 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| In-frame | ENST00000347869 | ENST00000418577 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| 5CDS-3UTR | ENST00000347869 | ENST00000419046 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| intron-3CDS | ENST00000469838 | ENST00000425346 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| intron-3CDS | ENST00000469838 | ENST00000424512 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| intron-3CDS | ENST00000469838 | ENST00000232508 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| intron-3CDS | ENST00000469838 | ENST00000418577 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| intron-3UTR | ENST00000469838 | ENST00000419046 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| intron-3CDS | ENST00000441812 | ENST00000425346 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| intron-3CDS | ENST00000441812 | ENST00000424512 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| intron-3CDS | ENST00000441812 | ENST00000232508 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| intron-3CDS | ENST00000441812 | ENST00000418577 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
| intron-3UTR | ENST00000441812 | ENST00000419046 | RBM5 | chr3 | 50143142 | + | CYB561D2 | chr3 | 50390672 | + |
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FusionProtFeatures for RBM5_CYB561D2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RBM5 | CYB561D2 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RBM5_CYB561D2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RBM5_ENST00000347869_chr3_50143142_+_CYB561D2_ENST00000418577_chr3_50390672_+_453aa MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHD ISDERESKTIMLRGLPITITESDIREMMESFEGPQPADVRLMKRKTGVSRGFAFVEFYHLQDATSWMEANQKKLVIQGKHIAMHYSNPRP KFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESVQSVDYYCDTIILRNIAPHTVVDSIMTALSPYASLAVNNIRLIKDKQT QQNRGFAFVQLSSAMFSFLMTEALLVFSPESSLLHSLSRKGRARCHWVLQLLALLCALLGLGLVILHKEQLGKAHLVTRHGQAGLLAVLW AGLQCSGGVGLLYPKLLPRWPLAKLKLYHATSGLVGYLLGSASLLLGMCSLWFTASVTGAAWYLAVLCPVLTSLVIMNQVSNAYLYRKRI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RBM5_ENST00000347869_chr3_50143142_+_CYB561D2_ENST00000418577_chr3_50390672_+_1359nt ATGGGTTCAGACAAAAGAGTGAGTAGAACAGAGCGTAGTGGAAGATACGGTTCCATCATAGACAGGGATGACCGTGATGAGCGTGAATCC CGAAGCAGGCGGAGGGACTCAGATTACAAAAGATCTAGTGATGATCGGAGGGGTGATAGATATGATGACTACCGAGACTATGACAGTCCA GAGAGAGAGCGTGAAAGAAGGAACAGTGACCGATCCGAAGATGGCTACCATTCAGATGGTGACTATGGTGAGCACGACTATAGGCATGAC ATCAGTGACGAGAGGGAGAGCAAGACCATCATGCTGCGCGGCCTTCCCATCACCATCACAGAGAGCGATATTCGAGAAATGATGGAGTCC TTCGAAGGCCCTCAGCCTGCGGATGTGAGGCTGATGAAGAGGAAAACAGGTGTAAGCCGTGGTTTCGCCTTCGTGGAGTTTTATCACTTG CAAGATGCTACCAGCTGGATGGAAGCCAATCAGAAAAAGTTGGTGATTCAAGGAAAGCACATTGCAATGCATTATAGCAATCCCAGACCT AAGTTTGAAGATTGGCTTTGTAACAAGTGCTGCCTTAACAATTTCAGGAAAAGACTAAAATGCTTCCGATGTGGAGCAGACAAGTTTGAC TCTGAACAGGAAGTGCCTCCTGGAACCACAGAGTCGGTTCAGTCTGTGGATTACTACTGTGATACGATCATTCTTCGGAACATAGCTCCG CACACTGTGGTGGATTCCATCATGACAGCACTGTCTCCTTACGCGTCTTTAGCTGTCAATAACATCCGCCTCATAAAAGACAAACAGACC CAGCAGAACAGAGGCTTCGCATTTGTGCAGCTGTCCTCTGCAATGTTCTCCTTCCTGATGACCGAGGCACTACTGGTGTTTTCTCCTGAG