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Fusion gene ID: 3064 |
FusionGeneSummary for ASXL2_HADHA |
Fusion gene summary |
Fusion gene information | Fusion gene name: ASXL2_HADHA | Fusion gene ID: 3064 | Hgene | Tgene | Gene symbol | ASXL2 | HADHA | Gene ID | 55252 | 3030 |
Gene name | ASXL transcriptional regulator 2 | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | |
Synonyms | ASXH2|SHAPNS | ECHA|GBP|HADH|LCEH|LCHAD|MTPA|TP-ALPHA | |
Cytomap | 2p23.3 | 2p23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | putative Polycomb group protein ASXL2additional sex combs like 2, transcriptional regulatoradditional sex combs-like protein 2polycomb group protein ASXH2 | trifunctional enzyme subunit alpha, mitochondrial3-ketoacyl-Coenzyme A (CoA) thiolase, alpha subunit3-oxoacyl-CoA thiolase78 kDa gastrin-binding proteingastrin-binding proteinhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase ( | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q76L83 | P40939 | |
Ensembl transtripts involved in fusion gene | ENST00000435504, ENST00000336112, ENST00000272341, ENST00000404843, ENST00000497092, | ENST00000380649, ENST00000457468, ENST00000461025, | |
Fusion gene scores | * DoF score | 13 X 7 X 8=728 | 8 X 7 X 7=392 |
# samples | 15 | 10 | |
** MAII score | log2(15/728*10)=-2.27897594970282 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/392*10)=-1.97085365434048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ASXL2 [Title/Abstract] AND HADHA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ASXL2 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway | 21047783 |
Hgene | ASXL2 | GO:0045600 | positive regulation of fat cell differentiation | 21047783 |
Hgene | ASXL2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 21047783 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-L5-A43M-01A | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
TCGA | LD | UCEC | TCGA-AX-A3FW-01A | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000435504 | ENST00000380649 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
5CDS-intron | ENST00000435504 | ENST00000457468 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
5CDS-intron | ENST00000435504 | ENST00000461025 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
5UTR-3CDS | ENST00000336112 | ENST00000380649 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
5UTR-intron | ENST00000336112 | ENST00000457468 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
5UTR-intron | ENST00000336112 | ENST00000461025 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
5UTR-3CDS | ENST00000272341 | ENST00000380649 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
5UTR-intron | ENST00000272341 | ENST00000457468 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
5UTR-intron | ENST00000272341 | ENST00000461025 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
