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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30542

FusionGeneSummary for RASGEF1A_SFTA1P

check button Fusion gene summary
Fusion gene informationFusion gene name: RASGEF1A_SFTA1P
Fusion gene ID: 30542
HgeneTgene
Gene symbol

RASGEF1A

SFTA1P

Gene ID

221002

207107

Gene nameRasGEF domain family member 1Asurfactant associated 1, pseudogene
SynonymsCG4853SFTPF
Cytomap

10q11.21

10p14

Type of geneprotein-codingpseudo
Descriptionras-GEF domain-containing family member 1ACG4853 gene productsurfactant associated protein F
Modification date2018051920180329
UniProtAcc

Q8N9B8

Ensembl transtripts involved in fusion geneENST00000374459, ENST00000395810, 
ENST00000395809, ENST00000472864, 
ENST00000446372, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: RASGEF1A [Title/Abstract] AND SFTA1P [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRASGEF1A

GO:0016477

cell migration

17121879

HgeneRASGEF1A

GO:0046579

positive regulation of Ras protein signal transduction

17121879


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-04-1364-01ARASGEF1Achr10

43694381

-SFTA1Pchr10

10828718

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000374459ENST00000446372RASGEF1Achr10

43694381

-SFTA1Pchr10

10828718

-
5CDS-intronENST00000395810ENST00000446372RASGEF1Achr10

43694381

-SFTA1Pchr10

10828718

-
5CDS-intronENST00000395809ENST00000446372RASGEF1Achr10

43694381

-SFTA1Pchr10

10828718

-
intron-intronENST00000472864ENST00000446372RASGEF1Achr10

43694381

-SFTA1Pchr10

10828718

-

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FusionProtFeatures for RASGEF1A_SFTA1P


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASGEF1A

Q8N9B8

SFTA1P

Guanine nucleotide exchange factor (GEF) withspecificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays arole in cell migration. {ECO:0000269|PubMed:17121879,ECO:0000269|PubMed:19645719}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RASGEF1A_SFTA1P


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RASGEF1A_SFTA1P


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RASGEF1ANEDD4SFTA1P


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASGEF1A_SFTA1P


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RASGEF1A_SFTA1P


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource