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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30481

FusionGeneSummary for RARA_PSME3

check button Fusion gene summary
Fusion gene informationFusion gene name: RARA_PSME3
Fusion gene ID: 30481
HgeneTgene
Gene symbol

RARA

PSME3

Gene ID

5914

10197

Gene nameretinoic acid receptor alphaproteasome activator subunit 3
SynonymsNR1B1|RARHEL-S-283|Ki|PA28-gamma|PA28G|PA28gamma|REG-GAMMA
Cytomap

17q21.2

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionretinoic acid receptor alphaRAR-alphanuclear receptor subfamily 1 group B member 1nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long formretinoic acid nuclear receptor alpha variant 1retinoic acid nuclear receptor alpha variant 2proteasome activator complex subunit 311S regulator complex gamma subunit11S regulator complex subunit gammaKi antigenKi nuclear autoantigenPA28 gamma variant 5REG gamma-3activator of multicatalytic protease subunit 3epididymis secretory protein L
Modification date2018052320180523
UniProtAcc

P10276

P61289

Ensembl transtripts involved in fusion geneENST00000254066, ENST00000394089, 
ENST00000425707, ENST00000394086, 
ENST00000394081, ENST00000420042, 
ENST00000545225, ENST00000590720, 
ENST00000541124, ENST00000592578, 
ENST00000441946, ENST00000293362, 
ENST00000592169, 
Fusion gene scores* DoF score29 X 12 X 7=24363 X 3 X 2=18
# samples 424
** MAII scorelog2(42/2436*10)=-2.53605290024021
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RARA [Title/Abstract] AND PSME3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRARA

GO:0007165

signal transduction

2825025

HgeneRARA

GO:0030853

negative regulation of granulocyte differentiation

19917671

HgeneRARA

GO:0032689

negative regulation of interferon-gamma production

18416830

HgeneRARA

GO:0032720

negative regulation of tumor necrosis factor production

18416830

HgeneRARA

GO:0032736

positive regulation of interleukin-13 production

18416830

HgeneRARA

GO:0032753

positive regulation of interleukin-4 production

18416830

HgeneRARA

GO:0032754

positive regulation of interleukin-5 production

18416830

HgeneRARA

GO:0045630

positive regulation of T-helper 2 cell differentiation

18416830

HgeneRARA

GO:0045892

negative regulation of transcription, DNA-templated

20080953

HgeneRARA

GO:0045893

positive regulation of transcription, DNA-templated

18845237|19850744|20080953

HgeneRARA

GO:0045944

positive regulation of transcription by RNA polymerase II

19850744

HgeneRARA

GO:0071300

cellular response to retinoic acid

19917671

HgeneRARA

GO:0071391

cellular response to estrogen stimulus

20080953

TgenePSME3

GO:0061136

regulation of proteasomal protein catabolic process

18309296

TgenePSME3

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

18309296


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A041-01ARARAchr17

38512898

+PSME3chr17

40989666

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000254066ENST00000545225RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-3CDSENST00000254066ENST00000590720RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-3UTRENST00000254066ENST00000541124RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000254066ENST00000592578RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000254066ENST00000441946RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000254066ENST00000293362RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000254066ENST00000592169RARAchr17

38512898

+PSME3chr17

40989666

+
intron-3CDSENST00000394089ENST00000545225RARAchr17

38512898

+PSME3chr17

40989666

+
intron-3CDSENST00000394089ENST00000590720RARAchr17

38512898

+PSME3chr17

40989666

+
intron-3UTRENST00000394089ENST00000541124RARAchr17

38512898

+PSME3chr17

40989666

+
intron-intronENST00000394089ENST00000592578RARAchr17

38512898

+PSME3chr17

40989666

+
intron-intronENST00000394089ENST00000441946RARAchr17

38512898

+PSME3chr17

40989666

+
intron-intronENST00000394089ENST00000293362RARAchr17

38512898

+PSME3chr17

40989666

+
intron-intronENST00000394089ENST00000592169RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-3CDSENST00000425707ENST00000545225RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-3CDSENST00000425707ENST00000590720RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-3UTRENST00000425707ENST00000541124RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000425707ENST00000592578RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000425707ENST00000441946RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000425707ENST00000293362RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000425707ENST00000592169RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-3CDSENST00000394086ENST00000545225RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-3CDSENST00000394086ENST00000590720RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-3UTRENST00000394086ENST00000541124RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000394086ENST00000592578RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000394086ENST00000441946RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000394086ENST00000293362RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000394086ENST00000592169RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-3CDSENST00000394081ENST00000545225RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-3CDSENST00000394081ENST00000590720RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-3UTRENST00000394081ENST00000541124RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000394081ENST00000592578RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000394081ENST00000441946RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000394081ENST00000293362RARAchr17

38512898

+PSME3chr17

40989666

+
3UTR-intronENST00000394081ENST00000592169RARAchr17

38512898

+PSME3chr17

40989666

+
intron-3CDSENST00000420042ENST00000545225RARAchr17

38512898

+PSME3chr17

40989666

+
intron-3CDSENST00000420042ENST00000590720RARAchr17

38512898

+PSME3chr17

40989666

+
intron-3UTRENST00000420042ENST00000541124RARAchr17

38512898

+PSME3chr17

40989666

+
intron-intronENST00000420042ENST00000592578RARAchr17

38512898

+PSME3chr17

40989666

+
intron-intronENST00000420042ENST00000441946RARAchr17

38512898

+PSME3chr17

40989666

+
intron-intronENST00000420042ENST00000293362RARAchr17

38512898

+PSME3chr17

40989666

+
intron-intronENST00000420042ENST00000592169RARAchr17

38512898

+PSME3chr17

40989666

+

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FusionProtFeatures for RARA_PSME3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RARA

P10276

PSME3

P61289

Receptor for retinoic acid. Retinoic acid receptors bindas heterodimers to their target response elements in response totheir ligands, all-trans or 9-cis retinoic acid, and regulate geneexpression in various biological processes. The RXR/RARheterodimers bind to the retinoic acid response elements (RARE)composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In theabsence of ligand, the RXR-RAR heterodimers associate with amultiprotein complex containing transcription corepressors thatinduce histone acetylation, chromatin condensation andtranscriptional suppression. On ligand binding, the corepressorsdissociate from the receptors and associate with the coactivatorsleading to transcriptional activation. RARA plays an essentialrole in the regulation of retinoic acid-induced germ celldevelopment during spermatogenesis. Has a role in the survival ofearly spermatocytes at the beginning prophase of meiosis. InSertoli cells, may promote the survival and development of earlymeiotic prophase spermatocytes. In concert with RARG, required forskeletal growth, matrix homeostasis and growth plate function (Bysimilarity). {ECO:0000250|UniProtKB:P11416,ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19850744,ECO:0000269|PubMed:20215566}. Subunit of the 11S REG-gamma (also called PA28-gamma)proteasome regulator, a doughnut-shaped homoheptamer whichassociates with the proteasome. 11S REG-gamma activates thetrypsin-like catalytic subunit of the proteasome but inhibits thechymotrypsin-like and postglutamyl-preferring (PGPH) subunits.Facilitates the MDM2-p53/TP53 interaction which promotesubiquitination- and MDM2-dependent proteasomal degradation ofp53/TP53, limiting its accumulation and resulting in inhibitedapoptosis after DNA damage. May also be involved in cell cycleregulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition(PubMed:25361978). {ECO:0000269|PubMed:10835274,ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824,ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296,ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RARA_PSME3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RARA_PSME3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RARANRBF2, ZBTB16, MECR, RXRG, RXRB, NCOA6, GADD45G, GADD45A, NRIP1, KAT2B, HDAC3, HDAC4, TDG, PML, TRIP4, KDM5A, RXRA, POU2F1, NCOR2, NR0B2, BAG1, TADA3, NCOR1, NKX2-1, TRIM24, IRX4, SP1, NPAS2, CLOCK, ARNTL, NR2E3, CCND3, NCOA2, SRC, AJUBA, LIMD1, WTIP, SKI, HR, PIN1, SUV39H1, PSMC5, EP300, PARP1, MED6, TOP2B, SAP130, HNRNPU, RFC4, NPM1, MRTO4, SNRNP40, MED1, NCOA1, HMGA1, RUVBL1, RUNX1, SIAH1, RARA, HDAC2, NCOA3, CREBBP, LRIF1, KLF5, SMARCD3, ARID1A, SPI1, PRDX6, NR1H2, ITGB1BP2, MED25, MAPK6, FOXO1, MAPK1, TRIM32, PHF8, TNIP1, HACE1, SQSTM1, UBQLN1, ARID5A, UBE3A, PRAM1, FAS, PRAME, TBL1XR1, SUZ12, EZH2, USP7, TMEM54, MMS19, AKT1, FN1, WWOX, E2F1, MBD3, MTA2, CBX5, CEBPA, HDAC1, NSD1, TEKT4, SNW1, SIRT1, ACTN4, SRF, MDM2, ZNF131, RARG, RARB, TRIM25PSME3FXR2, WDR25, ZCCHC10, KANSL1, NUDT18, BBS2, SERF2, PSME3, ITPKB, MCC, RNPS1, ATP5B, ADAP1, HSPA5, MDM2, TP53, CDKN1A, CDKN2A, BAP1, TAF1D, USP43, WDR48, SLX1B, UBC, SMURF1, NCOA3, DTNBP1, TBXA2R, PML, CHEK2, PARD3, AICDA, PSMD4, ATN1, COIL, PSMA1, PSMA7, PSMB1, PSMB4, PSMA5, PSMB3, PSMA4, PSMA6, PSMB2, PSMD11, PSMC5, PSMD1, PSMD2, PSMD8, PSMC2, PSMD12, PSMA8, MYH9, VCAM1, ITGA4, CBX2, CBX4, PARK2, NPM1, BAG3, CLK3, CLK2, YWHAQ, C1QBP, ADARB2, GTPBP4, SHFM1, PSMD14, CREBBP, SIRT1, PRKAB2, TUBGCP3, HUWE1, PFDN5, SPG7, DIP2A, FBXO7, TXN2, PRR13, EAF1, TNFAIP8L1, MOV10, NXF1, CAMTA2, FAM192A, TSHZ3, CSRP2BP, YEATS2, PRR14L, SALL2, SNAPC4, ZKSCAN1, ZNF324, THAP11, FLYWCH2, GATAD2A, SNAPC1, MGA, CHD8, ZBTB9, STRBP, ZZZ3, TSR1, TRMT6, GTF2F1, DIEXF, L3MBTL2, MBTD1, TADA2A, FBXL19, RALY, ELF2, ZNF891, TRIM33, MBIP, PCGF6, RAD18, RTEL1, SNAPC3, RAB40A, CMSS1, RSRP1, LIG3, RAB40AL, LUC7L, PSMB9, CCAR2, AHCYL1, HDGF, HIBCH, AHNAK, ARHGEF2, NUP50, PSMA2, PSMA3, SF3A3, SF3B2, SRRT, SRSF2, SF3B3, SF3B5, SFN, MED4, LCA5, EAF2, DEPTOR, ZNF526, KLF2, PIAS1, UBE2I, HYPK, CDC25B, RASL10B, RPL15, MRPS34, CCDC69, TP53TG5, KLHDC8A, HUS1B, TSPYL6, ZMAT5, SSH3, PPM1E, GATAD2B, TSPYL1, DLD, HSD17B10, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RARA_PSME3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRARAP10276DB00210AdapaleneRetinoic acid receptor alphasmall moleculeapproved
HgeneRARAP10276DB00459AcitretinRetinoic acid receptor alphasmall moleculeapproved
HgeneRARAP10276DB00982IsotretinoinRetinoic acid receptor alphasmall moleculeapproved
HgeneRARAP10276DB00523AlitretinoinRetinoic acid receptor alphasmall moleculeapproved|investigational
HgeneRARAP10276DB00799TazaroteneRetinoic acid receptor alphasmall moleculeapproved|investigational
HgeneRARAP10276DB00755TretinoinRetinoic acid receptor alphasmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for RARA_PSME3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRARAC0023487Acute Promyelocytic Leukemia22CTD_human;HPO;ORPHANET
HgeneRARAC0036341Schizophrenia3PSYGENET
HgeneRARAC0005586Bipolar Disorder1PSYGENET
HgeneRARAC0010701Phyllodes Tumor1CTD_human
HgeneRARAC0085183Neoplasms, Second Primary1CTD_human
HgeneRARAC0149940Sciatic Neuropathy1CTD_human
HgeneRARAC0206650Fibroadenoma1CTD_human
HgeneRARAC0525045Mood Disorders1PSYGENET
HgeneRARAC1458155Mammary Neoplasms1CTD_human
HgeneRARAC2239176Liver carcinoma1CTD_human
TgenePSME3C0019693HIV Infections1CTD_human