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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30575

FusionGeneSummary for RASSF4_RFC3

check button Fusion gene summary
Fusion gene informationFusion gene name: RASSF4_RFC3
Fusion gene ID: 30575
HgeneTgene
Gene symbol

RASSF4

RFC3

Gene ID

83937

5983

Gene nameRas association domain family member 4replication factor C subunit 3
SynonymsAD037RFC38
Cytomap

10q11.21

13q13.2

Type of geneprotein-codingprotein-coding
Descriptionras association domain-containing protein 4Ras association (RalGDS/AF-6) domain family 4Ras association (RalGDS/AF-6) domain family member 4Ras association domain family 4tumor suppressor RASSF4replication factor C subunit 3A1 38 kDa subunitRF-C 38 kDa subunitRFC, 38 kD subunitactivator 1 38 kDa subunitactivator 1 subunit 3replication factor C (activator 1) 3, 38kDareplication factor C 38 kDa subunit
Modification date2018051920180523
UniProtAcc

Q9H2L5

P40938

Ensembl transtripts involved in fusion geneENST00000334940, ENST00000374417, 
ENST00000340258, ENST00000472561, 
ENST00000434425, ENST00000380071, 
Fusion gene scores* DoF score5 X 5 X 1=251 X 1 X 1=1
# samples 51
** MAII scorelog2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: RASSF4 [Title/Abstract] AND RFC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRFC3

GO:0006260

DNA replication

9488738

TgeneRFC3

GO:1900264

positive regulation of DNA-directed DNA polymerase activity

12930902


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB171776RASSF4chr10

45473448

-RFC3chr13

34392289

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000334940ENST00000434425RASSF4chr10

45473448

-RFC3chr13

34392289

+
intron-5UTRENST00000334940ENST00000380071RASSF4chr10

45473448

-RFC3chr13

34392289

+
intron-5UTRENST00000374417ENST00000434425RASSF4chr10

45473448

-RFC3chr13

34392289

+
intron-5UTRENST00000374417ENST00000380071RASSF4chr10

45473448

-RFC3chr13

34392289

+
intron-5UTRENST00000340258ENST00000434425RASSF4chr10

45473448

-RFC3chr13

34392289

+
intron-5UTRENST00000340258ENST00000380071RASSF4chr10

45473448

-RFC3chr13

34392289

+
intron-5UTRENST00000472561ENST00000434425RASSF4chr10

45473448

-RFC3chr13

34392289

+
intron-5UTRENST00000472561ENST00000380071RASSF4chr10

45473448

-RFC3chr13

34392289

+

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FusionProtFeatures for RASSF4_RFC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASSF4

Q9H2L5

RFC3

P40938

Potential tumor suppressor. May act as a KRAS effectorprotein. May promote apoptosis and cell cycle arrest.{ECO:0000269|PubMed:15574778}. The elongation of primed DNA templates by DNA polymerasedelta and epsilon requires the action of the accessory proteinsproliferating cell nuclear antigen (PCNA) and activator 1.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RASSF4_RFC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RASSF4_RFC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASSF4_RFC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RASSF4_RFC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRASSF4C0023893Liver Cirrhosis, Experimental1CTD_human