intron-3CDS | ENST00000404843 | ENST00000380649 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
intron-intron | ENST00000404843 | ENST00000457468 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
intron-intron | ENST00000404843 | ENST00000461025 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
intron-3CDS | ENST00000497092 | ENST00000380649 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
intron-intron | ENST00000497092 | ENST00000457468 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
intron-intron | ENST00000497092 | ENST00000461025 | ASXL2 | chr2 | 26101035 | - | HADHA | chr2 | 26432758 | - |
Frame-shift | ENST00000435504 | ENST00000380649 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
5CDS-intron | ENST00000435504 | ENST00000457468 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
5CDS-intron | ENST00000435504 | ENST00000461025 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
In-frame | ENST00000336112 | ENST00000380649 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
5CDS-intron | ENST00000336112 | ENST00000457468 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
5CDS-intron | ENST00000336112 | ENST00000461025 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
5UTR-3CDS | ENST00000272341 | ENST00000380649 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
5UTR-intron | ENST00000272341 | ENST00000457468 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
5UTR-intron | ENST00000272341 | ENST00000461025 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
intron-3CDS | ENST00000404843 | ENST00000380649 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
intron-intron | ENST00000404843 | ENST00000457468 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
intron-intron | ENST00000404843 | ENST00000461025 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
5UTR-3CDS | ENST00000497092 | ENST00000380649 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
5UTR-intron | ENST00000497092 | ENST00000457468 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
5UTR-intron | ENST00000497092 | ENST00000461025 | ASXL2 | chr2 | 26022254 | - | HADHA | chr2 | 26432758 | - |
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FusionProtFeatures for ASXL2_HADHA |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ASXL2 | HADHA |
Putative Polycomb group (PcG) protein. PcG proteins actby forming multiprotein complexes, which are required to maintainthe transcriptionally repressive state of homeotic genesthroughout development. PcG proteins are not required to initiaterepression, but to maintain it during later stages of development.They probably act via methylation of histones, rendering chromatinheritably changed in its expressibility (By similarity). Involvedin transcriptional regulation mediated by ligand-bound nuclearhormone receptors, such as peroxisome proliferator-activatedreceptor gamma (PPARG). Acts as coactivator for PPARG and enhancesits adipocyte differentiation-inducing activity; the functionseems to involve differential recruitment of acetylated andmethylated histone H3. {ECO:0000250, ECO:0000269|PubMed:21047783}. | Bifunctional subunit. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000272341 | - | 1 | 13 | 1173_1176 | -241 | 919 | Compositional bias | Note=Poly-Ser |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000272341 | - | 1 | 13 | 303_307 | -241 | 919 | Compositional bias | Note=Poly-Leu |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000272341 | - | 1 | 13 | 654_684 | -241 | 919 | Compositional bias | Note=Ala-rich |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000272341 | - | 1 | 13 | 687_739 | -241 | 919 | Compositional bias | Note=Gly-rich |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000272341 | - | 1 | 13 | 95_235 | -241 | 919 | Compositional bias | Note=Ser-rich |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000404843 | - | 1 | 10 | 1173_1176 | -146 | 919 | Compositional bias | Note=Poly-Ser |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000404843 | - | 1 | 10 | 303_307 | -146 | 919 | Compositional bias | Note=Poly-Leu |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000404843 | - | 1 | 10 | 654_684 | -146 | 919 | Compositional bias | Note=Ala-rich |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000404843 | - | 1 | 10 | 687_739 | -146 | 919 | Compositional bias | Note=Gly-rich |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000404843 | - | 1 | 10 | 95_235 | -146 | 919 | Compositional bias | Note=Ser-rich |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000435504 | - | 1 | 13 | 1173_1176 | 19 | 1436 | Compositional bias | Note=Poly-Ser |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000435504 | - | 1 | 13 | 303_307 | 19 | 1436 | Compositional bias | Note=Poly-Leu |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000435504 | - | 1 | 13 | 654_684 | 19 | 1436 | Compositional bias | Note=Ala-rich |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000435504 | - | 1 | 13 | 687_739 | 19 | 1436 | Compositional bias | Note=Gly-rich |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000435504 | - | 1 | 13 | 95_235 | 19 | 1436 | Compositional bias | Note=Ser-rich |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000272341 | - | 1 | 13 | 174_178 | -241 | 919 | Motif | Nuclear localization signal |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000272341 | - | 1 | 13 | 887_891 | -241 | 919 | Motif | Note=LXXLL motif 2 |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000404843 | - | 1 | 10 | 174_178 | -146 | 919 | Motif | Nuclear localization signal |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000404843 | - | 1 | 10 | 887_891 | -146 | 919 | Motif | Note=LXXLL motif 2 |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000435504 | - | 1 | 13 | 174_178 | 19 | 1436 | Motif | Nuclear