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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30486

FusionGeneSummary for RARA_STAT3

check button Fusion gene summary
Fusion gene informationFusion gene name: RARA_STAT3
Fusion gene ID: 30486
HgeneTgene
Gene symbol

RARA

STAT3

Gene ID

5914

6774

Gene nameretinoic acid receptor alphasignal transducer and activator of transcription 3
SynonymsNR1B1|RARADMIO|ADMIO1|APRF|HIES
Cytomap

17q21.2

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionretinoic acid receptor alphaRAR-alphanuclear receptor subfamily 1 group B member 1nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long formretinoic acid nuclear receptor alpha variant 1retinoic acid nuclear receptor alpha variant 2signal transducer and activator of transcription 3DNA-binding protein APRFacute-phase response factor
Modification date2018052320180527
UniProtAcc

P10276

P40763

Ensembl transtripts involved in fusion geneENST00000254066, ENST00000394089, 
ENST00000425707, ENST00000394086, 
ENST00000394081, ENST00000420042, 
ENST00000264657, ENST00000585517, 
ENST00000389272, ENST00000588969, 
ENST00000404395, ENST00000590776, 
Fusion gene scores* DoF score29 X 12 X 7=243612 X 12 X 7=1008
# samples 4213
** MAII scorelog2(42/2436*10)=-2.53605290024021
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1008*10)=-2.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RARA [Title/Abstract] AND STAT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRARA

GO:0007165

signal transduction

2825025

HgeneRARA

GO:0030853

negative regulation of granulocyte differentiation

19917671

HgeneRARA

GO:0032689

negative regulation of interferon-gamma production

18416830

HgeneRARA

GO:0032720

negative regulation of tumor necrosis factor production

18416830

HgeneRARA

GO:0032736

positive regulation of interleukin-13 production

18416830

HgeneRARA

GO:0032753

positive regulation of interleukin-4 production

18416830

HgeneRARA

GO:0032754

positive regulation of interleukin-5 production

18416830

HgeneRARA

GO:0045630

positive regulation of T-helper 2 cell differentiation

18416830

HgeneRARA

GO:0045892

negative regulation of transcription, DNA-templated

20080953

HgeneRARA

GO:0045893

positive regulation of transcription, DNA-templated

18845237|19850744|20080953

HgeneRARA

GO:0045944

positive regulation of transcription by RNA polymerase II

19850744

HgeneRARA

GO:0071300

cellular response to retinoic acid

19917671

HgeneRARA

GO:0071391

cellular response to estrogen stimulus

20080953

TgeneSTAT3

GO:0006355

regulation of transcription, DNA-templated

15664994|17344214

TgeneSTAT3

GO:0006606

protein import into nucleus

18234692

TgeneSTAT3

GO:0010628

positive regulation of gene expression

23820254

TgeneSTAT3

GO:0030522

intracellular receptor signaling pathway

17324931

TgeneSTAT3

GO:0032355

response to estradiol

12552091

TgeneSTAT3

GO:0032870

cellular response to hormone stimulus

12552091

TgeneSTAT3

GO:0033210

leptin-mediated signaling pathway

17344214

TgeneSTAT3

GO:0035278

miRNA mediated inhibition of translation

23820254

TgeneSTAT3

GO:0044320

cellular response to leptin stimulus

17344214

TgeneSTAT3

GO:0044321

response to leptin

17344214

TgeneSTAT3

GO:0045893

positive regulation of transcription, DNA-templated

19390056

TgeneSTAT3

GO:0045944

positive regulation of transcription by RNA polymerase II

17324931

TgeneSTAT3

GO:0051726

regulation of cell cycle

17344214

TgeneSTAT3

GO:0060396

growth hormone receptor signaling pathway

10925297

TgeneSTAT3

GO:0060397

JAK-STAT cascade involved in growth hormone signaling pathway

12552091

TgeneSTAT3

GO:0070102

interleukin-6-mediated signaling pathway

12359225|12552091|17324931

TgeneSTAT3

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

19390056|23820254

TgeneSTAT3

GO:2000637

positive regulation of gene silencing by miRNA

23820254


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-EW-A1J3-01ARARAchr17

38465538

+STAT3chr17

40500557

-
TCGALDBRCATCGA-EW-A1J3-01ARARAchr17

38465538

+STAT3chr17

40500538

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000254066ENST00000264657RARAchr17

38465538

+STAT3chr17

40500557

-
5UTR-intronENST00000254066ENST00000585517RARAchr17

38465538

+STAT3chr17

40500557

-
5UTR-intronENST00000254066ENST00000389272RARAchr17

38465538

+STAT3chr17

40500557

-
5UTR-intronENST00000254066ENST00000588969RARAchr17

38465538

+STAT3chr17

40500557

-
5UTR-intronENST00000254066ENST00000404395RARAchr17

38465538

+STAT3chr17

40500557

-
5UTR-intronENST00000254066ENST00000590776RARAchr17

38465538

+STAT3chr17

40500557

-
intron-5UTRENST00000394089ENST00000264657RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394089ENST00000585517RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394089ENST00000389272RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394089ENST00000588969RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394089ENST00000404395RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394089ENST00000590776RARAchr17

38465538

+STAT3chr17

40500557

-
intron-5UTRENST00000425707ENST00000264657RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000425707ENST00000585517RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000425707ENST00000389272RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000425707ENST00000588969RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000425707ENST00000404395RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000425707ENST00000590776RARAchr17

38465538

+STAT3chr17

40500557

-
intron-5UTRENST00000394086ENST00000264657RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394086ENST00000585517RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394086ENST00000389272RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394086ENST00000588969RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394086ENST00000404395RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394086ENST00000590776RARAchr17

38465538

+STAT3chr17

40500557

-
intron-5UTRENST00000394081ENST00000264657RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394081ENST00000585517RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394081ENST00000389272RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394081ENST00000588969RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394081ENST00000404395RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000394081ENST00000590776RARAchr17

38465538

+STAT3chr17

40500557

-
intron-5UTRENST00000420042ENST00000264657RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000420042ENST00000585517RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000420042ENST00000389272RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000420042ENST00000588969RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000420042ENST00000404395RARAchr17

38465538

+STAT3chr17

40500557

-
intron-intronENST00000420042ENST00000590776RARAchr17

38465538

+STAT3chr17

40500557

-
5UTR-5UTRENST00000254066ENST00000264657RARAchr17

38465538

+STAT3chr17

40500538

-
5UTR-5UTRENST00000254066ENST00000585517RARAchr17

38465538

+STAT3chr17

40500538

-
5UTR-intronENST00000254066ENST00000389272RARAchr17

38465538

+STAT3chr17

40500538

-
5UTR-5UTRENST00000254066ENST00000588969RARAchr17

38465538

+STAT3chr17

40500538

-
5UTR-5UTRENST00000254066ENST00000404395RARAchr17

38465538

+STAT3chr17

40500538

-
5UTR-intronENST00000254066ENST00000590776RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394089ENST00000264657RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394089ENST00000585517RARAchr17

38465538

+STAT3chr17

40500538

-
intron-intronENST00000394089ENST00000389272RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394089ENST00000588969RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394089ENST00000404395RARAchr17

38465538

+STAT3chr17

40500538

-
intron-intronENST00000394089ENST00000590776RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000425707ENST00000264657RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000425707ENST00000585517RARAchr17

38465538

+STAT3chr17

40500538

-
intron-intronENST00000425707ENST00000389272RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000425707ENST00000588969RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000425707ENST00000404395RARAchr17

38465538

+STAT3chr17

40500538

-
intron-intronENST00000425707ENST00000590776RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394086ENST00000264657RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394086ENST00000585517RARAchr17

38465538

+STAT3chr17

40500538

-
intron-intronENST00000394086ENST00000389272RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394086ENST00000588969RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394086ENST00000404395RARAchr17

38465538

+STAT3chr17

40500538

-
intron-intronENST00000394086ENST00000590776RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394081ENST00000264657RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394081ENST00000585517RARAchr17

38465538

+STAT3chr17

40500538

-
intron-intronENST00000394081ENST00000389272RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394081ENST00000588969RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000394081ENST00000404395RARAchr17

38465538

+STAT3chr17

40500538

-
intron-intronENST00000394081ENST00000590776RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000420042ENST00000264657RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000420042ENST00000585517RARAchr17

