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Fusion gene ID: 30720 |
FusionGeneSummary for RBM25_CENPT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RBM25_CENPT | Fusion gene ID: 30720 | Hgene | Tgene | Gene symbol | RBM25 | CENPT | Gene ID | 58517 | 80152 |
| Gene name | RNA binding motif protein 25 | centromere protein T | |
| Synonyms | NET52|RED120|RNPC7|S164|Snu71|fSAP94 | C16orf56|CENP-T | |
| Cytomap | 14q24.2 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein 25Arg/Glu/Asp-rich protein, 120 kDaRNA-binding region (RNP1, RRM) containing 7RNA-binding region-containing protein 7U1 small nuclear ribonucleoprotein 1SNRP homologarg/Glu/Asp-rich protein of 120 kDafunctional spliceosome-associ | centromere protein Tinterphase centromere complex protein 22 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P49756 | Q96BT3 | |
| Ensembl transtripts involved in fusion gene | ENST00000261973, ENST00000540173, ENST00000527432, ENST00000525321, ENST00000526754, ENST00000532483, | ENST00000562787, ENST00000440851, ENST00000219172, ENST00000564817, ENST00000562947, ENST00000445712, | |
| Fusion gene scores | * DoF score | 6 X 10 X 4=240 | 3 X 3 X 1=9 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RBM25 [Title/Abstract] AND CENPT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RBM25 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 18663000 |
| Hgene | RBM25 | GO:0042981 | regulation of apoptotic process | 18663000 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI029781 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000261973 | ENST00000562787 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000261973 | ENST00000440851 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000261973 | ENST00000219172 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000261973 | ENST00000564817 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000261973 | ENST00000562947 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000261973 | ENST00000445712 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000540173 | ENST00000562787 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000540173 | ENST00000440851 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000540173 | ENST00000219172 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000540173 | ENST00000564817 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000540173 | ENST00000562947 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000540173 | ENST00000445712 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000527432 | ENST00000562787 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000527432 | ENST00000440851 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000527432 | ENST00000219172 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000527432 | ENST00000564817 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000527432 | ENST00000562947 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000527432 | ENST00000445712 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000525321 | ENST00000562787 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000525321 | ENST00000440851 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000525321 | ENST00000219172 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000525321 | ENST00000564817 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000525321 | ENST00000562947 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000525321 | ENST00000445712 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000526754 | ENST00000562787 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000526754 | ENST00000440851 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000526754 | ENST00000219172 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000526754 | ENST00000564817 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000526754 | ENST00000562947 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000526754 | ENST00000445712 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000532483 | ENST00000562787 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000532483 | ENST00000440851 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000532483 | ENST00000219172 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000532483 | ENST00000564817 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000532483 | ENST00000562947 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
| intron-intron | ENST00000532483 | ENST00000445712 | RBM25 | chr14 | 73554901 | - | CENPT | chr16 | 67877641 | - |
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FusionProtFeatures for RBM25_CENPT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RBM25 | CENPT |
| Component of the CENPA-NAC (nucleosome-associated)complex, a complex that plays a central role in assembly ofkinetochore proteins, mitotic progression and chromosomesegregation. The CENPA-NAC complex recruits the CENPA-CAD(nucleosome distal) complex and may be involved in incorporationof newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed tonucleosomes containing CENPA. Component of the heterotetramericCENP-T-W-S-X complex that binds and supercoils DNA, and plays animportant role in kinetochore assembly. CENPT has a fundamentalrole in kinetochore assembly and function. It is one of the innerkinetochore proteins, with most further proteins bindingdownstream. Required for normal chromosome organization and normalprogress through mitosis. {ECO:0000269|PubMed:16716197,ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RBM25_CENPT |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RBM25_CENPT |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RBM25_CENPT |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RBM25_CENPT |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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