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Fusion gene ID: 30689 |
FusionGeneSummary for RBM10_YAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RBM10_YAP1 | Fusion gene ID: 30689 | Hgene | Tgene | Gene symbol | RBM10 | YAP1 | Gene ID | 8241 | 10413 |
| Gene name | RNA binding motif protein 10 | Yes associated protein 1 | |
| Synonyms | DXS8237E|GPATC9|GPATCH9|S1-1|TARPS|ZRANB5 | COB1|YAP|YAP2|YAP65|YKI | |
| Cytomap | Xp11.3 | 11q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein 10RNA-binding protein S1-1g patch domain-containing protein 9 | transcriptional coactivator YAP165 kDa Yes-associated proteinprotein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog | |
| Modification date | 20180520 | 20180527 | |
| UniProtAcc | P98175 | P46937 | |
| Ensembl transtripts involved in fusion gene | ENST00000377604, ENST00000329236, ENST00000345781, ENST00000478410, | ENST00000526343, ENST00000282441, ENST00000537274, ENST00000345877, ENST00000531439, ENST00000524575, ENST00000528834, | |
| Fusion gene scores | * DoF score | 11 X 8 X 5=440 | 13 X 7 X 11=1001 |
| # samples | 11 | 13 | |
| ** MAII score | log2(11/440*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/1001*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RBM10 [Title/Abstract] AND YAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | YAP1 | GO:0006974 | cellular response to DNA damage stimulus | 18280240 |
| Tgene | YAP1 | GO:0008283 | cell proliferation | 17974916 |
| Tgene | YAP1 | GO:0032570 | response to progesterone | 16772533 |
| Tgene | YAP1 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 16772533 |
| Tgene | YAP1 | GO:0045893 | positive regulation of transcription, DNA-templated | 20368466 |
| Tgene | YAP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 25796446 |
| Tgene | YAP1 | GO:0050767 | regulation of neurogenesis | 25433207 |
| Tgene | YAP1 | GO:0050847 | progesterone receptor signaling pathway | 16772533 |
| Tgene | YAP1 | GO:0060242 | contact inhibition | 17974916 |
| Tgene | YAP1 | GO:0065003 | protein-containing complex assembly | 20368466 |
| Tgene | YAP1 | GO:0071480 | cellular response to gamma radiation | 18280240 |
| Tgene | YAP1 | GO:0072091 | regulation of stem cell proliferation | 25433207 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0AY-01A | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000377604 | ENST00000526343 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000377604 | ENST00000282441 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000377604 | ENST00000537274 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000377604 | ENST00000345877 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000377604 | ENST00000531439 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000377604 | ENST00000524575 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000377604 | ENST00000528834 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000329236 | ENST00000526343 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000329236 | ENST00000282441 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000329236 | ENST00000537274 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000329236 | ENST00000345877 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000329236 | ENST00000531439 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000329236 | ENST00000524575 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000329236 | ENST00000528834 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000345781 | ENST00000526343 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000345781 | ENST00000282441 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000345781 | ENST00000537274 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000345781 | ENST00000345877 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000345781 | ENST00000531439 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000345781 | ENST00000524575 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| 5CDS-intron | ENST00000345781 | ENST00000528834 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| intron-intron | ENST00000478410 | ENST00000526343 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| intron-intron | ENST00000478410 | ENST00000282441 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| intron-intron | ENST00000478410 | ENST00000537274 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| intron-intron | ENST00000478410 | ENST00000345877 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| intron-intron | ENST00000478410 | ENST00000531439 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| intron-intron | ENST00000478410 | ENST00000524575 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
| intron-intron | ENST00000478410 | ENST00000528834 | RBM10 | chrX | 47006897 | + | YAP1 | chr11 | 102080248 | + |
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FusionProtFeatures for RBM10_YAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RBM10 | YAP1 |
| May be involved in post-transcriptional processing, mostprobably in mRNA splicing. Binds to RNA homopolymers, with apreference for poly(G) and poly(U) and little for poly(A) (Bysimilarity). May bind to specific miRNA hairpins(PubMed:28431233). {ECO:0000250|UniProtKB:P70501,ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:28431233}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RBM10_YAP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RBM10_YAP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RBM10 | PTBP2, FAM124A, NHP2L1, MYSM1, WDR82, SREK1, SF3A2, ARRB1, ARRB2, CUL3, UBQLN4, ATN1, EGFR, NOTCH1, MAGOH, EIF4A3, SMURF1, YWHAE, SNRPC, SF3A1, SF3B4, DHX15, U2AF2, U2AF1, U2SURP, CCAR1, RBM10, SF1, SUGP1, SRSF6, PRPF19, PRCC, IK, DHX38, DDX5, HNRNPK, RBM4, HNRNPH2, GPKOW, PTBP1, CSNK2A1, PAN2, LMNA, FBXO6, RPA3, RPA2, RPA1, ASB12, ZBTB1, AES, TBC1D22B, SHMT2, MOV10, NXF1, CUL7, OBSL1, WHSC1, FBXW11, SCARNA22, HIST1H3E, AHSA1, CSNK2A2, MYO1C, XRCC3, EMC2, HUWE1, SYNCRIP, PARD6B, MMGT1, ENTHD2, GAN, SNW1, RBM17, CYLD, YAP1, MTF1 | YAP1 | ERBB4, TP53BP2, KIF5A, SLC9A3R1, YWHAQ, RUNX3, RUNX2, RUNX1, TP73, TP63, WBP1, SMAD7, SMAD6, SCAMP3, AMOT, ITCH, EP300, BTRC, YWHAG, FBXW11, SMAD1, SMAD5, SMAD3, EGFR, ELAVL1, KLF5, LATS2, LATS1, PML, SUMO1, PTPN14, NFE2, POLR2A, AMOTL2, SRSF2, AHCYL1, UBQLN2, SULT1A1, UNK, UBA2, ZFYVE19, VPS4B, PRDX1, IGBP1, THUMPD1, ZPR1, NUBP2, UBE2L3, PIN1, USP9X, TTC9C, UCHL3, UBE2D1, UFM1, UBE2C, UBXN7, VPS25, TEAD1, CREB1, PPP1CA, AMOTL1, ARID1A, ARID1B, ATPIF1, BCL9L, CCDC85C, DPF2, INADL, LIN7C, MPDZ, MPP5, NF2, PARD3, PDLIM7, RAE1, RAPGEF2, RASSF8, SLC9A3R2, SMARCD1, TEAD3, TJP2, WBP2, YWHAB, YWHAE, YWHAH, YWHAZ, MAP2K1, ARFIP1, PAPOLA, PRMT3, RTF1, STAT1, TSNAX, TOM1, FBXW7, ABL1, ENO1, MOV10, NXF1, FAM189B, PRRG4, CYYR1, TEAD4, ARRDC1, LDLRAD4, STUB1, CPVL, ERP44, FASN, HSPH1, HSPA4L, HSPA4, HYOU1, MCMBP, RAPGEF6, PTCH1, PRRG2, NEDD8, TEAD2, XPO1, SMAD2, ENAH, CDH1, PTPN21, DEFA6, BAG4, CTNNB1, NUDT5, PRKD1, XRCC5, XRCC6, AHNAK, EPRS, THBS1, EEF1A1, EEF1A1P5, WWC3, TUBB, HRNR, PFKP, RPL6, COPA, VCP, EIF3B, CAD, RBM10, SUN2, SLC25A5, PSMD2, ACTN1, RRBP1, DDX3X, RPS4X, FAM120A, NCL, CSTF1, TMPO, MAP4, USP15, RPL7A, SNRPB, RPL18, SF3B3, FLG2, HSPB1, CCT2, SND1, PRPF8, EIF4B, HSP90B1, NPM1, PPP2R1A, CYFIP1, MATR3, TUBB6, HNRNPA2B1, RPS6, PSMC2, EIF3L, HNRNPR, IMMT, PHB2, RPS8, PTRF, RPL10A, PARP1, HIST1H1E, LMNB1, PA2G4, HNRNPF, ITGB1, NUMA1, SRSF6, TGM2, OGDH, PDIA3, RPL24, PHGDH, IPO5, TSR1, TRIP6, YBX1, SMARCA4, ATAD3A, RPL19, CCT5, PGAM5, SEC16A, AJUBA, PSMC5, UPF1, RPL15, XRN2, RPL13A, PSMC6, CNN2, HDAC1, HDAC2, SFN, SUPT16H, RBBP7, PRDX6, SEPT2, UQCRC2, MVD, MYH10, PLOD2, PSMD6, ADSS, PAICS, FUBP1, CIAPIN1, SFXN1, PSMA5, RPL9, DNAJC10, PTBP1, ANXA5, KPNA2, WDR1, C11orf84, H2AFY, JUN, RTN4, RPL14, H1FX, IGFBP7, ACTL6A, RPL17, ZYX, PSMB4, TWF1, HIST1H1B, TK1, CDC20, RAN, RPL21, SV2B, HN1L |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RBM10_YAP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RBM10_YAP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | YAP1 | C0027819 | Neuroblastoma | 1 | CTD_human |
| Tgene | YAP1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Tgene | YAP1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
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