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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 30531

FusionGeneSummary for RASAL2_KIF14

check button Fusion gene summary
Fusion gene informationFusion gene name: RASAL2_KIF14
Fusion gene ID: 30531
HgeneTgene
Gene symbol

RASAL2

KIF14

Gene ID

9462

9928

Gene nameRAS protein activator like 2kinesin family member 14
SynonymsNGAPMCPH20|MKS12
Cytomap

1q25.2

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionras GTPase-activating protein nGAPRASAL2/ACVR1 fusionRas protein activator like 1kinesin-like protein KIF14
Modification date2018052220180523
UniProtAcc

Q9UJF2

Q15058

Ensembl transtripts involved in fusion geneENST00000448150, ENST00000367649, 
ENST00000465723, ENST00000462775, 
ENST00000367350, 
Fusion gene scores* DoF score12 X 8 X 8=7682 X 2 X 2=8
# samples 132
** MAII scorelog2(13/768*10)=-2.5625946876927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: RASAL2 [Title/Abstract] AND KIF14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKIF14

GO:0008284

positive regulation of cell proliferation

24784001

TgeneKIF14

GO:0034446

substrate adhesion-dependent cell spreading

23209302

TgeneKIF14

GO:0045184

establishment of protein localization

23209302


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-BF-AAP4-01ARASAL2chr1

178252826

+KIF14chr1

200544819

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000448150ENST00000367350RASAL2chr1

178252826

+KIF14chr1

200544819

-
In-frameENST00000367649ENST00000367350RASAL2chr1

178252826

+KIF14chr1

200544819

-
3UTR-3CDSENST00000465723ENST00000367350RASAL2chr1

178252826

+KIF14chr1

200544819

-
intron-3CDSENST00000462775ENST00000367350RASAL2chr1

178252826

+KIF14chr1

200544819

-

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FusionProtFeatures for RASAL2_KIF14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RASAL2

Q9UJF2

KIF14

Q15058

Inhibitory regulator of the Ras-cyclic AMP pathway. Microtubule motor protein that binds to microtubuleswith high affinity through each tubulin heterodimer and has anATPase activity (By similarity). Plays a role in many processeslike cell division, cytokinesis and also in cell proliferation andapoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis,targets to central spindle and midbody through its interactionwith PRC1 and CIT respectively (PubMed:16431929). Regulates cellgrowth through regulation of cell cycle progression andcytokinesis (PubMed:24854087). During cell cycle progression actsthrough SCF-dependent proteasomal ubiquitin-dependent proteincatabolic process which controls CDKN1B degradation, resulting inpositive regulation of cyclins, including CCNE1, CCND1 and CCNB1(PubMed:24854087). During late neurogenesis, regulates thecerebellar, cerebral cortex and olfactory bulb development throughregulation of apoptosis, cell proliferation and cell division (Bysimilarity). Also is required for chromosome congression andalignment during mitotic cell cycle process (PubMed:15843429).Regulates cell spreading, focal adhesion dynamics, and cellmigration through its interaction with RADIL resulting inregulation of RAP1A-mediated inside-out integrin activation bytethering RADIL on microtubules (PubMed:23209302).{ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429,ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480,ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001,ECO:0000269|PubMed:24854087}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKIF14chr1:178252826chr1:200544819ENST00000367350-20301332_134811551649Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:178252826chr1:200544819ENST00000367350-20301468_150011551649Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASAL2chr1:178252826chr1:200544819ENST00000367649+218237_2431101281Compositional biasNote=Poly-Lys
HgeneRASAL2chr1:178252826chr1:200544819ENST00000367649+218922_9251101281Compositional biasNote=Poly-Ser
HgeneRASAL2chr1:178252826chr1:200544819ENST00000462775+116237_243-421140Compositional biasNote=Poly-Lys
HgeneRASAL2chr1:178252826chr1:200544819ENST00000462775+116922_925-421140Compositional biasNote=Poly-Ser
HgeneRASAL2chr1:178252826chr1:200544819ENST00000367649+218170_2661101281DomainNote=C2
HgeneRASAL2chr1:178252826chr1:200544819ENST00000367649+218327_5191101281DomainRas-GAP
HgeneRASAL2chr1:178252826chr1:200544819ENST00000367649+21841_1581101281DomainNote=PH
HgeneRASAL2chr1:178252826chr1:200544819ENST00000462775+116170_266-421140DomainNote=C2
HgeneRASAL2chr1:178252826chr1:200544819ENST00000462775+116327_519-421140DomainRas-GAP
HgeneRASAL2chr1:178252826chr1:200544819ENST00000462775+11641_158-421140DomainNote=PH
TgeneKIF14chr1:178252826chr1:200544819ENST00000367350-2030705_79111551649Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:178252826chr1:200544819ENST00000367350-2030922_107911551649Coiled coilOntology_term=ECO:0000255
TgeneKIF14chr1:178252826chr1:200544819ENST00000367350-2030358_70111551649DomainKinesin motor
TgeneKIF14chr1:178252826chr1:200544819ENST00000367350-2030825_89111551649DomainNote=FHA
TgeneKIF14chr1:178252826chr1:200544819ENST00000367350-2030447_45411551649Nucleotide bindingATP
TgeneKIF14chr1:178252826chr1:200544819ENST00000367350-20301_35611551649RegionNote=Required for PRC1-binding
TgeneKIF14chr1:178252826chr1:200544819ENST00000367350-2030356_73711551649RegionRequired for microtubule-binding with high affinity
TgeneKIF14chr1:178252826chr1:200544819ENST00000367350-2030901_164811551649RegionNote=Required for CIT-binding


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FusionGeneSequence for RASAL2_KIF14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RASAL2_ENST00000448150_chr1_178252826_+_KIF14_ENST00000367350_chr1_200544819_-_586aa
MFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKE
KESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRISGCLHDIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICK
ELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEESQDNLFSSDRAIQSLTIQTACAFEQLVVLMKHWLSDLLPCTN
IARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGL
GMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRRQVQEENFEYQDFKRMVNRAPEFLKLKHCLEKA
IEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESRVTHIVHQELESLAKSLLFCFESEESPDLLKPWETYNQNTKE

>In-frame_RASAL2_ENST00000367649_chr1_178252826_+_KIF14_ENST00000367350_chr1_200544819_-_604aa
MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTW
ERKYCILTDSQLVLLNKEKESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRISGCLHDIQVHPIKNLHSSHSSGLMDK
SSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEESQDNLFSSDRAIQSLTIQTACAFE
QLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNK
AASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRRQVQEENFEYQDFKR
MVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESRVTHIVHQELESLAKSLLFCFESE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RASAL2_ENST00000448150_chr1_178252826_+_KIF14_ENST00000367350_chr1_200544819_-_1758nt
ATGTTCCCGGCGCTGGAGTCCGACTCGCCGCTGCCCCCGGAGGACCTGGACGCGGTTGTCCCAGTCAGTGGAGCCGTCGCCGGTGGCATG
TTGGATCGGATCCTTCTGGAGTCCGTGTGCCAGCAACAGAGCTGGGTCCGGGTGTACGATGTGAAAGGACCACCCACCCACCGTCTGTCT
TGTGGTCAGTCACCCTACACCGAGACAACAACGTGGGAGCGGAAGTATTGCATCCTCACAGACAGCCAGTTGGTATTGCTCAACAAGGAG
AAGGAGAGTAATGGTAGTAACAGGGGTGAAGATGCCTTTTGTGATCCTGAAGATGAATGGGAACCCGACATTACAGATGCACCAGTTTCT
TCACTTTCTAGAAGGAGGAGTAGGAGTTTGATGAAGAACAGAAGAATTTCTGGTTGTTTACATGACATACAAGTCCATCCAATTAAGAAT
TTGCATTCTTCACATTCATCAGGTTTAATGGACAAATCAAGCACTATTTACTCAAATTCAGCAGAGTCCTTTCTTCCTGGAATTTGCAAA
GAATTGATTGGTTCTTCGTTAGATTTTTTTGGACAGAGTTATGATGAAGAAAGAACTATAGCAGACAGCCTAATTAATAGTTTTCTTAAA
ATTTATAATGGGCTATTTGCCATTTCCAAGGCTCATGAAGAACAAGATGAAGAAAGTCAAGATAACTTGTTTTCTTCTGATCGAGCAATC
CAGTCACTTACTATTCAGACTGCATGTGCTTTTGAGCAGCTAGTAGTGCTAATGAAACACTGGCTGAGTGATTTACTGCCTTGTACCAAC
ATAGCAAGACTTGAGGATGAGTTGAGACAAGAAGTTAAAAAACTGGGAGGCTACTTACAGTTATTTTTGCAGGGATGCTGTTTGGATATT
TCATCAATGATAAAAGAGGCTCAAAAGAATGCAATCCAAATTGTACAACAAGCTGTAAAGTATGTGGGGCAGTTAGCAGTTCTGAAAGGG
AGCAAGCTACATTTTCTAGAAAACGGTAACAATAAAGCTGCCAGTGTCCAGGAGGAATTCATGGATGCTGTTTGTGATGGTGTAGGCTTA
GGAATGAAGATTTTATTAGATTCTGGACTGGAAAAAGCAAAAGAACTTCAGCATGAACTCTTTAGGCAGTGTACAAAAAATGAGGTTACC
AAAGAAATGAAAACTAATGCCATGGGATTGATTAGATCTCTTGAAAACATCTTTGCTGAATCGAAAATTAAAAGTTTCAGAAGGCAAGTA
CAAGAAGAAAACTTTGAATACCAAGATTTCAAGAGGATGGTTAATCGTGCTCCAGAATTCTTAAAGTTAAAACATTGCTTAGAGAAAGCT
ATTGAAATTATTATTTCTGCACTGAAAGGATGCCATAGTGATATAAATCTTCTCCAGACTTGTGTTGAAAGTATTCGCAACTTGGCCAGT
GATTTTTACAGTGACTTCAGTGTGCCTTCTACTTCTGTTGGCAGCTATGAGAGTAGAGTAACTCACATTGTCCACCAGGAACTAGAATCT
CTAGCTAAGTCTCTCCTCTTTTGTTTTGAATCTGAAGAAAGCCCTGATTTGTTGAAACCCTGGGAAACTTATAATCAAAATACCAAAGAA
GAACACCAACAATCTAAATCAAGCGGGATTGACGGCAGTAAGAATAAAGGTGTACCAAAGCGTGTCTATGAGCTCCATGGCTCATCCCCA

>In-frame_RASAL2_ENST00000367649_chr1_178252826_+_KIF14_ENST00000367350_chr1_200544819_-_1812nt
ATGGAGCTCTCTCCGTCGTCCGGAGGAGCCGCGGAGGCGCTGTCCTGGCCGGAGATGTTCCCGGCGCTGGAGTCCGACTCGCCGCTGCCC
CCGGAGGACCTGGACGCGGTTGTCCCAGTCAGTGGAGCCGTCGCCGGTGGCATGTTGGATCGGATCCTTCTGGAGTCCGTGTGCCAGCAA
CAGAGCTGGGTCCGGGTGTACGATGTGAAAGGACCACCCACCCACCGTCTGTCTTGTGGTCAGTCACCCTACACCGAGACAACAACGTGG
GAGCGGAAGTATTGCATCCTCACAGACAGCCAGTTGGTATTGCTCAACAAGGAGAAGGAGAGTAATGGTAGTAACAGGGGTGAAGATGCC
TTTTGTGATCCTGAAGATGAATGGGAACCCGACATTACAGATGCACCAGTTTCTTCACTTTCTAGAAGGAGGAGTAGGAGTTTGATGAAG
AACAGAAGAATTTCTGGTTGTTTACATGACATACAAGTCCATCCAATTAAGAATTTGCATTCTTCACATTCATCAGGTTTAATGGACAAA
TCAAGCACTATTTACTCAAATTCAGCAGAGTCCTTTCTTCCTGGAATTTGCAAAGAATTGATTGGTTCTTCGTTAGATTTTTTTGGACAG
AGTTATGATGAAGAAAGAACTATAGCAGACAGCCTAATTAATAGTTTTCTTAAAATTTATAATGGGCTATTTGCCATTTCCAAGGCTCAT
GAAGAACAAGATGAAGAAAGTCAAGATAACTTGTTTTCTTCTGATCGAGCAATCCAGTCACTTACTATTCAGACTGCATGTGCTTTTGAG
CAGCTAGTAGTGCTAATGAAACACTGGCTGAGTGATTTACTGCCTTGTACCAACATAGCAAGACTTGAGGATGAGTTGAGACAAGAAGTT
AAAAAACTGGGAGGCTACTTACAGTTATTTTTGCAGGGATGCTGTTTGGATATTTCATCAATGATAAAAGAGGCTCAAAAGAATGCAATC
CAAATTGTACAACAAGCTGTAAAGTATGTGGGGCAGTTAGCAGTTCTGAAAGGGAGCAAGCTACATTTTCTAGAAAACGGTAACAATAAA
GCTGCCAGTGTCCAGGAGGAATTCATGGATGCTGTTTGTGATGGTGTAGGCTTAGGAATGAAGATTTTATTAGATTCTGGACTGGAAAAA
GCAAAAGAACTTCAGCATGAACTCTTTAGGCAGTGTACAAAAAATGAGGTTACCAAAGAAATGAAAACTAATGCCATGGGATTGATTAGA
TCTCTTGAAAACATCTTTGCTGAATCGAAAATTAAAAGTTTCAGAAGGCAAGTACAAGAAGAAAACTTTGAATACCAAGATTTCAAGAGG
ATGGTTAATCGTGCTCCAGAATTCTTAAAGTTAAAACATTGCTTAGAGAAAGCTATTGAAATTATTATTTCTGCACTGAAAGGATGCCAT
AGTGATATAAATCTTCTCCAGACTTGTGTTGAAAGTATTCGCAACTTGGCCAGTGATTTTTACAGTGACTTCAGTGTGCCTTCTACTTCT
GTTGGCAGCTATGAGAGTAGAGTAACTCACATTGTCCACCAGGAACTAGAATCTCTAGCTAAGTCTCTCCTCTTTTGTTTTGAATCTGAA
GAAAGCCCTGATTTGTTGAAACCCTGGGAAACTTATAATCAAAATACCAAAGAAGAACACCAACAATCTAAATCAAGCGGGATTGACGGC
AGTAAGAATAAAGGTGTACCAAAGCGTGTCTATGAGCTCCATGGCTCATCCCCAGCAGTGAGCTCAGAGGAATGCACACCCAGTAGGATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_RASAL2_ENST00000448150_chr1_178252826_+_KIF14_ENST00000367350_chr1_200544819_-_4464nt
CCCTCGATTGCTTCAGCCTATCACCCTGGGATGCCGCCTGCCGCTGCCGCCGCCGCCGCCGCCGCCACCGCCACCGCCACCGCCACCGCC
ACCGCCGTGGCTGCCGGGTTTGTGGGATCCGCCGCGGAGCAGGAGCCAGAGCTGTGGCCGGAGCTGTGGCCTGAGAGTCAGGGGGCGGGC
AGGCTCATTCCAGAAGTGGGGGCCGAGGACAGGCGGGCTAGAACCCGGGGCCACCGCCCCCTACCCCTCCTCAGGCTGAGGGAACGGGCA
CTCGGAGCTTCTGAGGCGGCGGCGGCGGGAGCCGGTCAGAGGGGGCGGCCCCTGGCGGCGACGCCCCCAAGCCCAGCCCTGCCCGGCCCC
GCTCCATCCCCAGCCAGAGCCTGGTCTGACCGCGAGAGACGCCGGCGGGGCTGAAGAAGGCGGCTCCGAGGAGGTGGGAGGGCGAGCCTC
CCCTCCCGGGTTCTTCTGCGTCCTCTCCCGGGAGGGACCCACACACACCTGAGCCCGGACCCACCCTTGGTCGGGGCCACGCTGGATCCT
CCTCCCGGCCTGGGTCCCGCCCGCCGACTGCAGGTGGGCTGCATCGCCCGAGCCTCGGGCAGTGGGCGACGGGGAAGGAGGTGAGAGGTG
TCCGCGCCGGCTGCCGCTCGGGTCCCTGCCCTCGCTGCGCGCTCTCCTCCTCCCCTTACCGCAGGCAGGGCGCGGAGCCGCGCGCCAGCC
CGCCCCGAAGCCGCCGCCTCGTCCCCCTCCCGCCTCGGGGCACCATGGAGCTCTCTCCGTCGTCCGGAGGAGCCGCGGAGGCGCTGTCCT
GGCCGGAGATGTTCCCGGCGCTGGAGTCCGACTCGCCGCTGCCCCCGGAGGACCTGGACGCGGTTGTCCCAGTCAGTGGAGCCGTCGCCG
GTGGCATGTTGGATCGGATCCTTCTGGAGTCCGTGTGCCAGCAACAGAGCTGGGTCCGGGTGTACGATGTGAAAGGACCACCCACCCACC
GTCTGTCTTGTGGTCAGTCACCCTACACCGAGACAACAACGTGGGAGCGGAAGTATTGCATCCTCACAGACAGCCAGTTGGTATTGCTCA
ACAAGGAGAAGGAGAGTAATGGTAGTAACAGGGGTGAAGATGCCTTTTGTGATCCTGAAGATGAATGGGAACCCGACATTACAGATGCAC
CAGTTTCTTCACTTTCTAGAAGGAGGAGTAGGAGTTTGATGAAGAACAGAAGAATTTCTGGTTGTTTACATGACATACAAGTCCATCCAA
TTAAGAATTTGCATTCTTCACATTCATCAGGTTTAATGGACAAATCAAGCACTATTTACTCAAATTCAGCAGAGTCCTTTCTTCCTGGAA
TTTGCAAAGAATTGATTGGTTCTTCGTTAGATTTTTTTGGACAGAGTTATGATGAAGAAAGAACTATAGCAGACAGCCTAATTAATAGTT
TTCTTAAAATTTATAATGGGCTATTTGCCATTTCCAAGGCTCATGAAGAACAAGATGAAGAAAGTCAAGATAACTTGTTTTCTTCTGATC
GAGCAATCCAGTCACTTACTATTCAGACTGCATGTGCTTTTGAGCAGCTAGTAGTGCTAATGAAACACTGGCTGAGTGATTTACTGCCTT
GTACCAACATAGCAAGACTTGAGGATGAGTTGAGACAAGAAGTTAAAAAACTGGGAGGCTACTTACAGTTATTTTTGCAGGGATGCTGTT
TGGATATTTCATCAATGATAAAAGAGGCTCAAAAGAATGCAATCCAAATTGTACAACAAGCTGTAAAGTATGTGGGGCAGTTAGCAGTTC
TGAAAGGGAGCAAGCTACATTTTCTAGAAAACGGTAACAATAAAGCTGCCAGTGTCCAGGAGGAATTCATGGATGCTGTTTGTGATGGTG
TAGGCTTAGGAATGAAGATTTTATTAGATTCTGGACTGGAAAAAGCAAAAGAACTTCAGCATGAACTCTTTAGGCAGTGTACAAAAAATG
AGGTTACCAAAGAAATGAAAACTAATGCCATGGGATTGATTAGATCTCTTGAAAACATCTTTGCTGAATCGAAAATTAAAAGTTTCAGAA
GGCAAGTACAAGAAGAAAACTTTGAATACCAAGATTTCAAGAGGATGGTTAATCGTGCTCCAGAATTCTTAAAGTTAAAACATTGCTTAG
AGAAAGCTATTGAAATTATTATTTCTGCACTGAAAGGATGCCATAGTGATATAAATCTTCTCCAGACTTGTGTTGAAAGTATTCGCAACT
TGGCCAGTGATTTTTACAGTGACTTCAGTGTGCCTTCTACTTCTGTTGGCAGCTATGAGAGTAGAGTAACTCACATTGTCCACCAGGAAC
TAGAATCTCTAGCTAAGTCTCTCCTCTTTTGTTTTGAATCTGAAGAAAGCCCTGATTTGTTGAAACCCTGGGAAACTTATAATCAAAATA
CCAAAGAAGAACACCAACAATCTAAATCAAGCGGGATTGACGGCAGTAAGAATAAAGGTGTACCAAAGCGTGTCTATGAGCTCCATGGCT
CATCCCCAGCAGTGAGCTCAGAGGAATGCACACCCAGTAGGATTCAGTGGGTGTGAATACTGATGTGTAGGCACTTTTATGACCACCCAT
GAAAGAAAAAGAACACTTGCTCGGTAATTTTCTTTATGCAGGAGAGTTTAAGAGAAATCAGCACAGATATTTCAAAAAAGTCCATGTCTT
TTTATCTTTAAAATATCTATTTATCAAAGGCCAGACACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCGGGCAGATCACAAGG
TCAGGAGTTTGAGACCGGCCTGGCCAACATGGCGAAACCCCGTCTCTACTAAAAATACAAAAATTTGCTGGGCATGGTGGCGCGTGCCTG
TAATCCCAGCTACTAGGGGGGCTGAGGCAGGAGGATCGCTTGAACCTGAGAGGCAGAGGTTGCAGTGAGCCAAGATCATGCCACTTTACT
CCAGTCTGAGCAACAGAACGAGACTTAGTCAAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAAATATATTTTTAT
CTTTAAAGTGTTTAACATTGGTATACTGTCTGTAGTTGGTTCATTAGTCGTTTATAAAGGGTTATTTTCTCATGAGTGGAAACCTGAACA
ATCAGTTACCTTTGTGCCTATGCCTTCTCTCTCCTCAGACAGCTGGGATGTTTATGGTGAAATGGCCTGTACAAGTTTAACTAAGACAAC
TTAACTTGCATTGTTAATCAAAAATTCTTTTCTCAAAGGGTTAACTGGTTGCCATTTTGAATAGTATGTTCAAGGGTGTAGCTTCCTGTT
TCTTTCCAAATTATAAGTAGCTACCTAAATATAGTATAATTATATATTAATAATATGGCTTGCTGGCACAGTAGTTTACCCTGTTATCTG
TGTTTCATAATGGGGGCTGTATGAATATTATTTAAAACTAATAAAATGTTGCCAGAATTATACTAAACTGTTGGATGAGATTAGGAGATC
AGAGGCTGGACCTTCTCTTGATAATGCTTGTTTTGTTAAAGGTATAATGAAATAATTTGTATATGATTTGATGAAGATTAAAGACCCTTA
TTTTCCACAGCTTTAAAAAAAAACCTTTATTTATGATCAAGTAATAAAGATAATATTCTACTTGTGGGATCTTACATTACGGAAATAGTT
TGACGTTTTTGACCTCAAGAGTATGTATAATTTGAAGAGATACTTTGTAACTATGCTTGGGTGATATTGAGCAGTTCCTAAAGAATAATT
CATTTAAAAAAAAAGAAGAAAAAAAAAGAAGAATTCATTTAAATAACCTGATCCTTTCATTTGCCCTTTTCGAATTTACAGATACTACTT
GTACATTTGGCATAACTAGTTGAAATTGGCCATTCGTACCATGAATAAATCTGATAGTTTCCTTGTTAGGAAGAGATTGTAAGTAAATAC
AGTCATTGCAGTCAGAACAGTATTAGTGAACCTTGTGTGGTGTTTTCAAGCTCTTTAAAATGGTACAATGTAGCACATTTGCTTTCATTT
CTTTTTTTATTTTTGGCATTTGACCTTGTATTCTTTCTGAAGCTCTATATGTGTTTTTATTAGTCAATAATCTGGCAAGTAGCACTTTGC
CTGTGCAGTTTGCTGGAGTGTAGATGTACATATGAGGATTTCCCGGGAGGTGCACTTCTTTGAAGAACTTCCTAAAGTACCTGTATAGTA
GTTTTCATCTTAATATTCAGTATTTAATCTTCAGTTTGTGCTTTGTAAACTCATGACTTAATTGGTCAGAAACTTTTTAGTGTCTTTATA
AAATTTTGTATACATATTTATACTAAACACATTGTGATACTGTATTTGAATGAATGGTGAAAAAATATTTGCTATTGGAATTATGTGCAC

>In-frame_RASAL2_ENST00000367649_chr1_178252826_+_KIF14_ENST00000367350_chr1_200544819_-_4052nt
GAAGAAGGCGGCTCCGAGGAGGTGGGAGGGCGAGCCTCCCCTCCCGGGTTCTTCTGCGTCCTCTCCCGGGAGGGACCCACACACACCTGA
GCCCGGACCCACCCTTGGTCGGGGCCACGCTGGATCCTCCTCCCGGCCTGGGTCCCGCCCGCCGACTGCAGGTGGGCTGCATCGCCCGAG
CCTCGGGCAGTGGGCGACGGGGAAGGAGGTGAGAGGTGTCCGCGCCGGCTGCCGCTCGGGTCCCTGCCCTCGCTGCGCGCTCTCCTCCTC
CCCTTACCGCAGGCAGGGCGCGGAGCCGCGCGCCAGCCCGCCCCGAAGCCGCCGCCTCGTCCCCCTCCCGCCTCGGGGCACCATGGAGCT
CTCTCCGTCGTCCGGAGGAGCCGCGGAGGCGCTGTCCTGGCCGGAGATGTTCCCGGCGCTGGAGTCCGACTCGCCGCTGCCCCCGGAGGA
CCTGGACGCGGTTGTCCCAGTCAGTGGAGCCGTCGCCGGTGGCATGTTGGATCGGATCCTTCTGGAGTCCGTGTGCCAGCAACAGAGCTG
GGTCCGGGTGTACGATGTGAAAGGACCACCCACCCACCGTCTGTCTTGTGGTCAGTCACCCTACACCGAGACAACAACGTGGGAGCGGAA
GTATTGCATCCTCACAGACAGCCAGTTGGTATTGCTCAACAAGGAGAAGGAGAGTAATGGTAGTAACAGGGGTGAAGATGCCTTTTGTGA
TCCTGAAGATGAATGGGAACCCGACATTACAGATGCACCAGTTTCTTCACTTTCTAGAAGGAGGAGTAGGAGTTTGATGAAGAACAGAAG
AATTTCTGGTTGTTTACATGACATACAAGTCCATCCAATTAAGAATTTGCATTCTTCACATTCATCAGGTTTAATGGACAAATCAAGCAC
TATTTACTCAAATTCAGCAGAGTCCTTTCTTCCTGGAATTTGCAAAGAATTGATTGGTTCTTCGTTAGATTTTTTTGGACAGAGTTATGA
TGAAGAAAGAACTATAGCAGACAGCCTAATTAATAGTTTTCTTAAAATTTATAATGGGCTATTTGCCATTTCCAAGGCTCATGAAGAACA
AGATGAAGAAAGTCAAGATAACTTGTTTTCTTCTGATCGAGCAATCCAGTCACTTACTATTCAGACTGCATGTGCTTTTGAGCAGCTAGT
AGTGCTAATGAAACACTGGCTGAGTGATTTACTGCCTTGTACCAACATAGCAAGACTTGAGGATGAGTTGAGACAAGAAGTTAAAAAACT
GGGAGGCTACTTACAGTTATTTTTGCAGGGATGCTGTTTGGATATTTCATCAATGATAAAAGAGGCTCAAAAGAATGCAATCCAAATTGT
ACAACAAGCTGTAAAGTATGTGGGGCAGTTAGCAGTTCTGAAAGGGAGCAAGCTACATTTTCTAGAAAACGGTAACAATAAAGCTGCCAG
TGTCCAGGAGGAATTCATGGATGCTGTTTGTGATGGTGTAGGCTTAGGAATGAAGATTTTATTAGATTCTGGACTGGAAAAAGCAAAAGA
ACTTCAGCATGAACTCTTTAGGCAGTGTACAAAAAATGAGGTTACCAAAGAAATGAAAACTAATGCCATGGGATTGATTAGATCTCTTGA
AAACATCTTTGCTGAATCGAAAATTAAAAGTTTCAGAAGGCAAGTACAAGAAGAAAACTTTGAATACCAAGATTTCAAGAGGATGGTTAA
TCGTGCTCCAGAATTCTTAAAGTTAAAACATTGCTTAGAGAAAGCTATTGAAATTATTATTTCTGCACTGAAAGGATGCCATAGTGATAT
AAATCTTCTCCAGACTTGTGTTGAAAGTATTCGCAACTTGGCCAGTGATTTTTACAGTGACTTCAGTGTGCCTTCTACTTCTGTTGGCAG
CTATGAGAGTAGAGTAACTCACATTGTCCACCAGGAACTAGAATCTCTAGCTAAGTCTCTCCTCTTTTGTTTTGAATCTGAAGAAAGCCC
TGATTTGTTGAAACCCTGGGAAACTTATAATCAAAATACCAAAGAAGAACACCAACAATCTAAATCAAGCGGGATTGACGGCAGTAAGAA
TAAAGGTGTACCAAAGCGTGTCTATGAGCTCCATGGCTCATCCCCAGCAGTGAGCTCAGAGGAATGCACACCCAGTAGGATTCAGTGGGT
GTGAATACTGATGTGTAGGCACTTTTATGACCACCCATGAAAGAAAAAGAACACTTGCTCGGTAATTTTCTTTATGCAGGAGAGTTTAAG
AGAAATCAGCACAGATATTTCAAAAAAGTCCATGTCTTTTTATCTTTAAAATATCTATTTATCAAAGGCCAGACACAGTGGCTCACGCCT
GTAATCCCAGCACTTTGGGAGGCGGGCAGATCACAAGGTCAGGAGTTTGAGACCGGCCTGGCCAACATGGCGAAACCCCGTCTCTACTAA
AAATACAAAAATTTGCTGGGCATGGTGGCGCGTGCCTGTAATCCCAGCTACTAGGGGGGCTGAGGCAGGAGGATCGCTTGAACCTGAGAG
GCAGAGGTTGCAGTGAGCCAAGATCATGCCACTTTACTCCAGTCTGAGCAACAGAACGAGACTTAGTCAAAATAAATAAATAAATAAATA
AATAAATAAATAAATAAATAAATAAAATATATTTTTATCTTTAAAGTGTTTAACATTGGTATACTGTCTGTAGTTGGTTCATTAGTCGTT
TATAAAGGGTTATTTTCTCATGAGTGGAAACCTGAACAATCAGTTACCTTTGTGCCTATGCCTTCTCTCTCCTCAGACAGCTGGGATGTT
TATGGTGAAATGGCCTGTACAAGTTTAACTAAGACAACTTAACTTGCATTGTTAATCAAAAATTCTTTTCTCAAAGGGTTAACTGGTTGC
CATTTTGAATAGTATGTTCAAGGGTGTAGCTTCCTGTTTCTTTCCAAATTATAAGTAGCTACCTAAATATAGTATAATTATATATTAATA
ATATGGCTTGCTGGCACAGTAGTTTACCCTGTTATCTGTGTTTCATAATGGGGGCTGTATGAATATTATTTAAAACTAATAAAATGTTGC
CAGAATTATACTAAACTGTTGGATGAGATTAGGAGATCAGAGGCTGGACCTTCTCTTGATAATGCTTGTTTTGTTAAAGGTATAATGAAA
TAATTTGTATATGATTTGATGAAGATTAAAGACCCTTATTTTCCACAGCTTTAAAAAAAAACCTTTATTTATGATCAAGTAATAAAGATA
ATATTCTACTTGTGGGATCTTACATTACGGAAATAGTTTGACGTTTTTGACCTCAAGAGTATGTATAATTTGAAGAGATACTTTGTAACT
ATGCTTGGGTGATATTGAGCAGTTCCTAAAGAATAATTCATTTAAAAAAAAAGAAGAAAAAAAAAGAAGAATTCATTTAAATAACCTGAT
CCTTTCATTTGCCCTTTTCGAATTTACAGATACTACTTGTACATTTGGCATAACTAGTTGAAATTGGCCATTCGTACCATGAATAAATCT
GATAGTTTCCTTGTTAGGAAGAGATTGTAAGTAAATACAGTCATTGCAGTCAGAACAGTATTAGTGAACCTTGTGTGGTGTTTTCAAGCT
CTTTAAAATGGTACAATGTAGCACATTTGCTTTCATTTCTTTTTTTATTTTTGGCATTTGACCTTGTATTCTTTCTGAAGCTCTATATGT
GTTTTTATTAGTCAATAATCTGGCAAGTAGCACTTTGCCTGTGCAGTTTGCTGGAGTGTAGATGTACATATGAGGATTTCCCGGGAGGTG
CACTTCTTTGAAGAACTTCCTAAAGTACCTGTATAGTAGTTTTCATCTTAATATTCAGTATTTAATCTTCAGTTTGTGCTTTGTAAACTC
ATGACTTAATTGGTCAGAAACTTTTTAGTGTCTTTATAAAATTTTGTATACATATTTATACTAAACACATTGTGATACTGTATTTGAATG
AATGGTGAAAAAATATTTGCTATTGGAATTATGTGCACTGACAAGAAATGTTATAAAGAGAATGCCTTTAATAAATCTTTTCAGCATTAG


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FusionGenePPI for RASAL2_KIF14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RASAL2YWHAG, SH3KBP1, UBC, LATS2, YWHAB, CSNK1A1, CSNK1E, CTAGE5, TRAF1, USHBP1, CEP128, TMEM17, SHC1, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, CGN, LRFN1, DENND1A, SH3PXD2A, RTKN, SRGAP2, MAST3, EIF4E2, SIPA1L1, PPM1H, LIMA1, MAGI1, DENND4C, TESK2, DCLK1, ZNF638, NF1, HDAC4, CBY1, SRSF12, SYDE1, MAPKAP1, CDC25C, AGAP1, CDC25B, NADK, CDK16, GIGYF2, CAMSAP2, FAM110B, RALGPS2, USP21, KIAA1804, TIAM1, FAM53C, ANKRD34A, PHLDB2, LPIN3, PLEKHA7, KIF1C, INPP5E, TRIM25KIF14SVIL, SIRT7, TJP2, ZBTB1, OBSL1, SPINT2, EFNB2, SCGN, CD274, VSIG2, CA14, CD68, PNKD, NTRK1, CENPJ, MED4, CLK1, PCM1, CEP104, CEP162, CEP290, CEP120, CEP152, CNTROB, SPICE1, CEP128, CEP135, CEP63, CEP89, CNTRL, NINL, NIN, ODF2, RPGRIP1L, DCTN1, LCA5, RPGRIP1, ATP5I, URB1, TSNAX, CCDC14, TUBA1C, KLC4, HNRNPA1L2, KIAA1279, TMCO1, MCM2, EYA2, TEX28, CCDC89, EPHA1, GORASP2, SIGLECL1, CLMP, FCGRT, TMEM206, TNFRSF1A, PTPRN, TUBGCP2, TUBG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RASAL2_KIF14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RASAL2_KIF14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource