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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30577

FusionGeneSummary for RASSF5_RASSF5

check button Fusion gene summary
Fusion gene informationFusion gene name: RASSF5_RASSF5
Fusion gene ID: 30577
HgeneTgene
Gene symbol

RASSF5

RASSF5

Gene ID

283349

283349

Gene nameRas association domain family member 3Ras association domain family member 3
SynonymsRASSF5RASSF5
Cytomap

12q14.2

12q14.2

Type of geneprotein-codingprotein-coding
Descriptionras association domain-containing protein 3Ras association (RalGDS/AF-6) domain family 3Ras association (RalGDS/AF-6) domain family member 3ras association domain-containing protein 3Ras association (RalGDS/AF-6) domain family 3Ras association (RalGDS/AF-6) domain family member 3
Modification date2018051920180519
UniProtAcc

Q8WWW0

Q8WWW0

Ensembl transtripts involved in fusion geneENST00000355294, ENST00000367117, 
ENST00000304534, ENST00000491368, 
ENST00000355294, ENST00000367117, 
ENST00000304534, ENST00000491368, 
Fusion gene scores* DoF score2 X 3 X 2=123 X 4 X 2=24
# samples 34
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RASSF5 [Title/Abstract] AND RASSF5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI907782RASSF5chr1

206762080

-RASSF5chr1

206762258

+
ChiTaRS3.1BE159686RASSF5chr1

206760374

+RASSF5chr1

206760755

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000355294ENST00000355294RASSF5chr1

206762080

-RASSF5chr1

206762258

+
intron-intronENST00000355294ENST00000367117RASSF5chr1

206762080

-RASSF5chr1

206762258

+
intron-3UTRENST00000355294ENST00000304534RASSF5chr1

206762080

-RASSF5chr1

206762258

+
intron-3UTRENST00000355294ENST00000491368RASSF5chr1

206762080

-RASSF5chr1

206762258

+
intron-intronENST00000367117ENST00000355294RASSF5chr1

206762080

-RASSF5chr1

206762258

+
intron-intronENST00000367117ENST00000367117RASSF5chr1

206762080

-RASSF5chr1

206762258

+
intron-3UTRENST00000367117ENST00000304534RASSF5chr1

206762080

-RASSF5chr1

206762258

+
intron-3UTRENST00000367117ENST00000491368RASSF5chr1

206762080

-RASSF5chr1

206762258

+
3UTR-intronENST00000304534ENST00000355294RASSF5chr1

206762080

-RASSF5chr1

206762258

+
3UTR-intronENST00000304534ENST00000367117RASSF5chr1

206762080

-RASSF5chr1

206762258

+
3UTR-3UTRENST00000304534ENST00000304534RASSF5chr1

206762080

-RASSF5chr1

206762258

+
3UTR-3UTRENST00000304534ENST00000491368RASSF5chr1

206762080

-RASSF5chr1

206762258

+
3UTR-intronENST00000491368ENST00000355294RASSF5chr1

206762080

-RASSF5chr1

206762258

+
3UTR-intronENST00000491368ENST00000367117RASSF5chr1

206762080

-RASSF5chr1

206762258

+
3UTR-3UTRENST00000491368ENST00000304534RASSF5chr1

206762080

-RASSF5chr1

206762258

+
3UTR-3UTRENST00000491368ENST00000491368RASSF5chr1

206762080

-RASSF5chr1

206762258

+
3UTR-3UTRENST00000355294ENST00000355294RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000355294ENST00000367117RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000355294ENST00000304534RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000355294ENST00000491368RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000367117ENST00000355294RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000367117ENST00000367117RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000367117ENST00000304534RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000367117ENST00000491368RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000304534ENST00000355294RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000304534ENST00000367117RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000304534ENST00000304534RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000304534ENST00000491368RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000491368ENST00000355294RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000491368ENST00000367117RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000491368ENST00000304534RASSF5chr1

206760374

+RASSF5chr1

206760755

-
3UTR-3UTRENST00000491368ENST00000491368RASSF5chr1

206760374

+RASSF5chr1

206760755

-

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FusionProtFeatures for RASSF5_RASSF5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASSF5

Q8WWW0

RASSF5

Q8WWW0

Potential tumor suppressor. Seems to be involved inlymphocyte adhesion by linking RAP1A activation upon T-cellreceptor or chemokine stimulation to integrin activation. Isoform2 stimulates lymphocyte polarization and the patch-likedistribution of ITGAL/LFA-1, resulting in an enhanced adhesion toICAM1. Together with RAP1A may participate in regulation ofmicrotubule growth. The association of isoform 2 with activatedRAP1A is required for directional movement of endothelial cellsduring wound healing. May be involved in regulation of Rasapoptotic function. The RASSF5-STK4/MST1 complex may mediate HRASand KRAS induced apoptosis. {ECO:0000269|PubMed:12676952,ECO:0000269|PubMed:12845325, ECO:0000269|PubMed:15569673}. Potential tumor suppressor. Seems to be involved inlymphocyte adhesion by linking RAP1A activation upon T-cellreceptor or chemokine stimulation to integrin activation. Isoform2 stimulates lymphocyte polarization and the patch-likedistribution of ITGAL/LFA-1, resulting in an enhanced adhesion toICAM1. Together with RAP1A may participate in regulation ofmicrotubule growth. The association of isoform 2 with activatedRAP1A is required for directional movement of endothelial cellsduring wound healing. May be involved in regulation of Rasapoptotic function. The RASSF5-STK4/MST1 complex may mediate HRASand KRAS induced apoptosis. {ECO:0000269|PubMed:12676952,ECO:0000269|PubMed:12845325, ECO:0000269|PubMed:15569673}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RASSF5_RASSF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RASSF5_RASSF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASSF5_RASSF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RASSF5_RASSF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRASSF5C0022665Kidney Neoplasm1CTD_human
HgeneRASSF5C0027819Neuroblastoma1CTD_human
TgeneRASSF5C0022665Kidney Neoplasm1CTD_human
TgeneRASSF5C0027819Neuroblastoma1CTD_human