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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30660

FusionGeneSummary for RBFOX2_MED16

check button Fusion gene summary
Fusion gene informationFusion gene name: RBFOX2_MED16
Fusion gene ID: 30660
HgeneTgene
Gene symbol

RBFOX2

MED16

Gene ID

23543

10025

Gene nameRNA binding fox-1 homolog 2mediator complex subunit 16
SynonymsFOX2|Fox-2|HNRBP2|HRNBP2|RBM9|RTA|dJ106I20.3|fxhDRIP92|THRAP5|TRAP95
Cytomap

22q12.3

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionRNA binding protein fox-1 homolog 2RNA binding protein, fox-1 homolog 2RNA-binding motif protein 9fox-1 homolog Bfox-1 homologuehexaribonucleotide-binding protein 2repressor of tamoxifen transcriptional activitymediator of RNA polymerase II transcription subunit 16thyroid hormone receptor-associated protein 5thyroid hormone receptor-associated protein complex 95 kDa componentthyroid hormone receptor-associated protein, 95-kD subunitvitamin D3 receptor-intera
Modification date2018052320180523
UniProtAcc

O43251

Q9Y2X0

Ensembl transtripts involved in fusion geneENST00000405409, ENST00000414461, 
ENST00000449924, ENST00000262829, 
ENST00000397303, ENST00000359369, 
ENST00000416721, ENST00000438146, 
ENST00000395808, ENST00000589119, 
ENST00000312090, ENST00000269814, 
ENST00000325464, ENST00000606828, 
Fusion gene scores* DoF score13 X 8 X 8=8325 X 5 X 3=75
# samples 145
** MAII scorelog2(14/832*10)=-2.57115670119613
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBFOX2 [Title/Abstract] AND MED16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBFOX2

GO:0030520

intracellular estrogen receptor signaling pathway

11875103

HgeneRBFOX2

GO:0045892

negative regulation of transcription, DNA-templated

11875103

TgeneMED16

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

TgeneMED16

GO:0030518

intracellular steroid hormone receptor signaling pathway

11867769

TgeneMED16

GO:0030521

androgen receptor signaling pathway

12218053

TgeneMED16

GO:0045893

positive regulation of transcription, DNA-templated

10198638


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF766064RBFOX2chr22

36137340

+MED16chr19

876580

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000405409ENST00000395808RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000405409ENST00000589119RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000405409ENST00000312090RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000405409ENST00000269814RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000405409ENST00000325464RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000405409ENST00000606828RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000414461ENST00000395808RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000414461ENST00000589119RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000414461ENST00000312090RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000414461ENST00000269814RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000414461ENST00000325464RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000414461ENST00000606828RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000449924ENST00000395808RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000449924ENST00000589119RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000449924ENST00000312090RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000449924ENST00000269814RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000449924ENST00000325464RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000449924ENST00000606828RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000262829ENST00000395808RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000262829ENST00000589119RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000262829ENST00000312090RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000262829ENST00000269814RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000262829ENST00000325464RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000262829ENST00000606828RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000397303ENST00000395808RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000397303ENST00000589119RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000397303ENST00000312090RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000397303ENST00000269814RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000397303ENST00000325464RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000397303ENST00000606828RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000359369ENST00000395808RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000359369ENST00000589119RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000359369ENST00000312090RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000359369ENST00000269814RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000359369ENST00000325464RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000359369ENST00000606828RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000416721ENST00000395808RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000416721ENST00000589119RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000416721ENST00000312090RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000416721ENST00000269814RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000416721ENST00000325464RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000416721ENST00000606828RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000438146ENST00000395808RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000438146ENST00000589119RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000438146ENST00000312090RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000438146ENST00000269814RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000438146ENST00000325464RBFOX2chr22

36137340

+MED16chr19

876580

-
intron-intronENST00000438146ENST00000606828RBFOX2chr22

36137340

+MED16chr19

876580

-

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FusionProtFeatures for RBFOX2_MED16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RBFOX2

O43251

MED16

Q9Y2X0

Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:10198638,ECO:0000269|PubMed:10235266}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RBFOX2_MED16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RBFOX2_MED16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RBFOX2_MED16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RBFOX2_MED16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRBFOX2C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneRBFOX2C0036095Salivary Gland Neoplasms1CTD_human
TgeneMED16C0014175Endometriosis1CTD_human