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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30677

FusionGeneSummary for RBL2_LCORL

check button Fusion gene summary
Fusion gene informationFusion gene name: RBL2_LCORL
Fusion gene ID: 30677
HgeneTgene
Gene symbol

RBL2

LCORL

Gene ID

5934

254251

Gene nameRB transcriptional corepressor like 2ligand dependent nuclear receptor corepressor like
SynonymsP130|Rb2MLR1
Cytomap

16q12.2

4p15.31

Type of geneprotein-codingprotein-coding
Descriptionretinoblastoma-like protein 2130 kDa retinoblastoma-associated proteinPRB2RBR-2retinoblastoma-like 2retinoblastoma-related protein 2ligand-dependent nuclear receptor corepressor-like proteinLCOR-like proteinMBLK1-related proteintranscription factor MLR1
Modification date2018052320180519
UniProtAcc

Q08999

Q8N3X6

Ensembl transtripts involved in fusion geneENST00000262133, ENST00000379935, 
ENST00000544545, 
ENST00000326877, 
ENST00000539056, ENST00000382224, 
ENST00000382226, ENST00000512376, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 2=8
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: RBL2 [Title/Abstract] AND LCORL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBL2

GO:0043550

regulation of lipid kinase activity

16286473


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB149026RBL2chr16

53493412

+LCORLchr4

17894370

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262133ENST00000326877RBL2chr16

53493412

+LCORLchr4

17894370

-
5CDS-intronENST00000262133ENST00000539056RBL2chr16

53493412

+LCORLchr4

17894370

-
5CDS-intronENST00000262133ENST00000382224RBL2chr16

53493412

+LCORLchr4

17894370

-
5CDS-intronENST00000262133ENST00000382226RBL2chr16

53493412

+LCORLchr4

17894370

-
5CDS-intronENST00000262133ENST00000512376RBL2chr16

53493412

+LCORLchr4

17894370

-
3UTR-intronENST00000379935ENST00000326877RBL2chr16

53493412

+LCORLchr4

17894370

-
3UTR-intronENST00000379935ENST00000539056RBL2chr16

53493412

+LCORLchr4

17894370

-
3UTR-intronENST00000379935ENST00000382224RBL2chr16

53493412

+LCORLchr4

17894370

-
3UTR-intronENST00000379935ENST00000382226RBL2chr16

53493412

+LCORLchr4

17894370

-
3UTR-intronENST00000379935ENST00000512376RBL2chr16

53493412

+LCORLchr4

17894370

-
5CDS-intronENST00000544545ENST00000326877RBL2chr16

53493412

+LCORLchr4

17894370

-
5CDS-intronENST00000544545ENST00000539056RBL2chr16

53493412

+LCORLchr4

17894370

-
5CDS-intronENST00000544545ENST00000382224RBL2chr16

53493412

+LCORLchr4

17894370

-
5CDS-intronENST00000544545ENST00000382226RBL2chr16

53493412

+LCORLchr4

17894370

-
5CDS-intronENST00000544545ENST00000512376RBL2chr16

53493412

+LCORLchr4

17894370

-

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FusionProtFeatures for RBL2_LCORL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBL2

Q08999

LCORL

Q8N3X6

Key regulator of entry into cell division. Directlyinvolved in heterochromatin formation by maintaining overallchromatin structure and, in particular, that of constitutiveheterochromatin by stabilizing histone methylation. Recruits andtargets histone methyltransferases KMT5B and KMT5C, leading toepigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor byrecruiting chromatin-modifying enzymes to promoters. Potentinhibitor of E2F-mediated trans-activation, associatespreferentially with E2F5. Binds to cyclins A and E. Binds to andmay be involved in the transforming capacity of the adenovirus E1Aprotein. May act as a tumor suppressor. May act as transcription activator that binds DNAelements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May playa role in spermatogenesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBL2_LCORL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBL2_LCORL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBL2_LCORL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBL2_LCORL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRBL2C0023434Chronic Lymphocytic Leukemia1CTD_human
HgeneRBL2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneRBL2C0919267ovarian neoplasm1CTD_human
TgeneLCORLC0005612Birth Weight1CTD_human