38465538

+STAT3chr17

40500538

-
intron-intronENST00000420042ENST00000389272RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000420042ENST00000588969RARAchr17

38465538

+STAT3chr17

40500538

-
intron-5UTRENST00000420042ENST00000404395RARAchr17

38465538

+STAT3chr17

40500538

-
intron-intronENST00000420042ENST00000590776RARAchr17

38465538

+STAT3chr17

40500538

-

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FusionProtFeatures for RARA_STAT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RARA

P10276

STAT3

P40763

Receptor for retinoic acid. Retinoic acid receptors bindas heterodimers to their target response elements in response totheir ligands, all-trans or 9-cis retinoic acid, and regulate geneexpression in various biological processes. The RXR/RARheterodimers bind to the retinoic acid response elements (RARE)composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In theabsence of ligand, the RXR-RAR heterodimers associate with amultiprotein complex containing transcription corepressors thatinduce histone acetylation, chromatin condensation andtranscriptional suppression. On ligand binding, the corepressorsdissociate from the receptors and associate with the coactivatorsleading to transcriptional activation. RARA plays an essentialrole in the regulation of retinoic acid-induced germ celldevelopment during spermatogenesis. Has a role in the survival ofearly spermatocytes at the beginning prophase of meiosis. InSertoli cells, may promote the survival and development of earlymeiotic prophase spermatocytes. In concert with RARG, required forskeletal growth, matrix homeostasis and growth plate function (Bysimilarity). {ECO:0000250|UniProtKB:P11416,ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19850744,ECO:0000269|PubMed:20215566}. Signal transducer and transcription activator thatmediates cellular responses to interleukins, KITLG/SCF, LEP andother growth factors (PubMed:10688651, PubMed:12359225,PubMed:12873986, PubMed:15194700, PubMed:17344214,PubMed:18242580, PubMed:23084476). Once activated, recruitscoactivators, such as NCOA1 or MED1, to the promoter region of thetarget gene (PubMed:17344214). May mediate cellular responses toactivated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Bindsto the interleukin-6 (IL-6)-responsive elements identified in thepromoters of various acute-phase protein genes (PubMed:12359225).Activated by IL31 through IL31RA (PubMed:15194700). Acts as aregulator of inflammatory response by regulating differentiationof naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells(Treg): deacetylation and oxidation of lysine residues by LOXL3,leads to disrupt STAT3 dimerization and inhibit its transcriptionactivity (PubMed:28065600). Involved in cell cycle regulation byinducing the expression of key genes for the progression from G1to S phase, such as CCND1 (PubMed:17344214). Mediates the effectsof LEP on melanocortin production, body energy homeostasis andlactation (By similarity). May play an apoptotic role bytransctivating BIRC5 expression under LEP activation(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy byinhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucialrole in basal beta cell functions, such as regulation of insulinsecretion (By similarity). {ECO:0000250|UniProtKB:P42227,ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:12359225,ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15194700,ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580,ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:28065600}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RARA_STAT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RARA_STAT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RARANRBF2, ZBTB16, MECR, RXRG, RXRB, NCOA6, GADD45G, GADD45A, NRIP1, KAT2B, HDAC3, HDAC4, TDG, PML, TRIP4, KDM5A, RXRA, POU2F1, NCOR2, NR0B2, BAG1, TADA3, NCOR1, NKX2-1, TRIM24, IRX4, SP1, NPAS2, CLOCK, ARNTL, NR2E3, CCND3, NCOA2, SRC, AJUBA, LIMD1, WTIP, SKI, HR, PIN1, SUV39H1, PSMC5, EP300, PARP1, MED6, TOP2B, SAP130, HNRNPU, RFC4, NPM1, MRTO4, SNRNP40, MED1, NCOA1, HMGA1, RUVBL1, RUNX1, SIAH1, RARA, HDAC2, NCOA3, CREBBP, LRIF1, KLF5, SMARCD3, ARID1A, SPI1, PRDX6, NR1H2, ITGB1BP2, MED25, MAPK6, FOXO1, MAPK1, TRIM32, PHF8, TNIP1, HACE1, SQSTM1, UBQLN1, ARID5A, UBE3A, PRAM1, FAS, PRAME, TBL1XR1, SUZ12, EZH2, USP7, TMEM54, MMS19, AKT1, FN1, WWOX, E2F1, MBD3, MTA2, CBX5, CEBPA, HDAC1, NSD1, TEKT4, SNW1, SIRT1, ACTN4, SRF, MDM2, ZNF131, RARG, RARB, TRIM25STAT3RPA2, RET, EGFR, EPHA5, JAK1, TRIP10, AR, NR3C1, MYOD1, NDUFA13, KAT5, CREBBP, EP300, SMAD1, STAT1, PTPN11, IL1RAP, IL2RB, FES, NCOA1, ESR1, PIAS3, PTPN2, CCND1, HSP90AA1, KHDRBS1, ERBB2, MTOR, ELP2, PML, PTK2, JUN, IFNAR1, TSHR, HNF1A, IL6ST, PDIA3, NFKB1, RELA, IL6R, NMI, EIF2AK2, RAC1, SRC, BMX, GTF2I, CDKN1A, GHR, CCR5, JAK2, HIF1A, MET, CTR9, ALK, HOXC11, STAT6, SS18L1, PCBD2, SP1, BCL3, PELP1, DNMT1, HDAC1, RB1, HDAC2, HDAC3, STAT3, NFKBIZ, CEBPB, SMARCA4, CDK9, FGFR1, FGFR2, PPP2R1B, TIRAP, PRKCD, MAPK8, PGR, SIRT1, SETD7, KDM1A, RUNX2, ELAVL1, BHLHE40, CD44, DAXX, SOCS7, IRAK1, MAP3K7, MAPK1, FHL2, TRAF6, ZFHX3, APEX1, PTPN1, JAK3, TRIM28, HCK, LYN, FYN, FGR, HES1, HES5, SIN3A, BICD1, ECH1, SRI, SULT2A1, MRPS31, BCKDK, CORO1A, GNL3, OGDHL, NR4A1, CAPN1, MORC4, RPS9, HIVEP1, ASXL1, RPL11, NIF3L1, SUPT20H, HLA-A, AMBP, CAPNS1, LAMB2, HNRNPM, SIAH1, SIAH2, SCAF11, MAP3K13, SPRY1, SSSCA1, ZFPM2, ARFIP2, SRRT, ERBB2IP, IL22RA1, CEP120, LUC7L2, PSMG3, ARFIP1, IVNS1ABP, MSH2, PUS7, TBC1D15, TBCD, BRD4, ADRB2, COPS5, HIC1, USP22, GNB2, GADD45A, BLK, LMO2, SYK, SHMT2, MOV10, NXF1, NFKB2, AZU1, CACNG2, NXPH2, DDX19B, RP2, TRPV5, TCEAL1, IDE, NTRK1, BRWD1, FAM208B, CCDC87, DOK2, DOK3, FAM117B, GSTCD, HESX1, KRTAP10-7, MAPKAPK2, MPZL1, NUFIP2, PAQR7, PIK3R3, RABGAP1, SH2D2A, TM4SF19, TWIST1, VPS39, WDFY3, ZNF281, ZNF829, ABL2, CA8, CBL, DTNA, LASP1, LCK, PIK3R1, PIK3R2, PPARD, SH3BP2, BATF3, CHTF18, CNDP2, KLF15, NACAD, NXT2, OFCC1, PINK1, TDG, ZNF557, ATF3, MNDA, PAFAH1B2, IGF1R, PDGFRA, PDGFRB, STAT5B, ANKRD26P1, KIF27, PLA2G4A, LRRFIP2, HSP90B1, RRAD, FBXW7, STMN1, MAGEC2, RFWD2, CREB1, RELB, CDK15, LRRC32, IL20RA, TBC1D22B, TMEM206, MBLAC2, VASN, C3AR1, PVR, DLK2, ANXA2, TRIM25, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RARA_STAT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRARAP10276DB00210AdapaleneRetinoic acid receptor alphasmall moleculeapproved
HgeneRARAP10276DB00459AcitretinRetinoic acid receptor alphasmall moleculeapproved
HgeneRARAP10276DB00982IsotretinoinRetinoic acid receptor alphasmall moleculeapproved
HgeneRARAP10276DB00523AlitretinoinRetinoic acid receptor alphasmall moleculeapproved|investigational
HgeneRARAP10276DB00799TazaroteneRetinoic acid receptor alphasmall moleculeapproved|investigational
HgeneRARAP10276DB00755TretinoinRetinoic acid receptor alphasmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for RARA_STAT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRARAC0023487Acute Promyelocytic Leukemia22CTD_human;HPO;ORPHANET
HgeneRARAC0036341Schizophrenia3PSYGENET
HgeneRARAC0005586Bipolar Disorder1PSYGENET
HgeneRARAC0010701Phyllodes Tumor1CTD_human
HgeneRARAC0085183Neoplasms, Second Primary1CTD_human
HgeneRARAC0149940Sciatic Neuropathy1CTD_human
HgeneRARAC0206650Fibroadenoma1CTD_human
HgeneRARAC0525045Mood Disorders1PSYGENET
HgeneRARAC1458155Mammary Neoplasms1CTD_human
HgeneRARAC2239176Liver carcinoma1CTD_human
TgeneSTAT3C3489795Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant4CTD_human;ORPHANET;UNIPROT
TgeneSTAT3C0018800Cardiomegaly3CTD_human
TgeneSTAT3C0033578Prostatic Neoplasms3CTD_human
TgeneSTAT3C0001418Adenocarcinoma2CTD_human
TgeneSTAT3C0007137Squamous cell carcinoma2CTD_human
TgeneSTAT3C0009324Ulcerative Colitis2CTD_human
TgeneSTAT3C0021368Inflammation2CTD_human
TgeneSTAT3C0027627Neoplasm Metastasis2CTD_human
TgeneSTAT3C0030297Pancreatic Neoplasm2CTD_human
TgeneSTAT3C0878544Cardiomyopathies2CTD_human
TgeneSTAT3C0004153Atherosclerosis1CTD_human
TgeneSTAT3C0004364Autoimmune Diseases1CTD_human;HPO
TgeneSTAT3C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneSTAT3C0007621Neoplastic Cell Transformation1CTD_human
TgeneSTAT3C0007786Brain Ischemia1CTD_human
TgeneSTAT3C0007873Uterine Cervical Neoplasm1CTD_human
TgeneSTAT3C0009375Colonic Neoplasms1CTD_human
TgeneSTAT3C0011581Depressive disorder1PSYGENET
TgeneSTAT3C0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
TgeneSTAT3C0015967Fever1CTD_human
TgeneSTAT3C0016059Fibrosis1CTD_human
TgeneSTAT3C0019189Hepatitis, Chronic1CTD_human
TgeneSTAT3C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneSTAT3C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneSTAT3C0023492Leukemia, T-Cell1CTD_human
TgeneSTAT3C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
TgeneSTAT3C0023903Liver neoplasms1CTD_human
TgeneSTAT3C0024232Lymphatic Metastasis1CTD_human
TgeneSTAT3C0024667Animal Mammary Neoplasms1CTD_human
TgeneSTAT3C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneSTAT3C0025149Medulloblastoma1CTD_human
TgeneSTAT3C0025261Memory Disorders1CTD_human
TgeneSTAT3C0033860Psoriasis1CTD_human
TgeneSTAT3C0035126Reperfusion Injury1CTD_human
TgeneSTAT3C0038356Stomach Neoplasms1CTD_human
TgeneSTAT3C0079772T-Cell Lymphoma1CTD_human
TgeneSTAT3C0206180Ki-1+ Anaplastic Large Cell Lymphoma1CTD_human
TgeneSTAT3C0235833Congenital diaphragmatic hernia1CTD_human
TgeneSTAT3C0333641Atrophic1CTD_human
TgeneSTAT3C0740392Infarction, Middle Cerebral Artery1CTD_human
TgeneSTAT3C0919267ovarian neoplasm1CTD_human
TgeneSTAT3C0993582Arthritis, Experimental1CTD_human
TgeneSTAT3C1168401Squamous cell carcinoma of the head and neck1CTD_human
TgeneSTAT3C1458155Mammary Neoplasms1CTD_human
TgeneSTAT3C1876165Copper-Overload Cirrhosis1CTD_human
TgeneSTAT3C3495559Juvenile arthritis1CTD_human
TgeneSTAT3C3887645Job Syndrome1CTD_human
TgeneSTAT3C4014795AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET1ORPHANET;UNIPROT