AGTTCGCTGCTGCACTCCCTCTCACGGAAAGGCCGAGCACGCTGCCACTGGGTGCTGCAGCTGCTGGCCCTGCTGTGTGCACTGCTGGGC CTCGGCCTTGTCATCCTCCACAAAGAGCAGCTTGGCAAAGCCCACCTGGTTACGCGGCATGGGCAGGCAGGGCTGCTGGCTGTGCTGTGG GCAGGGCTGCAGTGCTCAGGTGGGGTGGGGCTGCTCTACCCCAAGCTGCTGCCCCGATGGCCCCTGGCGAAGCTCAAGCTATACCATGCT ACTTCTGGGCTGGTGGGCTACCTGCTGGGTAGTGCCAGCCTCTTGCTGGGCATGTGCTCACTCTGGTTCACTGCCTCTGTCACTGGTGCA GCCTGGTACCTGGCTGTATTATGCCCTGTCCTCACCAGCTTGGTCATTATGAACCAGGTGAGCAATGCCTACCTATACCGCAAGAGGATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RBM5_ENST00000347869_chr3_50143142_+_CYB561D2_ENST00000418577_chr3_50390672_+_1822nt AAGCGTGAGGTACTGTGGGTAGGAGACGGCCGTCGGCGGAGGCGCCATTTTGTGTAGCCGCCGAACCTTGTTGGAGGTTCTGGGGCGCAG AACCGCTACTGCTGCTTCGGTCTCTCCTTGGGAAAAAATAAAATTTGAACCTTTTGGAGCTGTGTGCTAAATCTTCAGTGGGACAATGGG TTCAGACAAAAGAGTGAGTAGAACAGAGCGTAGTGGAAGATACGGTTCCATCATAGACAGGGATGACCGTGATGAGCGTGAATCCCGAAG CAGGCGGAGGGACTCAGATTACAAAAGATCTAGTGATGATCGGAGGGGTGATAGATATGATGACTACCGAGACTATGACAGTCCAGAGAG AGAGCGTGAAAGAAGGAACAGTGACCGATCCGAAGATGGCTACCATTCAGATGGTGACTATGGTGAGCACGACTATAGGCATGACATCAG TGACGAGAGGGAGAGCAAGACCATCATGCTGCGCGGCCTTCCCATCACCATCACAGAGAGCGATATTCGAGAAATGATGGAGTCCTTCGA AGGCCCTCAGCCTGCGGATGTGAGGCTGATGAAGAGGAAAACAGGTGTAAGCCGTGGTTTCGCCTTCGTGGAGTTTTATCACTTGCAAGA TGCTACCAGCTGGATGGAAGCCAATCAGAAAAAGTTGGTGATTCAAGGAAAGCACATTGCAATGCATTATAGCAATCCCAGACCTAAGTT TGAAGATTGGCTTTGTAACAAGTGCTGCCTTAACAATTTCAGGAAAAGACTAAAATGCTTCCGATGTGGAGCAGACAAGTTTGACTCTGA ACAGGAAGTGCCTCCTGGAACCACAGAGTCGGTTCAGTCTGTGGATTACTACTGTGATACGATCATTCTTCGGAACATAGCTCCGCACAC TGTGGTGGATTCCATCATGACAGCACTGTCTCCTTACGCGTCTTTAGCTGTCAATAACATCCGCCTCATAAAAGACAAACAGACCCAGCA GAACAGAGGCTTCGCATTTGTGCAGCTGTCCTCTGCAATGTTCTCCTTCCTGATGACCGAGGCACTACTGGTGTTTTCTCCTGAGAGTTC GCTGCTGCACTCCCTCTCACGGAAAGGCCGAGCACGCTGCCACTGGGTGCTGCAGCTGCTGGCCCTGCTGTGTGCACTGCTGGGCCTCGG CCTTGTCATCCTCCACAAAGAGCAGCTTGGCAAAGCCCACCTGGTTACGCGGCATGGGCAGGCAGGGCTGCTGGCTGTGCTGTGGGCAGG GCTGCAGTGCTCAGGTGGGGTGGGGCTGCTCTACCCCAAGCTGCTGCCCCGATGGCCCCTGGCGAAGCTCAAGCTATACCATGCTACTTC TGGGCTGGTGGGCTACCTGCTGGGTAGTGCCAGCCTCTTGCTGGGCATGTGCTCACTCTGGTTCACTGCCTCTGTCACTGGTGCAGCCTG GTACCTGGCTGTATTATGCCCTGTCCTCACCAGCTTGGTCATTATGAACCAGGTGAGCAATGCCTACCTATACCGCAAGAGGATCCAACC ATGAGCTCTTCCCAGCCTAGGGGAAGCCTGGATTTGCCCCTCCATGTAGGAGCTGGGCCTAGGGACCTGTTGAACTCTCTCAGCTGAGTC AGGGGACACCTCAGGCACTGGGACAGTTGGGCATTTGGAGGCCCGTGTGTGAATTCCTGCTCCTCATGCTGGAGTGCCTCCCATTTCCTT CCCCTTTCTCTGTCATCCCAGAGGAACATAGGCATCATGTGTCTGGATGAAGCTGGGGCTGCAAGACTGCCTCTCCTGCAAGGCAGCTCA |
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FusionGenePPI for RBM5_CYB561D2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RBM5 | LRIF1, BCL2L1, GAPDH, SF3A2, COPS5, LIG4, DHX15, U2SURP, ILF3, LSM8, PRPF19, WBP11, WDR77, PRPF8, SNRNP200, U2AF2, MOV10, NXF1, ZDHHC17, SUZ12, RNF2, PHF19, RPL14, RPS8, ZRSR2, FBXW11, MYO1C, XRCC3, EMC2, FGFR1OP, MMGT1, RBM17, SNRPE, WDR46, VTN | CYB561D2 | UNC119, APP, CLNK, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RBM5_CYB561D2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RBM5_CYB561D2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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