localization signal |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000435504 | - | 1 | 13 | 887_891 | 19 | 1436 | Motif | Note=LXXLL motif 2 |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000272341 | - | 1 | 13 | 1397_1434 | -241 | 919 | Zinc finger | Note=PHD-type%3B atypical |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000404843 | - | 1 | 10 | 1397_1434 | -146 | 919 | Zinc finger | Note=PHD-type%3B atypical |
Hgene | >ASXL2 | chr2:26101035 | chr2:26432758 | ENST00000435504 | - | 1 | 13 | 1397_1434 | 19 | 1436 | Zinc finger | Note=PHD-type%3B atypical |
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FusionGeneSequence for ASXL2_HADHA |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ASXL2_ENST00000336112_chr2_26022254_-_HADHA_ENST00000380649_chr2_26432758_-_545aa MSHKEILQVIQREGLKEISSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSS DGGSNKEGKKSRWKRKEIWRACNDQRIKGLDGTLPWSGPVQEEXIWSSTEGCXASGYSWCRADGSRHRPSLRGXGAKDYTXRCHPHCARP RTATSVQRIEXQSEEESSNIIXKGFHLQQLDWAAXLPRFXKGRHGDXSCVXGPXSXAQSAKGSRSGDSRSLYLCQXHICSPNQXNRCCQQ KTXEGDWHALLLSRGQDAAAGDYHDRENFQRHQCFSCSSWSQAGEGHHCGXGWTWLLYYQVSCAHDVXSHPNPPGRSXPEEAGFPDHKLW LSCGCRHTGGXSWCGCSETCGGRSGQSLWGAVWRWKPRTADTDGVQGLPRSXIWEGLLHLSGGCEEEGFEFXHGXYFSESEAASXVXSLI RRRHPVPPGDKICEXGSHVPARGDLGHTCRGRHRSRLWAWLPALSGRAFPLCGSVWRPEDSGPAQEIXSCLWKTVHPMPAASXPCXQPXQ >In-frame_ASXL2_ENST00000435504_chr2_26101035_-_HADHA_ENST00000380649_chr2_26432758_-_458aa MREKGRRKKGRTWAEAAKTKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQKDVKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTA LDRGQQQVFKGLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAA VSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTT SFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLKLPPKSE VSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKIVDRLKKYEAAYGKQFTPCQLLADHANS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ASXL2_ENST00000336112_chr2_26022254_-_HADHA_ENST00000380649_chr2_26432758_-_1636nt ATGAGTCATAAAGAAATTCTTCAAGTTATCCAGAGAGAAGGACTAAAAGAAATCAGCAGTGGGACTTCTCCTCTTGCATGCCTGAATGCA ATGCTTCACACAAACTCCAGAGGTGAAGAGGGCATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACTTTGAAGAAAGATGTGCCG GATGGGGTGAAAGAGCTGTCAGAAGGTTCAGAAGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAGAACAGCAGCAGCAGCAGT GATGGTGGCAGCAACAAGGAGGGAAAAAAGAGCAGGTGGAAAAGGAAAGAAATTTGGAGAGCTTGTAATGACCAAAGAATCAAAGGCCTT GATGGGACTCTACCATGGTCAGGTCCTGTGCAAGAAGAATAAATTTGGAGCTCCACAGAAGGATGTTAAGCATCTGGCTATTCTTGGTGC AGGGCTGATGGGAGCAGGCATCGCCCAAGTCTCCGTGGATAAGGGGCTAAAGACTATACTTAAAGATGCCACCCTCACTGCGCTAGACCG AGGACAGCAACAAGTGTTCAAAGGATTGAATGACAAAGTGAAGAAGAAAGCTCTAACATCATTTGAAAGGGATTCCATCTTCAGCAACTT GACTGGGCAGCTTGATTACCAAGGTTTTGAAAAGGCCGACATGGTGATTGAAGCTGTGTTTGAGGACCTTAGTCTTAAGCACAGAGTGCT AAAGGAAGTAGAAGCGGTGATTCCAGATCACTGTATCTTTGCCAGTAACACATCTGCTCTCCCAATCAGTGAAATCGCTGCTGTCAGCAA AAGACCTGAGAAGGTGATTGGCATGCACTACTTCTCTCCCGTGGACAAGATGCAGCTGCTGGAGATTATCACGACCGAGAAAACTTCCAA AGACACCAGTGCTTCAGCTGTAGCAGTTGGTCTCAAGCAGGGGAAGGTCATCATTGTGGTTAAGGATGGACCTGGCTTCTATACTACCAG GTGTCTTGCGCCCATGATGTCTGAAGTCATCCGAATCCTCCAGGAAGGAGTTGACCCGAAGAAGCTGGATTCCCTGACCACAAGCTTTGG CTTTCCTGTGGGTGCCGCCACACTGGTGGATGAAGTTGGTGTGGATGTAGCGAAACATGTGGCGGAAGATCTGGGCAAAGTCTTTGGGGA GCGGTTTGGAGGTGGAAACCCAGAACTGCTGACACAGATGGTGTCCAAGGGCTTCCTAGGTCGTAAATCTGGGAAGGGCTTTTACATCTA TCAGGAGGGTGTGAAGAGGAAGGATTTGAATTCTGACATGGATAGTATTTTAGCGAGTCTGAAGCTGCCTCCTAAGTCTGAAGTCTCATC AGACGAAGACATCCAGTTCCGCCTGGTGACAAGATTTGTGAATGAGGCAGTCATGTGCCTGCAAGAGGGGATCTTGGCCACACCTGCAGA GGGAGACATCGGAGCCGTCTTTGGGCTTGGCTTCCCGCCTTGTCTGGGAGGGCCTTTCCGCTTTGTGGATCTGTATGGCGCCCAGAAGAT AGTGGACCGGCTCAAGAAATATGAAGCTGCCTATGGAAAACAGTTCACCCCATGCCAGCTGCTAGCTGACCATGCTAACAGCCCTAACAA >In-frame_ASXL2_ENST00000435504_chr2_26101035_-_HADHA_ENST00000380649_chr2_26432758_-_1374nt ATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGAAATTTGGAGAGCTTGTAATGACCAAAGAATCA AAGGCCTTGATGGGACTCTACCATGGTCAGGTCCTGTGCAAGAAGAATAAATTTGGAGCTCCACAGAAGGATGTTAAGCATCTGGCTATT CTTGGTGCAGGGCTGATGGGAGCAGGCATCGCCCAAGTCTCCGTGGATAAGGGGCTAAAGACTATACTTAAAGATGCCACCCTCACTGCG CTAGACCGAGGACAGCAACAAGTGTTCAAAGGATTGAATGACAAAGTGAAGAAGAAAGCTCTAACATCATTTGAAAGGGATTCCATCTTC AGCAACTTGACTGGGCAGCTTGATTACCAAGGTTTTGAAAAGGCCGACATGGTGATTGAAGCTGTGTTTGAGGACCTTAGTCTTAAGCAC AGAGTGCTAAAGGAAGTAGAAGCGGTGATTCCAGATCACTGTATCTTTGCCAGTAACACATCTGCTCTCCCAATCAGTGAAATCGCTGCT GTCAGCAAAAGACCTGAGAAGGTGATTGGCATGCACTACTTCTCTCCCGTGGACAAGATGCAGCTGCTGGAGATTATCACGACCGAGAAA ACTTCCAAAGACACCAGTGCTTCAGCTGTAGCAGTTGGTCTCAAGCAGGGGAAGGTCATCATTGTGGTTAAGGATGGACCTGGCTTCTAT ACTACCAGGTGTCTTGCGCCCATGATGTCTGAAGTCATCCGAATCCTCCAGGAAGGAGTTGACCCGAAGAAGCTGGATTCCCTGACCACA AGCTTTGGCTTTCCTGTGGGTGCCGCCACACTGGTGGATGAAGTTGGTGTGGATGTAGCGAAACATGTGGCGGAAGATCTGGGCAAAGTC TTTGGGGAGCGGTTTGGAGGTGGAAACCCAGAACTGCTGACACAGATGGTGTCCAAGGGCTTCCTAGGTCGTAAATCTGGGAAGGGCTTT TACATCTATCAGGAGGGTGTGAAGAGGAAGGATTTGAATTCTGACATGGATAGTATTTTAGCGAGTCTGAAGCTGCCTCCTAAGTCTGAA GTCTCATCAGACGAAGACATCCAGTTCCGCCTGGTGACAAGATTTGTGAATGAGGCAGTCATGTGCCTGCAAGAGGGGATCTTGGCCACA CCTGCAGAGGGAGACATCGGAGCCGTCTTTGGGCTTGGCTTCCCGCCTTGTCTGGGAGGGCCTTTCCGCTTTGTGGATCTGTATGGCGCC CAGAAGATAGTGGACCGGCTCAAGAAATATGAAGCTGCCTATGGAAAACAGTTCACCCCATGCCAGCTGCTAGCTGACCATGCTAACAGC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ASXL2_ENST00000336112_chr2_26022254_-_HADHA_ENST00000380649_chr2_26432758_-_2579nt GTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGGCAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACC CCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACTTCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCA GAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGCCTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAA GGGCAGGACCTGGGCGGAGGCCGCCAAGACGGTCTTAGAAAAATACCCCAATACACCCATGAGTCATAAAGAAATTCTTCAAGTTATCCA GAGAGAAGGACTAAAAGAAATCAGCAGTGGGACTTCTCCTCTTGCATGCCTGAATGCAATGCTTCACACAAACTCCAGAGGTGAAGAGGG CATCTTCTATAAGGTTCCAGGTAGAATGGGAGTATATACTTTGAAGAAAGATGTGCCGGATGGGGTGAAAGAGCTGTCAGAAGGTTCAGA AGAAAGCAGTGATGGTCAGTCAGATTCCCAGAGTTCTGAGAACAGCAGCAGCAGCAGTGATGGTGGCAGCAACAAGGAGGGAAAAAAGAG CAGGTGGAAAAGGAAAGAAATTTGGAGAGCTTGTAATGACCAAAGAATCAAAGGCCTTGATGGGACTCTACCATGGTCAGGTCCTGTGCA AGAAGAATAAATTTGGAGCTCCACAGAAGGATGTTAAGCATCTGGCTATTCTTGGTGCAGGGCTGATGGGAGCAGGCATCGCCCAAGTCT CCGTGGATAAGGGGCTAAAGACTATACTTAAAGATGCCACCCTCACTGCGCTAGACCGAGGACAGCAACAAGTGTTCAAAGGATTGAATG ACAAAGTGAAGAAGAAAGCTCTAACATCATTTGAAAGGGATTCCATCTTCAGCAACTTGACTGGGCAGCTTGATTACCAAGGTTTTGAAA AGGCCGACATGGTGATTGAAGCTGTGTTTGAGGACCTTAGTCTTAAGCACAGAGTGCTAAAGGAAGTAGAAGCGGTGATTCCAGATCACT GTATCTTTGCCAGTAACACATCTGCTCTCCCAATCAGTGAAATCGCTGCTGTCAGCAAAAGACCTGAGAAGGTGATTGGCATGCACTACT TCTCTCCCGTGGACAAGATGCAGCTGCTGGAGATTATCACGACCGAGAAAACTTCCAAAGACACCAGTGCTTCAGCTGTAGCAGTTGGTC TCAAGCAGGGGAAGGTCATCATTGTGGTTAAGGATGGACCTGGCTTCTATACTACCAGGTGTCTTGCGCCCATGATGTCTGAAGTCATCC GAATCCTCCAGGAAGGAGTTGACCCGAAGAAGCTGGATTCCCTGACCACAAGCTTTGGCTTTCCTGTGGGTGCCGCCACACTGGTGGATG AAGTTGGTGTGGATGTAGCGAAACATGTGGCGGAAGATCTGGGCAAAGTCTTTGGGGAGCGGTTTGGAGGTGGAAACCCAGAACTGCTGA CACAGATGGTGTCCAAGGGCTTCCTAGGTCGTAAATCTGGGAAGGGCTTTTACATCTATCAGGAGGGTGTGAAGAGGAAGGATTTGAATT CTGACATGGATAGTATTTTAGCGAGTCTGAAGCTGCCTCCTAAGTCTGAAGTCTCATCAGACGAAGACATCCAGTTCCGCCTGGTGACAA GATTTGTGAATGAGGCAGTCATGTGCCTGCAAGAGGGGATCTTGGCCACACCTGCAGAGGGAGACATCGGAGCCGTCTTTGGGCTTGGCT TCCCGCCTTGTCTGGGAGGGCCTTTCCGCTTTGTGGATCTGTATGGCGCCCAGAAGATAGTGGACCGGCTCAAGAAATATGAAGCTGCCT ATGGAAAACAGTTCACCCCATGCCAGCTGCTAGCTGACCATGCTAACAGCCCTAACAAGAAGTTCTACCAGTGAGCAGGCCTCATGCCTC GCTCAGTCAGTGCACTAACCCCAGCTGCCGGCAGTGCTGGTTCTCCAACAGAGTGGTGTCTAGATTTATCAGAGTAACGAGAAGACAAAC TCCGGCACTGGGTTTGCTCCCTGATTAAAGTGCCTTCAGCCAAGACCATCTCTCCCTCCTGGTGAAGTGTGACTTCGAATTAGTTTGCAC TTCCTGTTGGAAGGTAGAGCCCACTGCTCATTGTATAAGCCCCGAGGCCTAGAGTGGCAGCCAAGAGCCATCTGAAGCCACCTCTCTGCC TGTTCCTCCCAAGAGGCCAGGGTGGCCAGGGGTGGTGAGGGCAGTTCTGCACCCAGCCAAACACATAACAATAAAAACCAAACTCTGTGT CAGCATCTTTGCCCTTCTGGTTTAAACGCCTCCTTCAAAAAGCAATCTGGAAGAAAGCCCTGTGCTTTGGGGGAGTAAGAATGTGTGTGC AGAATTCTAGGCAGCACCTTAGGGAGGGACTGGGATGAGAGAAAGTGGGACCTGGTGGGCTCAACCACACACACCTGTCTGTGCAGATGC >In-frame_ASXL2_ENST00000435504_chr2_26101035_-_HADHA_ENST00000380649_chr2_26432758_-_2283nt ACAGTAGTGACGGCCGCGCGGGAGCGGTCACATGACCGTAGCGGCAGCCTGTACAGTAAGAACCCAATATGGCAGCGGCGGTAGCAGTGG CAACGGCAGCAAGAGGACCGGCCGCCCCATAGACCCCCCCGCGCACCACCCCCGCCGCTTCCTCTGCTTGGGTGCCCCCCCGGTCTGACT TCCCTTTTCTCCCACCTTTCCCGGCACCGCGGGAAAAGCAGCGCAGGGCAGAGCAGGCAGGGAGGGCGGCCGGAGCCCGGACACGGGAGC CTCCCAGTCAGTTCAAGACCCGACATGAGGGAAAAGGGACGTAGGAAGAAGGGCAGGACCTGGGCGGAGGCCGCCAAGACGAAATTTGGA GAGCTTGTAATGACCAAAGAATCAAAGGCCTTGATGGGACTCTACCATGGTCAGGTCCTGTGCAAGAAGAATAAATTTGGAGCTCCACAG AAGGATGTTAAGCATCTGGCTATTCTTGGTGCAGGGCTGATGGGAGCAGGCATCGCCCAAGTCTCCGTGGATAAGGGGCTAAAGACTATA CTTAAAGATGCCACCCTCACTGCGCTAGACCGAGGACAGCAACAAGTGTTCAAAGGATTGAATGACAAAGTGAAGAAGAAAGCTCTAACA TCATTTGAAAGGGATTCCATCTTCAGCAACTTGACTGGGCAGCTTGATTACCAAGGTTTTGAAAAGGCCGACATGGTGATTGAAGCTGTG TTTGAGGACCTTAGTCTTAAGCACAGAGTGCTAAAGGAAGTAGAAGCGGTGATTCCAGATCACTGTATCTTTGCCAGTAACACATCTGCT CTCCCAATCAGTGAAATCGCTGCTGTCAGCAAAAGACCTGAGAAGGTGATTGGCATGCACTACTTCTCTCCCGTGGACAAGATGCAGCTG CTGGAGATTATCACGACCGAGAAAACTTCCAAAGACACCAGTGCTTCAGCTGTAGCAGTTGGTCTCAAGCAGGGGAAGGTCATCATTGTG GTTAAGGATGGACCTGGCTTCTATACTACCAGGTGTCTTGCGCCCATGATGTCTGAAGTCATCCGAATCCTCCAGGAAGGAGTTGACCCG AAGAAGCTGGATTCCCTGACCACAAGCTTTGGCTTTCCTGTGGGTGCCGCCACACTGGTGGATGAAGTTGGTGTGGATGTAGCGAAACAT GTGGCGGAAGATCTGGGCAAAGTCTTTGGGGAGCGGTTTGGAGGTGGAAACCCAGAACTGCTGACACAGATGGTGTCCAAGGGCTTCCTA GGTCGTAAATCTGGGAAGGGCTTTTACATCTATCAGGAGGGTGTGAAGAGGAAGGATTTGAATTCTGACATGGATAGTATTTTAGCGAGT CTGAAGCTGCCTCCTAAGTCTGAAGTCTCATCAGACGAAGACATCCAGTTCCGCCTGGTGACAAGATTTGTGAATGAGGCAGTCATGTGC CTGCAAGAGGGGATCTTGGCCACACCTGCAGAGGGAGACATCGGAGCCGTCTTTGGGCTTGGCTTCCCGCCTTGTCTGGGAGGGCCTTTC CGCTTTGTGGATCTGTATGGCGCCCAGAAGATAGTGGACCGGCTCAAGAAATATGAAGCTGCCTATGGAAAACAGTTCACCCCATGCCAG CTGCTAGCTGACCATGCTAACAGCCCTAACAAGAAGTTCTACCAGTGAGCAGGCCTCATGCCTCGCTCAGTCAGTGCACTAACCCCAGCT GCCGGCAGTGCTGGTTCTCCAACAGAGTGGTGTCTAGATTTATCAGAGTAACGAGAAGACAAACTCCGGCACTGGGTTTGCTCCCTGATT AAAGTGCCTTCAGCCAAGACCATCTCTCCCTCCTGGTGAAGTGTGACTTCGAATTAGTTTGCACTTCCTGTTGGAAGGTAGAGCCCACTG CTCATTGTATAAGCCCCGAGGCCTAGAGTGGCAGCCAAGAGCCATCTGAAGCCACCTCTCTGCCTGTTCCTCCCAAGAGGCCAGGGTGGC CAGGGGTGGTGAGGGCAGTTCTGCACCCAGCCAAACACATAACAATAAAAACCAAACTCTGTGTCAGCATCTTTGCCCTTCTGGTTTAAA CGCCTCCTTCAAAAAGCAATCTGGAAGAAAGCCCTGTGCTTTGGGGGAGTAAGAATGTGTGTGCAGAATTCTAGGCAGCACCTTAGGGAG GGACTGGGATGAGAGAAAGTGGGACCTGGTGGGCTCAACCACACACACCTGTCTGTGCAGATGCTTTGCCCAGGCTTCTCACCACGGTGT |
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FusionGenePPI for ASXL2_HADHA |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ASXL2 | TRAF6, BAP1, APP, PRPF40A, HECW2, KDM1B, MBD6, FOXK1, MBD5, EXOSC2, KRBOX4, FOXK2, OGT, HCFC1, UBC, TRIM25 | HADHA | USP49, ATG101, DDA1, GABARAPL1, GABARAPL2, GBAS, MAP1LC3A, MAP1LC3B, SQSTM1, PSMD4, UBC, ICT1, HDAC5, SPG20, LEO1, RTF1, SIRT7, CDK2, CAND1, HADHB, STT3B, PLOD3, MSN, ETFA, ZFR, TUBB4B, HNRNPH1, CA9, BTK, FN1, ATF2, IQCB1, PAN2, ABCF2, CD74, NR4A1, ATXN2L, YWHAQ, PPP6R1, PIN1, WWOX, ZBTB1, CSNK2A2, GRSF1, EMD, TUBG1, CUL7, CCDC8, ATL3, ATP1B1, EPHX1, MRPL40, NDUFB8, TOMM40, NTRK1, SCARNA22, MED4, MED23, CAPZA2, MYC, NAF1, SKI, FBXW7, MCM2, POU5F1, HSD17B10, NFATC2, CDC73, ZNF746, PTPN2, PTPRD, CD44, RELL2, SDC2, CDH5, CDH8, PARK7, VDAC1, TES |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ASXL2_HADHA |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ASXL2_HADHA |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ASXL2 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | ASXL2 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | HADHA | C1969443 | Trifunctional Protein Deficiency With Myopathy And Neuropathy | 5 | CTD_human;HPO;ORPHANET;UNIPROT |
Tgene | HADHA | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | HADHA | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | HADHA | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |