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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30694

FusionGeneSummary for RBM12_LPO

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM12_LPO
Fusion gene ID: 30694
HgeneTgene
Gene symbol

RBM12

LPO

Gene ID

10137

4025

Gene nameRNA binding motif protein 12lactoperoxidase
SynonymsHRIHFB2091|SCZD19|SWANSPO
Cytomap

20q11.22

17q22

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 12SH3/WW domain anchor protein in the nucleuslactoperoxidasesalivary peroxidase
Modification date2018051920180523
UniProtAcc

Q9NTZ6

P22079

Ensembl transtripts involved in fusion geneENST00000374114, ENST00000359646, 
ENST00000374104, 
ENST00000582328, 
ENST00000421678, ENST00000262290, 
ENST00000543544, 
Fusion gene scores* DoF score5 X 2 X 4=404 X 3 X 2=24
# samples 54
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RBM12 [Title/Abstract] AND LPO [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLPO

GO:0001580

detection of chemical stimulus involved in sensory perception of bitter taste

24248522

TgeneLPO

GO:0042742

defense response to bacterium

12626341


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0AM-01ARBM12chr20

34252682

-LPOchr17

56344710

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000374114ENST00000582328RBM12chr20

34252682

-LPOchr17

56344710

+
5UTR-3CDSENST00000374114ENST00000421678RBM12chr20

34252682

-LPOchr17

56344710

+
5UTR-3CDSENST00000374114ENST00000262290RBM12chr20

34252682

-LPOchr17

56344710

+
5UTR-3CDSENST00000374114ENST00000543544RBM12chr20

34252682

-LPOchr17

56344710

+
5UTR-3CDSENST00000359646ENST00000582328RBM12chr20

34252682

-LPOchr17

56344710

+
5UTR-3CDSENST00000359646ENST00000421678RBM12chr20

34252682

-LPOchr17

56344710

+
5UTR-3CDSENST00000359646ENST00000262290RBM12chr20

34252682

-LPOchr17

56344710

+
5UTR-3CDSENST00000359646ENST00000543544RBM12chr20

34252682

-LPOchr17

56344710

+
5UTR-3CDSENST00000374104ENST00000582328RBM12chr20

34252682

-LPOchr17

56344710

+
5UTR-3CDSENST00000374104ENST00000421678RBM12chr20

34252682

-LPOchr17

56344710

+
5UTR-3CDSENST00000374104ENST00000262290RBM12chr20

34252682

-LPOchr17

56344710

+
5UTR-3CDSENST00000374104ENST00000543544RBM12chr20

34252682

-LPOchr17

56344710

+

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FusionProtFeatures for RBM12_LPO


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBM12

Q9NTZ6

LPO

P22079

Antimicrobial agent which utilizes hydrogen peroxide andthiocyanate (SCN) to generate the antimicrobial substancehypothiocyanous acid (HOSCN) (By similarity). May contribute toairway host defense against infection.{ECO:0000250|UniProtKB:A5JUY8, ECO:0000269|PubMed:12626341}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBM12_LPO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBM12_LPO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RBM12UBC, TBC1D4, HNRNPA1, SDHAF2, IGBP1, PSMD1, PLBD2, FN1, BIN1, GMPPB, GNE, RAB3GAP2, UBE4B, MOV10, NXF1, KLHL20, GAS2L1, HOXB5, WRAP73, CYP1A1, ADK, CBR1, DAZAP1, MTAP, PCBP1, SNX3, NTRK1, BRAP, SNRNP27, CCDC83, TMA16, USP47, GTF2E2, MRPS11, GSTO2, NAT16, FGB, CIR1, CNTF, TRIM25LPODDX31


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBM12_LPO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBM12_LPO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource