|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 30600 |
FusionGeneSummary for RB1CC1_PTPN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RB1CC1_PTPN3 | Fusion gene ID: 30600 | Hgene | Tgene | Gene symbol | RB1CC1 | PTPN3 | Gene ID | 9821 | 5774 |
| Gene name | RB1 inducible coiled-coil 1 | protein tyrosine phosphatase, non-receptor type 3 | |
| Synonyms | ATG17|CC1|FIP200|PPP1R131 | PTP-H1|PTPH1 | |
| Cytomap | 8q11.23 | 9q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RB1-inducible coiled-coil protein 1200 kDa FAK family kinase-interacting proteinFAK family kinase-interacting protein of 200 kDaphosphatase 1, regulatory subunit 131 | tyrosine-protein phosphatase non-receptor type 3cytoskeletal-associated protein tyrosine phosphataseprotein-tyrosine phosphatase H1 | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | Q8TDY2 | P26045 | |
| Ensembl transtripts involved in fusion gene | ENST00000025008, ENST00000435644, ENST00000521611, ENST00000539297, | ENST00000412145, ENST00000446349, ENST00000374541, ENST00000262539, ENST00000394827, ENST00000497739, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 4 X 4 X 3=48 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RB1CC1 [Title/Abstract] AND PTPN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTPN3 | GO:0006470 | protein dephosphorylation | 10364224 |
| Tgene | PTPN3 | GO:0045930 | negative regulation of mitotic cell cycle | 10364224 |
| Tgene | PTPN3 | GO:0098902 | regulation of membrane depolarization during action potential | 16930557 |
| Tgene | PTPN3 | GO:2000649 | regulation of sodium ion transmembrane transporter activity | 16930557 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A8IJ-01A | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000025008 | ENST00000412145 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| Frame-shift | ENST00000025008 | ENST00000446349 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| Frame-shift | ENST00000025008 | ENST00000374541 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| Frame-shift | ENST00000025008 | ENST00000262539 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| Frame-shift | ENST00000025008 | ENST00000394827 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| 5CDS-5UTR | ENST00000025008 | ENST00000497739 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| Frame-shift | ENST00000435644 | ENST00000412145 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| Frame-shift | ENST00000435644 | ENST00000446349 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| Frame-shift | ENST00000435644 | ENST00000374541 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| Frame-shift | ENST00000435644 | ENST00000262539 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| Frame-shift | ENST00000435644 | ENST00000394827 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| 5CDS-5UTR | ENST00000435644 | ENST00000497739 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| intron-3CDS | ENST00000521611 | ENST00000412145 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| intron-3CDS | ENST00000521611 | ENST00000446349 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| intron-3CDS | ENST00000521611 | ENST00000374541 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| intron-3CDS | ENST00000521611 | ENST00000262539 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| intron-3CDS | ENST00000521611 | ENST00000394827 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| intron-5UTR | ENST00000521611 | ENST00000497739 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| In-frame | ENST00000539297 | ENST00000412145 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| In-frame | ENST00000539297 | ENST00000446349 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| In-frame | ENST00000539297 | ENST00000374541 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| In-frame | ENST00000539297 | ENST00000262539 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| In-frame | ENST00000539297 | ENST00000394827 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
| 5CDS-5UTR | ENST00000539297 | ENST00000497739 | RB1CC1 | chr8 | 53580581 | - | PTPN3 | chr9 | 112153841 | - |
Top |
FusionProtFeatures for RB1CC1_PTPN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RB1CC1 | PTPN3 |
| Involved in autophagy (PubMed:21775823). Regulates earlyevents but also late events of autophagosome formation throughdirect interaction with Atg16L1 (PubMed:23392225). Required forthe formation of the autophagosome-like double-membrane structurethat surrounds the Salmonella-containing vacuole (SCV) duringS.typhimurium infection and subsequent xenophagy (By similarity).Involved in repair of DNA damage caused by ionizing radiation,which subsequently improves cell survival by decreasing apoptosis(By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinaseactivity, affecting their downstream signaling pathways(PubMed:10769033, PubMed:12221124). Plays a role as a modulator ofTGF-beta-signaling by restricting substrate specificity of RNF111(By similarity). Functions as a DNA-binding transcription factor(PubMed:12095676). Is a potent regulator of the RB1 pathwaythrough induction of RB1 expression (PubMed:14533007). Plays acrucial role in muscular differentiation (PubMed:12163359). Playsan indispensable role in fetal hematopoiesis and in the regulationof neuronal homeostasis (By similarity).{ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033,ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359,ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007,ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. | May act at junctions between the membrane and thecytoskeleton. Possesses tyrosine phosphatase activity. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for RB1CC1_PTPN3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000412145_chr9_112153841_-_654aa MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKT TFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTA DAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK AIKGLEDRLYALDQMIASCGRLVNEQKELAQQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANL VNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHT VTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQ >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000446349_chr9_112153841_-_654aa MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKT TFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTA DAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK AIKGLEDRLYALDQMIASCGRLVNEQKELAQQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANL VNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHT VTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQ >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000374541_chr9_112153841_-_654aa MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKT TFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTA DAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK AIKGLEDRLYALDQMIASCGRLVNEQKELAQQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANL VNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHT VTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQ >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000262539_chr9_112153841_-_654aa MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKT TFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTA DAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK AIKGLEDRLYALDQMIASCGRLVNEQKELAQQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANL VNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHT VTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQ >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000394827_chr9_112153841_-_654aa MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKT TFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQ SIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTA DAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMK AIKGLEDRLYALDQMIASCGRLVNEQKELAQQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANL VNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHT VTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000412145_chr9_112153841_-_1962nt ATGAAGTTATATGTATTTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCAT GCCATTCAAAGCAAATACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGT ACCTACAGTGCTGGGACGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACT ACCTTTTCGACAGAAAATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAG CTTGCATTGGAAATGTATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGG GCTGCAATCATGGCCAACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAG TCCATAGAAGACATCAAGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGA CATAGTTACAGAGAATGTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTG GTGCTCTCTCCTGATATGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCA GATGCTGAAAGTGGCAAAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGAT CTGCCCTTTTTTAATGTCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGAT TCTATGAGCAGGCTTGATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAA GCCATTAAAGGACTTGAAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCT CAGCAACTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTG CCTTATGACACCACCCGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTACGTGAACATGGAAATTCCTGCTGCTAACCTT GTGAACAAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATT GTCATGTTGACGACTCTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATGAACCACGGCGGCTTT CACATCCAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACA GTGACACATCTCCAGTACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTAAACTATGTGAGGTCT CTGAGAGTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGC CTAACTGAGAGGAACCTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTGCAGACATCAAGCCAG >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000446349_chr9_112153841_-_1962nt ATGAAGTTATATGTATTTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCAT GCCATTCAAAGCAAATACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGT ACCTACAGTGCTGGGACGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACT ACCTTTTCGACAGAAAATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAG CTTGCATTGGAAATGTATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGG GCTGCAATCATGGCCAACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAG TCCATAGAAGACATCAAGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGA CATAGTTACAGAGAATGTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTG GTGCTCTCTCCTGATATGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCA GATGCTGAAAGTGGCAAAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGAT CTGCCCTTTTTTAATGTCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGAT TCTATGAGCAGGCTTGATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAA GCCATTAAAGGACTTGAAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCT CAGCAACTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTG CCTTATGACACCACCCGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTACGTGAACATGGAAATTCCTGCTGCTAACCTT GTGAACAAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATT GTCATGTTGACGACTCTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATGAACCACGGCGGCTTT CACATCCAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACA GTGACACATCTCCAGTACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTAAACTATGTGAGGTCT CTGAGAGTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGC CTAACTGAGAGGAACCTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTGCAGACATCAAGCCAG >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000374541_chr9_112153841_-_1962nt ATGAAGTTATATGTATTTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCAT GCCATTCAAAGCAAATACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGT ACCTACAGTGCTGGGACGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACT ACCTTTTCGACAGAAAATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAG CTTGCATTGGAAATGTATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGG GCTGCAATCATGGCCAACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAG TCCATAGAAGACATCAAGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGA CATAGTTACAGAGAATGTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTG GTGCTCTCTCCTGATATGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCA GATGCTGAAAGTGGCAAAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGAT CTGCCCTTTTTTAATGTCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGAT TCTATGAGCAGGCTTGATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAA GCCATTAAAGGACTTGAAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCT CAGCAACTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTG CCTTATGACACCACCCGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTACGTGAACATGGAAATTCCTGCTGCTAACCTT GTGAACAAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATT GTCATGTTGACGACTCTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATGAACCACGGCGGCTTT CACATCCAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACA GTGACACATCTCCAGTACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTAAACTATGTGAGGTCT CTGAGAGTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGC CTAACTGAGAGGAACCTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTGCAGACATCAAGCCAG >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000262539_chr9_112153841_-_1962nt ATGAAGTTATATGTATTTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCAT GCCATTCAAAGCAAATACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGT ACCTACAGTGCTGGGACGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACT ACCTTTTCGACAGAAAATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAG CTTGCATTGGAAATGTATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGG GCTGCAATCATGGCCAACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAG TCCATAGAAGACATCAAGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGA CATAGTTACAGAGAATGTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTG GTGCTCTCTCCTGATATGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCA GATGCTGAAAGTGGCAAAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGAT CTGCCCTTTTTTAATGTCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGAT TCTATGAGCAGGCTTGATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAA GCCATTAAAGGACTTGAAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCT CAGCAACTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTG CCTTATGACACCACCCGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTACGTGAACATGGAAATTCCTGCTGCTAACCTT GTGAACAAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATT GTCATGTTGACGACTCTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATGAACCACGGCGGCTTT CACATCCAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACA GTGACACATCTCCAGTACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTAAACTATGTGAGGTCT CTGAGAGTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGC CTAACTGAGAGGAACCTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTGCAGACATCAAGCCAG >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000394827_chr9_112153841_-_1962nt ATGAAGTTATATGTATTTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCAT GCCATTCAAAGCAAATACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGT ACCTACAGTGCTGGGACGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACT ACCTTTTCGACAGAAAATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAG CTTGCATTGGAAATGTATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGG GCTGCAATCATGGCCAACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAG TCCATAGAAGACATCAAGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGA CATAGTTACAGAGAATGTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTG GTGCTCTCTCCTGATATGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCA GATGCTGAAAGTGGCAAAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGAT CTGCCCTTTTTTAATGTCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGAT TCTATGAGCAGGCTTGATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAA GCCATTAAAGGACTTGAAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCT CAGCAACTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTG CCTTATGACACCACCCGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTACGTGAACATGGAAATTCCTGCTGCTAACCTT GTGAACAAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATT GTCATGTTGACGACTCTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATGAACCACGGCGGCTTT CACATCCAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACA GTGACACATCTCCAGTACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTAAACTATGTGAGGTCT CTGAGAGTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGC CTAACTGAGAGGAACCTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTGCAGACATCAAGCCAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000412145_chr9_112153841_-_5824nt ATGAAGTTATATGTATTTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCAT GCCATTCAAAGCAAATACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGT ACCTACAGTGCTGGGACGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACT ACCTTTTCGACAGAAAATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAG CTTGCATTGGAAATGTATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGG GCTGCAATCATGGCCAACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAG TCCATAGAAGACATCAAGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGA CATAGTTACAGAGAATGTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTG GTGCTCTCTCCTGATATGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCA GATGCTGAAAGTGGCAAAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGAT CTGCCCTTTTTTAATGTCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGAT TCTATGAGCAGGCTTGATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAA GCCATTAAAGGACTTGAAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCT CAGCAACTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTG CCTTATGACACCACCCGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTACGTGAACATGGAAATTCCTGCTGCTAACCTT GTGAACAAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATT GTCATGTTGACGACTCTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATGAACCACGGCGGCTTT CACATCCAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACA GTGACACATCTCCAGTACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTAAACTATGTGAGGTCT CTGAGAGTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGC CTAACTGAGAGGAACCTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTGCAGACATCAAGCCAG TACAAGTTTGTGTGTGAAGCGATTCTTCGTGTGTATGAAGAAGGTTTAGTCCAAATGCTGGATCCTAGTTAAGACAACTGTGAAAAAGTT CATTCCTCTTTCCCAAGGGCATCCTCCTTGAAAGAGGAGGACAGACCTCTCTGGAAGCAGCAAGAGGAACCAGTAGCTGTGGGAAAGGAA TGGGCACCTCTGAACCCAGGCACTTTAAACTTCTATAGAAAAGATATCGTGTACATAGGAACTGGTGTAGATAAGCATGCAATTATGGCA TCATTTAGGCCTGTATTTCTATGGAAAGATACAAAAAGGATCTCAGTTTGGGGCCTGTCCTAATGCCTTCTTCCCTAACATCACCACACA CACCCCTGTCGGCATCCTGGAGCAATTGAGACCGGACACCCACAGAGCTGTTGTCCTCCCAGCAACAAGATGGTGTGGTTATCTTGGGTC ATTTGGATGTTTTGTTTGTTTCTGTGTGTCAGACTGTAAGGGCTGAGCTTTCTGTGCTTCTAGGTGGAGCTGGAACAATTCAGATTCACC CGCCCTGATGCTAAGGAAACCCTGACGTATGTACTAGATGGCAGGGCACTGGGGGTCAGGCTGAAGGCTGAGCAACACCTCTCTGCCCTC CCTCCCTTTGTCCCATCTCCCAGCGACTTCCAATATTCATGTTTCTGAGAATTGTGTCCCTCTTCAGGTTCCCTCTTGGTGCCTAACCTG GATTAGTAATGTGCATTCAGGTGAATTTTCAGCTGAGGCTCTGAGAACTGGTACTCTCAGTGTGTTCTGGTCATCTTGTGGCTTAGTTGT AGAAGCAGGTGTGTCTCTTGCCTCTGCTTGCCTCCTACTGCACACTCAGCACCCAGGACTGGAATCACCGACTACTGAATCTCCTACATG TATTGCTGCTACTTCAAGCTCCTCCACTTGAAACCTTATGATTTTCCCAAGGGGAGATGGGACAGTGTCATCTAAATATTCCGAATGTTT GGCCTTCTGAGAAAAGAGCTTCTAGTAATTGAACCATGGGAAACCCAGCTTCTGGAGGGTTGGCCGTGGGGCTGTGTACATGTGTGTGCC CAGGGGTGAGTGTTTCTCAGGATTCCTAACGATTCAAATTACCGTTGAGTATATATAAAGAATGAGTCTCTGTATGGAAGAACAAATGTG TGCATTCACCCCCAGTCACAATGGTCTCCATTGCATTTCAAAGGAGAGGATCAGACTATCTGAATATAAACACAATCTGATGTTAATTTA TTCTAAGAACACCATCATTTTGATTGTCCTAAAGAATTCTGCCTTTGTGAATACCGTGTTAAATTTTTTTAAATTTGTGACAGGATTGTA GCAAATTATTATTTAAGGAAAATAAATTGTGTAAACATTTAATGTGGTATTTTTGAACAGCGGTTTTTATGTACTCAGAAGAGGAAGTAA AGCCAGGTTCTTAATGGTATTTATAGAAAAGATGTTTTCATATTATAATGCACATAAATGAAGCCATTTTGATATTCAGCAAATTCGGTG CCAATTGAATAGTTTGCTGGTAGCAAGACGGATGAAGACCTATATGGGAGATTCTTTATCTCTAGAGCTAGCATATTTACTTGCATACTT TGTTTCTTTTCCACATGGATATTTTACTGCTAAATGGCAGAGGTGGGAGGGAGATGTCACACAGTACCATAACCCCATATTGAAAACAAG AAACCACCAGAAAGTTTGCAGCTAAGGGGCAGGGGATTCAGTTCCTACGCCCACTCAGCACTAACTACTTGCGGGCCTGGTTGCTTAGAA GCTCTACCTCTCTTTCATTATCTGTAAAATAGAAACAATACTTAGGACTTTAGTTGGAACATGAGGATTGAATAAGATCACGCTATTCAT GTGACTTTTTATCGGCTAGAACAGCAACAGACACTGCTGTGGGTGAGTTACTTAGAAAAGTTTAGTTATCAGTGATTAGCCCAAAAACAC ATCAGTCAAAAATAGAATCCACTGGATTTTTGTCTCTCTTTTTAGAGACAGGGTCTCACTGTCGCCCAGGCTGGAGTACAGTGGCATGAT CATTGTTCACTGCAGCCTCAAATTCCTGGGCTCAAGCAATCCTCGCACCTCAGCCTCCTGAGTAGCCGGGACTATAGGCACATGCCACCT CACCTGGCTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAGAGACAGGATCTTGATG TGTTGCCTAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCTTCCCACCTCAGCCTCCAAAACTGTTGGGATTATAGGCGTGAGCCACTG TGCCCAGCCTAACTGGGTTTTTATGAGAGGAAAATAGAAAATGCTCTTCTAGAAGAGAGAGAACAAGAGCACAAAATAATCTGGACTCAC AAAAATTCAGCAAGCTCCAAGAAAGGGGGATGGAGGGAACGCTGGCAAAAATTTAAATGCCATTAGGATATTTAGCAAGTTATTACTGTT TGGTAAAAATGCATCATCACCCTGTGTGCAAAATGCTTGCAAAGTAGTCTAAATGTCTTTGGAGATGGGTGTTTTACTGCTTTTTTCCAA AAACAAATTGTTTATTATGGTTGCAGAAATGCAGCCATTACGGTCACATAAATTTCTAAAAAGCCTACCAAAGGTTGCAAGCAGTCTTCT GCCACTGGGCAGGCCAGCAGTTCAGACCCAGCGAGGTTGCCAGGAACAAATCCAGGAAATACTGGGAAGAACAAGACAAGAGAATTACCT AAAAGAGCAAACAATTCAAGTAAATCCTGTAGCTATTACCACTTAAAATCCGTAGCTCAAGATTCCTGTTTCACCACCTTATACACTTAA GCAATTATACTTAAGCCTTTTTTTAGTCCTAAGTGAAGAACTACATCAGAATCAGGATAAGTATTTTGCCTGGGAAATTTGGCTGCATAT GAATGGAGAAGACATTTACATCCTATGTTCTGGCACTTTCTGAAAGATCTAATTAAACATGTTGATGTGCCAATTTAATCAAGATGAGAG ATCCCTGCTGGTGTCACCCTCTAGAACCTGCACTTGGTGTTTTGACTTTCCAGAAGAAAAAAATGCAACTTTGGTTAGGGGGCAGTGGTT GGATCACACAGTTGTCTTTCGTTTCCTACCACAGTAATTCATATTTAAATATGCTTTTAGATTAGTGTGGATACTATTGCTGCTGTGTTG CTACCTGACCTTTTTCTGGGGGGGGTACCTCAGAAATGAGCATTTGAGGGCAAGCGAAAAAGCCCTCTTCATCCTCCAGAGGCAACAAAG AGGCAGCAGAAATGGGGAAAGATTGTGAGAGGCAGGGCTTGGGTCTAGACCTGGACTTAGGCAAGATATGTTGCCCTCAACCCTGAGTTT TCTTATATGTAAAAAGGGAAGGTTGGGCTGGACTAGATGAGGTCAAGATTTGCCATTCTGGGAGGCTGATATTCCAGAGAATCAAAATTA ATCCTAAACCAAAGCTTTATGGCTGCTACAGAGACATGTCACATTTCTGAGACTTGTCACCAAGAGTTTGTCCCTCAGACTTTGGCGCTG TTGAATGCAAAGACAAGGATGGCCACCTTCTGGTTCTTGCCTGTTGTCCTCAGCTGAGAGCAGTCTCGGTAAAGGTGGCAAAGATTCTGT GACCTCAGACCGGGGACCAAATGCTTGGGAGTCTGATGGCCGGGCTGGGCCACCATTCTCATAGCTCTCATTCTGTTTGGAGCAACCAAA GGATTTGTGTGAAGTTATTTGGAAAAGGACCTTAACTGAGCAGTAATCTTTTTTCTGTATATTTGGAATGTTTTTCATTCTGACCTGTTC >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000446349_chr9_112153841_-_5824nt ATGAAGTTATATGTATTTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCAT GCCATTCAAAGCAAATACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGT ACCTACAGTGCTGGGACGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACT ACCTTTTCGACAGAAAATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAG CTTGCATTGGAAATGTATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGG GCTGCAATCATGGCCAACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAG TCCATAGAAGACATCAAGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGA CATAGTTACAGAGAATGTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTG GTGCTCTCTCCTGATATGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCA GATGCTGAAAGTGGCAAAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGAT CTGCCCTTTTTTAATGTCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGAT TCTATGAGCAGGCTTGATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAA GCCATTAAAGGACTTGAAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCT CAGCAACTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTG CCTTATGACACCACCCGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTACGTGAACATGGAAATTCCTGCTGCTAACCTT GTGAACAAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATT GTCATGTTGACGACTCTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATGAACCACGGCGGCTTT CACATCCAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACA GTGACACATCTCCAGTACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTAAACTATGTGAGGTCT CTGAGAGTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGC CTAACTGAGAGGAACCTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTGCAGACATCAAGCCAG TACAAGTTTGTGTGTGAAGCGATTCTTCGTGTGTATGAAGAAGGTTTAGTCCAAATGCTGGATCCTAGTTAAGACAACTGTGAAAAAGTT CATTCCTCTTTCCCAAGGGCATCCTCCTTGAAAGAGGAGGACAGACCTCTCTGGAAGCAGCAAGAGGAACCAGTAGCTGTGGGAAAGGAA TGGGCACCTCTGAACCCAGGCACTTTAAACTTCTATAGAAAAGATATCGTGTACATAGGAACTGGTGTAGATAAGCATGCAATTATGGCA TCATTTAGGCCTGTATTTCTATGGAAAGATACAAAAAGGATCTCAGTTTGGGGCCTGTCCTAATGCCTTCTTCCCTAACATCACCACACA CACCCCTGTCGGCATCCTGGAGCAATTGAGACCGGACACCCACAGAGCTGTTGTCCTCCCAGCAACAAGATGGTGTGGTTATCTTGGGTC ATTTGGATGTTTTGTTTGTTTCTGTGTGTCAGACTGTAAGGGCTGAGCTTTCTGTGCTTCTAGGTGGAGCTGGAACAATTCAGATTCACC