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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30682

FusionGeneSummary for RBM10_PAPD4

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM10_PAPD4
Fusion gene ID: 30682
HgeneTgene
Gene symbol

RBM10

PAPD4

Gene ID

8241

Gene nameRNA binding motif protein 10
SynonymsDXS8237E|GPATC9|GPATCH9|S1-1|TARPS|ZRANB5
Cytomap

Xp11.3

Type of geneprotein-coding
DescriptionRNA-binding protein 10RNA-binding protein S1-1g patch domain-containing protein 9
Modification date20180520
UniProtAcc

P98175

Ensembl transtripts involved in fusion geneENST00000377604, ENST00000329236, 
ENST00000345781, ENST00000478410, 
ENST00000453514, ENST00000423041, 
ENST00000504233, ENST00000428308, 
ENST00000502269, ENST00000296783, 
Fusion gene scores* DoF score11 X 8 X 5=4405 X 5 X 2=50
# samples 115
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: RBM10 [Title/Abstract] AND PAPD4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI909496RBM10chrX

47004776

+PAPD4chr5

78908441

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000377604ENST00000453514RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000377604ENST00000423041RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000377604ENST00000504233RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000377604ENST00000428308RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-3UTRENST00000377604ENST00000502269RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000377604ENST00000296783RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000329236ENST00000453514RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000329236ENST00000423041RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000329236ENST00000504233RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000329236ENST00000428308RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-3UTRENST00000329236ENST00000502269RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000329236ENST00000296783RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000345781ENST00000453514RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000345781ENST00000423041RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000345781ENST00000504233RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000345781ENST00000428308RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-3UTRENST00000345781ENST00000502269RBM10chrX

47004776

+PAPD4chr5

78908441

+
5UTR-5UTRENST00000345781ENST00000296783RBM10chrX

47004776

+PAPD4chr5

78908441

+
intron-5UTRENST00000478410ENST00000453514RBM10chrX

47004776

+PAPD4chr5

78908441

+
intron-5UTRENST00000478410ENST00000423041RBM10chrX

47004776

+PAPD4chr5

78908441

+
intron-5UTRENST00000478410ENST00000504233RBM10chrX

47004776

+PAPD4chr5

78908441

+
intron-5UTRENST00000478410ENST00000428308RBM10chrX

47004776

+PAPD4chr5

78908441

+
intron-3UTRENST00000478410ENST00000502269RBM10chrX

47004776

+PAPD4chr5

78908441

+
intron-5UTRENST00000478410ENST00000296783RBM10chrX

47004776

+PAPD4chr5

78908441

+

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FusionProtFeatures for RBM10_PAPD4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBM10

P98175

PAPD4

May be involved in post-transcriptional processing, mostprobably in mRNA splicing. Binds to RNA homopolymers, with apreference for poly(G) and poly(U) and little for poly(A) (Bysimilarity). May bind to specific miRNA hairpins(PubMed:28431233). {ECO:0000250|UniProtKB:P70501,ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:28431233}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBM10_PAPD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBM10_PAPD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBM10_PAPD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBM10_PAPD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource