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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3048

FusionGeneSummary for ASTN2_TNFAIP8L1

check button Fusion gene summary
Fusion gene informationFusion gene name: ASTN2_TNFAIP8L1
Fusion gene ID: 3048
HgeneTgene
Gene symbol

ASTN2

TNFAIP8L1

Gene ID

23245

126282

Gene nameastrotactin 2TNF alpha induced protein 8 like 1
SynonymsbA67K19.1TIPE1
Cytomap

9q33.1

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionastrotactin-2tumor necrosis factor alpha-induced protein 8-like protein 1TNF alpha-induced protein 8-like protein 1TNFAIP8-like protein 1oxidative stress-regulated gene-betaoxy-betatumor necrosis factor, alpha induced protein 8 like 1tumor necrosis factor, alpha
Modification date2018051920180523
UniProtAcc

O75129

Q8WVP5

Ensembl transtripts involved in fusion geneENST00000373996, ENST00000313400, 
ENST00000361209, ENST00000361477, 
ENST00000288520, ENST00000341734, 
ENST00000358637, 
ENST00000327473, 
ENST00000598107, ENST00000536716, 
Fusion gene scores* DoF score11 X 11 X 6=7261 X 1 X 1=1
# samples 111
** MAII scorelog2(11/726*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ASTN2 [Title/Abstract] AND TNFAIP8L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-G9-A9S7-01AASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000373996ENST00000327473ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-intronENST00000373996ENST00000598107ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-5UTRENST00000373996ENST00000536716ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-5UTRENST00000313400ENST00000327473ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-intronENST00000313400ENST00000598107ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-5UTRENST00000313400ENST00000536716ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-5UTRENST00000361209ENST00000327473ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-intronENST00000361209ENST00000598107ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-5UTRENST00000361209ENST00000536716ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-5UTRENST00000361477ENST00000327473ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-intronENST00000361477ENST00000598107ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-5UTRENST00000361477ENST00000536716ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-5UTRENST00000288520ENST00000327473ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-intronENST00000288520ENST00000598107ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-5UTRENST00000288520ENST00000536716ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-5UTRENST00000341734ENST00000327473ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-intronENST00000341734ENST00000598107ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
5CDS-5UTRENST00000341734ENST00000536716ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
intron-5UTRENST00000358637ENST00000327473ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
intron-intronENST00000358637ENST00000598107ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+
intron-5UTRENST00000358637ENST00000536716ASTN2chr9

119249638

-TNFAIP8L1chr19

4651879

+

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FusionProtFeatures for ASTN2_TNFAIP8L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASTN2

O75129

TNFAIP8L1

Q8WVP5

Acts as a negative regulator of mTOR activity.{ECO:0000250|UniProtKB:Q8K288}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ASTN2_TNFAIP8L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ASTN2_TNFAIP8L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ASTN2CCT6B, FBXL12, CCT4TNFAIP8L1DVL3, GRK5, APP, FBXW5, PSME3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ASTN2_TNFAIP8L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ASTN2_TNFAIP8L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASTN2C0036341Schizophrenia2PSYGENET
HgeneASTN2C0004352Autistic Disorder1CTD_human
HgeneASTN2C0005586Bipolar Disorder1PSYGENET
HgeneASTN2C0236733Amphetamine-Related Disorders1CTD_human
HgeneASTN2C0338480Common Migraine1CTD_human