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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30543

FusionGeneSummary for RASGEF1B_LNPEP

check button Fusion gene summary
Fusion gene informationFusion gene name: RASGEF1B_LNPEP
Fusion gene ID: 30543
HgeneTgene
Gene symbol

RASGEF1B

LNPEP

Gene ID

153020

4012

Gene nameRasGEF domain family member 1Bleucyl and cystinyl aminopeptidase
SynonymsGPIG4CAP|IRAP|P-LAP|PLAP
Cytomap

4q21.21

5q15

Type of geneprotein-codingprotein-coding
Descriptionras-GEF domain-containing family member 1BGPI gamma-4leucyl-cystinyl aminopeptidaseAT (4) receptorangiotensin IV receptorcystinyl aminopeptidaseinsulin-regulated aminopeptidaseinsulin-regulated membrane aminopeptidaseinsulin-responsive aminopeptidaseotaseoxytocinaseplacental leucine aminopeptidase
Modification date2018051920180523
UniProtAcc

Q0VAM2

Q9UIQ6

Ensembl transtripts involved in fusion geneENST00000509081, ENST00000264400, 
ENST00000335927, ENST00000436139, 
ENST00000514889, 
ENST00000231368, 
ENST00000395770, ENST00000395784, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 41
** MAII scorelog2(4/4*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: RASGEF1B [Title/Abstract] AND LNPEP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI909609RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000509081ENST00000231368RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-3CDSENST00000509081ENST00000395770RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-intronENST00000509081ENST00000395784RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-3CDSENST00000264400ENST00000231368RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-3CDSENST00000264400ENST00000395770RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-intronENST00000264400ENST00000395784RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-3CDSENST00000335927ENST00000231368RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-3CDSENST00000335927ENST00000395770RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-intronENST00000335927ENST00000395784RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-3CDSENST00000436139ENST00000231368RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-3CDSENST00000436139ENST00000395770RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-intronENST00000436139ENST00000395784RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-3CDSENST00000514889ENST00000231368RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-3CDSENST00000514889ENST00000395770RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+
intron-intronENST00000514889ENST00000395784RASGEF1Bchr4

82392035

+LNPEPchr5

96363436

+

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FusionProtFeatures for RASGEF1B_LNPEP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASGEF1B

Q0VAM2

LNPEP

Q9UIQ6

Guanine nucleotide exchange factor (GEF) withspecificity for RAP2A, it doesn't seems to activate other Rasfamily proteins (in vitro). {ECO:0000269|PubMed:19645719,ECO:0000269|PubMed:23894443}. Release of an N-terminal amino acid, cleaves beforecysteine, leucine as well as other amino acids. Degrades peptidehormones such as oxytocin, vasopressin and angiotensin III, andplays a role in maintaining homeostasis during pregnancy. May beinvolved in the inactivation of neuronal peptides in the brain.Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and maybe the angiotensin IV receptor in the brain.{ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427,ECO:0000269|PubMed:1731608}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RASGEF1B_LNPEP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RASGEF1B_LNPEP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASGEF1B_LNPEP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RASGEF1B_LNPEP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRASGEF1BC3495559Juvenile arthritis1CTD_human
TgeneLNPEPC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneLNPEPC0025261Memory Disorders1CTD_human