CGCCCTGATGCTAAGGAAACCCTGACGTATGTACTAGATGGCAGGGCACTGGGGGTCAGGCTGAAGGCTGAGCAACACCTCTCTGCCCTC CCTCCCTTTGTCCCATCTCCCAGCGACTTCCAATATTCATGTTTCTGAGAATTGTGTCCCTCTTCAGGTTCCCTCTTGGTGCCTAACCTG GATTAGTAATGTGCATTCAGGTGAATTTTCAGCTGAGGCTCTGAGAACTGGTACTCTCAGTGTGTTCTGGTCATCTTGTGGCTTAGTTGT AGAAGCAGGTGTGTCTCTTGCCTCTGCTTGCCTCCTACTGCACACTCAGCACCCAGGACTGGAATCACCGACTACTGAATCTCCTACATG TATTGCTGCTACTTCAAGCTCCTCCACTTGAAACCTTATGATTTTCCCAAGGGGAGATGGGACAGTGTCATCTAAATATTCCGAATGTTT GGCCTTCTGAGAAAAGAGCTTCTAGTAATTGAACCATGGGAAACCCAGCTTCTGGAGGGTTGGCCGTGGGGCTGTGTACATGTGTGTGCC CAGGGGTGAGTGTTTCTCAGGATTCCTAACGATTCAAATTACCGTTGAGTATATATAAAGAATGAGTCTCTGTATGGAAGAACAAATGTG TGCATTCACCCCCAGTCACAATGGTCTCCATTGCATTTCAAAGGAGAGGATCAGACTATCTGAATATAAACACAATCTGATGTTAATTTA TTCTAAGAACACCATCATTTTGATTGTCCTAAAGAATTCTGCCTTTGTGAATACCGTGTTAAATTTTTTTAAATTTGTGACAGGATTGTA GCAAATTATTATTTAAGGAAAATAAATTGTGTAAACATTTAATGTGGTATTTTTGAACAGCGGTTTTTATGTACTCAGAAGAGGAAGTAA AGCCAGGTTCTTAATGGTATTTATAGAAAAGATGTTTTCATATTATAATGCACATAAATGAAGCCATTTTGATATTCAGCAAATTCGGTG CCAATTGAATAGTTTGCTGGTAGCAAGACGGATGAAGACCTATATGGGAGATTCTTTATCTCTAGAGCTAGCATATTTACTTGCATACTT TGTTTCTTTTCCACATGGATATTTTACTGCTAAATGGCAGAGGTGGGAGGGAGATGTCACACAGTACCATAACCCCATATTGAAAACAAG AAACCACCAGAAAGTTTGCAGCTAAGGGGCAGGGGATTCAGTTCCTACGCCCACTCAGCACTAACTACTTGCGGGCCTGGTTGCTTAGAA GCTCTACCTCTCTTTCATTATCTGTAAAATAGAAACAATACTTAGGACTTTAGTTGGAACATGAGGATTGAATAAGATCACGCTATTCAT GTGACTTTTTATCGGCTAGAACAGCAACAGACACTGCTGTGGGTGAGTTACTTAGAAAAGTTTAGTTATCAGTGATTAGCCCAAAAACAC ATCAGTCAAAAATAGAATCCACTGGATTTTTGTCTCTCTTTTTAGAGACAGGGTCTCACTGTCGCCCAGGCTGGAGTACAGTGGCATGAT CATTGTTCACTGCAGCCTCAAATTCCTGGGCTCAAGCAATCCTCGCACCTCAGCCTCCTGAGTAGCCGGGACTATAGGCACATGCCACCT CACCTGGCTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAGAGACAGGATCTTGATG TGTTGCCTAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCTTCCCACCTCAGCCTCCAAAACTGTTGGGATTATAGGCGTGAGCCACTG TGCCCAGCCTAACTGGGTTTTTATGAGAGGAAAATAGAAAATGCTCTTCTAGAAGAGAGAGAACAAGAGCACAAAATAATCTGGACTCAC AAAAATTCAGCAAGCTCCAAGAAAGGGGGATGGAGGGAACGCTGGCAAAAATTTAAATGCCATTAGGATATTTAGCAAGTTATTACTGTT TGGTAAAAATGCATCATCACCCTGTGTGCAAAATGCTTGCAAAGTAGTCTAAATGTCTTTGGAGATGGGTGTTTTACTGCTTTTTTCCAA AAACAAATTGTTTATTATGGTTGCAGAAATGCAGCCATTACGGTCACATAAATTTCTAAAAAGCCTACCAAAGGTTGCAAGCAGTCTTCT GCCACTGGGCAGGCCAGCAGTTCAGACCCAGCGAGGTTGCCAGGAACAAATCCAGGAAATACTGGGAAGAACAAGACAAGAGAATTACCT AAAAGAGCAAACAATTCAAGTAAATCCTGTAGCTATTACCACTTAAAATCCGTAGCTCAAGATTCCTGTTTCACCACCTTATACACTTAA GCAATTATACTTAAGCCTTTTTTTAGTCCTAAGTGAAGAACTACATCAGAATCAGGATAAGTATTTTGCCTGGGAAATTTGGCTGCATAT GAATGGAGAAGACATTTACATCCTATGTTCTGGCACTTTCTGAAAGATCTAATTAAACATGTTGATGTGCCAATTTAATCAAGATGAGAG ATCCCTGCTGGTGTCACCCTCTAGAACCTGCACTTGGTGTTTTGACTTTCCAGAAGAAAAAAATGCAACTTTGGTTAGGGGGCAGTGGTT GGATCACACAGTTGTCTTTCGTTTCCTACCACAGTAATTCATATTTAAATATGCTTTTAGATTAGTGTGGATACTATTGCTGCTGTGTTG CTACCTGACCTTTTTCTGGGGGGGGTACCTCAGAAATGAGCATTTGAGGGCAAGCGAAAAAGCCCTCTTCATCCTCCAGAGGCAACAAAG AGGCAGCAGAAATGGGGAAAGATTGTGAGAGGCAGGGCTTGGGTCTAGACCTGGACTTAGGCAAGATATGTTGCCCTCAACCCTGAGTTT TCTTATATGTAAAAAGGGAAGGTTGGGCTGGACTAGATGAGGTCAAGATTTGCCATTCTGGGAGGCTGATATTCCAGAGAATCAAAATTA ATCCTAAACCAAAGCTTTATGGCTGCTACAGAGACATGTCACATTTCTGAGACTTGTCACCAAGAGTTTGTCCCTCAGACTTTGGCGCTG TTGAATGCAAAGACAAGGATGGCCACCTTCTGGTTCTTGCCTGTTGTCCTCAGCTGAGAGCAGTCTCGGTAAAGGTGGCAAAGATTCTGT GACCTCAGACCGGGGACCAAATGCTTGGGAGTCTGATGGCCGGGCTGGGCCACCATTCTCATAGCTCTCATTCTGTTTGGAGCAACCAAA GGATTTGTGTGAAGTTATTTGGAAAAGGACCTTAACTGAGCAGTAATCTTTTTTCTGTATATTTGGAATGTTTTTCATTCTGACCTGTTC >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000374541_chr9_112153841_-_5818nt ATGAAGTTATATGTATTTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCAT GCCATTCAAAGCAAATACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGT ACCTACAGTGCTGGGACGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACT ACCTTTTCGACAGAAAATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAG CTTGCATTGGAAATGTATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGG GCTGCAATCATGGCCAACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAG TCCATAGAAGACATCAAGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGA CATAGTTACAGAGAATGTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTG GTGCTCTCTCCTGATATGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCA GATGCTGAAAGTGGCAAAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGAT CTGCCCTTTTTTAATGTCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGAT TCTATGAGCAGGCTTGATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAA GCCATTAAAGGACTTGAAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCT CAGCAACTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTG CCTTATGACACCACCCGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTACGTGAACATGGAAATTCCTGCTGCTAACCTT GTGAACAAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATT GTCATGTTGACGACTCTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATGAACCACGGCGGCTTT CACATCCAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACA GTGACACATCTCCAGTACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTAAACTATGTGAGGTCT CTGAGAGTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGC CTAACTGAGAGGAACCTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTGCAGACATCAAGCCAG TACAAGTTTGTGTGTGAAGCGATTCTTCGTGTGTATGAAGAAGGTTTAGTCCAAATGCTGGATCCTAGTTAAGACAACTGTGAAAAAGTT CATTCCTCTTTCCCAAGGGCATCCTCCTTGAAAGAGGAGGACAGACCTCTCTGGAAGCAGCAAGAGGAACCAGTAGCTGTGGGAAAGGAA TGGGCACCTCTGAACCCAGGCACTTTAAACTTCTATAGAAAAGATATCGTGTACATAGGAACTGGTGTAGATAAGCATGCAATTATGGCA TCATTTAGGCCTGTATTTCTATGGAAAGATACAAAAAGGATCTCAGTTTGGGGCCTGTCCTAATGCCTTCTTCCCTAACATCACCACACA CACCCCTGTCGGCATCCTGGAGCAATTGAGACCGGACACCCACAGAGCTGTTGTCCTCCCAGCAACAAGATGGTGTGGTTATCTTGGGTC ATTTGGATGTTTTGTTTGTTTCTGTGTGTCAGACTGTAAGGGCTGAGCTTTCTGTGCTTCTAGGTGGAGCTGGAACAATTCAGATTCACC CGCCCTGATGCTAAGGAAACCCTGACGTATGTACTAGATGGCAGGGCACTGGGGGTCAGGCTGAAGGCTGAGCAACACCTCTCTGCCCTC CCTCCCTTTGTCCCATCTCCCAGCGACTTCCAATATTCATGTTTCTGAGAATTGTGTCCCTCTTCAGGTTCCCTCTTGGTGCCTAACCTG GATTAGTAATGTGCATTCAGGTGAATTTTCAGCTGAGGCTCTGAGAACTGGTACTCTCAGTGTGTTCTGGTCATCTTGTGGCTTAGTTGT AGAAGCAGGTGTGTCTCTTGCCTCTGCTTGCCTCCTACTGCACACTCAGCACCCAGGACTGGAATCACCGACTACTGAATCTCCTACATG TATTGCTGCTACTTCAAGCTCCTCCACTTGAAACCTTATGATTTTCCCAAGGGGAGATGGGACAGTGTCATCTAAATATTCCGAATGTTT GGCCTTCTGAGAAAAGAGCTTCTAGTAATTGAACCATGGGAAACCCAGCTTCTGGAGGGTTGGCCGTGGGGCTGTGTACATGTGTGTGCC CAGGGGTGAGTGTTTCTCAGGATTCCTAACGATTCAAATTACCGTTGAGTATATATAAAGAATGAGTCTCTGTATGGAAGAACAAATGTG TGCATTCACCCCCAGTCACAATGGTCTCCATTGCATTTCAAAGGAGAGGATCAGACTATCTGAATATAAACACAATCTGATGTTAATTTA TTCTAAGAACACCATCATTTTGATTGTCCTAAAGAATTCTGCCTTTGTGAATACCGTGTTAAATTTTTTTAAATTTGTGACAGGATTGTA GCAAATTATTATTTAAGGAAAATAAATTGTGTAAACATTTAATGTGGTATTTTTGAACAGCGGTTTTTATGTACTCAGAAGAGGAAGTAA AGCCAGGTTCTTAATGGTATTTATAGAAAAGATGTTTTCATATTATAATGCACATAAATGAAGCCATTTTGATATTCAGCAAATTCGGTG CCAATTGAATAGTTTGCTGGTAGCAAGACGGATGAAGACCTATATGGGAGATTCTTTATCTCTAGAGCTAGCATATTTACTTGCATACTT TGTTTCTTTTCCACATGGATATTTTACTGCTAAATGGCAGAGGTGGGAGGGAGATGTCACACAGTACCATAACCCCATATTGAAAACAAG AAACCACCAGAAAGTTTGCAGCTAAGGGGCAGGGGATTCAGTTCCTACGCCCACTCAGCACTAACTACTTGCGGGCCTGGTTGCTTAGAA GCTCTACCTCTCTTTCATTATCTGTAAAATAGAAACAATACTTAGGACTTTAGTTGGAACATGAGGATTGAATAAGATCACGCTATTCAT GTGACTTTTTATCGGCTAGAACAGCAACAGACACTGCTGTGGGTGAGTTACTTAGAAAAGTTTAGTTATCAGTGATTAGCCCAAAAACAC ATCAGTCAAAAATAGAATCCACTGGATTTTTGTCTCTCTTTTTAGAGACAGGGTCTCACTGTCGCCCAGGCTGGAGTACAGTGGCATGAT CATTGTTCACTGCAGCCTCAAATTCCTGGGCTCAAGCAATCCTCGCACCTCAGCCTCCTGAGTAGCCGGGACTATAGGCACATGCCACCT CACCTGGCTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAGAGACAGGATCTTGATG TGTTGCCTAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCTTCCCACCTCAGCCTCCAAAACTGTTGGGATTATAGGCGTGAGCCACTG TGCCCAGCCTAACTGGGTTTTTATGAGAGGAAAATAGAAAATGCTCTTCTAGAAGAGAGAGAACAAGAGCACAAAATAATCTGGACTCAC AAAAATTCAGCAAGCTCCAAGAAAGGGGGATGGAGGGAACGCTGGCAAAAATTTAAATGCCATTAGGATATTTAGCAAGTTATTACTGTT TGGTAAAAATGCATCATCACCCTGTGTGCAAAATGCTTGCAAAGTAGTCTAAATGTCTTTGGAGATGGGTGTTTTACTGCTTTTTTCCAA AAACAAATTGTTTATTATGGTTGCAGAAATGCAGCCATTACGGTCACATAAATTTCTAAAAAGCCTACCAAAGGTTGCAAGCAGTCTTCT GCCACTGGGCAGGCCAGCAGTTCAGACCCAGCGAGGTTGCCAGGAACAAATCCAGGAAATACTGGGAAGAACAAGACAAGAGAATTACCT AAAAGAGCAAACAATTCAAGTAAATCCTGTAGCTATTACCACTTAAAATCCGTAGCTCAAGATTCCTGTTTCACCACCTTATACACTTAA GCAATTATACTTAAGCCTTTTTTTAGTCCTAAGTGAAGAACTACATCAGAATCAGGATAAGTATTTTGCCTGGGAAATTTGGCTGCATAT GAATGGAGAAGACATTTACATCCTATGTTCTGGCACTTTCTGAAAGATCTAATTAAACATGTTGATGTGCCAATTTAATCAAGATGAGAG ATCCCTGCTGGTGTCACCCTCTAGAACCTGCACTTGGTGTTTTGACTTTCCAGAAGAAAAAAATGCAACTTTGGTTAGGGGGCAGTGGTT GGATCACACAGTTGTCTTTCGTTTCCTACCACAGTAATTCATATTTAAATATGCTTTTAGATTAGTGTGGATACTATTGCTGCTGTGTTG CTACCTGACCTTTTTCTGGGGGGGGTACCTCAGAAATGAGCATTTGAGGGCAAGCGAAAAAGCCCTCTTCATCCTCCAGAGGCAACAAAG AGGCAGCAGAAATGGGGAAAGATTGTGAGAGGCAGGGCTTGGGTCTAGACCTGGACTTAGGCAAGATATGTTGCCCTCAACCCTGAGTTT TCTTATATGTAAAAAGGGAAGGTTGGGCTGGACTAGATGAGGTCAAGATTTGCCATTCTGGGAGGCTGATATTCCAGAGAATCAAAATTA ATCCTAAACCAAAGCTTTATGGCTGCTACAGAGACATGTCACATTTCTGAGACTTGTCACCAAGAGTTTGTCCCTCAGACTTTGGCGCTG TTGAATGCAAAGACAAGGATGGCCACCTTCTGGTTCTTGCCTGTTGTCCTCAGCTGAGAGCAGTCTCGGTAAAGGTGGCAAAGATTCTGT GACCTCAGACCGGGGACCAAATGCTTGGGAGTCTGATGGCCGGGCTGGGCCACCATTCTCATAGCTCTCATTCTGTTTGGAGCAACCAAA GGATTTGTGTGAAGTTATTTGGAAAAGGACCTTAACTGAGCAGTAATCTTTTTTCTGTATATTTGGAATGTTTTTCATTCTGACCTGTTC >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000262539_chr9_112153841_-_2146nt ATGAAGTTATATGTATTTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCAT GCCATTCAAAGCAAATACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGT ACCTACAGTGCTGGGACGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACT ACCTTTTCGACAGAAAATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAG CTTGCATTGGAAATGTATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGG GCTGCAATCATGGCCAACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAG TCCATAGAAGACATCAAGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGA CATAGTTACAGAGAATGTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTG GTGCTCTCTCCTGATATGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCA GATGCTGAAAGTGGCAAAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGAT CTGCCCTTTTTTAATGTCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGAT TCTATGAGCAGGCTTGATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAA GCCATTAAAGGACTTGAAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCT CAGCAACTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTG CCTTATGACACCACCCGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTACGTGAACATGGAAATTCCTGCTGCTAACCTT GTGAACAAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATT GTCATGTTGACGACTCTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATGAACCACGGCGGCTTT CACATCCAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACA GTGACACATCTCCAGTACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTAAACTATGTGAGGTCT CTGAGAGTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGC CTAACTGAGAGGAACCTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTGCAGACATCAAGCCAG TACAAGTTTGTGTGTGAAGCGATTCTTCGTGTGTATGAAGAAGGTTTAGTCCAAATGCTGGATCCTAGTTAAGACAACTGTGAAAAAGTT CATTCCTCTTTCCCAAGGGCATCCTCCTTGAAAGAGGAGGACAGACCTCTCTGGAAGCAGCAAGAGGAACCAGTAGCTGTGGGAAAGGAA >In-frame_RB1CC1_ENST00000539297_chr8_53580581_-_PTPN3_ENST00000394827_chr9_112153841_-_2431nt ATGAAGTTATATGTATTTCTGGTTAACACTGGAACTACTCTAACATTTGACACTGAACTTACAGTGCAAACTGTGGCAGACCTTAAGCAT GCCATTCAAAGCAAATACAAGATTGCTATTCAACACCAGGTGCTGGTGGTCAATGGAGGAGAATGCATGGCTGCAGATCGAAGAGTGTGT ACCTACAGTGCTGGGACGGATACAAATCCAATTTTTCTTTTTAACAAAGAAATGATCTTATGTGATCGTCCACCTGCTATTCCTAAAACT ACCTTTTCGACAGAAAATGACATGGAAATAAAAGTTGAAGAATCTCTTATGATGCCTGCAGTTTTTCATACTGTTGCTTCAAGGACACAG CTTGCATTGGAAATGTATGAAGTTGCCAAGAAACTTTGTTCTTTTTGTGAAGGTCTTGTACATGATGAACATCTTCAACACCAAGGCTGG GCTGCAATCATGGCCAACCTGGAGGACTGTTCAAATTCATACCAAAAGCTACTTTTCAAGTTTGAAAGTATTTATTCAAATTATCTGCAG TCCATAGAAGACATCAAGTTAAAACTTACTCATTTAGGAACTGCAGTTTCAGTAATGGCCAAGATTCCACTGTTGGAGTGCCTAACCAGA CATAGTTACAGAGAATGTTTGGGAAGACTGGATTCTTTACCTGAACATGAAGACTCAGAAAAAGCTGAGATGAAAAGATCCACTGAACTG GTGCTCTCTCCTGATATGCCTAGAACAACTAACGAATCTTTGTTAACCTCATTTCCCAAGTCAGTGGAACATGTGTCCCCAGATACCGCA GATGCTGAAAGTGGCAAAGAAATTAGGGAATCTTGTCAAAGTACTGTTCATCAGCAAGATGAAACTACGATTGACACTAAAGATGGTGAT CTGCCCTTTTTTAATGTCTCTTTGTTAGACTGGATAAATGTTCAAGATAGACCTAATGATGTGGAATCTTTGGTCAGGAAGTGCTTTGAT TCTATGAGCAGGCTTGATCCAAGGATTATTCGACCATTTATAGCAGAATGCCGTCAAACTATTGCCAAACTTGATAATCAGAATATGAAA GCCATTAAAGGACTTGAAGATCGGCTCTACGCCCTGGACCAGATGATTGCTAGCTGTGGCCGACTGGTGAATGAACAGAAAGAGCTTGCT CAGCAACTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGACAAAAACCGATATAAAGATGTGCTG CCTTATGACACCACCCGGGTATTATTGCAGGGAAATGAAGATTATATTAATGCAAGTTACGTGAACATGGAAATTCCTGCTGCTAACCTT GTGAACAAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTCTGGGATCAGAAGTTGTCACTCATT GTCATGTTGACGACTCTCACAGAACGAGGGCGGACCAAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATGAACCACGGCGGCTTT CACATCCAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAACACCCAGACCGGGGAAGAACACACA GTGACACATCTCCAGTACGTCGCATGGCCTGACCACGGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTAAACTATGTGAGGTCT CTGAGAGTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTGGTCACTATGGAAACAGCCATGTGC CTAACTGAGAGGAACCTGCCCATTTACCCACTGGATATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTGCAGACATCAAGCCAG TACAAGTTTGTGTGTGAAGCGATTCTTCGTGTGTATGAAGAAGGTTTAGTCCAAATGCTGGATCCTAGTTAAGACAACTGTGAAAAAGTT CATTCCTCTTTCCCAAGGGCATCCTCCTTGAAAGAGGAGGACAGACCTCTCTGGAAGCAGCAAGAGGAACCAGTAGCTGTGGGAAAGGAA TGGGCACCTCTGAACCCAGGCACTTTAAACTTCTATAGAAAAGATATCGTGTACATAGGAACTGGTGTAGATAAGCATGCAATTATGGCA TCATTTAGGCCTGTATTTCTATGGAAAGATACAAAAAGGATCTCAGTTTGGGGCCTGTCCTAATGCCTTCTTCCCTAACATCACCACACA CACCCCTGTCGGCATCCTGGAGCAATTGAGACCGGACACCCACAGAGCTGTTGTCCTCCCAGCAACAAGATGGTGTGGTTATCTTGGGTC ATTTGGATGTTTTGTTTGTTTCTGTGTGTCAGACTGTAAGGGCTGAGCTTTCTGTGCTTCTAGGTGGAGCTGGAACAATTCAGATTCACC |
Top |
FusionGenePPI for RB1CC1_PTPN3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RB1CC1 | ERCC6L, CDK19, MOB4, DBNL, MAP3K5, TRAF2, PTK2B, PTK2, ATG13, MAP1LC3C, PRKAA2, PRKAB2, SMCR8, HSBP1, ATG101, TBK1, RPA1, SAFB2, SAFB, RPA2, RBMX, YLPM1, ULK1, ULK2, SMARCB1, TP53, TBKBP1, RNF111, SKI, SKIL, VHL, CTNNB1, UBC, GABARAP, GABARAPL1, RFWD2, PINK1, CALCOCO2, DYRK2, ATG16L1, EXOC1, ATG5, SESN2, CCDC8, VAPB, BAP1, BLID, EPSTI1, ERRFI1, GLCE, GREB1, IL13RA2, IL24, ITIH5, LYPD3, MRC2, PSMC3IP, RNF20, THRSP, VPS45, WHSC1L1, WIF1, HBP1, MADD, SYN1, UMPS, DLG3, TACC1, HUWE1, SGTB, TCEAL4, SGOL1, NANOG, CDH1, MTMR4, DUPD1, FAM221B, CCDC53, DENR, VAPA, SYCE3, TRAF1, TRIM25 | PTPN3 | SFN, YWHAB, YWHAG, GHR, VDR, UBE3A, YWHAQ, AKR1C1, LMO1, WDR6, DIP2A, ZCCHC10, NXT2, HSPB1, AKT1, ACOT8, KCTD3, SHKBP1, SLC1A5, SRRM2, VANGL1, YWHAE, YWHAH, YWHAZ, IGFBP1, PTPN3, CACYBP, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RB1CC1_PTPN3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for RB1CC1_PTPN3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RB1CC1 | C0036341 | Schizophrenia | 1 | CTD_human |
| Hgene | RB1CC1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|