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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30583

FusionGeneSummary for RASSF8_CMAS

check button Fusion gene summary
Fusion gene informationFusion gene name: RASSF8_CMAS
Fusion gene ID: 30583
HgeneTgene
Gene symbol

RASSF8

CMAS

Gene ID

11228

55907

Gene nameRas association domain family member 8cytidine monophosphate N-acetylneuraminic acid synthetase
SynonymsC12orf2|HOJ1CSS
Cytomap

12p12.1

12p12.1

Type of geneprotein-codingprotein-coding
Descriptionras association domain-containing protein 8Ras association (RalGDS/AF-6) domain family (N-terminal) member 8carcinoma-associated protein HOJ-1N-acylneuraminate cytidylyltransferaseCMP-N-acetylneuraminic acid synthaseCMP-N-acetylneuraminic acid synthetaseCMP-Neu5Ac synthetaseCMP-NeuNAc synthaseCMP-NeuNAc synthetaseCMP-sialic acid synthetasecytidine 5'-monophosphate N-acetylneuraminic acid
Modification date2018052220180523
UniProtAcc

Q8NHQ8

Q8NFW8

Ensembl transtripts involved in fusion geneENST00000381352, ENST00000405154, 
ENST00000542865, ENST00000541490, 
ENST00000282884, ENST00000538081, 
ENST00000229329, 
Fusion gene scores* DoF score8 X 4 X 7=2247 X 5 X 4=140
# samples 97
** MAII scorelog2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RASSF8 [Title/Abstract] AND CMAS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-ZF-A9R3-01ARASSF8chr12

26112081

+CMASchr12

22215215

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000381352ENST00000229329RASSF8chr12

26112081

+CMASchr12

22215215

+
5UTR-3CDSENST00000405154ENST00000229329RASSF8chr12

26112081

+CMASchr12

22215215

+
intron-3CDSENST00000542865ENST00000229329RASSF8chr12

26112081

+CMASchr12

22215215

+
intron-3CDSENST00000541490ENST00000229329RASSF8chr12

26112081

+CMASchr12

22215215

+
intron-3CDSENST00000282884ENST00000229329RASSF8chr12

26112081

+CMASchr12

22215215

+
3UTR-3CDSENST00000538081ENST00000229329RASSF8chr12

26112081

+CMASchr12

22215215

+

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FusionProtFeatures for RASSF8_CMAS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASSF8

Q8NHQ8

CMAS

Q8NFW8

Catalyzes the activation of N-acetylneuraminic acid(NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid(CMP-NeuNAc), a substrate required for the addition of sialicacid. Has some activity toward NeuNAc, N-glycolylneuraminic acid(Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RASSF8_CMAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RASSF8_CMAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RASSF8FRMD6, PSMD4, YWHAG, PARD3, YWHAH, APP, KLC1, YWHAE, LYN, AMOT, ANKRD28, YAP1, KDM1A, PPP1CC, PPP1CA, PARD6B, SFRP4, PPP1R13B, TP53BP2, GOLGA2, PRKCI, ZBTB2, PCM1, ZNF639, POC1A, C17orf70, GOLPH3, PPP1CB, CEP152, NINL, NIN, POLR2H, TCOF1, TRIB1, APPBP2, PDK1, RAB5C, TIMM13, PARD6A, SETD2, TBC1D24, NLN, RAB11FIP1, PARP10, CEP44, CORO1A, RAB3IPCMASAPP, FBXO6, BRCA1, FGL1, LIMS1, LUC7L, DBNL, COG3, FIG4, NAA10, DDB1, NAA15, HIST1H2BG, HIST1H3A, RC3H1, CHCHD10, FAM98A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASSF8_CMAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RASSF8_CMAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRASSF8C0149925Small cell carcinoma of lung1CTD_human